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ATC Code: L01XX23

Side effects

Options: Hide MedDRA Preferred Terms

MedDRA Preferred Term Side effect Data for drug Placebo Labels
1 2 3 4 5
Lethargy Lethargy 25% x x x x
Somnolence Somnolence 25% x x x x
Drowsiness x
Dizziness Dizziness 15% x x x x x
Vertigo Vertigo 15% x x x x
Adrenal insufficiency Adrenal insufficiency x x x
Aggression Aggression x
Albuminuria Albuminuria x x x x
Anaemia Anaemia x
Decreased appetite Anorexia x x x x x
Asthenia Asthenia x x x
Ataxia Ataxia x x x
Mental disorder Mental disorder x x
Breast disorder Breast disorder x x
Infection Infection x x
Confusional state Confusional state x x x
Feeling abnormal Confusional state x x x
Connective tissue disorder Connective tissue disorder x
Diarrhoea Diarrhoea x x x x x
Diplopia Diplopia x x x x x
Dysarthria Dysarthria x x
Osteoarthritis Dysarthria x x
Dysgeusia Dysgeusia x
Dyspepsia Dyspepsia x
Digestion impaired x x x
Endocrine disorder Endocrine disorder x x
Dermatitis Rash x x x
Rash Rash x x x
Eye disorder Eye disorder x x
Body temperature increased Body temperature increased x
Flushing Flushing x x x x
Gastrointestinal disorder Gastrointestinal disorder x
Digestion impaired x x x
Gynaecomastia Gynaecomastia x x
Headache Headache x x
Haematuria Haematuria x x x x x
Hepatitis Hepatitis x
Hypercholesterolaemia Hypercholesterolaemia x
Hypersensitivity Hypersensitivity x
Hypertension Hypertension x x x x
Hypertriglyceridaemia Hypertriglyceridaemia x
Blood triglycerides increased Hypertriglyceridaemia x
Blood triglycerides increased x
Plasma triglycerides increased x
Hypotension Hypotension x
Orthostatic hypotension Orthostatic hypotension x x x x
Hypothyroidism Hypothyroidism x x
Irritability Irritability x
Dyskinesia Movement disorder x
Movement disorder Movement disorder x
Nausea Nausea x x x x x
Neoplasm Neoplasm x
Nervous system disorder Nervous system disorder x x
Neutropenia Neutropenia x
Fungal infection Opportunistic mycosis x
Pain Pain x
Ache x
Generalized aching x x x x
Paraesthesia Paraesthesia x
Proteinuria Proteinuria x
Protein urine present Proteinuria x
Retinal disorder Retinal disorder x x x x
Shock Shock x
Salivary hypersecretion Salivary hypersecretion x
Thrombocytopenia Thrombocytopenia x
Tremor Tremor x
Urethral disorder Urinary tract disorder x
Urinary tract disorder Urinary tract disorder x
Angiopathy Angiopathy x
Vomiting Vomiting x x x x x
Injury Trauma x
Encephalopathy Encephalopathy x
Cystitis haemorrhagic Cystitis haemorrhagic x x x x x
Cataract Cataract x
Hepatitis cholestatic Hepatitis cholestatic x
Bleeding time prolonged Bleeding time prolonged x
Growth retardation Growth retardation x x
Hepatocellular injury Hepatocellular injury x
Liver injury Hepatocellular injury x
Polyneuropathy Polyneuropathy x
Malnutrition Malnutrition x
Skin disorder Unspecified disorder of skin and subcutaneous tissue x
Hypouricaemia Hypouricaemia x
Speech disorder Speech impairment NOS x
Hepatic enzyme increased Hepatic enzyme increased x
Autoimmune hepatitis Autoimmune hepatitis x
Hepatobiliary disease Hepatobiliary disease x x
Brain injury Brain injury x
Secondary adrenocortical insufficiency Secondary adrenocortical insufficiency x
Mucosal inflammation Mucosal inflammation x
Vision blurred Vision blurred x x x x x
Hyperpyrexia Hyperpyrexia x x x x
Orthostatic hypertension Orthostatic hypertension x
Balance disorder Balance disorder x
Dermatitis atopic Cutaneous hypersensitivity x
Blood cholesterol increased Blood cholesterol increased x
Plasma cholesterol increased x
Maculopathy Maculopathy x x
Amnesia Memory loss x
Infestation Infestation NOS x
Blood uric acid decreased Blood uric acid decreased x x
Retinal toxicity Retinal toxicity x
Muscular weakness Myasthenia x
Gastrointestinal toxicity Gastrointestinal toxicity x
Skin toxicity Skin toxicity x x x
Epigastric discomfort Epigastric discomfort x
Mental retardation Mental disability x x
Mental disability Mental disability x x
Lenticular opacities Lenticular opacities x x x x
Mineralocorticoid deficiency Mineralocorticoid deficiency x
Visual impairment Visual impairment x


Information about indications was extracted from the indications and usage sections of the labels.


Side effects:34
Source:BC Cancer

mitotane tablets / Lysodren

Side effects:23


Side effects:26
Source:Health Canada


Side effects:45
Source:FDA Structured Product Label

mitotane / mitotane

Side effects:73

Color scheme:


    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    no frequency information
    not found on label