MedDRA Preferred Term
|
Side effect
|
Data for drug
|
Placebo
|
Labels
|
|
1
|
2
|
3
|
Dyspnoea
|
Dyspnoea
|
postmarketing — 10.7% - 29%
|
1.1% - 2.6%
|
x
|
x
|
x
|
Headache
|
Headache
|
very common, 17% - 27%
|
|
x
|
x
|
x
|
Flushing
|
Flushing
|
very common, 16% - 25%
|
|
x
|
x
|
x
|
Chest pain
|
Chest discomfort
|
13% - 18%
|
|
x
|
x
|
|
Chest pain
|
very common, 7% - 19%
|
|
x
|
x
|
x
|
Chest discomfort
|
Chest discomfort
|
13% - 18%
|
|
x
|
x
|
|
Electrocardiogram ST segment
|
Electrocardiogram ST segment
|
very common
|
|
|
|
x
|
Abdominal discomfort
|
Gastrointestinal discomfort
|
very common, 15%
|
|
|
|
x
|
Abdominal discomfort
|
2% - 5%
|
|
x
|
x
|
|
Electrocardiogram ST segment depression
|
Electrocardiogram ST segment depression
|
12% - 18%
|
|
x
|
x
|
|
Angina pectoris
|
Angina pectoris
|
common, 12% - 18%
|
|
x
|
x
|
x
|
Dizziness
|
Dizziness
|
very common, 7% - 11%
|
|
x
|
x
|
x
|
Syncope
|
postmarketing, uncommon
|
|
|
x
|
x
|
Feeling hot
|
Feeling hot
|
5% - 8%
|
|
x
|
x
|
|
Nausea
|
Nausea
|
postmarketing — 6%
|
|
x
|
x
|
x
|
Asthenia
|
Asthenia
|
common
|
|
|
|
x
|
Atrioventricular block
|
Atrioventricular block
|
common
|
|
x
|
x
|
x
|
Block heart
|
postmarketing
|
|
|
x
|
|
Nodal block
|
|
|
|
x
|
|
Cough
|
Cough
|
common
|
|
|
|
x
|
Dysgeusia
|
Dysgeusia
|
common, 5% - 7%
|
|
x
|
x
|
x
|
Hyperhidrosis
|
Hyperhidrosis
|
common
|
|
|
|
x
|
Hypoaesthesia
|
Hypoaesthesia
|
common
|
|
|
|
x
|
Pain in extremity
|
Pain in extremity
|
common
|
|
|
|
x
|
Palpitations
|
Palpitations
|
common
|
|
|
|
x
|
Paraesthesia
|
Paraesthesia
|
common
|
|
|
|
x
|
Tachycardia
|
Tachycardia
|
common
|
|
|
|
x
|
Malaise
|
Malaise
|
common
|
|
|
|
x
|
Discomfort
|
Malaise
|
common
|
|
|
|
x
|
Feeling abnormal
|
Malaise
|
common
|
|
|
|
x
|
Ill-defined disorder
|
Malaise
|
common
|
|
|
|
x
|
Pain in jaw
|
Pain in jaw
|
common
|
|
|
|
x
|
Oral discomfort
|
Oral discomfort
|
common
|
|
|
|
x
|
Throat irritation
|
Throat irritation
|
common
|
|
|
|
x
|
Musculoskeletal discomfort
|
Musculoskeletal discomfort
|
common
|
|
|
|
x
|
Arthralgia
|
uncommon
|
|
|
|
x
|
Myalgia
|
postmarketing
|
|
|
x
|
|
Hypotension
|
Hypotension
|
postmarketing, common
|
|
|
x
|
x
|
Hypotension symptomatic
|
postmarketing
|
|
|
x
|
|
Vomiting
|
Vomiting
|
postmarketing, common
|
|
|
x
|
x
|
Throat tightness
|
Throat tightness
|
postmarketing, common
|
|
|
x
|
x
|
Electrocardiogram QT prolonged
|
Electrocardiogram QT corrected interval prolonged
|
postmarketing, common
|
|
|
x
|
x
|
Wheezing
|
Wheezing
|
postmarketing, 0.9% - 3.1%
|
0.7% - 1.1%
|
|
x
|
|
Abdominal distension
|
Abdominal distension
|
uncommon
|
|
|
|
x
|
Anxiety
|
Anxiety
|
uncommon
|
|
|
|
x
|
Arthralgia
|
Arthralgia
|
uncommon
|
|
|
|
x
|
Cardiac flutter
|
Cardiac flutter
|
uncommon
|
|
x
|
|
x
|
Pallor
|
Pallor
|
uncommon
|
|
|
|
x
|
Tinnitus
|
Tinnitus
|
uncommon
|
|
|
|
x
|
Erythema
|
Erythema
|
uncommon
|
|
|
|
x
|
Atrioventricular block complete
|
Atrioventricular block complete
|
uncommon
|
|
|
|
x
|
Eye pain
|
Eye pain
|
uncommon
|
|
|
|
x
|
Injection site pain
|
Injection site pain
|
uncommon
|
|
|
|
x
|
Tachypnoea
|
Tachypnoea
|
uncommon
|
|
|
|
x
|
Peripheral coldness
|
Peripheral coldness
|
uncommon
|
|
|
|
x
|
Pain
|
Generalized aching
|
uncommon
|
|
|
|
x
|
Pain
|
postmarketing
|
|
|
x
|
|
Vision blurred
|
Vision blurred
|
uncommon
|
|
|
|
x
|
Bradycardia
|
Bradycardia
|
uncommon
|
|
|
|
x
|
Altered state of consciousness
|
Depressed level of consciousness
|
uncommon
|
|
|
|
x
|
Depressed level of consciousness
|
Depressed level of consciousness
|
uncommon
|
|
|
|
x
|
Insomnia
|
Insomnia
|
uncommon
|
|
|
|
x
|
Somnolence
|
Somnolence
|
uncommon
|
|
|
|
x
|
Atrial fibrillation
|
Atrial fibrillation
|
postmarketing, uncommon
|
|
x
|
x
|
x
|
Diarrhoea
|
Diarrhoea
|
postmarketing, uncommon
|
|
|
x
|
x
|
Faecal incontinence
|
Faecal incontinence
|
postmarketing, uncommon
|
|
|
x
|
x
|
Cardiac arrest
|
Cardiac arrest
|
postmarketing, uncommon
|
|
|
x
|
x
|
Hypertension
|
Hypertension
|
postmarketing, uncommon
|
|
|
x
|
x
|
Myocardial infarction
|
Myocardial infarction
|
postmarketing, uncommon
|
|
|
x
|
x
|
Acute coronary syndrome
|
Myocardial infarction
|
postmarketing, uncommon
|
|
|
x
|
x
|
Shock
|
Syncope
|
postmarketing, uncommon
|
|
|
x
|
x
|
Syncope
|
Syncope
|
postmarketing, uncommon
|
|
|
x
|
x
|
Loss of consciousness
|
Syncope
|
postmarketing, uncommon
|
|
|
x
|
x
|
Tremor
|
Tremor
|
postmarketing, uncommon
|
|
|
x
|
x
|
Abdominal pain
|
Abdominal pain
|
postmarketing
|
|
|
x
|
|
Gastrointestinal pain
|
Abdominal pain
|
postmarketing
|
|
|
x
|
|
Anaphylactic shock
|
Anaphylactic shock
|
postmarketing
|
|
|
x
|
x
|
Angioedema
|
Angioedema
|
postmarketing
|
|
|
x
|
x
|
Atrial flutter
|
Atrial flutter
|
postmarketing
|
|
|
x
|
|
Transient ischaemic attack
|
Transient ischaemic attack
|
postmarketing, uncommon
|
|
|
x
|
x
|
Dermatitis
|
Rash
|
postmarketing
|
|
|
x
|
x
|
Rash
|
Rash
|
postmarketing
|
|
|
x
|
x
|
Hypersensitivity
|
Hypersensitivity
|
postmarketing
|
|
|
x
|
x
|
Musculoskeletal pain
|
Musculoskeletal pain
|
postmarketing
|
|
|
x
|
|
Convulsion
|
Convulsion
|
postmarketing, uncommon
|
|
|
x
|
x
|
Cerebrovascular accident
|
Cerebrovascular accident
|
postmarketing
|
|
|
x
|
|
Urticaria
|
Urticaria
|
postmarketing
|
|
|
x
|
x
|
Ventricular arrhythmia
|
Ventricular arrhythmia
|
postmarketing
|
|
x
|
x
|
x
|
Haemorrhage intracranial
|
Haemorrhage intracranial
|
postmarketing
|
|
|
x
|
|
Respiratory arrest
|
Respiratory arrest
|
postmarketing
|
|
|
x
|
|
Myalgia
|
Myalgia
|
postmarketing
|
|
|
x
|
|
Respiratory distress
|
Respiratory distress
|
postmarketing
|
|
|
x
|
|
Oxygen saturation decreased
|
Oxygen saturation decreased
|
postmarketing
|
|
|
x
|
|
Supraventricular tachyarrhythmia
|
Supraventricular tachyarrhythmia
|
postmarketing
|
|
|
x
|
|
Asthma
|
Asthma
|
|
|
|
x
|
|
Mental disorder
|
Mental disorder
|
|
|
|
|
x
|
Connective tissue disorder
|
Connective tissue disorder
|
|
|
|
|
x
|
Eye disorder
|
Eye disorder
|
|
|
|
|
x
|
Gastrointestinal disorder
|
Gastrointestinal disorder
|
|
|
|
|
x
|
Cardiac disorder
|
Cardiac disorder
|
|
|
|
|
x
|
Immune system disorder
|
Immune system disorder
|
|
|
|
|
x
|
Ischaemia
|
Ischaemia
|
|
|
|
|
x
|
Chronic obstructive pulmonary disease
|
Chronic obstructive pulmonary disease
|
|
|
|
x
|
|
Bronchial hyperreactivity
|
Chronic obstructive pulmonary disease
|
|
|
|
x
|
|
Mediastinal disorder
|
Mediastinal disorder
|
|
|
|
|
x
|
Nervous system disorder
|
Nervous system disorder
|
|
|
|
|
x
|
Angiopathy
|
Angiopathy
|
|
|
|
|
x
|
Vasodilation procedure
|
Vasodilation
|
|
|
|
|
x
|
Bronchospasm
|
Bronchoconstriction
|
|
|
|
x
|
|
Sinus bradycardia
|
Sinus bradycardia
|
|
|
|
|
x
|
Atrioventricular block first degree
|
Atrioventricular block first degree
|
|
|
x
|
x
|
x
|
Myocardial ischaemia
|
Myocardial ischaemia
|
|
|
|
x
|
x
|
Skin disorder
|
Unspecified disorder of skin and subcutaneous tissue
|
|
|
|
|
x
|
Atrioventricular block second degree
|
Atrioventricular block second degree
|
|
|
x
|
x
|
x
|
Blood pressure systolic decreased
|
Blood pressure systolic decreased
|
|
|
|
|
x
|
Blood pressure diastolic decreased
|
Blood pressure diastolic decreased
|
|
|
|
|
x
|
Extrasystoles
|
Dropped beats
|
|
|
|
|
x
|
Electrocardiogram PR prolongation
|
Electrocardiogram PR prolongation
|
|
|
x
|
x
|
x
|
Wandering pacemaker
|
Wandering pacemaker
|
|
|
x
|
|
|
Renal failure
|
Renal impairment
|
|
|
|
x
|
|
Renal impairment
|
Renal impairment
|
|
|
|
x
|
|