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Pemetrexed

More information: STITCH, PubChem and possibly Wikipedia

ATC Code: L01BA04

Side effects

Options: Hide MedDRA Preferred Terms

MedDRA Preferred Term Side effect Data for drug Placebo Labels
1 2 3 4 5 6 7 8 9 10
Agranulocytosis Agranulocytosis 23% - 38% x
Asthenia Fatigue 0% - 87% 0.6% - 11% x x x x x x x x x x
Fatigue Fatigue 0% - 87% 0.6% - 11% x x x x x x x x x x
Leukopenia Leukopenia 0% - 55% 1% x x x x x x x x x
Alopecia Alopecia 6% - 42% x x x x x x x x
Nausea Nausea 0% - 84% 0% - 6% x x x x x x x x x x
Vomiting Vomiting 0% - 58% 0% - 1.8% x x x x x x x x x x
Creatinine renal clearance decreased Creatinine renal clearance decreased 2% - 18% x x x
Dyspnoea Dyspnoea 1% - 66% x x x x x x x
Chest pain Chest pain 1% - 40% x x x x x x x x x x
Dysgeusia Dysgeusia 6% x x x x
Neutropenia Neutropenia common, 0% - 58% 0% - 0.6% x x x x x x x x x x
Abdominal pain Abdominal pain common x x x x
Gastrointestinal pain Abdominal pain common x x x x
Anaemia Anaemia 0% - 33% 0.6% - 6% x x x x x x x x x
Erythema multiforme Erythema multiforme common x x x
Stevens-Johnson syndrome postmarketing x x x
Peripheral sensory neuropathy Peripheral sensory neuropathy common x x x x
Blood creatinine increased Creatinine increased common x x x
Neuritis Peripheral motor neuropathy common x x x x
Peripheral motor neuropathy Peripheral motor neuropathy common x x x x
Diarrhoea Diarrhoea 0% - 34% 0% - 3% x x x x x x x x x x
Mucosal inflammation Mucosal inflammation 0.3% - 7% 0% - 2.4% x x x
Embolism Embolism 1% - 7% x x x x x x x x
Thrombosis Thrombosis 1% - 7% x x x x x x x x
Decreased appetite Anorexia 0% - 62% 0% - 5% x x x x x x x x x x
Myalgia Myalgia 0% - 20% x x x x
Musculoskeletal discomfort Myalgia 0% - 20% x x x x
Arthralgia 0% - 13% x x x x
Thrombocytopenia Thrombocytopenia 0% - 27% x x x x x x x x x
Arthralgia Arthralgia 0% - 13% x x x x
Myocardial ischaemia Myocardial ischaemia 0% - 3% x x x x
Alanine aminotransferase increased Alanine aminotransferase increased 0% - 10% 0% - 4% x
Infection Infection common, 0% - 11% 0% - 2% x x x x x x x x x x
Constipation Constipation 0% - 44% x x x x x x x x x x
Dysphagia Dysphagia 0% - 7% x x x x x x x
Dehydration Dehydration 0% - 9% x x x x x x x x x x
Oesophagitis Oesophagitis 0% - 7% x x x x x x x x x x
Pharyngitis Pharyngitis 0% - 28% x x x x x x x x x x
Pruritus Pruritus 0% - 7% x x x x
Stomatitis Stomatitis 0% - 28% 0% - 2.4% x x x x x x x x x x
Aspartate aminotransferase increased Aspartate aminotransferase increased 0% - 8% 0% - 4% x x x x
Odynophagia Odynophagia 0% - 7% x x x x x x x
Neuropathy peripheral Neuropathy 0% - 17% 0% - 4% x x x x x x x x x
Febrile neutropenia Febrile neutropenia common, 0% - 9% x x x x x x x x x x
Mood swings Mood alteration NOS 0% - 14% x x x x x x x
Conjunctivitis Conjunctivitis 0% - 1% x x x x
Dyspepsia Dyspepsia 0% - 1% x x x
Heartburn x x x x
Oedema Oedema postmarketing, 0% - 24% 0% - 3.6% x x x x x x x x
Dermatitis Rash 0% - 22% 0% - 3% x x x x x x x x x x
Rash Rash 0% - 22% 0% - 3% x x x x x x x x x x
Body temperature increased Body temperature increased 0% - 26% x x x x x x x x x x
Skin exfoliation Skin exfoliation 0% - 22% 0% - 3% x x x x x x x x x x
Blood creatinine decreased Creatinine low 0% - 5% x x x x x x x
Haemolytic anaemia Haemolytic anaemia postmarketing x x x
Colitis Colitis postmarketing x x x x x x x
Toxic epidermal necrolysis Toxic epidermal necrolysis postmarketing x x x
Pancreatitis Pancreatitis postmarketing x
Stevens-Johnson syndrome Stevens-Johnson syndrome postmarketing x x x
Interstitial lung disease Interstitial pneumonia postmarketing x x x x
Anaphylactic shock Anaphylactic shock x
Angina pectoris Angina pectoris x
Arrhythmia Arrhythmia x x x x
Neoplasm malignant Neoplasm malignant x x x
Transient ischaemic attack Transient ischaemic attack x
Dizziness Dizziness x
Syncope x
Eye disorder Eye disorder x x x
Gastrointestinal disorder Gastrointestinal disorder x x
Hepatitis Hepatitis x
Hypersensitivity Hypersensitivity common, 0% - 2% x x x x x x x x x x
Hypertension Hypertension x x x x x x x
Intestinal perforation Intestinal perforation x
Nephropathy Nephropathy x x
Renal failure acute Renal failure acute x x
Mesothelioma Mesothelioma x x x
Myocardial infarction Myocardial infarction x
Acute coronary syndrome Myocardial infarction x
Nervous system disorder Nervous system disorder x x
Pain Pain x x x x x x x x x
Pancytopenia Pancytopenia x
Pulmonary embolism Pulmonary embolism x x
Renal failure Renal failure 0% - 2% x x x x x x x x x x
Respiratory failure Respiratory insufficiency x
Cerebrovascular accident Cerebrovascular accident x
Shock Syncope x
Syncope Syncope x
Loss of consciousness Syncope x
Erythema Erythema x
Urethral disorder Urinary tract disorder x
Urinary tract disorder Urinary tract disorder x
Urticaria Urticaria x x x x
Ventricular tachycardia Ventricular tachycardia x
Gamma-glutamyltransferase increased Gamma-glutamyltransferase increased x
Lacrimation increased Lacrimation increased x x x
Haemoglobin decreased Haemoglobin decreased x
Malnutrition Malnutrition x x
Skin disorder Unspecified disorder of skin and subcutaneous tissue x x
Radiation pneumonitis Radiation pneumonitis x
Peripheral ischaemia Peripheral ischaemia x
Gastrointestinal obstruction Gastrointestinal obstruction x
Radiation oesophagitis Radiation oesophagitis x
Sepsis Sepsis x x x x
Caecitis Caecitis x
Rectal haemorrhage Rectal haemorrhage x
Hepatobiliary disease Hepatobiliary disease x x
Platelet count decreased Platelet count decreased x x
Arrhythmia supraventricular Arrhythmia supraventricular x x x x
Metastases to liver Metastases to liver x x x x x x x
Hepatic cancer metastatic Metastases to liver x x x x x x x
White blood cell count decreased White blood cell count decreased x
Infestation Infestation NOS x
Glomerular filtration rate decreased Glomerular filtration rate decreased x x x
Extremity necrosis Extremity necrosis x
Ocular surface disease Ocular surface disease x x x
Gastrointestinal necrosis Intestinal necrosis x

Indications

Information about indications was extracted from the indications and usage sections of the labels.

PEMETREXED DISODIUM / ALIMTA

Side effects:31
Source:FDA

Premetrexed / Alimta

Side effects:31
Source:FDA

PEMETREXED / ALIMTA

Side effects:38
Source:FDA

PEMETREXED DISODIUM / ALIMTA

Side effects:39
Source:FDA

PEMETREXED DISODIUM / ALIMTA

Side effects:39
Source:FDA

PEMETREXED DISODIUM / ALIMTA

Side effects:39
Source:FDA

PEMETREXED (PEMETREXED DISODIUM) / ALIMTA

Side effects:52
Source:Health Canada

Pemetrexed

Side effects:65
Source:FDA Structured Product Label

ALIMTA / Alimta, Powder for infusion

Side effects:61
Source:Medsafe

pemetrexed / pemetrexed

Side effects:86
Source:EMA

Color scheme:

standardalternative

    100%
    75%
    50%
    10%
    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    postmarketing
    0%
    no frequency information
    not found on label