Leuprolide acetate

Side effects and indications

Whenever possible, frequency information about the side effects was extracted from the labels. Aggregated frequency information for the drug and, if available, placebo is shown. To the right, you can click on shaded boxes to be taken to mentions of the side effect on the label. (In some cases, the side effect cannot be highlighted due to conversion problems.) Information about indications was extracted from the indications and usage sections of the labels.

Show MedDRA Preferred Terms

Side effect Data for drug Placebo Labels (show all 17)
1 2 3 4 5 6 7 8 9 10
Sweating def 57% - 98% 17.8% - 29% x x x x x x x
Hot flush def postmarketing, 57% - 98% 17.8% - 29% x x x x x x x x
Headache def postmarketing, 2.61% - 65% 6% - 17.8% x x x x x x x x
Migraine def 46% - 65% x x
Mood swings postmarketing, 4.51% - 34% 3% - 4.3% x x x x x
Sleep disorder def postmarketing, 12.7% - 31.4% x x x x
Insomnia def 12.7% - 31.4% x x x x x x x
Nausea def postmarketing, 12.5% - 29.1% 3% - 3.7% x x x x x x x
Pain def postmarketing, 2% - 29.1% 0% - 6.13% x x x x x x x x x x
Vomiting def postmarketing, 12.5% - 29.1% 3% - 3.7% x x x x x x
Vaginal inflammation def 2% - 20% 0% - 1.84% x x x
Asthenia def 11% - 18.2% 0% - 4.91% x x x x x x x
Dizziness def 7% - 16% 0% - 3.7% x x x x x x x
Vertigo def 7% - 16% x x x
Tenderness def 5.88% - 13% 0% - 4.3% x x x x
Nervousness def 3.64% - 11% 0% - 0.613% x x x x
Mucous membrane disorder 3.92% - 11% x x
Alopecia def 0% - 9.09% x x x x x x x
Oedema def 0% - 9.09% 1.2% - 3.23% x x x x x x x
Neuromyopathy def 1.96% - 9.09% 0% x x x
Injection site reaction def postmarketing, 1.96% - 9.09% x x x x x
Abscess def postmarketing, 5% - 9% x x x x x x
Anxiety def 0% - 8.09% x x x x
Memory impairment def 1.82% - 6% x x x
Menstrual disorder def 0% - 5.15% x x
Haemorrhage def 2% - 3.09% x x x x
Seborrhoeic dermatitis def 2% - 3.09% x
Bleeding vaginal def 3% - 3.09%
Vaginal discharge def 3% - 3.09%
Acne def 2% - 3.09% 0% x x x
Erythema multiforme def 2% - 3% x
Rash def postmarketing, 2% - 3% x x x x x x x
Erythema def 2% - 3% x x x x x x
Vasodilation def 2% - 2.14% x x x
Abdominal pain def postmarketing x x
Adenoma benign def postmarketing x x x x x x
Asthma def postmarketing x x x x x
Mental disorder def postmarketing x x x
Breast disorder def postmarketing x x
Transient ischaemic attack def postmarketing x x x
Chest pain def postmarketing x x
Connective tissue disorder def postmarketing x
Convulsion def postmarketing x x x x
Diabetes mellitus def postmarketing x x x
Dyspnoea def postmarketing x x x x x
Embolism def postmarketing x x x
Fibromyalgia def postmarketing x x x x
Flushing def postmarketing x
Gastrointestinal disorder def postmarketing x
Hyperhidrosis def postmarketing x
Hypersensitivity def postmarketing x
Hypertension def postmarketing x x
Hypotension def postmarketing x x x x x x
Infarction def postmarketing x x x x x x
Myocardial infarction def postmarketing x x x x
Nervous system disorder def postmarketing x
Nodule def postmarketing x
Ophthalmoplegia def postmarketing x x x x x x
Neuropathy peripheral def postmarketing x x x x x x
Pituitary adenoma def postmarketing x x x x x x
Pituitary apoplexy def postmarketing x x x x x x
Pulmonary embolism def postmarketing x x x
Respiratory disorder def postmarketing x x
Shock def postmarketing x x x x x x
Cerebrovascular accident def postmarketing x x x x x x
Tenosynovitis def postmarketing x x x x x x
Thromboembolism def postmarketing x x
Thrombosis def postmarketing x x x
Urticaria def postmarketing x x x x x x
Angiopathy def postmarketing x
Venous thrombosis def postmarketing x x
Weight increased def postmarketing 0% - 1.23% x x x x x x x x
Hepatic function abnormal postmarketing x x
Deep vein thrombosis def postmarketing x x
Photosensitivity reaction def postmarketing x x x x x x
Sickness postmarketing x x
Myalgia def postmarketing 0% x x x x x
Prostatic pain def postmarketing x x x x x x
Auditory disorder NOS def postmarketing x
Mental state abnormal postmarketing x x x x x x
Induration def postmarketing x x x x x x x
Pituitary infarction postmarketing x x x x x x
Photosensitivity def postmarketing x x x x x x
Suicidal ideation def postmarketing x x
Neuropathy def postmarketing x x x x x x
Paralysis def postmarketing x x x x x x
Distress gastrointestinal postmarketing x x x x
White blood cell count decreased postmarketing x x x x x x
Bone density decreased postmarketing x x x x x
Abdominal distension def x
Amnesia def x
Anaemia def x x x
Aneurysm def x
Angina pectoris def x x
Anorexia def x x
Anosmia def x
Aortic aneurysm def x
Arrhythmia def x
Arthralgia def x x
Arthritis def x x
Back pain def x
Balanitis def x
Blister def x
Breast feeding def x x
Bronchitis def x
Carcinoma def x
Cardiovascular disorder def x x
Carotid bruit x
Cellulitis def x
Cervix disorder def x
Pleuritic pain def x
Colitis def x
Conjunctivitis def x x
Constipation def x x x
Cough def x x
Libido decreased def 0% x x x x x
Dysphagia def x x x
Delusion def x x
Dermatitis def x
Diarrhoea def x x x
Distention def x
Dysgeusia def x x
Dysmenorrhoea def
Dyspepsia def
Dysuria def x x x x
Ear pain def x
Ecchymosis def x x x x x x
Effusion def x
Toxic epidermal necrolysis def
Epidermodysplasia verruciformis def
Epistaxis def x
Eructation def x
Fatigue def x x
Feminization def
Body temperature increased def x x x
Fibrosis def x
Fistula def x
Flatulence def x x
Gastroenteritis def x
Gastrointestinal haemorrhage def x
Gingivitis def x
Goitre def x
Gynaecomastia def x x x x x
Hair disorder def x x x
Hallucination def x
Cardiac failure def x x
Cardiac failure congestive def x x
Haematoma def x
Haematuria def x x x x x x
Haemoptysis def x x
Hepatitis def x
Hepatomegaly def x
Hernia def x
Inguinal hernia def x
Herpes zoster def x
Hirsutism def 0% - 3.23% x x x
Hyperglycaemia def x
Hypertrophy def x x x x
Hypoglycaemia def x
Hypoproteinaemia def x
Incontinence def x x x x
Infection def x x x x x
Inflammation def x x x
Influenza def x x x
Irritability def x
Ischaemia def x
Arthropathy def 0% - 3.1% x x
Keratosis def x
Laryngitis def x
Lethargy def x x
Leukopenia def x
Breast pain def x x
Mediastinal disorder def x
Menopause def x
Cramp muscle def x
Muscle atrophy def x
Myopathy def
Musculoskeletal pain def x
Nail disorder def x x
Metastasis def x x x x x x
Melanocytic naevus def x
Night sweats def x
Numbness def x
Nocturia def x x
Obesity def x
Obstruction def x x x x x x
Osteopenia def x x
Pain in extremity def x x x x
Pallor def x
Palpitations def x x x
Paraesthesia def 0% - 0.613% x x x x x x x x
Penis disorder def x x
Peptic ulcer def x x
Personality disorder def x x x
Pharyngitis def
Phlebitis def x
Pigmentation def x
Pleural disorder def x
Pleural rub x
Pneumonia def x
Polyp def x
Pruritus def x x x x
Pulmonary oedema def x
Emphysema def x
Pulmonary fibrosis def x
Purpura def
Pyuria def x
Rales x
Rectal fistula def x
Rectal polyp def x
Rhinitis def x x x
Rhonchi def x
Pharyngitis streptococcal x
Sinusitis def
Muscle spasms def x
Spondylosis def x
Gastric disorder def
Streptococcal infection def x
Swelling def x x
Syncope def x x x x x
Tachycardia def x x x
Testicular disorder def x
Testicular pain def x x
Thirst def x x
Thyroid nodule def x
Tinnitus def x
Tremor def x
Ulcer def x x x
Deficiency anaemia x
Pollakiuria def x x
Urinary incontinence def x x
Urinary tract infection def x x x
Visual impairment def
Weight decreased def x
Wheezing def x
Dry mouth def x x x
Urinary retention def x x
Peripheral vascular disorder def
Chills def x x
Body odor def x x x
Micturition urgency def x x
Agitation def x x
Oedema peripheral def x x x x
Injection site abscess x
Antinuclear antibody positive def
Blood urea increased x x
Creatinine increased def x x
Swelling face x
Red blood cell sedimentation rate increased
Growth retardation def
High density lipoprotein decreased x x
Skin hypertrophy
Bone pain def x x
Injection site pain x
Hyporeflexia x
Hyperreflexia x
Dry skin def x
Sinus congestion x
Skin striae def x
Testicular atrophy x x x
Haemoglobin decreased def x
Iron deficiency anaemia def x
Leukoderma def
Prostatic specific antigen decreased x
Urinary tract obstruction def x x x x x x
Lightheadedness x
Muscle stiffness x
Blood urine
Malaise def x
Burning foot x
Chest tightness x
Digestion impaired x
Increased appetite
Decreased appetite x
Hallucination, auditory x
Injection site abscess sterile x
Euphoric mood def x
Upset stomach
Sputum increased x
Breast enlargement female
Condition aggravated x x
Lung infiltration x
Respiratory sounds decreased x
Oestrogen low x x
Iron deficiency x
Tenderness muscle x
Testosterone low x x
Furuncle def x
Erectile dysfunction def x x x x x
Breast tenderness x
Blood bilirubin increased def x x
Blacked-out (not amnesia) x
Atrophy def x x x x
Extrasystoles def x
Pelvic fibrosis x
Effusion of knee x
Vision blurred def x
Sticky skin x
Disequilibrium syndrome x
Tearfulness x
Hyperkinesia def
Rigors
Bladder spasm def x
Stiffness x
Red blood cell count decreased x
Specific gravity urine increased x
Bradycardia def x
Lymphadenopathy def x x
Abscess sterile x
Injection site haematoma x
Face oedema def x
Ca++ increased x
Gait disturbance def x
Sodium high
Stinging x x
Systolic ejection murmur x
Skin carcinoma def x
Emotional distress def
Sweating increased
Dissecting aortic aneurysm, thoracic x
Hyperuricaemia def x
Aortic aneurysm rupture x
Thrombocytosis def x
Local reaction x x
Albumin low x
Protein total decreased x
Raised liver function tests x
Prostate cancer metastatic def x x
Paresthesia lower limb x x x x x x
Penile swelling x
Hearing impaired def x
High cholesterol def x
Weakness def x x x x x x
Breast enlargement x x
Somnolence def x
Loss of libido
Indication Labels
Adverse reaction def x x
Anaemia def x x
Congenital adrenal hyperplasia def x x
Endometriosis def x x
Hyperplasia def x x
Hyperplasia adrenal def x x
Leiomyoma def x x
Neoplasm def x x
Neoplasm malignant def x x x x x
Pain def x x
Precocious puberty def x x
Prostate cancer def x x x x x
Prostatic disorder def x x x
Puberty def x x
Uterine leiomyoma def x x

Information

More information: STITCH, PubChem and possibly Wikipedia

ATC Code: L02AE02

Legend

Color scheme: standard – alternative

100%    
75%    
50%    
10%    
frequent (1% to 100%)    
infrequent (0.1% to 1%)    
rare (<0.1%)    
postmarketing    
0%    
no frequency information    
not found on label    

Labels

Labels were obtained from different sources and potentially contain different sets of side effects. If you click on the label name, a HTML version of the label will be shown with proteins, chemicals and side efffects highlighted using Reflect.

  1. LEUPROLIDE ACETATE / VIADUR : 28 side effects (Drugs@FDA)
  2. Leuprolide Acetate / Eligard : 37 side effects (FDA CDER)
  3. LEUPROLIDE ACETATE / ELIGARD : 38 side effects (Drugs@FDA)
  4. leuprolide : 56 side effects (FDA XML label)
  5. LEUPROLIDE ACETATE / VIADUR : 60 side effects (Drugs@FDA)
  6. LEUPROLIDE : 65 side effects (FDA XML label)
  7. LEUPROLIDE : 91 side effects (FDA XML label)
  8. LEUPROLIDE : 95 side effects (FDA XML label)
  9. LEUPROLIDE : 96 side effects (FDA XML label)
  10. LEUPROLIDE : 188 side effects (FDA XML label)