Tenofovir disoproxil fumarate
Side effects
Options:
Hide MedDRA Preferred Terms
MedDRA Preferred Term
|
Side effect
|
Data for drug
|
Placebo
|
Labels
|
|
1
|
2
|
3
|
4
|
5
|
6
|
7
|
8
|
9
|
10
|
11
|
12
|
13
|
Pruritus
|
Pruritus
|
16%
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Nasopharyngitis
|
Nasopharyngitis
|
9.86% - 11.2%
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Nausea
|
Nausea
|
postmarketing — 2.79% - 20%
|
5% - 10%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Fasting
|
Fasting
|
2% - 24%
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Pain
|
Pain
|
7% - 12%
|
7%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Diarrhoea
|
Diarrhoea
|
postmarketing — 5.12% - 16%
|
8% - 10%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Asthenia
|
Fatigue
|
7.44% - 8.45%
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Asthenia
|
postmarketing — 7% - 11%
|
6% - 8%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Fatigue
|
Fatigue
|
7.44% - 8.45%
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Headache
|
Headache
|
5% - 14%
|
5% - 7%
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Abdominal pain upper
|
Abdominal pain upper
|
5.12% - 7.04%
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
x
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Depression
|
Depression
|
4% - 8%
|
3%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Vomiting
|
Vomiting
|
postmarketing — 4% - 13%
|
1% - 2%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Procedural pain
|
Procedural pain
|
3.76% - 5.58%
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
Back pain
|
Back pain
|
3% - 7.04%
|
3%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Laryngeal pain
|
Pharyngolaryngeal pain
|
3.52% - 5.12%
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
Upper respiratory tract infection
|
Upper respiratory tract infection
|
3.05% - 5.12%
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Body temperature increased
|
Body temperature increased
|
2% - 11%
|
2%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Flatulence
|
Flatulence
|
postmarketing — 3% - 4%
|
0% - 1%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Neuropathy peripheral
|
Neuropathy peripheral
|
3% - 5%
|
3%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Neuritis
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Neuropathy
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Insomnia
|
Insomnia
|
3% - 18%
|
2%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Dyspepsia
|
Dyspepsia
|
3% - 4%
|
2%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Myalgia
|
Myalgia
|
3% - 4%
|
3%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Musculoskeletal discomfort
|
Myalgia
|
3% - 4%
|
3%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Arthralgia
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Dizziness
|
Dizziness
|
postmarketing — 1% - 13%
|
3%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Decreased appetite
|
Anorexia
|
3% - 4%
|
1% - 2%
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Chest pain
|
Chest pain
|
3%
|
1%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Hyperhidrosis
|
Sweating
|
3%
|
2%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Weight decreased
|
Weight decreased
|
2% - 4%
|
1%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Transaminases increased
|
Transaminases increased
|
postmarketing, common
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
Pneumonia
|
Pneumonia
|
2% - 3%
|
0%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Haematuria
|
Haematuria
|
2% - 3%
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Glycosuria
|
Glycosuria
|
1% - 3%
|
|
|
|
|
|
|
|
|
x
|
|
|
|
x
|
|
Hyperglycaemia
|
Hyperglycaemia
|
postmarketing, 1% - 2%
|
|
|
|
x
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Abdominal pain
|
Abdominal pain
|
postmarketing, 3% - 22%
|
3%
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Gastrointestinal pain
|
Abdominal pain
|
postmarketing, 3% - 22%
|
3%
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Lactic acidosis
|
Lactic acidosis
|
postmarketing, rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Angioedema
|
Angioedema
|
postmarketing, rare
|
|
|
|
x
|
|
|
|
|
x
|
|
|
|
|
|
Autoimmune disorder
|
Autoimmune disorder
|
postmarketing
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
Connective tissue disorder
|
Connective tissue disorder
|
postmarketing
|
|
|
|
x
|
|
|
|
|
x
|
|
x
|
x
|
x
|
x
|
Dyspnoea
|
Dyspnoea
|
postmarketing
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Dermatitis
|
Rash
|
postmarketing — 5% - 7%
|
4%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Rash
|
Rash
|
postmarketing — 5% - 7%
|
4%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Fanconi syndrome
|
Fanconi syndrome
|
postmarketing, rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Renal tubular disorder
|
Fanconi syndrome
|
postmarketing, rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Multiple fractures
|
Fracture
|
postmarketing, rare
|
|
|
|
x
|
|
|
|
|
x
|
|
|
|
|
x
|
Fracture
|
Fracture
|
postmarketing, rare
|
|
|
|
x
|
|
|
|
|
x
|
|
|
|
|
x
|
Gastrointestinal disorder
|
Gastrointestinal disorder
|
postmarketing
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Basedow's disease
|
Basedow's disease
|
postmarketing
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
Hepatitis
|
Hepatitis
|
postmarketing, rare
|
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Hepatomegaly
|
Hepatomegaly
|
postmarketing
|
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
|
Hypercholesterolaemia
|
Hypercholesterolaemia
|
postmarketing
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
Hypersensitivity
|
Hypersensitivity
|
postmarketing
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Hypertriglyceridaemia
|
Hypertriglyceridaemia
|
postmarketing
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
Blood triglycerides increased
|
Hypertriglyceridaemia
|
postmarketing
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
Breast enlargement
|
Hypertrophy of breast
|
postmarketing
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
Hypokalaemia
|
Hypokalaemia
|
postmarketing, uncommon
|
|
|
|
x
|
|
|
|
|
x
|
|
|
|
|
x
|
Immune system disorder
|
Immune system disorder
|
postmarketing
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Inflammation
|
Inflammation
|
postmarketing
|
|
|
|
x
|
|
|
|
|
x
|
|
|
|
|
x
|
Insulin resistance
|
Insulin resistance
|
postmarketing
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
Renal failure acute
|
Renal failure acute
|
postmarketing, rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Renal tubular necrosis
|
Nephrosis lower nephron
|
postmarketing, rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Lipodystrophy acquired
|
Lipodystrophy
|
postmarketing
|
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Mediastinal disorder
|
Mediastinal disorder
|
postmarketing
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Myopathy
|
Myopathy
|
postmarketing, rare
|
|
|
|
x
|
|
|
|
|
x
|
|
x
|
x
|
x
|
x
|
Nephritis
|
Nephritis
|
postmarketing, rare
|
|
|
|
x
|
|
|
|
|
|
x
|
|
|
|
|
Tubulointerstitial nephritis
|
Nephritis interstitial
|
postmarketing
|
|
|
|
|
|
|
|
|
x
|
|
x
|
x
|
x
|
x
|
Acute interstitial nephritis
|
postmarketing, rare
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
Nervous system disorder
|
Nervous system disorder
|
postmarketing
|
|
|
|
x
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Opportunistic infection
|
Opportunistic infection
|
postmarketing
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
Osteomalacia
|
Osteomalacia
|
postmarketing, rare
|
|
|
|
x
|
|
|
|
|
x
|
|
x
|
x
|
x
|
x
|
Osteonecrosis
|
Osteonecrosis
|
postmarketing
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
Pancreatitis
|
Pancreatitis
|
postmarketing, uncommon
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Polyuria
|
Polyuria
|
postmarketing
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Urine output increased
|
Polyuria
|
postmarketing
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Proteinuria
|
Proteinuria
|
postmarketing
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Protein urine present
|
Proteinuria
|
postmarketing
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Renal failure
|
Renal failure
|
postmarketing, rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Renal impairment
|
postmarketing
|
|
|
|
x
|
|
|
x
|
x
|
|
x
|
|
x
|
x
|
x
|
Rhabdomyolysis
|
Rhabdomyolysis
|
postmarketing, uncommon
|
|
|
|
x
|
|
|
|
|
x
|
|
|
|
|
x
|
Thrombocytopenia
|
Thrombocytopenia
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Urethral disorder
|
Urinary tract disorder
|
postmarketing
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Urinary tract disorder
|
Urinary tract disorder
|
postmarketing
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Hypophosphataemia
|
Hypophosphataemia
|
postmarketing, very common
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Amylase increased
|
Amylase increased
|
postmarketing
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Blood creatinine increased
|
Creatinine increased
|
postmarketing, uncommon
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Serum creatinine increased
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
Muscular weakness
|
Muscular weakness
|
postmarketing, uncommon
|
|
|
|
x
|
|
|
|
|
x
|
|
|
|
|
x
|
Bone pain
|
Bone pain
|
postmarketing, rare
|
|
|
|
x
|
|
|
|
|
x
|
|
|
|
|
x
|
Nephrogenic diabetes insipidus
|
Nephrogenic diabetes insipidus
|
postmarketing, rare
|
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Malnutrition
|
Malnutrition
|
postmarketing
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Skin disorder
|
Unspecified disorder of skin and subcutaneous tissue
|
postmarketing, 5%
|
|
|
|
x
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Hepatobiliary disease
|
Hepatobiliary disease
|
postmarketing
|
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Lipohypertrophy
|
Buffalo hump
|
postmarketing
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
Hyperlactacidaemia
|
Hyperlactacidaemia
|
postmarketing
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
Symptomatic hyperlactatemia
|
postmarketing
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
Renal impairment
|
Renal impairment
|
postmarketing
|
|
|
|
x
|
|
|
x
|
x
|
|
x
|
|
x
|
x
|
x
|
Hepatic steatosis
|
Hepatic steatosis
|
postmarketing, rare
|
|
|
|
x
|
|
|
|
|
x
|
|
|
|
|
x
|
Anaemia
|
Anaemia
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
x
|
Anxiety
|
Anxiety
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Arthralgia
|
Arthralgia
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Mental disorder
|
Mental disorder
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Hepatitis B
|
Hepatitis B
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
x
|
|
Metabolic disorder
|
Metabolic disorder
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Neuritis
|
Neuritis
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Paraesthesia
|
Paraesthesia
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
Prurigo
|
Prurigo
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Sinusitis
|
Sinusitis
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Urticaria
|
Urticaria
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Rash pustular
|
Rash pustular
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Vesiculobullous rash
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Dermatitis bullous
|
Vesiculobullous rash
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Alanine aminotransferase increased
|
Alanine aminotransferase increased
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Haemoglobin decreased
|
Haemoglobin decreased
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
Rash macular
|
Rash macular
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Rash vesicular
|
Rash vesicular
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Abnormal dreams
|
Abnormal dreams
|
|
|
|
|
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
|
x
|
Rash maculo-papular
|
Rash maculo-papular
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Rash generalised
|
Rash generalised
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Infestation
|
Infestation NOS
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Exfoliative rash
|
Exfoliative rash
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Somnolence
|
Somnolence
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
|
x
|
Indications
Information about indications was extracted from the indications and usage sections of the labels.
Side effects: | 8 |
Source: | FDA |
---|
Side effects: | 17 |
Source: | FDA |
---|
Side effects: | 52 |
Source: | EMA |
---|
Side effects: | 49 |
Source: | FDA |
---|
Side effects: | 49 |
Source: | FDA |
---|
Side effects: | 55 |
Source: | FDA |
---|
Side effects: | 55 |
Source: | FDA |
---|
Side effects: | 83 |
Source: | Medsafe |
---|
Side effects: | 69 |
Source: | FDA |
---|
Side effects: | 71 |
Source: | FDA |
---|
Side effects: | 72 |
Source: | FDA |
---|
Side effects: | 78 |
Source: | FDA |
---|
Side effects: | 84 |
Source: | Health Canada |
---|
Color scheme:
standard – alternative
|
|
100%
|
|
|
75%
|
|
|
50%
|
|
|
10%
|
|
|
frequent (1% to 100%)
|
|
|
infrequent (0.1% to 1%)
|
|
|
rare (<0.1%)
|
|
|
postmarketing
|
|
|
0%
|
|
|
no frequency information
|
|
|
not found on label
|