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Nilotinib

More information: STITCH, PubChem and possibly Wikipedia

ATC Code: L01XE08

Side effects

Options: Show MedDRA Preferred Terms

Side effect Data for drug Placebo Labels
1 2 3 4 5
Thrombocytopenia very common, 9% - 42% x x x x x
Hyperbilirubinaemia very common x x x x
Neutropenia very common, 11% - 42% x x x x x
Unspecified disorder of skin and subcutaneous tissue 0% - 36% x x x x x
Lipase increased very common, 4% - 18% x x x x x
Blood phosphorus decreased very common x x x
Hypophosphataemia uncommon — 6% - 17% x x x x x
Malnutrition 1% - 17% x x x x x
Anaemia common, 4% - 27% x x x x x
Blood bilirubin increased common — 1% - 9% x x x x x
Mediastinal disorder 0% - 27% x x x x x
Angiopathy 1% - 11% x x x x x
Infection 0% - 24% x x x x x
Infestation NOS 0% - 24% x x x x x
Abdominal distension uncommon, common x x x x x
Amnesia common x x x x
Angina pectoris uncommon, common x x x x x
Anorexia common x x x
Anxiety uncommon, common x x x x x
Arrhythmia common x x x x
Atrial fibrillation uncommon, common x x x x x
Atrioventricular block common x x x x
Back pain common x x x x x
Neck pain common x x x
Chest pain uncommon, common x x x x x
Confusional state common x x x x
Conjunctivitis uncommon, common x x x x x
Connective tissue disorder common, 0% - 19% x x x x x
Contusion common x x x x
Cough common x x x x x
Dermatitis common x x x x
Diabetes mellitus common x x x x x
Dizziness common x x x x x
Dysgeusia common x x x x
Dyspnoea common x x x x x
Ear pain common x x x x
Eczema common x x x x x
Eosinophilia common x x x x
Epistaxis uncommon, common x x x x x
Eye haemorrhage uncommon, common x x x x
Body temperature increased common x x x x x
Flank pain uncommon, common x x x x
Flatulence common x x x x x
Flushing common x x x x x
Cardiac flutter common x x x x
Folliculitis common x x x x
Hypercalcaemia common x x x x
Hypercholesterolaemia common, 0% - 1% x x x x
Hyperglycaemia common, 1% - 12% x x x x x
Hyperhidrosis common x x x x x
Hyperkalaemia uncommon — 1% - 6% x x x x x
Hyperlipidaemia common x x x x
Hypertension common x x x x x
Hypertriglyceridaemia common x x x x
Hypoaesthesia uncommon, common x x x x x
Hyponatraemia uncommon — 1% - 7% x x x x
Eye pruritus common x x x x
Lymphopenia common x x x x
Musculoskeletal pain uncommon, common x x x x x
Nasopharyngitis common x x x x x
Night sweats common x x x x x
Pain uncommon, common x x x x
Palpitations common x x x x x
Pancreatitis uncommon, common x x x x x
Pancytopenia uncommon, common x x x x x
Paraproteinaemia common x x x x
Paraesthesia uncommon, common x x x x x
Neuropathy peripheral common x x x x x
Pharyngitis uncommon, common x x x x x
Rhinitis common x x x x
Tachycardia common x x x x
Tinnitus common x x x
Upper respiratory tract infection common x x x x
Pollakiuria uncommon, common x x x x x
Urticaria common x x x x x
Vertigo common x x x x x
Weight increased common x x x x x
Weight decreased common x x x x x
Xerophthalmia common x x x x
Hyperphosphataemia common x x x x
Hepatic function abnormal common x x x x
Periorbital oedema uncommon, common x x x x x
Ventricular extrasystoles common x
Gamma-glutamyltransferase increased common x x x x x
Hypomagnesaemia common x x x x
Electrocardiogram QT prolonged common x x x x x
Dry skin common, 0% - 10% x x x x x
Haemoglobin decreased uncommon, common x x x x
Malaise uncommon, common x x x x x
Dyspnoea exertional common x x x x x
Abdominal discomfort common x x x x x
Disorientation common x x x x
Dysphoria common x x x x
Chest discomfort common x x x x
Dry eye uncommon, common x x x x x
Extrasystoles common x x x
Electrolyte imbalance common x x x
Skin papilloma common x x x x
Bradycardia uncommon, common x x x x x
Musculoskeletal chest pain common x x x x
Non-cardiac chest pain common x x x x
Blood glucose increased common x
Febrile neutropenia common x x x x x
Blood insulin increased common x x x
Blood alkaline phosphatase increased common x x x x x
Blood amylase increased common x x x x x
Blood creatine phosphokinase increased common x
Insomnia common x x x x x
Oral papilloma common x x x x
Hearing impaired common x x x x
Dysphonia common x x x x
Mental disorder 0% - 12% x x x x x
Dyspepsia common, 0% - 6% x x x x x
Alanine aminotransferase increased common — 3% - 9% x x x x x
Nervous system disorder very common, 1% - 35% x x x x x
Erythema common, 0% - 6% x x x x x
Aspartate aminotransferase increased common — 1% - 3% x x x x x
Oedema peripheral common, 0% - 17% x x x x
Rash 0% - 37% x x x x x
Diarrhoea 0% - 30% x x x x x
Hypocalcaemia uncommon — 1% - 5% x x x x x
Hypokalaemia uncommon — 1% - 9% x x x x x
Bone pain common, 0% - 6% x x x x x
Albumin low 0% - 4% x x
Headache 1% - 22% x x x x x
Fatigue very common, 0% - 17% x x x x x
Gastrointestinal disorder very common, 1% - 37% x x x x x
Arthralgia 0% - 9% x x x x x
Nausea 0% - 34% x x x x x
Muscle spasms 0% - 29% x x x x x
Vomiting 0% - 18% x x x x x
Arteriosclerosis uncommon x x x x
Arthritis uncommon x x x x
Blepharitis uncommon x x x x x
Blister uncommon x x x x
Body temperature altered uncommon x x x x
Bronchitis uncommon x x x x
Candida infection uncommon x x x x
Oral candidiasis uncommon x x x x
Pleuritic pain uncommon x x x x
Cholestasis uncommon x x x
Conjunctival haemorrhage uncommon x x x x
Conjunctivitis allergic uncommon x x x x
Cyanosis uncommon x x x x
Dehydration uncommon x x x x
Sensitivity of teeth uncommon x x x x
Drug eruption uncommon x x x x
Diplopia uncommon x x x x
Dysuria uncommon x x x x x
Ecchymosis uncommon x x x x
Localised oedema uncommon x x x x
Enterocolitis uncommon x x x x
Erythema multiforme uncommon x x x x
Erythema nodosum uncommon x x x x
Gastritis uncommon x x x x
Gastroenteritis uncommon x x x x
Gastrooesophageal reflux disease uncommon x x x x
Gastrointestinal haemorrhage uncommon x x x x x
Gingivitis uncommon x x x x
Gout uncommon x x x x
Gynaecomastia uncommon x x x x x
Cardiomegaly uncommon x x
Cardiac failure uncommon x x x x x
Cardiac murmur uncommon x x x x
Haematemesis uncommon x x x x
Haematoma uncommon x x x x x
Haematuria uncommon x x x x
Haemorrhoids uncommon x x x x
Hepatitis uncommon x
Hepatitis toxic uncommon x x x x
Hepatomegaly uncommon x x x x
Herpes virus infection uncommon x x x
Hyperaemia uncommon x x x x
Hyperaesthesia uncommon x x x x x
Hyperparathyroidism secondary uncommon x x x x
Pulmonary hypertension uncommon x x x x
Hypertensive crisis uncommon x x x x
Hyperthyroidism uncommon x x x x
Hypoglycaemia uncommon x x x x
Hypotension uncommon x x x x
Hypothyroidism uncommon x x x x
Intermittent claudication uncommon x x
Jaundice uncommon x x x x x
Lethargy uncommon x x x x
Leukocytosis uncommon x x x x
Breast pain uncommon x x x x
Melaena uncommon x x x x
Myocardial infarction uncommon x x x x x
Nocturia uncommon x x x x
Optic neuritis uncommon x x x x
Papilloedema uncommon x x x x
Pericardial effusion uncommon x x x x x
Pericarditis uncommon x x x x x
Petechiae uncommon x x x x
Pleural effusion uncommon x x x x x
Pleurisy uncommon x x x x x
Pneumonia uncommon x x x x
Psoriasis uncommon x x x x
Pulmonary oedema uncommon x x x x
Renal failure uncommon x x x x
Restless legs syndrome uncommon x x x x
Shock haemorrhagic uncommon x x x x
Skin ulcer uncommon x x x x
Gastric ulcer uncommon x x x x x
Stomatitis uncommon x x x x x
Syncope uncommon x x x x
Thrombosis uncommon x x x x
Thyroiditis uncommon x x x x
Tinea pedis uncommon x x x x
Tremor uncommon x x x x x
Loss of consciousness uncommon x x x x
Urinary incontinence uncommon x x x x
Urinary tract infection uncommon x x x x
Wheezing uncommon x x x
Dry mouth uncommon x x x x x
Chills uncommon x x x x x
Micturition urgency uncommon x x x x
Photopsia uncommon x x x x
Photophobia uncommon x x x x
Mouth ulceration uncommon x x x x
Migraine uncommon x x x x x
Skin atrophy uncommon x x x x
Blood urea increased uncommon x x x x
Swelling face uncommon x x x x x
Globulins decreased uncommon x x x x
Haemorrhage intracranial uncommon x x x x
Retroperitoneal haemorrhage uncommon x x x x
Skin hypertrophy uncommon x x x x
Muscular weakness uncommon x x x x x
Eye pain uncommon x x x x x
Skin discolouration uncommon x x x x
Joint swelling uncommon x x x x
Eyelid oedema uncommon x x x x
Skin hyperpigmentation uncommon x x x x
Interstitial lung disease uncommon x x x x
Oesophageal pain uncommon x x x x
Increased appetite uncommon x x x x
Disturbance in attention uncommon x x x
Visual acuity reduced uncommon x x x x
Eye irritation uncommon x x x x
Hepatotoxicity uncommon x x x x
Blood creatinine increased uncommon x x
Gravitational oedema uncommon x x x x
Skin exfoliation uncommon x x x x
Dermal cyst uncommon x x x x
Pain of skin uncommon x x x x
Subcutaneous abscess uncommon x x x x
Furuncle uncommon x x x
Dyslipidaemia uncommon x x x
Erectile dysfunction uncommon x x x x x
Ventricular dysfunction uncommon x x x x
Sepsis uncommon x x x x
Arterial occlusion uncommon x
Rectal haemorrhage uncommon x x x x
Eye swelling uncommon x x x x
Anal abscess uncommon x x x x
Chorioretinopathy uncommon x x x x
Vision blurred uncommon x x x x x
Photosensitivity uncommon x x x x
Dysaesthesia uncommon x x x x
Sebaceous hyperplasia uncommon x x x x
Blood pressure increased uncommon x
Influenza like illness uncommon x x x x
Chromaturia uncommon x x x x
Face oedema uncommon x x x x x
Blood glucose decreased uncommon x x
Throat irritation uncommon x x x x
Hyperuricaemia uncommon x x x x
Thrombocytosis uncommon x x x x
Blood parathyroid hormone increased uncommon x x x x
Blood lactate dehydrogenase increased uncommon x x x x
Blood bilirubin unconjugated increased uncommon x x x x
Blood insulin decreased uncommon x x x
Gastrointestinal ulcer perforation uncommon x x x x
Pharyngolaryngeal pain uncommon x x x x
Insulin C-peptide decreased uncommon x x x x
Hyperkeratosis uncommon x x x x
Arterial stenosis limb uncommon x
Subileus uncommon x x x x
Musculoskeletal stiffness uncommon x x x
Troponin increased uncommon x x x x
Peripheral arterial occlusive disease uncommon x x x
Brain oedema uncommon x x x x
Ocular surface disease uncommon x x x x
Exfoliative rash uncommon x x x x
Coronary artery disease uncommon x x x x
Oropharyngeal pain uncommon x x x x
Oesophagitis ulcerative uncommon x x x x
Feeling hot uncommon x x x x
Hiatus hernia uncommon x x x x
Visual impairment uncommon x x x
Decreased appetite uncommon — 0% - 8% x x x x x
Abdominal pain 0% - 10% x x x x x
Asthenia common, 0% - 9% x x x x x
Constipation 0% - 12% x x x x x
Pain in extremity 1% - 7% x x x x x
Pruritus 0% - 24% x x x x x
Creatinine increased 0% - 1% x x x x x
Phosphatase alkaline increased 0% - 1% x x
Myalgia 1% - 12% x x x x x
Tumour lysis syndrome rare x x x
Alopecia common, 0% - 14% x x x x x
Appetite disorder x
Breast disorder x x x x x
Transient ischaemic attack x
Cyst x
Oedema x
Endocrine disorder x x x x x
Eye disorder x x x x x
Cardiac disorder x x x x x
Haemorrhage x x
Herpes simplex x
Hypersensitivity x x x x
Immune system disorder x x x x
Influenza x
Bundle branch block left x
Leukopenia x x
Menorrhagia x x x x
Neoplasm x x x x
Polyp x
Torsade de pointes x x x
Urinary tract disorder x x x x x
Oesophageal ulcer x
Abdominal pain upper x x x x
Nipple swelling x x x x
Hepatobiliary disease x x x x x
Fluid retention x x
Breast induration x x x x
Diastolic dysfunction x
Blood and lymphatic system disorders x x x x x
Ear and labyrinth disorders x x x x x
Blood potassium decreased x
Myelosuppression x x x x x

Indications

Information about indications was extracted from the indications and usage sections of the labels.

nilotinib / nilotinib

Side effects:225
Source:EMA

NILOTINIB

Side effects:305
Source:FDA Structured Product Label

Nilotinib / Tasigna, Capsule

Side effects:309
Source:Medsafe

nilotinib / TASIGNA

Side effects:312
Source:medicines.org.au

Color scheme:

standard – alternative

    100%
    75%
    50%
    10%
    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    postmarketing
    0%
    no frequency information
    not found on label