Zidovudine
Side effects
Options:
Hide MedDRA Preferred Terms
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display all 26 labels
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MedDRA Preferred Term
|
Side effect
|
Data for drug
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Placebo
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Labels
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1
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2
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3
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4
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5
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6
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7
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8
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9
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11
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12
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13
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14
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15
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16
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17
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18
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19
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20
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Headache
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Headache
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very common, 8.5% - 63%
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37% - 53%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Malaise
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Malaise
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common, 8% - 55.6%
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7% - 45%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Sickness
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x
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x
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x
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x
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x
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Discomfort
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Malaise
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common, 8% - 55.6%
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7% - 45%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Feeling abnormal
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Malaise
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common, 8% - 55.6%
|
7% - 45%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Confusional state
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postmarketing
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|
|
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Ill-defined disorder
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Malaise
|
common, 8% - 55.6%
|
7% - 45%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Nausea
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Nausea
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rare — 7% - 61%
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18% - 41%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Body temperature increased
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Body temperature increased
|
uncommon, 2.13% - 32%
|
12%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Decreased appetite
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Anorexia
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rare, 6.38% - 20.1%
|
8% - 11%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Gastrointestinal pain
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Gastrointestinal pain
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20%
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19%
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x
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x
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x
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x
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x
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Abdominal pain
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common, 8.51% - 21.3%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Cough
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Cough
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rare, 15% - 18%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Vomiting
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Vomiting
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common, 2.13% - 25%
|
3% - 13%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Dermatitis
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Rash
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postmarketing — 12% - 17%
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15%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Rash
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Rash
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postmarketing — 12% - 17%
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15%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Stomatitis
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Stomatitis
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6% - 12%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Mouth ulceration
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postmarketing, 4.26% - 27.7%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Hepatomegaly
|
Hepatomegaly
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postmarketing — 11%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Nasopharyngitis
|
Rhinorrhoea
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8% - 11%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Rhinorrhoea
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Rhinorrhoea
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8% - 11%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Asthenia
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Asthenia
|
uncommon, 8.6% - 9%
|
5.8% - 6%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Fatigue
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Wheezing
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Wheezing
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7% - 9%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Breath sounds abnormal
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Breath sounds abnormal
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7% - 9%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Lymphadenopathy
|
Lymphadenopathy
|
postmarketing, 9% - 11%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Splenomegaly
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Splenomegaly
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5% - 8%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Myalgia
|
Myalgia
|
common, 8%
|
2%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Musculoskeletal discomfort
|
Myalgia
|
common, 8%
|
2%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Arthralgia
|
|
|
|
|
x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Abdominal pain
|
Abdominal pain
|
common, 8.51% - 21.3%
|
|
x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Abdominal cramps
|
|
|
|
|
|
x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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|
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Constipation
|
Constipation
|
6% - 8.1%
|
3.5% - 4%
|
|
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Diarrhoea
|
Diarrhoea
|
common, 6% - 14.9%
|
18%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Weight decreased
|
Weight decreased
|
4.26% - 6.38%
|
|
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Chills
|
Rigors
|
2.13% - 8.51%
|
|
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|
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x
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x
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Chills
|
rare
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|
x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Dyspepsia
|
Dyspepsia
|
rare, 5% - 6%
|
1% - 4%
|
x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Hyperhidrosis
|
Sweating increased
|
5%
|
4%
|
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x
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x
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x
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x
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x
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Sweating
|
rare
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|
x
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x
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x
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x
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Hyperlactacidaemia
|
Hyperlactacidaemia
|
common
|
|
x
|
x
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x
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x
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Insomnia
|
Insomnia
|
rare, 5%
|
1%
|
x
|
x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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|
Neuropathy peripheral
|
Neuropathy peripheral
|
4% - 25.5%
|
|
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|
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x
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|
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x
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x
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Neuropathy
|
|
|
|
|
|
x
|
x
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x
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x
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x
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x
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x
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x
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|
x
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x
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x
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x
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x
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Neutropenia
|
Neutropenia
|
common, 3%
|
|
x
|
x
|
x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
|
x
|
|
Pharyngitis
|
Pharyngitis
|
2.1% - 8.51%
|
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
|
x
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|
|
|
|
x
|
x
|
|
Agranulocytosis
|
Agranulocytosis
|
1.8% - 2%
|
1.6% - 2%
|
|
|
x
|
x
|
x
|
x
|
x
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x
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x
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x
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x
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|
x
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x
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x
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x
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x
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x
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x
|
x
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Anaemia
|
Anaemia
|
common, 1% - 2%
|
0.2% - 1%
|
x
|
x
|
x
|
x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Pain
|
Pain
|
uncommon
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
x
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x
|
x
|
x
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|
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|
Generalized aching
|
postmarketing
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
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|
x
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|
x
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x
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x
|
x
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Thrombocytopenia
|
Thrombocytopenia
|
uncommon, 0% - 3%
|
0.5% - 1%
|
x
|
x
|
x
|
x
|
x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
|
x
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|
Lactic acidosis
|
Lactic acidosis
|
postmarketing, rare
|
|
x
|
x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Amblyopia
|
Amblyopia
|
postmarketing
|
|
|
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x
|
x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
|
x
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Anaphylactic shock
|
Anaphylactic shock
|
postmarketing
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
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x
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x
|
x
|
x
|
x
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x
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x
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x
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x
|
x
|
|
Aplastic anaemia
|
Aplastic anaemia
|
very rare, postmarketing
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
|
x
|
|
Haemolytic anaemia
|
Haemolytic anaemia
|
postmarketing
|
|
|
|
|
x
|
x
|
x
|
x
|
x
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x
|
x
|
x
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|
x
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x
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x
|
x
|
x
|
|
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Angioedema
|
Angioedema
|
postmarketing
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
x
|
|
x
|
x
|
x
|
x
|
|
|
|
Anxiety
|
Anxiety
|
postmarketing, rare
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Back pain
|
Back pain
|
postmarketing
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Chest pain
|
Chest pain
|
postmarketing — 2.13% - 6.38%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Confusional state
|
Confusional state
|
postmarketing
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dysphagia
|
Dysphagia
|
postmarketing
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dizziness
|
Dizziness
|
postmarketing — 6% - 20.8%
|
4% - 15.2%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Syncope
|
postmarketing
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dysgeusia
|
Dysgeusia
|
postmarketing — 5%
|
8%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dyspnoea
|
Dyspnoea
|
postmarketing — 5%
|
3%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Toxic epidermal necrolysis
|
Toxic epidermal necrolysis
|
postmarketing
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
x
|
|
|
x
|
x
|
x
|
|
|
|
Flatulence
|
Flatulence
|
postmarketing, uncommon
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Gynaecomastia
|
Gynaecomastia
|
postmarketing, rare
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hepatitis
|
Hepatitis
|
postmarketing
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Influenza
|
Influenza
|
rare
|
|
x
|
x
|
x
|
|
|
|
|
|
|
|
|
x
|
|
x
|
|
|
|
|
x
|
x
|
|
Jaundice
|
Jaundice
|
postmarketing
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
x
|
|
x
|
x
|
x
|
x
|
|
|
|
Leukopenia
|
Leukopenia
|
postmarketing, common
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Liver disorder
|
Liver disorder
|
rare
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
Hepatocellular injury
|
Liver disorder
|
rare
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
Foetor hepaticus
|
Liver disorder
|
rare
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
Myopathy
|
Myopathy
|
postmarketing, uncommon
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Myositis
|
Myositis
|
postmarketing
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pancreatitis
|
Pancreatitis
|
postmarketing
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pancytopenia
|
Pancytopenia
|
postmarketing, uncommon
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Bone marrow depression
|
postmarketing, uncommon
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Paraesthesia
|
Paraesthesia
|
postmarketing — 6%
|
3%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pruritus
|
Pruritus
|
postmarketing, uncommon
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Aplasia pure red cell
|
Aplasia pure red cell
|
postmarketing, rare
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
|
Red cell aplasia
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
Rhabdomyolysis
|
Rhabdomyolysis
|
postmarketing
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
x
|
|
x
|
x
|
x
|
x
|
|
|
|
Rhinitis
|
Rhinitis
|
postmarketing
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Convulsion
|
Convulsion
|
postmarketing, rare
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Sinusitis
|
Sinusitis
|
postmarketing
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pigmentation disorder
|
Pigmentation skin
|
rare
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Muscle spasms
|
Muscle spasms
|
postmarketing
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Erythema multiforme
|
Stevens-Johnson syndrome
|
postmarketing
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
x
|
|
x
|
x
|
x
|
x
|
|
|
|
Stevens-Johnson syndrome
|
Stevens-Johnson syndrome
|
postmarketing
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
x
|
|
x
|
x
|
x
|
x
|
|
|
|
Shock
|
Syncope
|
postmarketing
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Syncope
|
Syncope
|
postmarketing
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Loss of consciousness
|
Syncope
|
postmarketing
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Tremor
|
Tremor
|
postmarketing
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pollakiuria
|
Pollakiuria
|
postmarketing, rare
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Urticaria
|
Urticaria
|
postmarketing, rare
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Vasculitis
|
Vasculitis
|
postmarketing
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Vertigo
|
Vertigo
|
postmarketing
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Photophobia
|
Photophobia
|
postmarketing
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Mouth ulceration
|
Mouth ulceration
|
postmarketing, 4.26% - 27.7%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Blood lactate dehydrogenase increased
|
Lactic dehydrogenase activity increased
|
postmarketing
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
x
|
|
x
|
x
|
x
|
x
|
|
|
|
Urinary hesitation
|
Urinary hesitation
|
postmarketing
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Macular oedema
|
Macular oedema
|
postmarketing
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Mania
|
Mania
|
postmarketing
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
x
|
|
x
|
x
|
x
|
x
|
|
|
|
Cardiomyopathy
|
Cardiomyopathy
|
postmarketing, rare
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Nail pigmentation
|
Nail pigmentation
|
postmarketing
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Sensitisation
|
Sensitisation
|
postmarketing
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Deafness
|
Hearing impaired
|
postmarketing
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hearing impaired
|
Hearing impaired
|
postmarketing
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Mucosal pigmentation
|
Mucosal pigmentation
|
postmarketing, rare
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Somnolence
|
Somnolence
|
postmarketing — 8%
|
9%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Congenital anomaly
|
Congenital anomaly
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
Developmental delay
|
Congenital anomaly
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
Acidosis
|
Acidosis
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
Acquired immunodeficiency syndrome
|
Acquired immunodeficiency syndrome
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
Autoimmune disorder
|
Acquired immunodeficiency syndrome
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
Arthralgia
|
Arthralgia
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Bacteraemia
|
Bacteraemia
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
x
|
x
|
|
Mental disorder
|
Mental disorder
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Breast disorder
|
Breast disorder
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Connective tissue disorder
|
Connective tissue disorder
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Cystitis
|
Cystitis
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
x
|
x
|
|
Bladder pain
|
Cystitis
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
x
|
x
|
|
Cystitis noninfective
|
Cystitis
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
x
|
x
|
|
Dysuria
|
Dysuria
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
|
x
|
|
|
|
|
x
|
x
|
|
Oedema
|
Oedema
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Epistaxis
|
Epistaxis
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
|
x
|
|
|
|
|
x
|
x
|
|
Eructation
|
Eructation
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
|
x
|
|
|
|
|
x
|
x
|
|
Fatigue
|
Fatigue
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Gastrointestinal disorder
|
Gastrointestinal disorder
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Gingival bleeding
|
Gingival bleeding
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
|
x
|
|
|
|
|
x
|
x
|
|
Cardiac disorder
|
Cardiac disorder
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Cardiac failure congestive
|
Cardiac failure congestive
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Haematuria
|
Haematuria
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hepatitis C
|
Hepatitis C
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
|
|
|
|
x
|
|
|
|
Dysphonia
|
Hoarseness
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
|
x
|
|
|
|
|
x
|
x
|
|
Hyperpathia
|
Hyperpathia
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
|
x
|
|
|
|
|
x
|
x
|
|
Hyperaesthesia
|
Hyperpathia
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
|
x
|
|
|
|
|
x
|
x
|
|
Hyperbilirubinaemia
|
Hyperbilirubinaemia
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Irritability
|
Irritability
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Mediastinal disorder
|
Mediastinal disorder
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Musculoskeletal pain
|
Musculoskeletal pain
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
x
|
|
x
|
x
|
x
|
x
|
|
|
|
Nervous system disorder
|
Nervous system disorder
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Nervousness
|
Nervousness
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Tension
|
Nervousness
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Night sweats
|
Night sweats
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
x
|
x
|
|
Phlebitis
|
Phlebitis
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
x
|
x
|
|
Polyuria
|
Polyuria
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
|
x
|
|
|
|
|
x
|
x
|
|
Urine output increased
|
Polyuria
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
|
x
|
|
|
|
|
x
|
x
|
|
Erythema
|
Erythema
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
x
|
x
|
x
|
x
|
|
|
|
Urethral disorder
|
Urinary tract disorder
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Urinary tract disorder
|
Urinary tract disorder
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Vasodilation procedure
|
Vasodilation
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
|
x
|
|
|
|
|
x
|
x
|
|
Skin odour abnormal
|
Body odor
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
|
x
|
|
|
|
|
x
|
x
|
|
Mood swings
|
Mood swings
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
|
x
|
|
|
|
|
x
|
x
|
|
Affect lability
|
Mood swings
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
|
x
|
|
|
|
|
x
|
x
|
|
Generalised oedema
|
Generalised oedema
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
x
|
x
|
|
Fluid retention
|
Generalised oedema
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
x
|
x
|
|
Tongue disorder
|
Tongue oedema
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
x
|
|
|
Tongue oedema
|
Tongue oedema
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
x
|
|
|
Hyporeflexia
|
Hyporeflexia
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Aspartate aminotransferase increased
|
Aspartate aminotransferase increased
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
Skin discolouration
|
Skin discolouration
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Malnutrition
|
Malnutrition
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
Skin disorder
|
Unspecified disorder of skin and subcutaneous tissue
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Muscle twitching
|
Muscle twitching
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
|
x
|
|
|
|
|
x
|
x
|
|
Rash erythematous
|
Rash erythematous
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
x
|
x
|
|
Rash follicular
|
Rash follicular
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
x
|
x
|
|
Swollen tongue
|
Swollen tongue
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
x
|
|
|
Localised oedema
|
Oedema auricular
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
x
|
x
|
x
|
x
|
|
|
|
Rectal haemorrhage
|
Rectal haemorrhage
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
|
x
|
|
|
|
|
x
|
x
|
|
Hepatobiliary disease
|
Hepatobiliary disease
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Rash maculo-papular
|
Rash maculo-papular
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
x
|
x
|
|
Auricular swelling
|
Auricular swelling
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
x
|
x
|
x
|
x
|
|
|
|
Drug interaction
|
Drug interaction
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
Hypoxia
|
Hypoxemia
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
Acne
|
Acne
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
x
|
|
Local reaction
|
Local reaction
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
x
|
|
|
x
|
|
x
|
|
|
|
|
Fat redistribution
|
Fat redistribution
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Indications
Information about indications was extracted from the indications and usage sections of the labels.
| Side effects: | 59 |
|---|
| Source: | Medsafe |
|---|
| Side effects: | 61 |
|---|
| Source: | Medsafe |
|---|
| Side effects: | 93 |
|---|
| Source: | FDA |
|---|
| Side effects: | 94 |
|---|
| Source: | FDA Structured Product Label |
|---|
| Side effects: | 94 |
|---|
| Source: | FDA Structured Product Label |
|---|
| Side effects: | 94 |
|---|
| Source: | FDA Structured Product Label |
|---|
| Side effects: | 94 |
|---|
| Source: | FDA Structured Product Label |
|---|
| Side effects: | 94 |
|---|
| Source: | FDA Structured Product Label |
|---|
| Side effects: | 94 |
|---|
| Source: | FDA Structured Product Label |
|---|
| Side effects: | 94 |
|---|
| Source: | FDA Structured Product Label |
|---|
| Side effects: | 94 |
|---|
| Source: | FDA Structured Product Label |
|---|
| Side effects: | 94 |
|---|
| Source: | FDA |
|---|
| Side effects: | 94 |
|---|
| Source: | FDA |
|---|
| Side effects: | 95 |
|---|
| Source: | medicines.org.au |
|---|
| Side effects: | 97 |
|---|
| Source: | FDA |
|---|
| Side effects: | 97 |
|---|
| Source: | FDA |
|---|
| Side effects: | 98 |
|---|
| Source: | FDA Structured Product Label |
|---|
| Side effects: | 98 |
|---|
| Source: | FDA Structured Product Label |
|---|
| Side effects: | 107 |
|---|
| Source: | Health Canada |
|---|
| Side effects: | 108 |
|---|
| Source: | Health Canada |
|---|
Color scheme:
standard – alternative
|
|
|
100%
|
|
|
|
75%
|
|
|
|
50%
|
|
|
|
10%
|
|
|
|
frequent (1% to 100%)
|
|
|
|
infrequent (0.1% to 1%)
|
|
|
|
rare (<0.1%)
|
|
|
|
postmarketing
|
|
|
|
0%
|
|
|
|
no frequency information
|
|
|
|
not found on label
|
