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Dexmedetomidine

More information: STITCH, PubChem (stereo-specific compound: 1) and possibly Wikipedia

ATC Code: N05CM18

Side effects

Options: Hide MedDRA Preferred Terms

MedDRA Preferred Term Side effect Data for drug Placebo Labels
1 2 3 4 5
Systolic hypertension Systolic hypertension 28% - 42% x x
Respiratory depression Respiratory depression 37% 32% x x x
Pulmonary function test decreased Respiratory depression 37% 32% x x x
Hypotension Hypotension postmarketing — 13% - 56% 12% - 30% x x x x x
Diastolic hypertension Diastolic hypertension 12% - 15% x x
Hypertension Hypertension postmarketing — 4% - 30% 18% - 24% x x x x x
Hypertension worsened x
Hypokalaemia Hypokalaemia 9% - 13.1% x x
Hypomagnesaemia Hypomagnesaemia 1% - 7% x x
Constipation Constipation 6% - 6.1% x x
Generalised oedema Generalised oedema 2% - 6% x x
Fluid retention Generalised oedema 2% - 6% x x
Hypoglycaemia Hypoglycaemia postmarketing — 5% - 6% x x x x
Infarction Infarction common x
Withdrawal syndrome Withdrawal syndrome common x
Tachycardia Tachycardia postmarketing — 1% - 44.3% 4% - 17% x x x x x
Myocardial ischaemia Myocardial ischaemia common x
Bradycardia Bradycardia postmarketing — 0% - 42% 3% - 4% x x x x
Atrial fibrillation Atrial fibrillation postmarketing, 4% - 7% 3% x x x x
Respiratory failure Respiratory failure 3% - 5% x x
Hypoventilation postmarketing x x x x
Atelectasis Atelectasis 3% - 6% 3% x
Pneumothorax Atelectasis 3% - 6% 3% x
Nausea Nausea postmarketing — 3% - 11% 2% - 9% x x x x x
Vomiting Vomiting postmarketing — 3% - 4% 5% - 6% x x x x x
Dry mouth Dry mouth common, 1% - 4% 1% x x x x
Body temperature increased Body temperature increased postmarketing — 0% - 7% 3% - 4% x x x x x
Anaemia Anaemia postmarketing, 2% - 3% 2% x x x x
Hyperglycaemia Hyperglycaemia common, 1.64% - 7% 2% x x x
Pleural effusion Pleural effusion 2% - 6% 1% x x x
Chills Chills 2% 3% x
Rigors postmarketing, 2% 3% x x x x
Agitation Agitation postmarketing — 1% - 7% 3% x x x x x
Respiratory rate decreased Respiratory rate decreased 2% 4% x x
Hypoxia Hypoxia 2% - 4% 2% - 4% x x x x
Hypoventilation postmarketing x x x x
Post procedural haemorrhage Post procedural haemorrhage 2% - 4% 3% x
Hypovolaemia Hypovolaemia postmarketing, 3% - 5% 2% x x x x
Renal failure acute Renal failure acute 1% - 2% x x
Acute respiratory distress syndrome Acute respiratory distress syndrome 1% - 2% x x
Acidosis Acidosis postmarketing, 1% - 2% 1% - 2% x x x x
Hypocalcaemia Hypocalcaemia 1% - 2% 0% x
Oliguria Oliguria postmarketing, 1% - 2% 0% - 1% x x x x
Pulmonary oedema Pulmonary oedema 1% - 3% 1% x x
Sinus tachycardia Sinus tachycardia 1% - 2% 1% x
Wheezing Wheezing 1% - 2% 0% x
Abdominal distension Abdominal distension uncommon x x
Cardiac output decreased Cardiac output decreased uncommon x
Atrioventricular block first degree Atrioventricular block first degree uncommon x
Metabolic acidosis Metabolic acidosis uncommon x
Hypoalbuminaemia Hypoalbuminaemia uncommon x
Drug ineffective Drug ineffective uncommon x
Oedema peripheral Oedema peripheral 0% - 2% 1% x x
Ventricular tachycardia Ventricular tachycardia postmarketing, 1% - 5% 1% x x x x
Abdominal pain Abdominal pain postmarketing x x x x
Gastrointestinal pain Abdominal pain postmarketing x x x x
Respiratory acidosis Respiratory acidosis postmarketing x x x x
Apnoea Apnoea postmarketing x x x x
Arrhythmia Arrhythmia postmarketing x x x x
Atrioventricular block Atrioventricular block postmarketing x x x x
Block heart postmarketing x x x x
Mental disorder Mental disorder postmarketing x x x x x
Bronchospasm Bronchospasm postmarketing x x x x
Cardiovascular disorder Cardiovascular disorder postmarketing x x x
Confusional state Confusional state postmarketing x x x x
Feeling abnormal Confusional state postmarketing x x x x
Delirium Delirium postmarketing x x x x
Diarrhoea Diarrhoea postmarketing x x x x
Dizziness Dizziness postmarketing x x x x
Dyspnoea Dyspnoea postmarketing, uncommon x x x x x
Hallucination Hallucination postmarketing, uncommon x x x x x
Headache Headache postmarketing x x x x
Cardiac arrest Cardiac arrest postmarketing x x x x x
Cardiac disorder Cardiac disorder postmarketing x x x x x
Haemorrhage Haemorrhage postmarketing, 3% 4% x x x
Haemoglobin Haemorrhage postmarketing, 3% 4% x x x
Hyperbilirubinaemia Hyperbilirubinaemia postmarketing x x x
Hypercapnia Hypercapnia postmarketing x x x x
Carbon dioxide increased Hypercapnia postmarketing x x x x
Hyperkalaemia Hyperkalaemia postmarketing x x x x
Illusion Illusion postmarketing x x x x
Nephropathy Nephropathy postmarketing x x x
Myocardial infarction Myocardial infarction postmarketing x x x
Acute coronary syndrome Myocardial infarction postmarketing x x x
Neuralgia Neuralgia postmarketing x x x x
Neuritis Neuritis postmarketing x x x x
Neuropathy peripheral Neuritis postmarketing x x x x
Neuropathy peripheral postmarketing x x x
Pain Pain postmarketing, 2% 2% x x x x
Convulsion Convulsion postmarketing x x x
Speech disorder Speech disorder postmarketing x x x x
Supraventricular tachycardia Supraventricular tachycardia postmarketing x x x x
Thirst Thirst postmarketing — 2% 1% x x x x x
Angiopathy Angiopathy postmarketing x x x x
Visual impairment Disorder sight postmarketing x x x x
Abnormal vision postmarketing x x x x
Ventricular arrhythmia Ventricular arrhythmia postmarketing x x x x
Photopsia Photopsia postmarketing x x x x
Hepatic function abnormal Hepatic function abnormal postmarketing x x
Blood urea increased Blood urea increased postmarketing x x
Urea increased x
Blood alkaline phosphatase increased Phosphatase alkaline increased postmarketing x x x x
Malnutrition Malnutrition postmarketing x x x x x
Pulmonary congestion Pulmonary congestion postmarketing x x x
Respiratory tract congestion Pulmonary congestion postmarketing x x x
Extrasystoles Extrasystoles postmarketing x x x x
Hyperpyrexia Hyperpyrexia postmarketing, 2% 3% x x x x
Light anaesthesia Light anaesthesia postmarketing x x x
Electrocardiogram T wave inversion Electrocardiogram T wave inversion postmarketing x x x x
Blood pressure fluctuation Blood pressure fluctuation postmarketing x x x x
Hyperhidrosis Sweating increased postmarketing x x x x
Hypoventilation Hypoventilation postmarketing x x x x
Anxiety Anxiety x x
Infection Infection x
Decubitus ulcer Decubitus ulcer x
Dermatitis Rash x
Rash Rash x
Gastrointestinal disorder Gastrointestinal disorder x x
Hypernatraemia Hypernatraemia x
Body temperature decreased Body temperature decreased x
Hypothermia Body temperature decreased x
Leukocytosis Leukocytosis x
Mediastinal disorder Mediastinal disorder x
Pneumonia Pneumonia x
Pregnancy Pregnancy x
Septic shock Septic shock x
Thrombocytopenia Thrombocytopenia x
Urinary tract infection Urinary tract infection x
Hypophosphataemia Hypophosphataemia x
Gamma-glutamyltransferase increased Gamma-glutamyltransferase increased x
Aspartate aminotransferase increased Aspartate aminotransferase increased x
Alanine aminotransferase increased Alanine aminotransferase increased x
Haemoglobin decreased Haemoglobin decreased x
Sepsis Sepsis x
Electrolyte imbalance Electrolyte imbalance x
Sinus arrest Sinus arrest x x x
Fluid overload Fluid overload x
Laryngeal pain Pharyngolaryngeal pain x
Somnolence Somnolence x

Indications

Information about indications was extracted from the indications and usage sections of the labels.

DEXMEDETOMIDINE

Side effects:72
Source:FDA Structured Product Label

DEXMEDETOMIDINE

Side effects:92
Source:FDA Structured Product Label

Color scheme:

standard – alternative

    100%
    75%
    50%
    10%
    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    postmarketing
    0%
    no frequency information
    not found on label