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Pazopanib

More information: STITCH, PubChem and possibly Wikipedia

ATC Code: L01XE11

Side effects

Options: Show MedDRA Preferred Terms

Side effect Data for drug Placebo Labels
1 2 3
Alanine aminotransferase increased 2% - 53% 0% - 22% x x x
Tumour pain 0% - 29% 2% - 21% x x
Fatigue 0% - 65% 1% - 48% x x x
Lymphopenia 0% - 43% 0% - 36% x x
Aspartate aminotransferase increased 1% - 53% 0% - 22% x x x
Decreased appetite 0% - 40% 0% - 19% x x x
Hypertension 0% - 42% 0% - 10% x x x
Dyspnoea 1% - 20% 1% - 17% x x x
Diarrhoea 0% - 59% 0% - 15% x x x
Weight decreased 0% - 48% 0% - 15% x x x
Sodium decreased 0% - 31% 0% - 24% x x
Phosphorus low 0% - 34% 0% - 11% x x
Anorexia common, 0% - 22% 0% - 10% x x x
Asthenia 0% - 14% 0% - 8% x x x
Phosphatase alkaline increased 0% - 32% 0% - 23% x
Gastrointestinal pain 0% - 23% 0% - 9% x x x
Neutropenia 0% - 34% 0% - 7% x x x
Vomiting 0% - 33% 0% - 11% x x x
Abdominal pain 0% - 11% 0% - 1% x x x
Chest pain 0% - 10% 0% - 6% x x x
Musculoskeletal pain 0% - 23% 0% - 20% x x x
Skin disorder 0% - 11% 0% - 1% x x x
Thrombocytopenia 1% - 36% 0% - 6% x x x
Oedema peripheral 0% - 14% 0% - 9% x x x
Myalgia 0% - 23% 0% - 9% x x x
Mucosal inflammation 0% - 12% 0% - 2% x x
Bilirubin total increased 0% - 36% 0% - 10% x x
Nausea 0% - 56% 0% - 22% x x x
Dizziness 0% - 11% 0% - 4% x x x
Mg reduced 1% - 26% 0% - 14% x x
Potassium increased 0% - 16% 0% - 11% x x
Albumin low 0% - 34% 0% - 21% x
Cough 0% - 17% 0% - 12% x x x
Headache 0% - 23% 0% - 8% x x x
Leukopenia 0% - 44% 0% - 15% x x x
Stomatitis 0% - 11% 0% - 3% x x x
Glucose increased 0% - 45% 0% - 35% x x
Exfoliative rash 0% - 18% 0% - 9% x x x
Glucose decreased 0% - 17% 0% - 3% x x
Hair colour changes 0% - 39% 0% - 3% x x
Gastrointestinal disorder postmarketing x x x
Pancreatitis postmarketing x x x
Abdominal distension x
Alopecia 0% - 12% 0% - 1% x x x
Anaemia x
Arthralgia x x x
Mental disorder x
Breast disorder x
Neoplasm malignant x
Restrictive cardiomyopathy x
Cerebral infarction x
Transient ischaemic attack x
Infection x x x
Connective tissue disorder x x x
Cyst x
Dehydration x
Dysgeusia 0% - 28% 0% - 3% x x x
Dyspepsia x x x
Oedema x
Localised oedema x
Endocrine disorder x x
Epistaxis x x x
Rash x x x
Eye disorder x
Fistula x x
Flatulence x x
Flushing x
Gastrointestinal haemorrhage x x
Cardiac disorder x x
Cardiac failure x
Cardiac failure congestive x
Haematemesis x
Haematochezia x
Haematuria x
Haemolytic uraemic syndrome x x
Haemoptysis x
Haemorrhage x
Hiccups x
Hyperbilirubinaemia x x
Hyperhidrosis x
Hypertensive crisis x
Hypoaesthesia x
Hypothyroidism x x x
Intestinal perforation x
Jaundice x
Lethargy x
Mediastinal disorder x x
Melaena x
Menorrhagia x
Metabolic disorder x
Metrorrhagia x
Myocardial infarction x x
Nail disorder x x x
Nervous system disorder x x
Mouth haemorrhage x
Pain x
Paraesthesia x
Peritonitis x
Pneumothorax x x
Polyp x
Proteinuria x x x
Prurigo x
Pruritus x
Pulmonary embolism x
Thrombotic thrombocytopenic purpura x x
Skin ulcer x
Muscle spasms x x
Cerebrovascular accident x
Syncope x
Thrombosis x
Torsade de pointes x x
Erythema x
Upper gastrointestinal haemorrhage x
Urinary tract disorder x x
Angiopathy x x
Dry mouth x
Encephalopathy x
Chills x x x
Hepatic failure x
Sinus bradycardia x
Hypophosphataemia x
Hepatic function abnormal x x
Mouth ulceration x
Deep vein thrombosis x
Peripheral sensory neuropathy x
Amylase increased x
Blood urea increased x
Creatinine increased x
Gamma-glutamyltransferase increased x x
Gastrointestinal perforation x x x
Pulmonary haemorrhage x x
Retroperitoneal haemorrhage x
Hypomagnesaemia x
Large intestine perforation x
Myocardial ischaemia x x
Liver function test abnormal x
Mucous membrane disorder x
Electrocardiogram QT prolonged x
Dry skin x x x
Hypogeusia x
Eyelid oedema x
Malnutrition x
Photosensitivity reaction x
Leukoderma 0% - 11% 0% x x x
Unspecified disorder of skin and subcutaneous tissue x
Rash macular x
Rash vesicular x
Abdominal pain upper x
Abdominal pain lower x
Rash erythematous x
Gastric haemorrhage x
Hepatotoxicity x x
Blood creatinine increased x
Haemorrhage urinary tract x
Hepatic enzyme increased x
Skin exfoliation x
Oesophageal haemorrhage x
Frequent bowel movements x
Plantar erythema x
Left ventricular dysfunction x x
Skin depigmentation x x x
Haemorrhoidal haemorrhage x
Rectal haemorrhage x
Hepatobiliary disease x x
Blood pressure systolic increased x
Blood bilirubin increased x
Gastrointestinal fistula x
Enterocutaneous fistula x
Vision blurred x x x
Platelet count decreased x
Anal haemorrhage x
Bradycardia x x x
Pruritus generalised x
Thyroid function test abnormal x
Blood pressure increased x
Rash generalised x
Face oedema x x
Lipase increased x
Ileal perforation x
Blood glucose decreased x
Hot flush x
Taste altered x
Albumin high x
Eye oedema x
Gingival infection x
White blood cell count decreased x
Infestation NOS x x
Blood and lymphatic system disorders x x
Blood thyroid stimulating hormone increased x
Blood cholesterol abnormal x
Neutrophil count decreased x
Thromboembolic event x x x
Drug-induced liver injury x
Calcium low x
Insomnia x x
Ischaemic stroke x x
Eyelash discolouration x
Hyperalbuminaemia x
Rhinorrhoea x
Infectious peritonitis x
Bronchial haemorrhage x
Rash papular x
Dysphonia x x x
Oropharyngeal pain x
Ageusia x
Thrombotic microangiopathy x x x
Somnolence x
Cerebral haemorrhage x x
Vaginal haemorrhage x
Posterior reversible encephalopathy syndrome x x x

Indications

Information about indications was extracted from the indications and usage sections of the labels.

PAZOPANIB

Side effects:74
Source:FDA Structured Product Label

pazopanib / pazopanib

Side effects:185
Source:EMA

Color scheme:

standard – alternative

    100%
    75%
    50%
    10%
    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    postmarketing
    0%
    no frequency information
    not found on label