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Trametinib

More information: STITCH, PubChem and possibly Wikipedia

ATC Codes: None found

Side effects

Options: Show MedDRA Preferred Terms

Side effect Data for drug Placebo Labels
1
Lymphopenia 6% - 59% x
Hyperglycaemia 2% - 67% x
Gamma-glutamyltransferase increased 2% - 56% x
Hyponatraemia 2% - 55% x
Hypophosphataemia 0% - 47% x
Fatigue 2% - 57% x
Anaemia 0% - 55% x
Headache 0% - 37% x
Arthralgia 0% - 44% x
Nausea 0% - 46% x
Leukopenia 0% - 62% x
Hypoalbuminaemia 0% - 53% x
Phosphatase alkaline increased 2% - 67% x
Myalgia 0% - 24% x
Neutropenia 2% - 55% x
Hypokalaemia 2% - 29% x
Aspartate aminotransferase increased 0% - 60% x
Hyperkalaemia 0% - 22% x
Hypertension 3% - 15% x
Vomiting 0% - 43% x
Chills 0% - 58% x
Decreased appetite 0% - 30% x
Diarrhoea 0% - 43% x
Rash 0% - 57% x
Body temperature increased 0% - 71% x
Oedema peripheral 0% - 31% x
Back pain 0% - 18% x
Alanine aminotransferase increased 0% - 42% x
Creatinine increased 0% - 24% x
Constipation 0% - 22% x
Pain in extremity 0% - 19% x
Thrombocytopenia 0% - 31% x
Cough 0% - 29% x
Insomnia 0% - 18% x
Dizziness 0% - 16% x
Hypocalcaemia 0% - 20% x
Urinary tract infection 0% - 13% x
Abdominal pain 1% - 33% x
Actinic keratosis 0% - 15% x
Hypercalcaemia 0% - 19% x
Night sweats 0% - 24% x
Dry mouth 0% - 11% x
Lymphoedema 0% - 32% x
Dehydration 0% - 11% x
Hyperbilirubinaemia 0% - 15% x
Stomatitis 0% - 15% x
Hypomagnesaemia 0% - 18% x
Pruritus 0% - 13% x
Haemorrhage 0% - 16% x
Renal failure 0% - 7% x
Muscle spasms 0% - 16% x
Erythema 0% - 15% x
Dermatitis acneiform 0% - 19% x
Paronychia 0% - 10% x
Arrhythmia x
Asthenia x
Mental disorder x
Bone disorder x
Neoplasm malignant x
Cellulitis x
Infection x
Conjunctival haemorrhage x
Connective tissue disorder x
Cyst x
Dysgeusia x
Oedema x
Epistaxis x
Eye disorder x
Eye haemorrhage x
Folliculitis x
Gastrointestinal disorder x
Gingival bleeding x
Cardiac disorder x
Cardiac failure congestive x
Haematochezia x
Haematuria x
Hyperhidrosis x
Renal failure acute x
Mediastinal disorder x
Malignant melanoma x
Melaena x
Neoplasm x
Nervous system disorder x
Pancreatitis x
Polyp x
Prurigo x
Rhabdomyolysis x
Aphthous stomatitis x
Urinary tract disorder x
Angiopathy x
Vitreous haemorrhage x
Rash pustular x
Mouth ulceration x
Haemorrhage intracranial x
Dry skin 0% - 18% x
Blindness transient x
Malnutrition x
Unspecified disorder of skin and subcutaneous tissue x
Rash macular x
Rash vesicular x
Abdominal discomfort x
Abdominal pain upper x
Abdominal pain lower x
Abdominal tenderness x
Rash erythematous x
Gastric haemorrhage x
Reaction febrile x
Disease progression x
Haemorrhoidal haemorrhage x
Rectal haemorrhage x
Dry eye x
Mucosal inflammation x
Vision blurred x
Skin papilloma x
Rash maculo-papular x
Bradycardia x
Rash generalised x
Brain stem haemorrhage x
Ejection fraction decreased x
Infestation NOS x
Refractory hypertension x
Hyperkeratosis x
Cardiomyopathy x
Left ventricular ejection fraction decreased x
Skin toxicity x
Ocular toxicity x
Rash papular x
Venous thromboembolism x
Oropharyngeal pain 0% - 13% x
Cerebral haemorrhage x
Vaginal haemorrhage x

Indications

Information about indications was extracted from the indications and usage sections of the labels.

TRAMETINIB

Side effects:131
Source:FDA Structured Product Label

Color scheme:

standard – alternative

    100%
    75%
    50%
    10%
    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    postmarketing
    0%
    no frequency information
    not found on label