Pamidronate
Side effects
Options: Show MedDRA Preferred Terms
| Side effect | Data for drug | Placebo | Labels | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | |||
| Bone pain | common, 59.4% - 70% | 69.1% - 75.4% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Cough | 21.2% - 26.3% | 18.8% - 22.5% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Headache | common, 0% - 27.2% | 19.7% - 23.6% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Asthenia | 16.1% - 25.6% | 15.4% - 19.2% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Metastasis | 1% - 31.3% | 3% - 24.4% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Agranulocytosis | 16.8% - 20.5% | 15.5% - 20.5% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Infection | postmarketing, 0% - 32.3% | 20.2% - 28.3% | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Body temperature increased | postmarketing — 0% - 38.5% | 30.5% - 38% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Urinary tract infection | 15.6% - 20.2% | 9.1% - 17.6% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Sinusitis | 14.6% - 16.1% | 10.4% - 16.6% | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||
| Flushing | very common | x | x | x | x | x | x | ||||||||||||||
| Fatigue | very common, 0% - 40.3% | 28.3% - 35.5% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Influenza-like symptoms | postmarketing — 0% - 11.9% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Arthralgia | common, 10.7% - 15.3% | 7% - 12.7% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Pleural effusion | 2.9% - 15% | 4.3% - 9.1% | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||
| Pain | common, 0% - 15% | 11.8% - 18.1% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Malaise | very common, 0% - 5.8% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Anaemia | postmarketing — 0% - 47.8% | 32.6% - 41.7% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Anorexia | common, 0% - 31.1% | 17.1% - 24.9% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Conjunctivitis | postmarketing, common | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Constipation | common, 0% - 36% | 30.9% - 38.6% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Rash | postmarketing, common | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Gastritis | common | x | x | x | x | x | x | ||||||||||||||
| Lymphopenia | common | x | x | x | x | x | x | ||||||||||||||
| Nausea | common, 0% - 63.5% | 37.4% - 59.1% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Paraesthesia | common | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Phlebitis | common | x | x | x | x | x | x | ||||||||||||||
| Swelling | common | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Tetany | common | x | x | x | x | x | x | ||||||||||||||
| Thrombophlebitis | common | x | x | x | x | x | x | ||||||||||||||
| Generalized aching | common | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||
| Induration | common | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Redness | common | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Serum creatinine increased | common | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||
| Hypokalaemia | common, 0% - 18% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Vomiting | common, 0% - 46.3% | 19.8% - 39.1% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Hypomagnesaemia | common, 3% - 12% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Hypophosphataemia | very common, 0% - 18% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Infusion site reaction | common, 0% - 18% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Abdominal pain | common, 0% - 24.3% | 14% - 18.1% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Diarrhoea | common, 0% - 29.4% | 26.2% - 30.6% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Hypocalcaemia | postmarketing — 0% - 12% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Thrombocytopenia | common, 0% - 16.6% | 13.1% - 17.1% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Myalgia | postmarketing — 0% - 26.4% | 15% - 22.5% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Insomnia | common, 0% - 25.1% | 17.2% - 19.4% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Bronchospasm | uncommon | x | x | x | x | x | x | ||||||||||||||
| Dizziness | uncommon | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Dyspepsia | uncommon, 0% - 22.6% | 12.4% - 17.5% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Iridocyclitis | uncommon | x | x | x | x | x | x | ||||||||||||||
| Iritis | uncommon | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Renal failure acute | uncommon | x | x | x | x | x | x | ||||||||||||||
| Lethargy | uncommon | x | x | x | x | x | x | ||||||||||||||
| Cramp muscle | uncommon | x | x | x | x | x | x | ||||||||||||||
| Pruritus | postmarketing, uncommon | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Uveitis | uncommon | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Agitation | uncommon | x | x | x | x | x | x | ||||||||||||||
| Liver function test abnormal | uncommon | x | x | x | x | x | x | ||||||||||||||
| Anaphylactoid reaction | uncommon | x | x | x | x | x | |||||||||||||||
| Serum urea increased | uncommon | x | x | x | x | x | x | ||||||||||||||
| Osteonecrosis of jaw | uncommon | x | x | ||||||||||||||||||
| Anaphylactic shock | very rare, postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Angioedema | postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||
| Neoplasm malignant | postmarketing | x | x | x | x | x | x | x | x | ||||||||||||
| Connective tissue disorder | postmarketing | x | x | x | |||||||||||||||||
| Dyspnoea | very rare — 0% - 35.1% | 18.7% - 24.4% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Femur fracture | postmarketing | x | x | x | |||||||||||||||||
| Focal segmental glomerulosclerosis | postmarketing, rare | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Hypercalcaemia | postmarketing | x | |||||||||||||||||||
| Hypersensitivity | postmarketing, uncommon | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||
| Hypotension | postmarketing, uncommon | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Inflammation | postmarketing | x | x | x | x | x | x | ||||||||||||||
| Mediastinal disorder | postmarketing | x | x | x | |||||||||||||||||
| Oral disorder | postmarketing | x | x | x | x | ||||||||||||||||
| Plasma cell myeloma | postmarketing | x | x | x | x | x | x | x | x | ||||||||||||
| Nephrotic syndrome | postmarketing, rare | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Obesity | postmarketing | x | |||||||||||||||||||
| Osteonecrosis | postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Acute respiratory distress syndrome | postmarketing, rare | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Tubulointerstitial nephritis | postmarketing | x | x | x | |||||||||||||||||
| Urinary tract disorder | postmarketing | x | x | x | |||||||||||||||||
| Interstitial pneumonia | rare | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||
| Interstitial lung disease | postmarketing | x | x | x | |||||||||||||||||
| Drug maladministration | postmarketing | x | |||||||||||||||||||
| Electrolyte imbalance | postmarketing | x | x | x | x | x | x | x | x | x | x | x | |||||||||
| Advanced breast cancer | postmarketing | x | x | x | x | x | x | x | x | x | x | x | |||||||||
| Confusional state | very rare, postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Episcleritis | very rare | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Cardiac failure congestive | very rare | x | x | x | x | x | x | ||||||||||||||
| Haematuria | very rare, postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Herpes simplex | very rare, postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Herpes zoster | very rare, postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Hyperkalaemia | very rare, postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Hypernatraemia | very rare, postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Nephropathy | very rare | x | x | x | x | x | x | ||||||||||||||
| Left ventricular failure | very rare | x | x | x | x | x | x | ||||||||||||||
| Acute lymphocytic leukaemia | very rare | x | x | x | x | ||||||||||||||||
| Pulmonary oedema | very rare | x | x | x | x | x | x | ||||||||||||||
| Scleritis | very rare | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Xanthopsia | very rare | x | x | x | x | x | x | ||||||||||||||
| Hallucination, visual | very rare, postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Alopecia | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||||
| Anxiety | 0% - 18% | 9.1% - 16.8% | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||
| Atrial fibrillation | common, 0% - 6% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||
| Atrial flutter | 0% - 1% | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Back pain | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||||
| Coagulopathy | x | x | |||||||||||||||||||
| Candida infection | 0% - 6% | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Dysgeusia | postmarketing, 0% - 3% | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Oedema | very rare — 0% - 1% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Epilepsy | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||||
| Eye disorder | x | ||||||||||||||||||||
| Gastrointestinal disorder | x | ||||||||||||||||||||
| Gastrointestinal haemorrhage | 0% - 6% | x | x | x | x | x | x | x | x | ||||||||||||
| Cardiac disorder | x | ||||||||||||||||||||
| Cardiac failure | 0% - 1% | x | x | x | x | x | x | x | x | x | x | x | x | ||||||||
| Haemorrhage | 0% - 6% | x | x | x | x | x | |||||||||||||||
| Hypertension | common, 0% - 6% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Hypothyroidism | 0% - 6% | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Immune system disorder | x | ||||||||||||||||||||
| Influenza | x | x | x | x | |||||||||||||||||
| Eye pruritus | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||||
| Arthropathy | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||||
| Leukopenia | very rare, 0% - 4% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Musculoskeletal pain | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||||
| Nervous system disorder | x | ||||||||||||||||||||
| Nervousness | 0% - 4% | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Neutropenia | 0% - 1% | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Osteomyelitis | x | x | x | ||||||||||||||||||
| Periodontal disease | x | ||||||||||||||||||||
| Pneumonia | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||||
| Psychotic disorder | 0% - 4% | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Rales | 0% - 6% | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Renal failure | x | x | x | x | |||||||||||||||||
| Rhinitis | 0% - 6% | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Convulsion | uncommon, 0% - 3% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Stomatitis | 0% - 3% | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Syncope | 0% - 6% | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Tachycardia | 0% - 6% | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Upper respiratory tract infection | 0% - 32.3% | 20.2% - 28.3% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Uremia | 0% - 4% | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Angiopathy | x | ||||||||||||||||||||
| Trauma | x | ||||||||||||||||||||
| Hepatic function abnormal | 0% - 3% | x | x | x | x | x | x | x | x | x | x | ||||||||||
| Malnutrition | x | ||||||||||||||||||||
| Neurological symptom | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||||
| Gangrenous cholecystitis | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||||
| Rigors | very common, 0% - 4% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Serum creatinine abnormal | x | x | x | x | |||||||||||||||||
| Fluid overload | very rare, 0% - 6% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Nephropathy toxic | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||
| Sweating increased | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||||
| Infestation NOS | x | ||||||||||||||||||||
| Blood and lymphatic system disorders | x | ||||||||||||||||||||
| Soft tissue inflammation | x | x | |||||||||||||||||||
| Local reaction | x | x | x | x | |||||||||||||||||
| Rhinorrhoea | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||||
| Somnolence | common, 0% - 6% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
Indications
Information about indications was extracted from the indications and usage sections of the labels.
| Indication | Labels | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Amyloidosis | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||||
| Bone cancer metastatic | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Breast cancer | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Cardiac failure | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||||
| Hydraemia | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||||
| Hypercalcaemia | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Hypercalcaemia of malignancy | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Hyperparathyroidism | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||||
| Hypersensitivity | x | x | x | x | x | x | x | x | x | x | x | x | |||||||||
| Hypovolaemia | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||||
| Metastatic bone pain | x | ||||||||||||||||||||
| Neoplasm | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Neoplasm malignant | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||
| Osteitis deformans | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Osteolytic lesion | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||||
| Plasma cell myeloma | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Urine output | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
Color scheme:
standard – alternative
| 100% | ||
| 75% | ||
| 50% | ||
| 10% | ||
| frequent (1% to 100%) | ||
| infrequent (0.1% to 1%) | ||
| rare (<0.1%) | ||
| postmarketing | ||
| 0% | ||
| no frequency information | ||
| not found on label |
