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Leuprorelin

More information: STITCH, PubChem (stereo-specific compound: 1) and possibly Wikipedia

ATC Code: L02AE02

Side effects

Options: Hide MedDRA Preferred Terms

MedDRA Preferred Term Side effect Data for drug Placebo Labels
1 2 3 4 5 6
Gynaecomastia Gynaecomastia 7% - 63% x x x x x x
Breast tenderness Breast tenderness 7% - 63% x x x x
Oedema peripheral Oedema peripheral 12% - 30% x x x x x
Ischaemia Ischaemia 19% - 22% x x x x
Injection site pain Injection site pain 19% - 21% x
Pain Pain postmarketing, 3% - 63% x x x x x x
Stinging x
Menopausal symptoms Hot flush postmarketing, 12% - 55% x x x x x x
Hot flush Hot flush postmarketing, 12% - 55% x x x x x x
Asthenia Asthenia 10% x x x x x x
Fatigue x x x x x
Constipation Constipation 7% - 9% x x x x x x
Erectile dysfunction Erectile dysfunction 4% - 12% x x x x x
Dermatitis Dermatitis 5% - 8% x x x x
Rash postmarketing, 3% x x x x x
Dizziness Dizziness 5% - 7% x x x x x x
Lightheadedness 5% - 7% x x x x
Syncope x x x x x x
Phlebitis Phlebitis 2% - 10% x x x x
Thrombosis Thrombosis 2% - 10% x x x x
Insomnia Insomnia 5% - 7% x x x x x
Decreased appetite Anorexia 5% - 6% x x x x
Decreased appetite x
Cardiac murmur Cardiac murmur 3% - 8% x x x x
Sinus congestion Sinus congestion 5% - 6% x x x x
Anaemia Anaemia 5% x x x x
Haematuria Haematuria 4% - 6% x x x x
Hypertension Hypertension postmarketing, 5% - 8% x x x x x x
Nausea Nausea postmarketing, 5% - 17% x x x x x x
Urinary tract infection Urinary tract infection 3% - 7% x x x x
Mood swings Mood swings 5% x x x x x
Affect lability Mood swings 5% x x x x x
Sleep disorder Sleep disorder postmarketing, 5% - 7% x x x x
Injection site reaction Injection site reaction postmarketing, 9% x x x
Bone pain Bone pain 2% - 5% x x x x
Cardiac failure congestive Cardiac failure congestive 1% - 5% x x x x
Erythema multiforme Erythema multiforme 3% x x x
Seborrhoeic dermatitis Seborrhoeic dermatitis 3% x x x
Vaginal inflammation Vaginal inflammation 3% x x x
Vaginal infection Vaginal inflammation 3% x x x
Vaginal discharge Vaginal discharge 3% x x
Myalgia Myalgia postmarketing, 3% - 9% x x x x x x
Musculoskeletal discomfort Myalgia postmarketing, 3% - 9% x x x x x x
Arthralgia x x x x x x
Acne Acne 3% x x x
Vaginal haemorrhage Vaginal haemorrhage 3% x x
Dyspnoea Dyspnoea postmarketing, 2% - 8% x x x x
Vasodilation procedure Vasodilation 2% x x x
Injection site swelling Injection site swelling 2% x
Abdominal pain Abdominal pain postmarketing x
Gastrointestinal pain Abdominal pain postmarketing x
Abscess Abscess postmarketing, 9% x x x x x
Asthma Asthma postmarketing x x x x x
Breast disorder Breast disorder postmarketing x x x
Chest pain Chest pain postmarketing x
Connective tissue disorder Connective tissue disorder postmarketing x
Diabetes mellitus Diabetes mellitus postmarketing x x x x x
Rash Rash postmarketing, 3% x x x x x
Fibromyalgia Fibromyalgia postmarketing x x x x
Flushing Flushing postmarketing x
Gastrointestinal disorder Gastrointestinal disorder postmarketing x
Digestion impaired x x x x
Headache Headache postmarketing, 2% - 7% x x x x x x
Hyperhidrosis Hyperhidrosis postmarketing x
Sweating x x
Sweating increased x
Hypersensitivity Hypersensitivity postmarketing x x
Hypotension Hypotension postmarketing x x x x x x
Myocardial infarction Myocardial infarction postmarketing x x x x
Acute coronary syndrome Myocardial infarction postmarketing x x x x
Nervous system disorder Nervous system disorder postmarketing x
Nodule Nodule postmarketing x x x x
IIIrd nerve paralysis Ophthalmoplegia postmarketing x x x x x x
Ophthalmoplegia Ophthalmoplegia postmarketing x x x x x x
Neuropathy peripheral Neuropathy peripheral postmarketing x x x x x
Pituitary tumour benign Pituitary adenoma postmarketing x x x x x x
Pituitary haemorrhage Pituitary apoplexy postmarketing x x x x x x
Pulmonary embolism Pulmonary embolism postmarketing x x
Convulsion Convulsion postmarketing x x x x
Shock Shock postmarketing x x x x x x
Syncope x x x x x x
Tenosynovitis Tenosynovitis postmarketing x x x x x
Urticaria Urticaria postmarketing x x x x x
Angiopathy Angiopathy postmarketing x
Vomiting Vomiting postmarketing, 5% - 17% x x x x x x
Weight increased Weight increased postmarketing, 7% x x x x x x
Spinal fracture Spinal fracture postmarketing x x x x x
Hepatic function abnormal Hepatic function abnormal postmarketing x x x x
Malnutrition Malnutrition postmarketing x x x
Photosensitivity reaction Photosensitivity reaction postmarketing x x x x x
Skin disorder Unspecified disorder of skin and subcutaneous tissue postmarketing x
Prostatic pain Prostatic pain postmarketing x x x x x
Hearing impaired Auditory disorder NOS postmarketing x x x x
Partial hearing loss x x x x
Mental disorder Mental state abnormal postmarketing x x x x x x
Mental disorder x
Induration Induration postmarketing x x x x x x
Pituitary infarction Pituitary infarction postmarketing x x x x x x
Prostate cancer Prostate cancer postmarketing x x x x
Paralysis Paralysis postmarketing x x x x x
Abdominal discomfort Distress gastrointestinal postmarketing x x x x
White blood cell count decreased White blood cell count decreased postmarketing x x x x x
Bone density decreased Bone density decreased postmarketing x x x x x
Abdominal distension Abdominal distension x x x x
Alopecia Alopecia x x x x x x
Angina pectoris Angina pectoris x x x x
Anosmia Anosmia x x x x
Anxiety Anxiety x x x x
Arrhythmia Arrhythmia x x x x
Arthralgia Arthralgia x x x x x x
Arthritis Arthritis x x x x
Back pain Back pain x
Blister Blister x x x x
Dermatitis bullous Blister x x x x
Bronchitis Bronchitis x x x x
Carotid bruit Carotid bruit x x x x
Transient ischaemic attack Transient ischaemic attack x x x x
Cervix disorder Cervix disorder x x x
Pleuritic pain Pleuritic pain x x x x
Colitis Colitis x
Infection Infection x x x x x
Contusion Contusion x x x x x
Cough Cough x x x x x
Libido decreased Libido decreased x
Disturbance in sexual arousal Libido decreased x
Dysphagia Dysphagia x x x x x
Depression Depression x x x x
Diarrhoea Diarrhoea x x x x
Dysmenorrhoea Dysmenorrhoea x x
Dyspepsia Dyspepsia x x x
Digestion impaired x x x x
Dysuria Dysuria x x x x
Ecchymosis Ecchymosis x x x x
Oedema Oedema x x x x
Epistaxis Epistaxis x x x
Fatigue Fatigue x x x x x
Feminisation acquired Feminization x x
Body temperature increased Body temperature increased x x x x x
Flatulence Flatulence x x x x x
Multiple fractures Fracture x x x x
Fracture Fracture x x x x
Gastroenteritis Gastroenteritis x
Gastrointestinal haemorrhage Gastrointestinal haemorrhage x x x x
Gingivitis Gingivitis x x x
Goitre Goitre x x x x x
Hair disorder Hair disorder x x
Haemoptysis Haemoptysis x x x x
Haemorrhage Haemorrhage x
Haemoglobin Haemorrhage x
Hepatitis Hepatitis x x x x
Hepatomegaly Hepatomegaly x x x x
Inguinal hernia Inguinal hernia x x x x
Herpes zoster Herpes zoster x x x x
Hirsutism Hirsutism x
Hypertrophy Hypertrophy x x
Hypoglycaemia Hypoglycaemia x x x x
Hypoproteinaemia Hypoproteinaemia x x x x
Incontinence Incontinence x x x x x
Inflammation Inflammation x x x x
Influenza Influenza x x
Irritability Irritability x
Arthropathy Arthropathy x x
Osteoarthritis Arthropathy x x
Hyperkeratosis Keratosis x x x x
Lethargy Lethargy x x x x x
Mediastinal disorder Mediastinal disorder x
Menstrual disorder Menstrual disorder x x
Muscle spasms Cramp muscle x x x x
Muscle spasms x x x x
Muscle atrophy Muscle atrophy x
Myopathy Myopathy x x
Musculoskeletal pain Musculoskeletal pain x
Nail disorder Nail disorder x x
Neoplasm Neoplasm x
Nervousness Nervousness x x x x x
Tension Nervousness x x x x x
Night sweats Night sweats x
Hypoaesthesia Numbness x x x x
Sensory loss Numbness x x x x
Nocturia Nocturia x
Nocturia aggravated x
Obesity Obesity x
Pain in extremity Pain in extremity x x
Pallor Pallor x
Palpitations Palpitations x x x x
Paraesthesia Paraesthesia x x x x
Paresthesia lower limb x x x x x
Penis disorder Penis disorder x
Peptic ulcer Peptic ulcer x x x x
Personality disorder Personality disorder x
Pharyngitis Pharyngitis x x
Pleural rub Pleural rub x x x x
Pneumonia Pneumonia x x x x
Pruritus Pruritus x x x x x
Puberty Puberty x
Precocious puberty Precocious puberty x x x
Pulmonary fibrosis Pulmonary fibrosis x x x x
Purpura Purpura x x
Vascular purpura Purpura x x
Pyuria Pyuria x x x x
Rales Rales x x x x
Anal fistula Rectal fistula x x x x
Rectal polyp Rectal polyp x x x x
Rhinitis Rhinitis x x x x x
Rhonchi Rhonchi x x x x
Pharyngitis streptococcal Pharyngitis streptococcal x x x x
Sinusitis Sinusitis x x
Spinal osteoarthritis Spondylosis x x x x
Cerebrovascular accident Cerebrovascular accident x x x x
Swelling Swelling x x x x
Syncope Syncope x x x x x x
Loss of consciousness Syncope x x x x x x
Blacked-out (not amnesia) x x x x
Tachycardia Tachycardia x x x x
Testicular pain Testicular pain x x x x x
Thyroid neoplasm Thyroid nodule x x x x
Tinnitus Tinnitus x x x x
Tremor Tremor x
Ulcer Ulcer x
Erythema Erythema x x x x x
Pollakiuria Pollakiuria x
Micturition urgency x
Urinary incontinence Urinary incontinence x x x
Vertigo Vertigo x
Wheezing Wheezing x x x x
Urinary retention Urinary retention x
Peripheral vascular disorder Peripheral vascular disorder x x
Chills Chills x x x x
Rigors x
Skin odour abnormal Body odor x x x
Micturition urgency Micturition urgency x
Antinuclear antibody positive Antinuclear antibody positive x x
Blood urea increased Blood urea increased x x x x
Blood creatinine increased Creatinine increased x x x x
Swelling face Swelling face x x x x
Red blood cell sedimentation rate increased Red blood cell sedimentation rate increased x x
Growth retardation Growth retardation x x
Skin hypertrophy Skin hypertrophy x x
Injury Accidental injury x x x x
Hyporeflexia Hyporeflexia x x x x
Hyperreflexia Hyperreflexia x x x x
Dry skin Dry skin x x x x
Skin striae Skin striae x
Testicular atrophy Testicular atrophy x
Leukoderma Leukoderma x x
Musculoskeletal stiffness Muscle stiffness x x x x
Malaise Malaise x
Discomfort Malaise x
Feeling abnormal Malaise x
Ill-defined disorder Malaise x
Burning sensation Burning foot x x x x
Chest discomfort Chest tightness x x x x
Increased appetite Increased appetite x x
Hallucination, auditory Hallucination, auditory x x x x
Tenderness Tenderness x x x x x
Injection site abscess sterile Injection site abscess sterile x
Euphoric mood Euphoric mood x x x x
Lung infiltration Lung infiltration x x x x
Breath sounds abnormal Respiratory sounds decreased x x x x
Furuncle Furuncle x x x x
Extrasystoles Extrasystoles x x x x
Pelvic fibrosis Pelvic fibrosis x x x x
Joint effusion Effusion of knee x x x x
Vision blurred Vision blurred x x x x
Cold sweat Sticky skin x
Sticky skin Sticky skin x
Crying Tearfulness x
Tearfulness Tearfulness x
Agitation Hyperkinesia x x
Hyperkinesia Hyperkinesia x x
Bladder pain Bladder spasm x
Bladder spasm Bladder spasm x
Red blood cell count decreased Red blood cell count decreased x
Bradycardia Bradycardia x x x x x
Injection site induration Injection site induration x
Injection site haematoma Injection site haematoma x
Hypercalcaemia Ca++ increased x x x x
Gait disturbance Gait disturbance x
Metastases to spine Metastases to spine x x x x x
Skin cancer Skin carcinoma x x x x
Aortic aneurysm rupture Aortic aneurysm rupture x x x x
Blood testosterone increased Serum testosterone increased x
Injection site inflammation Injection site warmth x
Injection site warmth Injection site warmth x
Penile swelling Penile swelling x x x x
Somnolence Somnolence x x x
Loss of libido Loss of libido x x x x x

Indications

Information about indications was extracted from the indications and usage sections of the labels.

leuprolide

Side effects:66
Source:FDA Structured Product Label

LEUPROLIDE

Side effects:114
Source:FDA Structured Product Label

LEUPROLIDE

Side effects:160
Source:FDA Structured Product Label

LEUPROLIDE

Side effects:161
Source:FDA Structured Product Label

leuprolide

Side effects:179
Source:FDA Structured Product Label

LEUPROLIDE

Side effects:201
Source:FDA Structured Product Label

Color scheme:

standard – alternative

    100%
    75%
    50%
    10%
    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    postmarketing
    0%
    no frequency information
    not found on label