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Bortezomib

More information: STITCH, PubChem (stereo-specific compound: 1) and possibly Wikipedia

ATC Code: L01XX32

Side effects

Options: Show MedDRA Preferred Terms

Side effect Data for drug Placebo Labels
1 2 3 4 5 6 7 8 9 10 11
Neuropathy 40% x x x x x x x x
Mental disorder 0.604% - 49.1% x x x x x x x x
Plasma cell myeloma 8% - 57% x x x
Asthenic conditions 0% - 72.3% x x x x x x x x x
Anaemia 0% - 37% x x x x x x x x x x x
Mantle cell lymphoma 3% - 55% x x x
Hypoaesthesia 11% x
Thrombocytopenia 1.2% - 55% x x x x x x x x x x x
Epistaxis 10% x x x x x x x
Musculoskeletal pain 10% x x
Neuropathy peripheral 0% - 54.8% x x x x x x x x x
Diarrhoea 0% - 57.4% x x x x x x x x x x
Peripheral sensory neuropathy 5% - 9% x x x x x x x x x x x
Pneumonia 0% - 11.9% x x x x x x x x x x x
Dyspnoea 0.302% - 22.6% x x x x x x x x x x x
Neuralgia 0% - 9% x x x x
Dehydration 0% - 18.4% x x x x x x x x x x x
Vomiting 0% - 36% x x x x x x x x x x x
Body temperature increased 0% - 36.8% x x x x x x x x x x x
Nausea 0% - 64% x x x x x x x x x x x
Infection 0.301% - 20.8% x x x x x x x x x x x
Hypotension 0% - 14.8% x x x x x x x x x x x
Hyperglycaemia 2% - 3% x x x x x x x
Neutropenia 0% - 24.1% x x x x x x x x x x x
Bone pain 0% - 16.2% x x x x x x x x x x
Decreased appetite 0% - 43.4% x x x x x x x x x x
Constipation 0% - 49.7% x x x x x x x x x x x
Oedema 0% - 28.4% x x x x x x x x x x
Abdominal pain 0% - 16% x x x x x x x x x x x
Fatigue 0% - 41% x x x x x x x x x x x
Hypercalcaemia 2% x x x x x x x
Herpes zoster 0% - 13% x x x x x x x x x x x
Pain in extremity 0% - 25.9% x x x x x x x x x x x
Arthralgia 0% - 26.3% x x x x x x x x x x
Dysaesthesia 0% - 27.5% x x x x x x x x x x
Paraesthesia 0% - 27.5% x x x x x x x x x x x
Dizziness 0% - 23.2% x x x x x x x x x x x
Back pain 0% - 14.9% x x x x x x x x x x
Headache 0% - 27.6% x x x x x x x x x x x
Insomnia 0% - 27.2% x x x x x x x x x x
Rash 0% - 27.7% x x x x x x x x x x x
Anxiety 0% - 14% x x x x x x x x x x
Angina pectoris 1% x x x x x
Arrhythmia 1% x x
Diplopia 1% x x x x x
Enteritis 1% x x
Haemorrhage 1% x x
Hyperbilirubinaemia 1% x x x x x x x
Hypersensitivity 1% x x x x x x x
Pulmonary hypertension 1% x x x x x
Psychotic disorder 1% x x x x x x x x x x x
Renal failure 1% x x x x x x x
Convulsion 1% x
Stomatitis 1% x x x x x x x
Tumour lysis syndrome 1% x x x x x x x
Hepatic failure 1% x x x x x
Sepsis 1% x
Febrile neutropenia 1% x x x x x
Left ventricular ejection fraction decreased 1% x
Respiratory failure 1% x x x x x x x x x x x
Hearing impaired 1% x x x x x
Cough 0% - 21.1% x x x x x x x x x x x
Myalgia 0% - 14% x x x x x x x x x x
Acute febrile neutrophilic dermatosis postmarketing, 1% x x x
Nasopharyngitis 0% - 14% x x x x x x x x
Anorexia 0% - 33.8% x x x x x x x x x x
Cramp muscle 0% - 24% x x x x x x x x x
Pancreatitis acute postmarketing, 1% x x x x x x x
Cardiac tamponade postmarketing x x x x
Disseminated intravascular coagulation postmarketing, 1% x x x x x x x
Dysautonomia postmarketing x x x x x
Toxic epidermal necrolysis postmarketing x x x x
Hepatitis postmarketing x x x x
Herpes NOS postmarketing x x x
Ophthalmic herpes simplex postmarketing x x x
Progressive multifocal leukoencephalopathy postmarketing x
Lung disorder postmarketing x x x x
Meningoencephalitis postmarketing x x x
Optic nerve disorder postmarketing x x
Encephalopathy postmarketing, 1% x x x x x
Atrioventricular block complete postmarketing x x x
Colitis ischaemic postmarketing x x x x
Blindness postmarketing x x
Deafness bilateral postmarketing x x x
Abdominal distension x
Acidosis x
Adjustment disorder x
Respiratory alkalosis x
Amyloidosis x
Anaphylactic shock x x x x x x
Haemolytic anaemia x
Angina unstable x
Angioedema x x x x
Anxiety disorder x
Apnoea x
Arthritis x
Ascites x x x x x x
Aspergillosis x x x
Asthenia 0% - 11% x x x x x x x x x x
Ataxia x x x x x
Atelectasis x x x x x x
Atrial flutter x x x x x x
Atrioventricular block x
Bacteraemia x x x x x x
Bacterial infection x
Blister x
Coagulopathy x
Platelet disorder x
Bone disorder x
Breast disorder x
Bronchial disorder x
Bronchospasm x
Bronchitis x x
Bronchopneumonia x
Burn x
Neoplasm malignant x
Oral candidiasis x x x
Renal cell carcinoma x
Cardiovascular disorder x
Cellulitis x
Transient ischaemic attack x x x x x x
Cerebrovascular disorder x
Cheilitis x
Chest pain x
Cholelithiasis x
Cholestasis x x x x
Tongue coated x
Cognitive disorder x
Colitis x
Coma x x x x x x
Confusional state x x x x x x
Conjunctivitis x
Connective tissue disorder x x x
Contusion x
Cushing's syndrome x
Cyst x
Deafness x
Sudden death x x x x x x x
Libido decreased x
Decubitus ulcer x
Dysphagia x x x x x x
Delirium x
Dermatitis x
Diabetes mellitus x
Gastrointestinal malformation x
Drooling x
Drug hypersensitivity x x x x x
Dysarthria x x x x x
Dysgeusia 0% - 13% x x x x x x x x x x
Dyskinesia x
Dyspepsia 0% - 13.2% x x x x x x x x x x
Ear disorder x
Ecchymosis x
Endocrine disorder x
Endophthalmitis x
Epididymitis x
Epilepsy x
Grand mal convulsion x x x x x
Erythema multiforme x
Erythromelalgia x
Oesophagitis x
Exophthalmos x
Extravasation x x
Eye disorder x x x x
Eye haemorrhage x
Face injury x
Failure to thrive x
Chronic fatigue syndrome x
Faecal incontinence x
Faecalith x x x x x
Anal fissure x
Fistula x
Flatulence x
Flushing x
Fracture x x x x x x
Gastritis x
Gastroenteritis x x x
Gastrooesophageal reflux disease x x x x
Gastrointestinal disorder x x x x x x
Gastrointestinal haemorrhage x x x
Gingival bleeding x
Gingival hypertrophy x
Gout x
Hair disorder x
Hallucination x
Cardiac arrest x x x x x x x x x
Cardiac disorder x x x x x x
Cardiac failure x
Cardiac failure congestive x x x x x x x x x x
Cardiac valve disease x
Haematemesis x x x x x x
Blood disorder x
Haematoma x
Subdural haematoma x x x x x
Haematuria x x x x x x
Haemoptysis x x x x x x
Haemorrhagic disorder x
Hepatomegaly x
Hernia x
Genital herpes x
Herpes simplex x x x x
Ophthalmic herpes zoster x
Herpes virus infection x x x x
Meningoencephalitis herpetic x
Hiccups x
Hordeolum x
Hyperaemia x
Hyperhidrosis x
Hyperkalaemia x x x x
Hypernatraemia x x x x
Hypertension x x x x x
Hyperthyroidism x
Hyperventilation x
Hypocalcaemia x x x x x x
Hypokalaemia x x x x x x
Hyponatraemia x x x x x x
Orthostatic hypotension x x x x x
Hypothyroidism x
Hypovolaemic shock x
Ichthyosis x
Immune system disorder x x x x x x
Inappropriate antidiuretic hormone secretion x
Infarction x
Infertility x
Inflammation x
Influenza x
Intestinal obstruction x x x x x
Irritable bowel syndrome x
Irritability x
Ischaemia x
Calculus of kidney x x x x x
Renal failure acute x x
Renal failure chronic x
Laryngeal oedema x x x
Lethargy x
Leukaemia x
Plasma cell leukaemia x
Leukocytosis x
Leukopenia x x x x
Listeriosis x x x
Liver disorder x
Chronic obstructive pulmonary disease x
Lymphoedema x
Lymphoma x
Lymphopenia x x x x
Mastoiditis x
Mediastinal disorder x x x x
Megacolon x
Melaena x x x x x
Meningitis x
Metabolic disorder x
Oral disorder x
Multi-organ failure x
Hypotonia x
Myopathy x
Fungal infection x
Mycosis fungoides x
Myocardial infarction x x x x x x
Nail disorder x
Neoplasm x x
Nephritis x x x x x
Nervous system disorder x x x x
Night sweats x
Numbness x
Oliguria x
Pain x x
Pallor x
Palpitations x
Pancreatitis x
Pancytopenia x
Ileus paralytic x x x x x
Paresis x
Pelvic pain x
Pericardial effusion x x x x x x
Pericarditis x x x x
Periodontitis x
Peritonitis x x x x
Petechiae x
Phlebitis x x x x
Pleural effusion x x x x x x
Pleurisy x
Pneumonia aspiration x x x
Pneumothorax x
Polyp x
Post herpetic neuralgia x x x x
Prostatitis x
Proteinuria x
Pruritus 0% - 12% x x x x x x x x x
Psoriasis x
Pulmonary oedema x x x
Pulmonary embolism x x x x x x
Pulmonary fibrosis x
Purpura x
Radiation injury x
Radiculitis x
Proctalgia x
Reflexes abnormal x
Acute respiratory distress syndrome x x x x x x
Respiratory insufficiency x x x x x x x
Respiratory tract infection x
Restless legs syndrome x
Retinitis x
Rhabdomyolysis x
Salivary gland disorder x
Sciatica x
Scotoma x
Seborrhoeic dermatitis x
Shock x
Cardiogenic shock x x x x x x x x
Septic shock x x x x
Sinusitis x x x
Skin disorder x
Skin infection x
Skin lesion x
Skin ulcer x
Muscle spasms x
Speech disorder x
Spinal cord compression x x x x x x
Staphylococcal infection x
Stevens-Johnson syndrome x
Syncope x
Tachycardia x
Temporomandibular joint syndrome x
Testicular disorder x
Thirst x
Thrombophlebitis x
Tinnitus x
Tonsillitis x
Torsade de pointes x x x x
Toxoplasmosis x x x
Tremor x
Ulcer x
Loss of consciousness x
Erythema x
Upper respiratory tract infection 0% - 18% x x x x x x
Ureteric obstruction x
Pollakiuria x
Urinary incontinence x x x x x
Urinary tract infection x x x x
Micturition disorder x
Urinary tract disorder x x x
Urticaria x x x x x
Angiopathy x x x x
Vasculitis x
Venous insufficiency x
Ventricular tachycardia x x x x x
Vertigo 0% - 21.1% x x x x x x x x x x x
Viral infection x
Vitamin B12 deficiency x
Vitamin B complex deficiency x
Weight increased x
Weight decreased x x
Wheezing x
Laceration x
Urinary retention x x x x x x
Hypocapnia x
Meningitis bacterial x x x x x x x
Chills x x
Orthopnoea x
Agitation x x x x x x
Photopsia x
Photophobia x
Livedo reticularis x
Synovial cyst x
Oedema peripheral x x x
Hyperchloraemia x
Hypochloraemia x
Hyperphosphataemia x
Hypophosphataemia x
Cystitis haemorrhagic x x x
Epstein-Barr virus infection x
Lower respiratory tract infection x
Mouth ulceration x
Deep vein thrombosis x x x x x x
Migraine x
Alcohol intolerance x
Corneal lesion x
Tongue oedema x
Enzyme abnormality x
Impaired healing x
Injection site haemorrhage x
Haemorrhage intracranial x
Hypermagnesaemia x
Hypomagnesaemia x
Injection site reaction x
Large intestine perforation x x x x x
Myocardial ischaemia x x x x x
Muscular weakness x
Eye pain x
Injection site pain x x x x
Dry skin x
Polyneuropathy x
Joint swelling x
Lacrimation increased x
Portal vein thrombosis x x x x x
Vulval ulceration x
Abnormal faeces x
Joint stiffness x
Malnutrition x x x x x x
Photosensitivity reaction x
Unspecified disorder of skin and subcutaneous tissue x x x x
Interstitial lung disease x
Hyperviscosity syndrome x
Rectal discharge x
Disability x x x x x x x x x
Malaise x x x x x x x x x x
Muscle twitching x
Dyspnoea exertional x x x x x
Tachypnoea x
Cardiac fibrillation x
Cold sweat x
Increased appetite x
Abdominal discomfort x
Abdominal pain upper 0% x x
Disturbance in attention x
Motor dysfunction x x x x x x
Tenderness x
Peripheral motor neuropathy x x x x x x
Neurotoxicity x
Dry throat x
Eye irritation x
Small intestinal obstruction x x x x x
Hepatotoxicity x
Oral mucosal petechiae x x x
Chest discomfort x
Lung infiltration x x x x x x
Hepatic haemorrhage x x x x
Nerve root lesion x
Pain in jaw x
Throat tightness x
Gastrointestinal obstruction x
Epididymal tenderness x
Edema of lower extremities 0% - 13% x x x x x x
Genital pain x
Frequent bowel movements x
Lip swelling x
Skin induration x
Hypoxia x
Erectile dysfunction x
Azotaemia x
Ventricular dysfunction x
Aplasia x
Autonomic neuropathy x
Autonomic nervous system imbalance x
Cutaneous vasculitis x
Lip pain x
Hepatobiliary disease x x x x
Fluid retention x
Cardiac amyloidosis x x x x x
Eye swelling x
Ear haemorrhage x
Transfusion reaction x
Cytomegalovirus hepatitis x
Change of bowel habit x
Solid tumour x x x x x
Skin mass x
Dry eye x
Papule x
Redness x
Duodenitis haemorrhagic x x x
Electrolyte imbalance x
Vision blurred 0% - 11% x x x x x x x x x
Platelet count decreased x x x x x
Joint injury x
Eye discharge x
Sensation of foreign body x
Suicidal ideation x x x x x x
Rigors 0% - 11.8% x x x x x x x x x x
Bladder spasm x x x x x
Bradycardia x x x x
Urine analysis abnormal x
Large intestinal obstruction x x x x x
Respiratory distress x x x x x
Non-cardiac chest pain x
Blood gases abnormal x
Lymphadenopathy x
Dementia x
Poor peripheral circulation x
Toxic skin eruption x
Bilateral hydronephrosis x x x x x
Paralysis x x x x x x
Affective disorder x
Sinus arrest x x x x
Coronary artery insufficiency x x
Injection site phlebitis x
Face oedema x x x x
Fluid overload x
Hypovolaemia x
Fibrillation atrial aggravated x x x x x
Eyelid infection x
Feeling of body temperature change x
Vein discolouration x
Pigmentation disorder x
Haemorrhagic stroke x x x x x
Gait disturbance x
Jessner's lymphocytic infiltration x
International normalised ratio abnormal x
Blood glucose abnormal x
Sensation of heaviness x
Cardio-respiratory arrest x x x x x x
Breast disorder female x
Ear infection x
Throat irritation x
Presyncope x
Hypoxemia x
Acne x
COPD exacerbation x x x x x
Hyperuricaemia x x x x x x
C-reactive protein increased x
Memory loss x
Vestibular neuronitis x
Thrombocytosis x
Infestation NOS x x x x x x
Blood and lymphatic system disorders x x x x x x
Ear and labyrinth disorders x x x x
Sleep disorder x
Injection site erythema x x x
Pulmonary alveolar haemorrhage x
Dacryoadenitis acquired x
Peripheral neuropathy aggravated x x x x x x x x
Local reaction x
Haemorrhage subcutaneous x
Gastrointestinal motility disorder x
Blood test abnormal x
Peripheral embolism x x x x x x
Budd-Chiari syndrome x
Thrombocytopenic purpura x
Gastrointestinal ulcer perforation x
Catheter related infection x x x
Cardiotoxicity x
Tooth infection x
General physical health deterioration x
Anal sphincter atony x
Cardiomyopathy x
Pulmonary toxicity x x
Ear discomfort x
Respiratory tract congestion x
Catheter related complication x x x x
Urinary tract signs and symptoms x
Catheter site pain x
Erythrosis x
Peripheral sensorimotor neuropathy x
Troponin I increased x
Gastrointestinal toxicity x
Gastric pH decreased x
Joint effusion x
Ileus x x
Rhinorrhoea x
Lymphocytic infiltration x
Urine output x
Increased upper airway secretion x
Brain stem syndrome x
Parosmia x
Dysacusis x
Brain oedema x
Dysphonia x
Gastrointestinal inflammation x
Renal impairment x
Device related infection x
Procedural pain x
Uric acid abnormal x
Gastritis haemorrhagic x x x x x
Oropharyngeal blistering x
Oropharyngeal pain x
Platelet aggregation increased x
Cerebral haemorrhage x x x x x
Upper-airway cough syndrome x
Bladder irritation x
Leukocytoclastic vasculitis x x x
Vaginal haemorrhage x
Posterior reversible encephalopathy syndrome x x x x
Visual impairment x
Abnormal vision x

Indications

Information about indications was extracted from the indications and usage sections of the labels.

BORTEZOMIB / VELCADE

Side effects:58
Source:FDA

bortezomib / Velcade

Side effects:63
Source:FDA

bortezomib / Velcade

Side effects:63
Source:FDA

BORTEZOMIB / VELCADE

Side effects:63
Source:FDA

Bortezomib

Side effects:84
Source:BC Cancer

bortezomib / Velcade

Side effects:133
Source:FDA

bortezomib / Velcade

Side effects:133
Source:FDA

BORTEZOMIB / VELCADE

Side effects:203
Source:FDA

bortezomib / Velcade

Side effects:206
Source:FDA

bortezomib

Side effects:214
Source:FDA Structured Product Label

bortezomib / bortezomib

Side effects:473
Source:EMA

Color scheme:

standardalternative

    100%
    75%
    50%
    10%
    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    postmarketing
    0%
    no frequency information
    not found on label