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Crizotinib

More information: STITCH, PubChem (stereo-specific compound: 1) and possibly Wikipedia

ATC Codes: None found

Side effects

Options: Hide MedDRA Preferred Terms

MedDRA Preferred Term Side effect Data for drug Placebo Labels
1 2 3
Diarrhoea Diarrhoea 0% - 60% x x x
Constipation Constipation 0% - 42% x x x
Lymphopenia Lymphopenia 9% - 60% x
Eye disorder Eye disorder 0% - 59.9% x x x
Nausea Nausea 1% - 55% x x x
Visual impairment Disorder sight 0% - 60% x x x
Visual disturbance x x
Visual impairment x x x
Asthenia Fatigue 26% - 27% x x x
Fatigue Fatigue 26% - 27% x x x
Decreased appetite Decreased appetite 2.33% - 27.3% x x x
Vomiting Vomiting 0% - 47% x x x
Oedema Oedema 0% - 39% x x x
Malnutrition Malnutrition 2.33% - 27.3% x x
Dysgeusia Dysgeusia 0% - 26% x x x
Neutropenia Neutropenia 2% - 49% x x
Leukopenia Leukopenia 9% x x
Dermatitis Rash 0% - 9% x x x
Rash Rash 0% - 9% x x x
Transaminases increased Transaminases increased 1% - 8% x x x
Blood alkaline phosphatase increased Blood alkaline phosphatase increased 8% x x
Phosphatase alkaline increased x
Hypokalaemia Hypokalaemia 1% - 18% x
Hypophosphataemia Hypophosphataemia 3% - 28% x x
Skin disorder Unspecified disorder of skin and subcutaneous tissue 0% - 8.72% x x
Pneumonia Pneumonia 4.1% x x x
Dyspepsia Dyspepsia 0% - 8% x x x
Renal cyst Renal cyst 0% - 4.07% x x x
Pulmonary embolism Pulmonary embolism 1.2% - 6% x
Dizziness Syncope 0% - 3% x x
Dizziness 0% - 22% x x x
Shock Syncope 0% - 3% x x
Syncope Syncope 0% - 3% x x
Loss of consciousness Syncope 0% - 3% x x
Electrocardiogram QT prolonged Electrocardiogram QT prolonged 0% - 5% x x x
Electrocardiogram QT corrected interval prolonged 2.9% x
Mediastinal disorder Mediastinal disorder 0.581% - 4.07% x x x
Urethral disorder Urinary tract disorder 0% - 4.07% x x
Urinary tract disorder Urinary tract disorder 0% - 4.07% x x
Interstitial lung disease Interstitial lung disease 0.581% - 4.07% x x x
Dyspnoea Dyspnoea 1.2% - 2.3% x
Upper respiratory tract infection Upper respiratory tract infection 0% - 26% x
Weight decreased Weight decreased 0% - 10% x
Hepatic failure Hepatic failure 1% x x x
Gastrointestinal perforation Gastrointestinal perforation 1% x
Abscess Abscess x
Anaemia Anaemia x
Arrhythmia Arrhythmia x
Infection Infection x x
Diplopia Diplopia x x
Localised oedema Localised oedema x x
Body temperature increased Body temperature increased x
Vitreous floaters Vitreous floaters x x x
Gastrointestinal disorder Gastrointestinal disorder x x x
Cardiac disorder Cardiac disorder x x x
Hypoaesthesia Hypoaesthesia x x x
Nervous system disorder Nervous system disorder x x x
Neuralgia Neuralgia x x x
Paraesthesia Paraesthesia x x x
Neuropathy peripheral Neuropathy peripheral x x x
Neuropathy x x x
Acute respiratory distress syndrome Acute respiratory distress syndrome x x x
Sinus bradycardia Sinus bradycardia x x
Burning sensation Burning sensation x
Photopsia Photopsia x x x
Photophobia Photophobia x x
Oedema peripheral Oedema peripheral x x
Hepatic function abnormal Hepatic function abnormal x x
Periorbital oedema Periorbital oedema x x
Peripheral sensory neuropathy Peripheral sensory neuropathy x x x
Generalised oedema Generalised oedema x x
Fluid retention Generalised oedema x x
Gamma-glutamyltransferase increased Gamma-glutamyltransferase increased x x
Muscular weakness Muscular weakness x x x
Aspartate aminotransferase increased Aspartate aminotransferase increased x x
Alanine aminotransferase increased Alanine aminotransferase increased x x
Polyneuropathy Polyneuropathy x x x
Haemoglobin decreased Haemoglobin decreased x
Visual acuity reduced Visual acuity reduced x x
Dizziness postural Dizziness postural x x
Hepatotoxicity Hepatotoxicity x x x
Skin burning sensation Skin burning sensation x x
Disease progression Disease progression x
Sepsis Sepsis x
Hepatobiliary disease Hepatobiliary disease x x
Congenital renal cyst Congenital renal cyst x x
Vision blurred Vision blurred x x x
Dysaesthesia Dysaesthesia x x x
Bradycardia Bradycardia 0% - 5% x x x
Face oedema Face oedema x x
Gait disturbance Gait disturbance x x x
Balance disorder Balance disorder x x
Febrile neutropenia Febrile neutropenia x x
Infestation Infestation NOS x
Local swelling Local swelling x x
Neutrophil count decreased Neutrophil count decreased x x
Drug-induced liver injury Drug-induced liver injury x
Respiratory failure Respiratory failure x

Indications

Information about indications was extracted from the indications and usage sections of the labels.

CRIZOTINIB

Side effects:60
Source:FDA Structured Product Label

Chemical Structure: / XALKORI (crizotinib)

Side effects:66
Source:medicines.org.au

crizotinib / crizotinib

Side effects:79
Source:EMA

Color scheme:

standard – alternative

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    infrequent (0.1% to 1%)
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    not found on label