Donepezil

Side effects and indications

Whenever possible, frequency information about the side effects was extracted from the labels. Aggregated frequency information for the drug and, if available, placebo is shown. To the right, you can click on shaded boxes to be taken to mentions of the side effect on the label. (In some cases, the side effect cannot be highlighted due to conversion problems.) Information about indications was extracted from the indications and usage sections of the labels.

Show MedDRA Preferred Terms

Side effect Data for drug Placebo Labels (show all 17)
1 2 3 4 5 6 7 8 9 10
Nausea def 1% - 19% 1% - 6% x x x x x x x x x
Diarrhoea def 0% - 15% 0% - 5% x x x x x x x x x
Insomnia def 6% - 14% 6% x x x x x x x x x
Fatigue def 3% - 8% 3% x x x x x x x x x
Cramp muscle def infrequent, 2% - 8% 2% x x x x x x x x x
Vomiting def 1% - 8% 1% - 3% x x x x x x x x x
Anorexia def 2% - 7% 2% x x x x x x x x x
Abdominal pain def postmarketing, frequent x x x x x x x x x x
Aggression def frequent x x x x x x x x
Anaemia def postmarketing — frequent x x x x x x x x x x
Anxiety def frequent x x x x x x x
Aphasia def frequent x x x x x x x x x
Arthritis def frequent x x x x x x x x
Asthenia def frequent x x x x x x x
Ataxia def infrequent, frequent x x x x x x x x x
Atrial fibrillation def infrequent, frequent x x x x x x x x x
Bronchitis def frequent x x x x x x x x
Chest pain def frequent x x x x x x x x x
Constipation def frequent x x x x x x
Convulsion def postmarketing — frequent x x x x x x x x x
Cough def frequent x x x x x x x
Cystitis def infrequent, frequent x x x x x x x x x
Dehydration def frequent x x x x x x x x x
Delusion def infrequent, frequent x x x x x x x x x
Dyspepsia def frequent x x x x x x
Dyspnoea def infrequent, frequent x x x x x x x x
Oedema def infrequent, frequent x x x x x x x x x
Rash def postmarketing — frequent x x x x x x x x x x
Faecal incontinence def frequent x x x x x x x x x
Gastroenteritis def infrequent, frequent x x x x x x x x x
Gastrointestinal haemorrhage def frequent x x x x x x x x x
Glycosuria def frequent x x x x x x
Cardiac failure def infrequent, frequent x x x x x x x x x
Haematuria def infrequent, frequent x x x x x x x x x
Haemorrhage def infrequent, frequent x x x x x x x x x
Hypertension def frequent x x x x x x x x x
Hypotension def infrequent, frequent x x x x x x x x x
Incontinence def frequent x x x x x x x x x
Libido increased def frequent x x x x x x x x x
Infection def frequent x x x x x x x
Influenza def frequent x x x x x x x x x
Irritability def infrequent, frequent x x x x x x x x x
Fungal infection def frequent x x x x x x
Nervousness def frequent x x x x x x x x
Nocturia def frequent x x x x x x x x x
Pain def postmarketing — frequent x x x x x x x x x x
Paraesthesia def frequent x x x x x x x x x
Pharyngitis def infrequent, frequent x x x x x x x x x
Pneumonia def infrequent, frequent x x x x x x x x x
Pruritus def frequent x x x x x x x x x
Skin ulcer def infrequent, frequent x x x x x x x x x
Toothache def frequent x x x x x x x x x
Tremor def frequent x x x x x x x x x
Ulcer def infrequent, frequent x x x x x x x x x
Urinary incontinence def frequent x x x x x x x x x
Urinary tract infection def frequent x x x x x x x
Urticaria def infrequent, frequent x x x x x x x x x
Vasodilation def infrequent, frequent x x x x x x x x x
Vertigo def infrequent, frequent x x x x x x x x x
Weight decreased def frequent x x x x x x x x
Agitation def postmarketing, frequent x x x x x x x x x x
Oedema peripheral def frequent x x x x x x
Cataract def frequent x x x x x x x x
Lactic dehydrogenase activity increased frequent x x x x x x
Phosphatase alkaline increased frequent x x x x x x
Cardiac fibrillation infrequent, frequent x x x x x x x x x
Epigastric pain frequent x x x x x x x x x
Physical wandering frequent x x x x x x
Tenderness def infrequent, frequent x x x x x x x x x
Eye irritation frequent x x x x x x x x
Crying abnormal frequent x x x x x x x x x
Throat sore def frequent x x x x x x x x
Vision blurred def frequent x x x x x x x x
Bradycardia def infrequent, frequent x x x x x x x x x
Electrocardiogram abnormal frequent x x x x x x
Cough increased frequent x x x x x x
Gait disturbance def infrequent, frequent x x x x x x x x x
Hot flush def frequent x x x x x x x x x
Sweating increased frequent x x x x x x x x x
Abdominal bloating def frequent x x x x x x x x x
Abscess def infrequent x x x x x x x x x
Albuminuria def infrequent x x x x x x
Alopecia def infrequent x x x x x x x x x
Angina pectoris def infrequent x x x x x x x x x
Apnoea def infrequent x x x x x x x x
Arteritis def infrequent x x x x x x x x x
Arthralgia def infrequent x x x x x x
Asthma def infrequent x x x x x x
Atelectasis def infrequent x x x x x x x x
Atrioventricular block def infrequent x x x x x x x x x
Blepharitis def infrequent x x x x x x x x x
Cellulitis def infrequent x x x x x x x x x
Cerebral infarction def infrequent x x x x x x
Transient ischaemic attack def infrequent x x x x x x x x x
Cholelithiasis def infrequent x x x x x x x x x
Conjunctival haemorrhage infrequent x x x x x x x x x
Conjunctivitis def infrequent x x x x x x
Cytopenia def infrequent x
Libido decreased def infrequent x x x x x x x x x
Dysphagia def infrequent x x x x x x
Dermatitis def infrequent x x x x x x x x x
Fungal skin infection def infrequent x x x x x x x x
Diabetes mellitus def infrequent x x x x x x x x x
Diverticulitis def infrequent x x x x x x x x x
Drooling infrequent x x x x x x x x x
Duodenal ulcer def infrequent x x x x x x x x x
Dysarthria def infrequent x x x x x x x x x
Dysuria def infrequent x x x x x x x x x
Ear pain def infrequent x x x x x x x x x
Enuresis def infrequent x x x x x x x x x
Eosinophilia def infrequent x x x x x x x x x
Grand mal convulsion def infrequent x x x x x x
Epistaxis def infrequent x x x x x x x
Eructation def infrequent x x x x x x x x x
Oesophagitis def infrequent x x x x x x
Extrapyramidal disorder def infrequent x x x x x x
Fasciculation def infrequent x x x x x x x x x
Body temperature increased def infrequent x x x x x x x x x
Fibrocystic breast disease def infrequent x x x x x x x x x
Flatulence def infrequent x x x x x x x x x
Gastritis def infrequent x x x x x x x x x
Gingivitis def infrequent x x x x x x x x x
Glaucoma def infrequent x x x x x x x x x
Goitre def infrequent x x x x x x x x x
Gout def infrequent x x x x x x x x
Cardiomegaly def infrequent x x x x x x
Cardiac failure congestive def infrequent x x x x x x x x x
Hemiplegia def infrequent x x x x x x
Haemorrhoids def infrequent x x x x x x x x x
Hernia def infrequent x x x x x x x x x
Diaphragmatic hernia def infrequent x x x x x x x x x
Herpes NOS def infrequent x x x x x x x x x
Herpes labialis def infrequent x x x x x x x x x
Herpes zoster def infrequent x x x x x x x x x
Hirsutism def infrequent x x x x x x x x x
Hostility def infrequent x x x x x x x x x
Hyperglycaemia def infrequent x x x x x x x x
Hypersensitivity def infrequent x x x x x
Hypertrophy def infrequent x x x x x x x x
Hyperventilation def infrequent x x x x x x x x
Hypokalaemia def infrequent x x x x x x x x
Orthostatic hypotension def infrequent x x x x x x x x x
Infarction def infrequent x x x x x x x x x
Irritable bowel syndrome def infrequent x x x x x x x x x
Ischaemia def infrequent x x x x x x
Jaundice def infrequent x x x x x x x x x
Arthropathy def infrequent x x x x x x
Lacrimal disorder def infrequent x x x x x x
Cramps of lower extremities infrequent x x x x x x
Leukocytosis def infrequent x x x x x x
Mastitis def infrequent x x x x x x x x x
Melancholia def infrequent x x x x x x x x x
Melaena def infrequent x x x x x x x x x
Metrorrhagia def infrequent x x x x x x x x x
Motion sickness def infrequent x x x x x x x x x
Hypertonia def infrequent x x x x x x x x x
Myocardial infarction def infrequent x x x x x x x x
Neuralgia def infrequent x x x x x x x x x
Neurodermatitis def infrequent x x x x x x x x
Night sweats def infrequent x x x x x x x x x
Numbness def infrequent x x x x x x x x x
Nystagmus def infrequent x x x x x x x x x
Osteoporosis def infrequent x x x x x x
Otitis def infrequent x x x x x x x x x
Otitis externa def infrequent x x x x x x x x x
Otitis media def infrequent x x x x x x x x x
Abscess periodontal def infrequent x x x x x x x x x
Periodontitis def infrequent x x x x x x
Pleurisy def infrequent x x x x x x x x
Postnasal drip def infrequent x x x x x x x x
Supraventricular extrasystoles def infrequent x x x x x x
Prostatic disorder def infrequent x x x x x x x x x
Psoriasis def infrequent x x x x x x
Pyelonephritis def infrequent x x x x x x x x x
Pyuria def infrequent x x x x x x x x x
Renal failure def infrequent x x x x x x x x x
Retinal haemorrhage def infrequent x x x x x x x x x
Rhinitis def infrequent x x x x x x
Salivation def infrequent x x x x x x
Salivary hypersecretion def infrequent x x x x x x
Sleep apnoea syndrome def infrequent x x x x x x x x
Snoring def infrequent x x x x x x x x
Muscle spasms def infrequent x x x x x x x x x
Gastric disorder def infrequent x x x x x x x x x
Gastric ulcer def infrequent x x x x x x x x x
Cerebrovascular accident def infrequent x x x x x x x x x
Sweating def infrequent x x x x x x x x x
Tachycardia def infrequent x x x x x x x x x
Supraventricular tachycardia def infrequent x x x x x x x x x
Thirst def infrequent x x x x x x x x x
Thrombocytopenia def infrequent x x x x x x x x
Thrombosis def infrequent x x x x x x x x x
Tinnitus def infrequent x x x x x x x x x
Erythema def infrequent x x x x x x x x x
Pollakiuria def infrequent x x x x x x x x
Vaginal inflammation def infrequent x x x x x x x x x
Angiopathy def infrequent x x x x x x x x x
Venous thrombosis def infrequent x x x x x x x x
Visual impairment def infrequent x x x x x x
Weight increased def infrequent x x x x x x x x
Wheezing def infrequent x x x x x x x
Dry mouth def infrequent x x x x x x x x x
Urinary retention def infrequent x x x x x x x x x
Peripheral vascular disorder def infrequent x x x x x x x x x
Chills def infrequent x x x x x x x x x
Polydipsia def infrequent x x x x x x x x x
Micturition urgency def infrequent x x x x x x x x x
Apathy def infrequent x x x x x x x x x
Mood swings infrequent x x x x x x x x x
Hypokinesia def infrequent x x x x x x x x x
Deep vein thrombosis def infrequent x x x x x x x x x
Periorbital oedema def infrequent x x x x x x x x
Creatine phosphokinase increased def infrequent x x x x x x x x x
Tongue oedema infrequent x x x x x x x x x
Ventricular extrasystoles def infrequent x x x x x x x
Haemorrhage intracranial def infrequent x x x x x x x x x
Liver function test abnormal infrequent x x x x x x
Muscular weakness def infrequent x x x x x x x x
Vesiculobullous rash infrequent x x x x x x
Skin discolouration def infrequent x x x x x x x x x
Dry skin def infrequent x x x x x x
Skin striae def infrequent x x x x x x x x x
Erythropenia infrequent x x x x x x x x x
Sickness infrequent x x x x x x x x x
Epigastric distress infrequent x x x x x x x x x
Malaise def infrequent x x x x x x
Myalgia def infrequent x x x x x x
Increased appetite infrequent x x x x x x x x x
Dysphoria infrequent x x x x x x x x x
Abnormal dreams infrequent x x x x x x x x
Withdrawal emotional infrequent x x x x x x x x x
Euphoric mood def infrequent x x x x x x
Ear buzzing infrequent x x x x x x x x x
Increased thirst infrequent x x x x x x x x x
Pulmonary congestion infrequent x x x x x x x x
Hypoxia def infrequent x x x x x x x x
Sepsis def infrequent x x x x x x
Rectal haemorrhage def infrequent x x x x x x
Dry eye infrequent x x x x x x x x
Extrasystoles def infrequent x x x x x x
Lacrimation def infrequent x x x x x x
Transaminases increased infrequent x x x x x x x x x
Spots before eyes infrequent x x x x x x x x x
Face oedema def infrequent x x x x x x x x x
Coldness infrequent x x x x x x x x x
Thrombocytosis def infrequent x x x x x x x x x
Headache fullness infrequent x x x x x x x x x
Hyperkeratosis def infrequent x x x x x x x x x
Cerebral ischaemia def infrequent x x x x x x
Dysphasia def infrequent x x x x x x x x x
Ileus def infrequent x x x x x x x x x
Rhinorrhoea def infrequent x x x x x x x x
Fibroadenosis of breast infrequent x x x x x x x x x
Hearing impaired def infrequent x x x x x x x x x
Paranoia def infrequent x x x x x x x x x
Prostatic hypertrophy infrequent x x x x x x x x
Weakness def infrequent x x x x x x x x
Cerebral haemorrhage def infrequent x x x x x x
Haemolytic anaemia def postmarketing x x x x x x x x x x
Cholecystitis def postmarketing x x x x x x x x x x
Confusional state def postmarketing x x x x x x x x x x
Hallucination def postmarketing x x x x x x x x x x
Block heart def postmarketing x x x x x x x x x x
Hepatitis def postmarketing x x x x x x x x x x
Hyponatraemia def postmarketing x x x x x x x x x x
Neuroleptic malignant syndrome def postmarketing x x x x x x x x x
Pancreatitis def postmarketing x x x x x x x x x x
Malignant syndrome NOS postmarketing x x x x x x x x x
Elderly def x
Dementia Alzheimer's type def x
Arrhythmia def x
Back pain def x x x x x x
Mental disorder def
Cachexia def x x x x x x
Cyst def x
Dizziness def x x x x x x x x
Ecchymosis def x x x x x x x x
Eczema def x x x x x x x
Gastrointestinal disorder def
Headache def x x x x x x x x
Hyperbilirubinaemia def x x x x x x
Hypercholesterolaemia def x x x x x x
Hyperlipidaemia def x x x x x x
Hypoglycaemia def x x x x x x
Hypoproteinaemia def x x x x x x
Nasopharyngitis def x
Osteoarthritis def x
Personality disorder def x x x x x
Seizures def x
Syncope def x x x x x x x x
Deficiency anaemia x x x x x x
Urinary tract disorder def
Blood urea increased x x x x x x
Creatinine increased def x x x x x x
Aspartate aminotransferase increased def x x x x x x
Alanine aminotransferase increased def x x x x x x
Iron deficiency anaemia def x x x x x x
Decreased appetite x
Head pressure x
Iron deficiency x x x x x x
Infestation NOS x
Anaemia vitamin B12 deficiency x x
Somnolence def x x x x x x x x
Indication Labels
Dementia def x x x x x x x x x x

Information

More information: STITCH, PubChem and possibly Wikipedia

ATC Code: N06DA02

Legend

Color scheme: standard – alternative

100%    
75%    
50%    
10%    
frequent (1% to 100%)    
infrequent (0.1% to 1%)    
rare (<0.1%)    
postmarketing    
0%    
no frequency information    
not found on label    

Labels

Labels were obtained from different sources and potentially contain different sets of side effects. If you click on the label name, a HTML version of the label will be shown with proteins, chemicals and side efffects highlighted using Reflect.

  1. DONEPEZIL : 16 side effects (FDA XML label)
  2. donepezil hydrochloride tablets / Aricept : 198 side effects (FDA MedWatch)
  3. DONEPEZIL HYDROCHLORIDE / ARICEPT 10MG : 210 side effects (Health Canada)
  4. DONEPEZIL HYDROCHLORIDE / ARICEPT : 219 side effects (Drugs@FDA)
  5. DONEPEZIL : 286 side effects (FDA XML label)
  6. DONEPEZIL : 286 side effects (FDA XML label)
  7. DONEPEZIL : 288 side effects (FDA XML label)
  8. DONEPEZIL : 289 side effects (FDA XML label)
  9. Donepezil : 289 side effects (FDA XML label)
  10. donepezil : 289 side effects (FDA XML label)