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Hydroxyurea

More information: STITCH, PubChem and possibly Wikipedia

ATC Code: L01XX05

Side effects

Options: Hide MedDRA Preferred Terms

MedDRA Preferred Term Side effect Data for drug Placebo Labels
1 2 3 4 5 6 7 8 9 10
Azoospermia Azoospermia very common x
Oligospermia very common x
Neutropenia Neutropenia very common x x
Pancytopenia Bone marrow depression very common x x x x x x x x
Myelosuppression x x
Reticulocytopenia Reticulocytopenia very common x
Anaemia Anaemia common x x x x x x x x x
Mucosal inflammation Mucosal inflammation common x x x x x x x x x
Thrombocytopenia Thrombocytopenia common, 1-5% x x x x x x x x x
Constipation Constipation 1-5% x x x x x x x x x
Stomatitis Stomatitis 1-5% x x x x x x x x x
Headache Headache common, 1% x x x x x x x x x x
Alopecia Alopecia uncommon, 1-5% x x x x x x x x x x
Dermatitis Rash uncommon x x x x
Dermatitis x
Rash Rash uncommon x x x x
Eruption x
Nausea Nausea uncommon x x x x x x x x x x
Nail pigmentation Melanonychia uncommon x x
Nail pigmentation x
Dizziness Dizziness uncommon, 1% x x x x x x x x x x
Dysuria Dysuria 1% x x x x x x x x x
Hallucination Hallucination 1% x x x x x x x x x
Convulsion Convulsion 1% x x x x x x x x x
Blood uric acid increased Hyperuricaemia 1% x
Hyperuricaemia Hyperuricaemia 1% x
Skin ulcer Leg ulcer rare x x
Skin ulcer x x x x x x x
Hepatic enzyme increased Hepatic enzyme increased rare x
Amenorrhoea Amenorrhoea x
Anaemia megaloblastic Anaemia megaloblastic x
Decreased appetite Anorexia x x x x x x x x x
Asthenia Asthenia x x x x x x x
Fatigue x
Blepharitis Blepharitis x
Blister Blister x
Dermatitis bullous Blister x
Breast disorder Breast disorder x
Skin cancer Skin cancer x x x x x x x x x
Infection Infection x
Dermatomyositis Dermatomyositis x x x x x x x
Diarrhoea Diarrhoea x x x x x x x x x
Somnolence Drowsiness x x x x x x x x x
Dyspnoea Dyspnoea x x x x x x x x
Oedema Oedema x x x x x x
Fatigue Fatigue x
Body temperature increased Body temperature increased x x x x x x x x x
Fibrosis Fibrosis x x x x
Folate deficiency Folate deficiency x
Gangrene Gangrene x x x x x x
Gastrointestinal disorder Gastrointestinal disorder x
Digestion impaired x x
Gastrointestinal symptom NOS x x x x x x x
Haemorrhage Haemorrhage x x
Haemoglobin Haemorrhage x x
Hypersensitivity Hypersensitivity x
Renal failure acute Renal failure acute x
Leukaemia Leukaemia x
Leukemia secondary x
Chronic myeloid leukaemia Chronic myeloid leukaemia x
Leukopenia Leukopenia x x x x x x x
Neoplasm Neoplasm x x x x
Solid tumour x x
Nervous system disorder Nervous system disorder x
Pain Pain x x x
Pancreatitis Pancreatitis x x x x x x x
Neuropathy peripheral Neuropathy peripheral x x x x x x
Pulmonary oedema Pulmonary oedema x
Pulmonary fibrosis Pulmonary fibrosis x x x x
Radiation injury Radiation injury x
Radiation skin injury Dermatitis radiation NOS x
Ulcer Ulcer x x x x x x
Erythema Erythema x x x x x
Erythema facial x x x x x x x x
Ureteric obstruction Ureteric obstruction x
Angiopathy Angiopathy x
Vomiting Vomiting x x x x x x x x x x
Weight increased Weight increased x x
Erythema infectiosum Erythema infectiosum x x
Chills Chills x x x x x x x x
Skin atrophy Skin atrophy x x x x x x x
Blood urea increased Blood urea increased x
Blood creatinine increased Creatinine increased x
Hypomagnesaemia Hypomagnesaemia x
Skin necrosis Skin necrosis x
Skin exfoliation Skin necrosis x
Skin exfoliation x
Skin hyperpigmentation Skin hyperpigmentation x x x x x x x x
Skin disorder Unspecified disorder of skin and subcutaneous tissue x
Aphagia Aphagia x x
Malaise Malaise x x x x x x x
Discomfort Malaise x x x x x x x
Discomfort x x
Feeling abnormal Malaise x x x x x x x
Ill-defined disorder Malaise x x x x x x x
Emotional distress Distress x x x x x x x
Dyspepsia Digestion impaired x x
Disorientation Disorientation x x x x x x x x x
Tenderness Tenderness x
Hepatotoxicity Hepatotoxicity x x x x x x x
Lung infiltration Lung infiltration x x x x x x x x
Blood iron decreased Serum iron decreased x
Gastrointestinal ulcer Gastrointestinal ulcer x
Hepatobiliary disease Hepatobiliary disease x
Papule Papule x x x x x x x x
Atrophy Atrophy x
Epigastric discomfort Gastric irritation x x x x x x x
Platelet count decreased Platelet count decreased x x
Systemic lupus erythematosus Lupus erythematosus x
Rash maculo-papular Rash maculo-papular x x x x x x x x x
Face oedema Face oedema x
Poisoning Intoxication x
Febrile neutropenia Febrile neutropenia x
Infestation Infestation NOS x
Hypersplenism Splenic sequestration x
Recall phenomenon Recall phenomenon x
Urine output Urine output x
Hepatic failure Hepatic insufficiency x
Metastatic neoplasm Metastatic disease x

Indications

Information about indications was extracted from the indications and usage sections of the labels.

hydroxycarbamide / hydroxycarbamide

Side effects:39
Source:EMA

HYDROXYUREA / APO-HYDROXYUREA

Side effects:30
Source:Health Canada

hydroxyurea

Side effects:44
Source:FDA Structured Product Label

hydroxyurea capsules / HYDREA®

Side effects:38
Source:FDA

hydroxyurea / HYDREA

Side effects:41
Source:FDA

hydroxyurea

Side effects:43
Source:FDA Structured Product Label

Hydroxyurea / HYDREA

Side effects:42
Source:medicines.org.au

Hydrea / Hydrea, Capsule

Side effects:46
Source:Medsafe

HYDROXYUREA / HYDREA CAP 500MG

Side effects:52
Source:Health Canada

Hydroxyurea

Side effects:65
Source:BC Cancer

Color scheme:

standard – alternative

    100%
    75%
    50%
    10%
    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    postmarketing
    0%
    no frequency information
    not found on label