Temozolomide
Side effects
Options:
Show MedDRA Preferred Terms
|
Side effect
|
Data for drug
|
Placebo
|
Labels
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1
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2
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3
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4
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5
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6
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7
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8
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9
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10
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11
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12
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13
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14
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15
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16
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17
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18
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Nausea
|
very common, 0.351% - 53.2%
|
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Alopecia
|
common — 0% - 69.1%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Anorexia
|
very common, 0.351% - 27.2%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Constipation
|
very common, 0% - 32.9%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Fatigue
|
very common, 2% - 61.2%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Headache
|
very common, 1.74% - 41.1%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Vomiting
|
very common, 0.347% - 41.8%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Rash
|
very rare — 0% - 19.4%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Clotting
|
4% - 9%
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x
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Convulsion
|
common — 1% - 22.8%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Abnormal vision
|
5.06%
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x
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x
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x
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x
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x
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x
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x
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Anxiety
|
common, 0.633% - 6.96%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Aphasia
|
common, 1% - 3%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Arthralgia
|
common, 0% - 6.25%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Oral candidiasis
|
common, 2%
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x
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x
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x
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x
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x
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x
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Infection
|
postmarketing, common
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Cough
|
common, 0% - 8.48%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Dysphagia
|
common, 1% - 3%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Dermatitis
|
common
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x
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x
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x
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x
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x
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x
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Diarrhoea
|
common, 0% - 15.8%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Diplopia
|
common, 0% - 5.06%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Dizziness
|
common, 0% - 12%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Dyspepsia
|
common, 2% - 3%
|
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Dyspnoea
|
common, 0.446% - 5.36%
|
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Body temperature increased
|
common, 1% - 13.3%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Haemorrhage
|
common, 1% - 9%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Paraesthesia
|
common, 0.633% - 9.49%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Pharyngitis
|
common, 0% - 7.59%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Radiation injury
|
common, 0% - 7%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Speech disorder
|
common
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x
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x
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x
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x
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x
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x
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Stomatitis
|
common, 0% - 9%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Thrombocytopenia
|
common — 0% - 9%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Tremor
|
common
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x
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x
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x
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x
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x
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x
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Urinary incontinence
|
common, 1% - 8.23%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Weight decreased
|
common, 1% - 3%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Wound infection
|
common
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x
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x
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x
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x
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x
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x
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Dry mouth
|
common
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x
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x
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x
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x
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x
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x
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Mood swings
|
common
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x
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x
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x
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x
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x
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x
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Deep vein thrombosis
|
common
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x
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x
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x
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x
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x
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x
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Muscular weakness
|
common, 1% - 3%
|
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Alanine aminotransferase increased
|
common, 2% - 4%
|
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Memory impairment
|
common, 0.347% - 7.14%
|
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Cerebration impaired
|
common, 1% - 3%
|
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x
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x
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x
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|
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x
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x
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x
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x
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x
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x
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Leg edema
|
common, 1% - 2%
|
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Vision blurred
|
common, 0% - 9.03%
|
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Neuropathy
|
common, 2% - 3%
|
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Depressed level of consciousness
|
common, 1%
|
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x
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x
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x
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x
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x
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x
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x
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Hearing impaired
|
common, 1% - 4%
|
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Somnolence
|
common, 1% - 9.49%
|
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Mental disorder
|
1% - 9%
|
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|
x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Dysgeusia
|
common, 0% - 6.25%
|
|
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Confusional state
|
common, 0% - 5.36%
|
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Leukopenia
|
uncommon — 0% - 4%
|
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|
x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Neutropenia
|
common — 0% - 4%
|
|
x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Insomnia
|
common, 0% - 10.1%
|
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Pruritus
|
common, 0% - 7.59%
|
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Pain
|
uncommon — 1% - 3%
|
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|
x
|
x
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x
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x
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x
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x
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x
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x
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x
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x
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Dysphasia
|
uncommon — 0.633% - 6.96%
|
|
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x
|
x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Oedema
|
uncommon, common
|
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x
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x
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x
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x
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x
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x
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x
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Hemiparesis
|
uncommon — 1% - 18.4%
|
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Herpes simplex
|
uncommon, common
|
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|
x
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x
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x
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x
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x
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x
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Musculoskeletal pain
|
uncommon, common
|
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x
|
x
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x
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x
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x
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x
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Nervous system disorder
|
uncommon, common
|
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Neuropathy peripheral
|
uncommon, common
|
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Scotoma
|
uncommon, common
|
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x
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x
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x
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x
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x
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x
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Tinnitus
|
uncommon, common
|
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x
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x
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x
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x
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x
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x
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Abdominal pain
|
common, 0% - 8.86%
|
|
|
x
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x
|
x
|
x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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|
Hypersensitivity
|
very rare — 0% - 5%
|
|
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|
x
|
x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
|
|
Dry skin
|
common, 0% - 4.91%
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Asthenia
|
uncommon — 1.05% - 12.7%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pollakiuria
|
common, 1% - 2%
|
|
|
|
x
|
x
|
x
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Malaise
|
common, 2%
|
|
|
x
|
x
|
x
|
x
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Paresis
|
1% - 8.23%
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
|
|
|
|
Depression
|
0% - 6.33%
|
|
|
|
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
|
|
|
|
|
|
Hyperglycaemia
|
uncommon — 1% - 2%
|
|
|
x
|
x
|
x
|
x
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Lymphopenia
|
uncommon — 0% - 2%
|
|
|
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Myalgia
|
uncommon — 1% - 5.06%
|
|
|
x
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Face oedema
|
uncommon — 1% - 3%
|
|
|
|
x
|
x
|
x
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Erythema
|
uncommon — 0% - 5.26%
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Abdominal distension
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Amenorrhoea
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Amnesia
|
uncommon, 3.8% - 10.1%
|
|
|
x
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Anaemia
|
uncommon — 1% - 2%
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Ataxia
|
uncommon, 1.9% - 7.59%
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Back pain
|
uncommon, 2.53% - 7.59%
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Behavior disorder
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Bronchitis
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Deafness
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dysuria
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Ear pain
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Extrapyramidal disorder
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Faecal incontinence
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Flushing
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Gastroenteritis
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Gastrointestinal disorder
|
uncommon
|
|
|
|
x
|
x
|
x
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hallucination
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hemianopia
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hemiplegia
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Haemorrhoids
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Herpes zoster
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hyperaesthesia
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypertension
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypoaesthesia
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypokalaemia
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Breast pain
|
uncommon, 3.8%
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Menorrhagia
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Myopathy
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Nasal congestion
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Otitis media
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Palpitations
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Petechiae
|
uncommon — 4%
|
|
|
x
|
x
|
x
|
x
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pulmonary embolism
|
uncommon, 1%
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hyperacusis
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Sinusitis
|
uncommon, 0% - 6.33%
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Status epilepticus
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Thirst
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Tooth disorder
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Upper respiratory tract infection
|
uncommon, 0% - 8.23%
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Vaginal inflammation
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Vertigo
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Disorder sight
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Weight increased
|
uncommon, 0% - 5.06%
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Agitation
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Apathy
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Oedema peripheral
|
uncommon, 0.633% - 10.8%
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Tongue discolouration
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Gamma-glutamyltransferase increased
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Eye pain
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Phosphatase alkaline increased
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
x
|
x
|
x
|
x
|
|
Aspartate aminotransferase increased
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Sensory disturbance
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Photosensitivity reaction
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Visual acuity reduced
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Condition aggravated
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hepatic enzyme increased
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Skin exfoliation
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Erectile dysfunction
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dry eye
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Influenza-like symptoms
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Rigors
|
uncommon — 1%
|
|
|
|
x
|
x
|
x
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Coordination abnormal
|
uncommon, 1.27% - 10.8%
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Gait disturbance
|
uncommon, 0.633% - 5.7%
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hot flush
|
uncommon
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Sweating increased
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Febrile neutropenia
|
uncommon, common
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Abnormal pigmentation
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Parosmia
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cerebral haemorrhage
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Vaginal haemorrhage
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pneumonia
|
postmarketing — 1%
|
|
|
x
|
x
|
x
|
x
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Transient ischaemic attack
|
1%
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
Dehydration
|
1%
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
Pancytopenia
|
postmarketing — 1%
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Purpura
|
1%
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
Haemorrhage intracranial
|
1%
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
Lung infection
|
1%
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
Anaphylactic shock
|
very rare, postmarketing
|
|
|
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Aplastic anaemia
|
postmarketing
|
|
|
|
x
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cholestasis
|
postmarketing
|
|
|
|
x
|
x
|
x
|
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
|
Toxic epidermal necrolysis
|
postmarketing
|
|
|
|
x
|
x
|
x
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Erythema multiforme
|
very rare, postmarketing
|
|
|
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hepatitis
|
postmarketing
|
|
|
|
x
|
x
|
x
|
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
|
Hyperbilirubinaemia
|
postmarketing
|
|
|
|
x
|
x
|
x
|
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
|
Immune system disorder
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
Myeloid leukaemia
|
postmarketing
|
|
|
|
x
|
x
|
x
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Lung disorder
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
Myelodysplastic syndrome
|
postmarketing
|
|
|
|
x
|
x
|
x
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Opportunistic infection
|
postmarketing
|
|
|
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pulmonary fibrosis
|
postmarketing
|
|
|
|
x
|
x
|
x
|
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
|
Skin disorder
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
Stevens-Johnson syndrome
|
postmarketing
|
|
|
|
x
|
x
|
x
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hepatic failure
|
postmarketing
|
|
|
|
x
|
x
|
x
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
|
Liver injury
|
postmarketing
|
|
|
|
x
|
x
|
x
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
|
Interstitial pneumonia
|
postmarketing
|
|
|
|
x
|
x
|
x
|
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
|
Fatal outcomes
|
postmarketing
|
|
|
|
x
|
x
|
x
|
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
|
Hepatotoxicity
|
postmarketing
|
|
|
|
x
|
x
|
x
|
|
|
|
x
|
x
|
x
|
x
|
|
|
|
|
|
|
|
Hepatobiliary disease
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
|
Alveolitis
|
postmarketing
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
|
|
|
|
|
|
Infestation NOS
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pneumocystis jirovecii pneumonia
|
postmarketing
|
|
|
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
|
|
|
|
Metastatic neoplasm
|
postmarketing
|
|
|
|
x
|
x
|
x
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Angioedema
|
very rare
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
|
Dermatitis exfoliative
|
very rare
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
|
Urticaria
|
very rare
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
|
Hyperadrenocorticism
|
0% - 8.23%
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
|
|
|
|
|
Astrocytoma
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
|
Coagulopathy
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
|
|
|
|
|
Edema cerebral
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
Breast disorder
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Connective tissue disorder
|
|
|
|
|
x
|
x
|
x
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Embolism
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Endocrine disorder
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Eye disorder
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cardiac disorder
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Infertility
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Mediastinal disorder
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Neoplasm
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
|
Thrombophlebitis
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
Urinary tract infection
|
0% - 7.59%
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
|
|
|
|
|
Urinary tract disorder
|
|
|
|
|
x
|
x
|
x
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Angiopathy
|
|
|
|
|
x
|
x
|
x
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Viral infection
|
0% - 10.8%
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
|
|
|
|
|
Abnormal platelets
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
|
|
|
|
Malnutrition
|
|
|
|
|
x
|
x
|
x
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Unspecified disorder of skin and subcutaneous tissue
|
|
|
|
|
x
|
x
|
x
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Digestion impaired
|
|
|
|
|
x
|
x
|
x
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
Anxiety depression
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
|
Brain stem glioma
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
|
Partial seizures
|
0% - 5.7%
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
|
|
|
|
|
Blood and lymphatic system disorders
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
|
Ear and labyrinth disorders
|
|
|
|
|
x
|
x
|
x
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Myelosuppression
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cerebral ischaemia
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
Respiratory failure
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Indications
Information about indications was extracted from the indications and usage sections of the labels.
| Side effects: | 7 |
|---|
| Source: | FDA |
|---|
| Side effects: | 47 |
|---|
| Source: | BC Cancer |
|---|
| Side effects: | 79 |
|---|
| Source: | medicines.org.au |
|---|
| Side effects: | 79 |
|---|
| Source: | medicines.org.au |
|---|
| Side effects: | 80 |
|---|
| Source: | Medsafe |
|---|
| Side effects: | 48 |
|---|
| Source: | FDA |
|---|
| Side effects: | 68 |
|---|
| Source: | FDA |
|---|
| Side effects: | 69 |
|---|
| Source: | FDA |
|---|
| Side effects: | 83 |
|---|
| Source: | FDA Structured Product Label |
|---|
| Side effects: | 83 |
|---|
| Source: | FDA Structured Product Label |
|---|
| Side effects: | 89 |
|---|
| Source: | FDA Structured Product Label |
|---|
| Side effects: | 89 |
|---|
| Source: | FDA Structured Product Label |
|---|
| Side effects: | 183 |
|---|
| Source: | Health Canada |
|---|
| Side effects: | 185 |
|---|
| Source: | EMA |
|---|
| Side effects: | 186 |
|---|
| Source: | EMA |
|---|
| Side effects: | 186 |
|---|
| Source: | EMA |
|---|
| Side effects: | 186 |
|---|
| Source: | EMA |
|---|
| Side effects: | 186 |
|---|
| Source: | EMA |
|---|
Color scheme:
standard – alternative
|
|
|
100%
|
|
|
|
75%
|
|
|
|
50%
|
|
|
|
10%
|
|
|
|
frequent (1% to 100%)
|
|
|
|
infrequent (0.1% to 1%)
|
|
|
|
rare (<0.1%)
|
|
|
|
postmarketing
|
|
|
|
0%
|
|
|
|
no frequency information
|
|
|
|
not found on label
|
