Alendronate
Side effects
Options: Show MedDRA Preferred Terms, display all 45 labels
| Side effect | Data for drug | Placebo | Labels | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | |||
| Musculoskeletal pain | postmarketing, 2.9% - 4.1% | 2.5% | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Dyspepsia | 0% - 4.2% | 0% - 3.5% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Abdominal pain | 0% - 6.6% | 0% - 4.8% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Pain | 0.4% - 4.1% | 0.3% - 2.5% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Regurgitation | 0% - 4.7% | 0% - 4.3% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Gastrooesophageal reflux disease | 0% - 3.2% | 0% - 3.2% | x | x | x | x | ||||||||||||||||
| Flatulence | 0% - 4.1% | 0% - 4.3% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Nausea | postmarketing, 0% - 3.6% | 0% - 4% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Diarrhoea | 0% - 3.1% | 0% - 1.8% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Abdominal distension | 0% - 1.6% | 0% - 1.3% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Dysphagia | 0% - 1% | 0% - 0.8% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Vomiting | postmarketing, 0.1% - 1% | 0% - 1.5% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Melaena | 0% - 1.3% | 0% - 0.6% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Constipation | 0% - 3.1% | 0% - 1.8% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Headache | 0% - 2.6% | 0.2% - 1.5% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Gastric ulcer | 0% - 1.1% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||
| Dysgeusia | postmarketing, 0.1% - 0.5% | 0% - 1% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Gastritis | 0% - 1.1% | 0.7% - 1.3% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Cramp muscle | 0% - 1.1% | 0.1% - 1% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Oesophageal ulcer | postmarketing, 0.1% - 1.5% | 0% - 1.5% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Acute phase reaction | postmarketing | x | x | x | x | x | x | x | x | x | x | x | ||||||||||
| Alopecia | postmarketing | x | x | x | x | x | x | x | ||||||||||||||
| Angioedema | postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Asthenia | postmarketing | x | x | x | x | x | x | x | ||||||||||||||
| Chest pain | postmarketing | x | ||||||||||||||||||||
| Infection | postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||||
| Duodenal ulcer | postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Toxic epidermal necrolysis | postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Episcleritis | postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | |||||||||
| Oesophageal stenosis | postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Oesophagitis | postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Rash | postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Femur fracture | postmarketing | x | ||||||||||||||||||||
| Body temperature increased | postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Hypersensitivity | postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Hypocalcaemia | postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Osteomyelitis | postmarketing | x | ||||||||||||||||||||
| Pruritus | postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Scleritis | postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||
| Stevens-Johnson syndrome | postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Ulcer | postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Erythema | postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Urticaria | postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Uveitis | postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Vertigo | postmarketing | x | x | x | x | x | x | x | x | x | x | |||||||||||
| Oedema peripheral | postmarketing | x | x | x | x | x | x | x | x | x | ||||||||||||
| Impaired healing | postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||||
| Dry skin | postmarketing | x | ||||||||||||||||||||
| Joint swelling | postmarketing | x | x | x | x | x | x | x | x | x | ||||||||||||
| Femur fracture subtrochanteric | postmarketing | x | x | x | x | x | ||||||||||||||||
| Malaise | postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Myalgia | postmarketing, 0% - 1.1% | 1% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Femur shaft fracture | postmarketing | |||||||||||||||||||||
| Esophageal erosions | postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Photosensitivity | postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Exacerbation of asthma | postmarketing | x | x | |||||||||||||||||||
| Osteonecrosis of jaw | postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||
| Atypical stress fracture | postmarketing | x | x | |||||||||||||||||||
| Anaemia | ||||||||||||||||||||||
| Dizziness | postmarketing, 0% | 0.1% - 1% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Oesophageal disorder | ||||||||||||||||||||||
| Heartburn | ||||||||||||||||||||||
| Haemorrhage | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Hypercalcaemia | ||||||||||||||||||||||
| Hypercalciuria | ||||||||||||||||||||||
| Leukaemia | x | x | x | x | x | x | ||||||||||||||||
| Lymphopenia | x | x | x | |||||||||||||||||||
| Menopause | x | |||||||||||||||||||||
| Oral disorder | ||||||||||||||||||||||
| Osteogenesis imperfecta | x | |||||||||||||||||||||
| Stomatitis | ||||||||||||||||||||||
| Retrosternal pain | ||||||||||||||||||||||
| Influenza-like symptoms | x | x | x | |||||||||||||||||||
| Nephrolithiasis | ||||||||||||||||||||||
| Transaminases increased | x | x | x | x | x | |||||||||||||||||
| Drug interaction | x | |||||||||||||||||||||
| Oesophageal irritation | ||||||||||||||||||||||
| Anastomotic ulcer | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Gastrointestinal tract irritation | x | |||||||||||||||||||||
Indications
Information about indications was extracted from the indications and usage sections of the labels.
| Indication | Labels | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Bone mass decreased | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||
| Fracture | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Gastrointestinal disorder | x | x | x | x | x | x | x | x | x | x | x | |||||||||||
| Neoplasm malignant | x | |||||||||||||||||||||
| Osteitis deformans | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||||
| Osteopenia | x | x | x | x | x | x | x | x | x | x | x | |||||||||||
| Osteoporosis | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Osteoporosis postmenopausal | x | x | x | x | ||||||||||||||||||
| Osteoporotic fracture | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||
| Peptic ulcer | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Spinal compression fracture | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Spinal fracture | x | |||||||||||||||||||||
Color scheme:
standard – alternative
| 100% | ||
| 75% | ||
| 50% | ||
| 10% | ||
| frequent (1% to 100%) | ||
| infrequent (0.1% to 1%) | ||
| rare (<0.1%) | ||
| postmarketing | ||
| 0% | ||
| no frequency information | ||
| not found on label |
