Tenofovir disoproxil fumarate
  
Side effects 
	
		
Options: 
			
			Show MedDRA Preferred Terms
		
	
	
| Side effect | Data for drug | Placebo | Labels | 
|  | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 
| Pruritus | 16% |  |  |  |  | x | x | x | x | x | x | x | x | x | x | 
| Nasopharyngitis | 9.86% - 11.2% |  |  |  |  |  |  |  |  | x | x | x | x | x | x | 
| Nausea | postmarketing — 2.79% - 20% | 5% - 10% | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Fasting | 2% - 24% |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Pain | 7% - 12% | 7% |  |  |  | x | x | x | x | x | x | x | x | x | x | 
| Diarrhoea | postmarketing — 5.12% - 16% | 8% - 10% | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Fatigue | 7.44% - 8.45% |  |  |  |  |  |  |  |  | x | x | x | x | x | x | 
| Asthenia | postmarketing — 7% - 11% | 6% - 8% | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Headache | 5% - 14% | 5% - 7% | x | x |  | x | x | x | x | x | x | x | x | x | x | 
| Abdominal pain upper | 5.12% - 7.04% |  |  |  |  |  |  |  |  | x |  |  |  |  | x | 
| Depression | 4% - 8% | 3% |  |  |  | x | x | x | x | x | x | x | x | x | x | 
| Vomiting | postmarketing — 4% - 13% | 1% - 2% | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Procedural pain | 3.76% - 5.58% |  |  |  |  |  |  |  |  | x |  |  |  |  |  | 
| Back pain | 3% - 7.04% | 3% |  |  |  | x | x | x | x | x | x | x | x | x | x | 
| Pharyngolaryngeal pain | 3.52% - 5.12% |  |  |  |  |  |  |  |  | x |  |  |  |  |  | 
| Upper respiratory tract infection | 3.05% - 5.12% |  |  |  |  |  |  |  |  | x | x | x | x | x | x | 
| Body temperature increased | 2% - 11% | 2% |  |  |  | x | x | x | x | x | x | x | x | x | x | 
| Flatulence | postmarketing — 3% - 4% | 0% - 1% | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Neuropathy peripheral | 3% - 5% | 3% |  |  |  | x | x | x | x | x | x | x | x | x | x | 
| Insomnia | 3% - 18% | 2% |  |  |  | x | x | x | x | x | x | x | x | x | x | 
| Dyspepsia | 3% - 4% | 2% |  |  |  | x | x | x | x | x | x | x | x | x | x | 
| Myalgia | 3% - 4% | 3% |  |  |  | x | x | x | x | x | x | x | x | x | x | 
| Dizziness | postmarketing — 1% - 13% | 3% |  | x | x | x | x | x | x | x | x | x | x | x | x | 
| Anorexia | 3% - 4% | 1% - 2% | x | x |  | x | x | x | x | x | x | x | x | x | x | 
| Chest pain | 3% | 1% |  |  |  | x | x | x | x | x | x | x | x | x | x | 
| Sweating | 3% | 2% |  |  |  | x | x | x | x | x | x | x | x | x | x | 
| Weight decreased | 2% - 4% | 1% |  |  |  | x | x | x | x | x | x | x | x | x | x | 
| Transaminases increased | postmarketing, common |  |  |  | x |  |  |  |  |  |  |  |  |  |  | 
| Pneumonia | 2% - 3% | 0% |  |  |  | x | x | x | x | x | x | x | x | x | x | 
| Haematuria | 2% - 3% |  |  |  |  | x | x | x | x | x | x | x | x | x | x | 
| Glycosuria | 1% - 3% |  |  |  |  |  |  |  |  | x |  |  |  | x |  | 
| Hyperglycaemia | postmarketing, 1% - 2% |  |  |  | x |  |  |  |  | x | x | x | x | x | x | 
| Abdominal pain | postmarketing, 3% - 22% | 3% | x | x |  | x | x | x | x | x | x | x | x | x | x | 
| Lactic acidosis | postmarketing, rare |  |  | x | x | x | x | x | x | x | x | x | x | x | x | 
| Angioedema | postmarketing, rare |  |  |  | x |  |  |  |  | x |  |  |  |  |  | 
| Autoimmune disorder | postmarketing |  |  |  | x |  |  |  |  |  |  |  |  |  |  | 
| Connective tissue disorder | postmarketing |  |  |  | x |  |  |  |  | x |  | x | x | x | x | 
| Dyspnoea | postmarketing |  |  | x |  | x | x | x | x | x | x | x | x | x | x | 
| Rash | postmarketing — 5% - 7% | 4% |  | x | x | x | x | x | x | x | x | x | x | x | x | 
| Fanconi syndrome | postmarketing, rare |  |  | x | x | x | x | x | x | x | x | x | x | x | x | 
| Fracture | postmarketing, rare |  |  |  | x |  |  |  |  | x |  |  |  |  | x | 
| Gastrointestinal disorder | postmarketing |  |  |  | x | x | x | x | x | x | x | x | x | x | x | 
| Basedow's disease | postmarketing |  |  |  | x |  |  |  |  |  |  |  |  |  |  | 
| Hepatitis | postmarketing, rare |  |  |  | x |  |  | x | x | x | x | x | x | x | x | 
| Hepatomegaly | postmarketing |  |  |  | x |  |  |  |  |  |  |  |  | x |  | 
| Hypercholesterolaemia | postmarketing |  |  |  | x |  |  |  |  |  |  |  |  |  |  | 
| Hypersensitivity | postmarketing |  |  |  |  | x | x | x | x | x | x | x | x | x | x | 
| Hypertriglyceridaemia | postmarketing |  |  |  | x |  |  |  |  |  |  |  |  |  |  | 
| Hypertrophy of breast | postmarketing |  |  |  | x |  |  |  |  |  |  |  |  |  |  | 
| Hypokalaemia | postmarketing, uncommon |  |  |  | x |  |  |  |  | x |  |  |  |  | x | 
| Immune system disorder | postmarketing |  |  |  |  | x | x | x | x | x | x | x | x | x | x | 
| Inflammation | postmarketing |  |  |  | x |  |  |  |  | x |  |  |  |  | x | 
| Insulin resistance | postmarketing |  |  |  | x |  |  |  |  |  |  |  |  |  |  | 
| Renal failure acute | postmarketing, rare |  |  |  | x | x | x | x | x | x | x | x | x | x | x | 
| Nephrosis lower nephron | postmarketing, rare |  |  |  | x | x | x | x | x | x | x | x | x | x | x | 
| Lipodystrophy | postmarketing |  |  |  | x |  |  | x | x | x | x | x | x | x | x | 
| Mediastinal disorder | postmarketing |  |  |  |  | x | x | x | x | x | x | x | x | x | x | 
| Myopathy | postmarketing, rare |  |  |  | x |  |  |  |  | x |  | x | x | x | x | 
| Nephritis | postmarketing, rare |  |  |  | x |  |  |  |  |  | x |  |  |  |  | 
| Nephritis interstitial | postmarketing |  |  |  |  |  |  |  |  | x |  | x | x | x | x | 
| Nervous system disorder | postmarketing |  |  |  | x |  |  |  |  | x | x | x | x | x | x | 
| Opportunistic infection | postmarketing |  |  |  | x |  |  |  |  |  |  |  |  |  |  | 
| Osteomalacia | postmarketing, rare |  |  |  | x |  |  |  |  | x |  | x | x | x | x | 
| Osteonecrosis | postmarketing |  |  |  | x |  |  |  |  |  |  |  |  |  |  | 
| Pancreatitis | postmarketing, uncommon |  |  | x | x | x | x | x | x | x | x | x | x | x | x | 
| Polyuria | postmarketing |  |  |  |  |  |  |  |  | x | x | x | x | x | x | 
| Proteinuria | postmarketing |  |  |  |  | x | x | x | x | x | x | x | x | x | x | 
| Renal failure | postmarketing, rare |  |  | x | x | x | x | x | x | x | x | x | x | x | x | 
| Rhabdomyolysis | postmarketing, uncommon |  |  |  | x |  |  |  |  | x |  |  |  |  | x | 
| Thrombocytopenia | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Urinary tract disorder | postmarketing |  |  |  | x | x | x | x | x | x | x | x | x | x | x | 
| Hypophosphataemia | postmarketing, very common |  |  | x | x | x | x | x | x | x | x | x | x | x | x | 
| Acute interstitial nephritis | postmarketing, rare |  |  |  | x |  |  |  |  |  |  |  |  |  |  | 
| Amylase increased | postmarketing |  |  |  |  |  |  | x | x | x | x | x | x | x | x | 
| Creatinine increased | postmarketing, uncommon |  |  | x | x | x | x | x | x | x | x | x | x | x | x | 
| Muscular weakness | postmarketing, uncommon |  |  |  | x |  |  |  |  | x |  |  |  |  | x | 
| Bone pain | postmarketing, rare |  |  |  | x |  |  |  |  | x |  |  |  |  | x | 
| Nephrogenic diabetes insipidus | postmarketing, rare |  |  |  | x |  |  | x | x | x | x | x | x | x | x | 
| Malnutrition | postmarketing |  |  |  | x | x | x | x | x | x | x | x | x | x | x | 
| Unspecified disorder of skin and subcutaneous tissue | postmarketing, 5% |  |  |  | x |  |  |  |  | x | x | x | x | x | x | 
| Hepatobiliary disease | postmarketing |  |  |  | x |  |  | x | x | x | x | x | x | x | x | 
| Buffalo hump | postmarketing |  |  |  | x |  |  |  |  |  |  |  |  |  |  | 
| Hyperlactacidaemia | postmarketing |  |  |  | x |  |  |  |  |  |  |  |  |  |  | 
| Symptomatic hyperlactatemia | postmarketing |  |  |  | x |  |  |  |  |  |  |  |  |  |  | 
| Renal impairment | postmarketing |  |  |  | x |  |  | x | x |  | x |  | x | x | x | 
| Hepatic steatosis | postmarketing, rare |  |  |  | x |  |  |  |  | x |  |  |  |  | x | 
| Anaemia |  |  |  |  |  |  |  |  |  | x |  |  |  |  | x | 
| Anxiety |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | 
| Arthralgia |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | 
| Mental disorder |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | 
| Hepatitis B |  |  |  |  |  |  |  |  |  | x |  |  |  | x |  | 
| Metabolic disorder |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | 
| Neuritis |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | 
| Paraesthesia |  |  |  |  |  | x | x |  |  |  |  |  |  |  |  | 
| Prurigo |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | 
| Sinusitis |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Urticaria |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | 
| Rash pustular |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | 
| Vesiculobullous rash |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | 
| Alanine aminotransferase increased |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Haemoglobin decreased |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | 
| Rash macular |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | 
| Rash vesicular |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | 
| Abnormal dreams |  |  |  |  |  | x | x |  |  | x | x | x | x |  | x | 
| Rash maculo-papular |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | 
| Neuropathy |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | 
| Rash generalised |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | 
| Serum creatinine increased |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | 
| Infestation NOS |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Blood and lymphatic system disorders |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Exfoliative rash |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | 
| Somnolence |  |  |  |  |  |  |  |  |  |  | x | x | x |  | x | 
	 
 
  Indications
	Information about indications was extracted from the indications and usage sections of the labels.
	
 
	  
	  
		| Side effects: | 8 | 
|---|
		| Source: | FDA | 
|---|
		 
	  
	  
		| Side effects: | 17 | 
|---|
		| Source: | FDA | 
|---|
		 
	  
	  
		| Side effects: | 52 | 
|---|
		| Source: | EMA | 
|---|
		 
	  
	  
		| Side effects: | 49 | 
|---|
		| Source: | FDA | 
|---|
		 
	  
	  
		| Side effects: | 49 | 
|---|
		| Source: | FDA | 
|---|
		 
	  
	  
		| Side effects: | 55 | 
|---|
		| Source: | FDA | 
|---|
		 
	  
	  
		| Side effects: | 55 | 
|---|
		| Source: | FDA | 
|---|
		 
	  
	  
		| Side effects: | 83 | 
|---|
		| Source: | Medsafe | 
|---|
		 
	  
	  
		| Side effects: | 69 | 
|---|
		| Source: | FDA | 
|---|
		 
	  
	  
		| Side effects: | 71 | 
|---|
		| Source: | FDA | 
|---|
		 
	  
	  
		| Side effects: | 72 | 
|---|
		| Source: | FDA | 
|---|
		 
	  
	  
		| Side effects: | 78 | 
|---|
		| Source: | FDA | 
|---|
		 
	  
	  
		| Side effects: | 84 | 
|---|
		| Source: | Health Canada | 
|---|
		 
	  
  
 
  
	Color scheme:
	  
	  standard – alternative
	  
	
	
|  |  | 100% | 
|  |  | 75% | 
|  |  | 50% | 
|  |  | 10% | 
|  |  | frequent (1% to 100%) | 
|  |  | infrequent (0.1% to 1%) | 
|  |  | rare (<0.1%) | 
|  |  | postmarketing | 
|  |  | 0% | 
|  |  | no frequency information | 
|  |  | not found on label |