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Tolcapone

More information: STITCH, PubChem and possibly Wikipedia

ATC Code: N04BX01

Side effects

Options: Show MedDRA Preferred Terms

Side effect Data for drug Placebo Labels
1 2 3 4
Dyskinesia 42% 20% x x x x
Nausea 30% 18% x x x x
Sleep disorder 24% 18% x x x x
Dreaming excessive 21% 17% x x x
Anorexia 19% 13% x x x x
Somnolence 18% 13% x x x x
Cramp muscle 17% 17% x x x
Diarrhoea 16% 8% x x x x
Mental disorder very common x
Gastrointestinal disorder very common x
Nervous system disorder very common x
Angiopathy very common x
Dizziness 13% 10% x x x x
Confusional state 11% 9% x x x x
Headache 10% 7% x x x x
Hallucination 8% 5% x x x x
Vomiting 8% 4% x x x x
Fatigue 7% 6% x x x
Constipation 6% 5% x x x x
Abdominal pain frequent, 5% 3% x x x x
Bronchitis frequent x x x
Infection common, frequent x x x x
Rash frequent x x x
Flank pain frequent x x x
Hypoaesthesia frequent x x x
Palpitations frequent x x x
Pharyngitis frequent x x x
Speech disorder frequent x x x
Tinnitus frequent x x x
Tooth disorder frequent x x x
Tremor frequent x x x
Upper respiratory tract infection 5% 3% x x x x
Urinary incontinence frequent x x x
Urinary tract infection 5% 4% x x x
Vertigo frequent x x x
Dry mouth 5% 2% x x x x
Mood swings frequent x x x
Accidental injury frequent x x x
Unspecified disorder of skin and subcutaneous tissue common x
Myalgia frequent x x x
Erectile dysfunction frequent x x x
Infestation NOS common x
Dyspepsia 4% 2% x x x x
Syncope 4% 3% x x x x
Fall 4% 4% x x x
Sweating increased 4% 2% x x x x
Chest pain 3% 1% x x x x
Dyspnoea 3% 2% x x x
Influenza 3% 2% x x x x
Paraesthesia 3% 2% x x x
Arthritis 2% 1% x x x
Neck pain 2% 1% x x x
Flatulence 2% 2% x x x
Hypotension 2% 1% x x x
Micturition disorder 2% 1% x x x
Sinus congestion 2% 0% x x x
Hyperkinesia 1% - 3% 0% - 1% x x x
Stiffness 2% 1% x x x
Urine color abnormal 2% 1% x x x x
Alopecia 1% 0% x x x
Haemorrhage 1% 0% x x x
Irritability 1% 0% x x x
Panic reaction 1% 0% x x x
Neoplasm skin 1% 0% x x x
Uterine neoplasm 1% 0% x x x
Agitation 1% 0% x x x
Hypokinesia 1% 1% x x x x
Cataract 1% 0% x x x
Ocular hyperaemia 1% 0% x x x
Malaise 1% 0% x x x
Euphoric mood 1% 0% x x x
Chest discomfort 1% 1% x x x
Mental deficiency 1% 0% x x x
Abscess infrequent x x x
Amnesia infrequent x x x
Anaemia infrequent x x x
Angina pectoris infrequent x x x
Aortic valve stenosis infrequent x x x
Arrhythmia infrequent x x x
Asthma infrequent x x x
Atrial fibrillation infrequent x x x
Bacterial infection infrequent x x x
Carcinoma infrequent x x x
Cellulitis infrequent x x x
Cholelithiasis infrequent x x x
Colitis infrequent x x x
Libido decreased infrequent x x x
Dysphagia infrequent x x x
Dehydration infrequent x x x
Delusion infrequent x x x
Diabetes mellitus infrequent x x x
Diplopia infrequent x x x
Dysuria infrequent x x x
Ear pain infrequent x x x
Eczema infrequent x x x
Oedema infrequent x x x
Epistaxis infrequent x x x
Erythema multiforme infrequent x x x
Oesophagitis infrequent x x x
Extrapyramidal disorder infrequent x x x
Eye haemorrhage infrequent x x x
Furunculosis infrequent x x x
Gastroenteritis infrequent x x x
Gastrointestinal haemorrhage infrequent x x x
Cardiac arrest infrequent x x x
Cardiac failure infrequent x x x
Haematuria infrequent x x x
Hernia infrequent x x x
Herpes simplex infrequent x x x
Herpes zoster infrequent x x x
Hiccups infrequent x x x
Hostility infrequent x x x
Hypercholesterolaemia infrequent x x x
Hypersensitivity infrequent x x x
Hypertension infrequent x x x
Hyperventilation infrequent x x x
Libido increased infrequent x x x x
Arthropathy infrequent x x x
Calculus of kidney infrequent x x x
Lacrimal disorder infrequent x x x
Laryngitis infrequent x x x
Fungal infection infrequent x x x
Myocardial infarction infrequent x x x
Myoclonus infrequent x x x
Neoplasm infrequent x x x
Nervousness infrequent x x x
Neuralgia infrequent x x x
Nocturia infrequent x x x
Oliguria infrequent x x x
Otitis media infrequent x x x
Pain infrequent x x x
Polyuria infrequent x x x
Prostatic disorder infrequent x x x
Pruritus infrequent x x x
Psychotic disorder infrequent x x x
Pulmonary embolism infrequent x x x
Rectal disorder infrequent x x x
Rhinitis infrequent x x x
Seborrhoeic dermatitis infrequent x x x
Salivary hypersecretion infrequent x x x
Skin disorder infrequent x x x
Cerebrovascular accident infrequent x x x
Tachycardia infrequent x x x
Tenosynovitis infrequent x x x
Thirst infrequent x x x
Tongue disorder infrequent x x x
Urinary tract disorder infrequent, common x x x x
Urticaria infrequent x x x
Uterine disorder infrequent x x x
Uterine atony infrequent x x x
Vaginal inflammation infrequent x x x
Vasodilation infrequent x x x
Viral infection infrequent x x x
Urinary retention infrequent x x x
Choreoathetosis infrequent x x x
Chills infrequent x x x
Arterial spasm infrequent x x x
Apathy infrequent x x x
Mouth ulceration infrequent x x x
Migraine infrequent x x x
Myocardial ischaemia infrequent x x x
Manic psychosis infrequent x x x
Eye pain infrequent x x x
Paranoid reaction infrequent x x x
Skin discolouration infrequent x x x
Abnormal faeces infrequent x x x
Muscle twitching infrequent x x x
Thinking abnormal infrequent x x x
Bradycardia infrequent x x x
Neuropathy infrequent x x x
Face oedema infrequent x x x
Cough increased infrequent x x x
Prostate carcinoma infrequent x x x
Cerebral ischaemia infrequent x x x
Breast neoplasm infrequent x x x
Parosmia infrequent x x x
Coronary artery disease infrequent x x x
Cerebral haemorrhage infrequent x x x
Apnoea rare x x x
Arteriosclerosis rare x x x
Calculus bladder rare x x x
Cardiovascular disorder rare x x x
Cholecystitis rare x x x
Delirium rare x x x
Duodenal ulcer rare x x x
Glaucoma rare x x x
Hemiplegia rare x x x
Leukaemia rare x x x
Meningitis rare x x x
Ovarian carcinoma rare x x x
Pericardial effusion rare x x x
Pulmonary oedema rare x x x
Thrombocytopenia rare x x x
Thrombosis rare x x x
Uterine haemorrhage rare x x x
Encephalopathy rare x x x
Gastrointestinal carcinoma rare x x x
Gastric atony rare x x x
Antisocial behaviour rare x x x
Anxiety x x
Arthralgia x x
Asthenia x x
Dysgeusia x x
Body temperature increased 0% 0% x x x
Fracture x x
Impulse-control disorder x
Lethargy x x
Mediastinal disorder x
Hypertonia 0% 0% x x x
Neuroleptic malignant syndrome x
Paresis x x
Pathological gambling x
Pneumonia x x
Rhabdomyolysis x
Sinusitis x x
Sweating x
Pollakiuria x x
Hepatitis viral x x x
Weight decreased x x
Oedema peripheral x x
Hepatocellular injury x x x x
Alanine aminotransferase increased x x
Acute hepatic failure x x x
Hypersexuality x
Vision blurred x x
Gait disturbance x x
Binge eating x

Indications

Information about indications was extracted from the indications and usage sections of the labels.

tolcapone / tolcapone

Side effects:39
Source:EMA

Tolcapone

Side effects:200
Source:FDA Structured Product Label

TOLCAPONE / TASMAR

Side effects:212
Source:FDA

TOLCAPONE / TASMAR

Side effects:213
Source:FDA

Color scheme:

standard – alternative

    100%
    75%
    50%
    10%
    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    postmarketing
    0%
    no frequency information
    not found on label