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Cladribine

More information: STITCH, PubChem (stereo-specific compound: 1) and possibly Wikipedia

ATC Code: L01BB04

Side effects

Options: Show MedDRA Preferred Terms

Side effect Data for drug Placebo Labels
1 2 3 4 5 6
Body temperature increased very common, 33% - 69% x x x x
Fatigue very common, 11% - 45% x x x x x x
Neurotoxicity 35-45% x x x x x
Renal impairment 19-45% x x x
Nausea very common, 5-28% - 28% x x x x x x
Rash very common, 10% - 27% x x x x x x
Bacterial infection 21.8% x
Infection very common, 28% x x x x x x
Viral skin infection 20.8% x
Injection site reaction very common, 9% - 19% x x x x
Headache very common, 7% - 22% x x x x x x
Decreased appetite very common, 8% - 17% x x x x x
Lymphopenia very common x x x x x x
Neutropenia very common x x x x x x
Pancytopenia very common x x x x x
Sweating increased very common x x x x
Myelosuppression very common x x x x x x
Vomiting very common, 1-13% - 13% x x x x x x
Upper respiratory tract infection 12.9% x
Thrombocytopenia very common, 6% - 12% x x x x x x
Oral candidiasis 11.9% x
Urinary tract infection 11.9% x
Breath sounds abnormal very common, 4% - 11% x x x x x x
Administration site reaction 11% x x
Inflammation 8.9% - 12.9% x
Purpura very common, 10% x x x x x x
Asthenia very common, 6% - 9% x x x x x x
Constipation very common, 4% - 9% x x x x x x
Dizziness very common, 6% - 9% x x x x x x
Chills very common, 2% - 9% x x x x x x
Abnormal chest sounds NOS very common, 9% x x x
Skin infection 5.7% - 11.9% x
Petechiae common, 2% - 8% x x x x x x
Febrile neutropenia 8% - 47% x x x
Diarrhoea very common, 7% - 3-12% x x x x x x
Pneumonia 6% - 28.7% x x x x x x
Cough very common, 7% - 10% x x x x x x
Dyspnoea common, 5% - 7% x x x x x x
Myalgia common, 6% - 7% x x x x x x
Insomnia common, 3% - 7% x x x x x x
Abdominal pain 4% - 6% x x x x x
Oedema common, 6% x x x x x x
Pain common, 6% x x x x x x
Pruritus common, 2% - 6% x x x x x x
Tachycardia common, 2% - 6% x x x x x x
Erythema common, 6% x x x x x
Haemorrhage common, 6% x x x x
Arthralgia common, 3% - 5% x x x x x x
Arthritis common x x x
Neoplasm malignant common x
Epistaxis common, 5% x x x x
Cardiac murmur common x
Hypotension common x
Urticaria common x x x x x x
Myocardial ischaemia common x
Bone pain common x x x
Malaise common, 5% - 7% x x x x x
Pain of skin common x
Mucosal inflammation common x
Gastrointestinal pain common x
Hyperhidrosis 3% x x
Bacteraemia 2% x x
Cellulitis 2% x x
Ecchymosis 2% x x
Phlebitis uncommon, 2% - 5% x x x x x x
Thrombosis 2% x x x
Oedema peripheral 2% x x
Anaemia very common, 1% x x x x x x
Anxiety common, 1% x x x
Contusion 1% x x
Flatulence common, 1% x x x
Localised infection 1% x x
Rales 1% x x
Muscular weakness 1% x x
Haemolytic anaemia uncommon x x x x x x
Ataxia uncommon x
Cachexia uncommon x
Confusional state uncommon x x x
Conjunctivitis uncommon x x x
Lethargy uncommon x
Paraesthesia uncommon x
Pharyngitis uncommon x
Polyneuropathy uncommon x x x x
Somnolence uncommon x
Toxic epidermal necrolysis rare, 1% x x x x x
Tumour lysis syndrome rare, 1% x x x x
Atrial fibrillation rare x
Graft versus host disease rare x
Cardiac failure rare x
Renal failure rare x x x
Stevens-Johnson syndrome rare x x x
Cerebrovascular accident rare x
Hepatic failure rare x
Hypereosinophilia rare x x x x x x
Ileus rare x
Decompensation cardiac rare x
Myelodysplastic syndrome 0.03% x x x x x
Amyloidosis very rare x
Blepharitis very rare x
Cholecystitis very rare x
Epilepsy very rare x
Pulmonary embolism very rare x
Alopecia x
Aplastic anaemia x x x x x
Autoimmune haemolytic anaemia x x x
Anorexia x
Arrhythmia x
Back pain x x
Mental disorder x x
Bone disorder x x
Chest pain x x
Connective tissue disorder x
Cyst x
Localised oedema x x
Extravasation x
Eye disorder x x x
Gastrointestinal disorder x x x
Cardiac disorder x x x
Blood disorder x x
Herpes NOS x
Herpes zoster x x x
Hypersensitivity x x
Immune system disorder x x x
Infarction x
Renal failure acute x x x x
Mediastinal disorder x x x
Musculoskeletal pain x
Fungal infection x x x x
Neoplasm x x
Nervous system disorder x x x
Opportunistic infection x x x x x x
Pain in extremity x x
Polyp x
Pulmonary fibrosis x x
Respiratory tract infection x
Septicemia x x x x x x
Septic shock x x
Swelling x x x
Ureteric obstruction x
Urinary tract disorder x x x
Angiopathy x x
Wheezing x x
Peripheral sensory neuropathy x x
Malnutrition x x x
Intestinal infections x
Unspecified disorder of skin and subcutaneous tissue x x x
Interstitial lung disease x x
Fatal outcomes x
Metabolic acidosis x
Paraparesis x x x
Rash macular x
Dyspnoea exertional x x
Abdominal discomfort x x
Disorientation x x
Rash erythematous x
Peripheral motor neuropathy x
Lung infiltration x x
Sepsis x x x x
Hepatobiliary disease x x x
Quadriparesis x
Blood bilirubin increased x
Redness x x x
Paralysis x x
Depressed level of consciousness x x
Hyperuricaemia x x
Infestation NOS x x x
Blood and lymphatic system disorders x x x
Culture negative x
Catheter site cellulitis x
Infusion site reaction x x
Urine output x
Death x

Indications

Information about indications was extracted from the indications and usage sections of the labels.

CLADRIBINE

Side effects:55
Source:FDA Structured Product Label

CLADRIBINE

Side effects:55
Source:FDA Structured Product Label

Cladribine

Side effects:63
Source:BC Cancer

cladribine / cladribine

Side effects:108
Source:EMA

CLADRIBINE

Side effects:106
Source:FDA Structured Product Label

LEUSTATIN / Leustatin, Solution for infusion

Side effects:117
Source:Medsafe

Color scheme:

standard – alternative

    100%
    75%
    50%
    10%
    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    postmarketing
    0%
    no frequency information
    not found on label