Dexmedetomidine

Side effects and indications

Whenever possible, frequency information about the side effects was extracted from the labels. Aggregated frequency information for the drug and, if available, placebo is shown. To the right, you can click on shaded boxes to be taken to mentions of the side effect on the label. (In some cases, the side effect cannot be highlighted due to conversion problems.) Information about indications was extracted from the indications and usage sections of the labels.

Hide MedDRA Preferred Terms

MedDRA Preferred Term Side effect Data for drug Placebo Labels
1
Hypotension def Hypotension def postmarketing, 24% - 56% 12% - 30% x
Bradycardia def Bradycardia def postmarketing, 5% - 42% 3% - 4% x
Respiratory depression Respiratory depression 37% 32% x
Pulmonary function test decreased Respiratory depression 37% 32% x
Hypertension def Hypertension def postmarketing, 11% - 28% 18% - 24% x
Systolic hypertension Systolic hypertension 28% x
Tachycardia def Tachycardia def postmarketing, 1% - 25% 1% - 17% x
Constipation def Constipation def 5% - 14% x
Agitation def Agitation def postmarketing, 2% - 14% 3% x
Diastolic hypertension def Diastolic hypertension def 12% x
Nausea def Nausea def postmarketing, 3% - 11% 2% - 9% x
Respiratory failure def Respiratory failure def 2% - 10% x
Hypoventilation def postmarketing x
Anxiety def Anxiety def 5% - 9% x
Atrial fibrillation def Atrial fibrillation def postmarketing, 2% - 9% 3% x
Hypokalaemia def Hypokalaemia def 9% x
Acute respiratory distress syndrome def Acute respiratory distress syndrome def 1% - 9% x
Cardiac fibrillation Cardiac fibrillation postmarketing, 2% - 9% 3% x
Respiratory distress def Respiratory distress def 1% - 9% x
Oedema def Oedema def 1% - 7% 1% x
Body temperature increased def Body temperature increased def postmarketing, 4% - 7% 4% x
Hyperglycaemia def Hyperglycaemia def 2% - 7% 2% x
Oedema peripheral def Oedema peripheral def 1% - 7% 1% x
Hypoglycaemia def Hypoglycaemia def postmarketing, 5% x
Vomiting def Vomiting def postmarketing, 3% - 4% 5% - 6% x
Dry mouth def Dry mouth def 3% - 4% 1% x
Hypoxia def Hypoxia def postmarketing, 2% - 4% 2% - 4% x
Hypoventilation def postmarketing x
Anaemia def Anaemia def postmarketing, 2% - 3% 2% x
Atelectasis def Atelectasis def 3% 3% x
Haemorrhage def Haemorrhage def postmarketing, 2% - 3% 3% - 4% x
Haemoglobin def Haemorrhage def postmarketing, 2% - 3% 3% - 4% x
Hypovolaemia def Hypovolaemia def postmarketing, 3% 2% x
Acidosis def Acidosis def postmarketing, 1% - 2% 1% - 2% x
Effusion def Effusion def 2% 1% x
Renal failure acute def Renal failure acute def 2% x
Oliguria def Oliguria def postmarketing, 1% - 2% 1% x
Pain def Pain def postmarketing, 2% 2% x
Pleural disorder def Pleural disorder def 2% 1% x
Pleural effusion def Pleural effusion def 2% 1% x
Renal failure def Renal failure def 2% x
Thirst def Thirst def postmarketing, 2% 1% x
Chills def Chills def 2% 3% x
Rigors postmarketing, 2% 3% x
Generalised oedema Generalised oedema 2% x
Fluid retention Generalised oedema 2% x
Respiratory rate decreased def Respiratory rate decreased def 2% 4% x
Hyperpyrexia Hyperpyrexia postmarketing, 2% 3% x
Hyperthermia def Hyperthermia def 2% 3% x
Hypocalcaemia def Hypocalcaemia def 1% x
Pulmonary oedema def Pulmonary oedema def 1% 1% x
Sinus tachycardia def Sinus tachycardia def 1% 1% x
Ventricular tachycardia def Ventricular tachycardia def postmarketing, 1% 1% x
Wheezing def Wheezing def 1% x
Hypomagnesaemia def Hypomagnesaemia def 1% x
Urine output Urine output 1% x
Abdominal pain def Abdominal pain def postmarketing x
Gastrointestinal pain def Abdominal pain def postmarketing x
Apnoea def Apnoea def postmarketing x
Arrhythmia def Arrhythmia def postmarketing x
Bronchospasm def Bronchospasm def postmarketing x
Confusional state def Confusional state def postmarketing x
Feeling abnormal Confusional state def postmarketing x
Convulsion def Convulsion def postmarketing x
Delirium def Delirium def postmarketing x
Diarrhoea def Diarrhoea def postmarketing x
Dizziness def Dizziness def postmarketing x
Dyspnoea def Dyspnoea def postmarketing x
Hallucination def Hallucination def postmarketing x
Headache def Headache def postmarketing x
Cardiac arrest def Cardiac arrest def postmarketing x
Atrioventricular block def Block heart def postmarketing x
Cardiac disorder def Cardiac disorder def postmarketing x
Hyperbilirubinaemia def Hyperbilirubinaemia def postmarketing x
Hypercapnia def Hypercapnia def postmarketing x
Carbon dioxide increased Hypercapnia def postmarketing x
Hyperkalaemia def Hyperkalaemia def postmarketing x
Illusion def Illusion def postmarketing x
Infarction def Infarction def postmarketing x
Myocardial infarction def Myocardial infarction def postmarketing x
Acute coronary syndrome def Myocardial infarction def postmarketing x
Neuralgia def Neuralgia def postmarketing x
Neuritis def Neuritis def postmarketing x
Neuropathy peripheral def Neuritis def postmarketing x
Hyperhidrosis def Sweating def postmarketing x
Photopsia Photopsia postmarketing x
Extrasystoles def Extrasystoles def postmarketing x
Hypoventilation def Hypoventilation def postmarketing x
Sinus arrest def Sinus arrest def x
Indication Labels
Sedation x

Information

More information: STITCH, PubChem and possibly Wikipedia or Medpedia

ATC Code: N05CM18

Legend

Color scheme: standard – alternative

100%    
75%    
50%    
10%    
frequent (1% to 100%)    
infrequent (0.1% to 1%)    
rare (<0.1%)    
postmarketing    
0%    
no frequency information    
not found on label    

Labels

Labels were obtained from different sources and potentially contain different sets of side effects. If you click on the label name, a HTML version of the label will be shown with proteins, chemicals and side efffects highlighted using Reflect.

  1. Dexmedetomidine : 79 side effects (FDA XML label)