Clozapine

Side effects and indications

Whenever possible, frequency information about the side effects was extracted from the labels. Aggregated frequency information for the drug and, if available, placebo is shown. To the right, you can click on shaded boxes to be taken to mentions of the side effect on the label. (In some cases, the side effect cannot be highlighted due to conversion problems.) Information about indications was extracted from the indications and usage sections of the labels.

Show MedDRA Preferred Terms

Side effect Data for drug Placebo Labels
1 2 3 4 5 6 7 8 9 10
Weight increased def 4% - 56% x x x x x x x x x x
Salivary hypersecretion def 6% - 48% x x x x x x x x
Somnolence def 25% - 46% x x x x x x
Drowsiness def 39% x x x x x x x x x x
Sedation 39% x x x x x x x x x x
Insomnia def 2% - 33% x x x x x x x x x x
Salivation def 31% x x x x x x x x x x
Dizziness def 12% - 27% x x x x x x x x x x
Vertigo def 12% - 27% x x x x x x x x x x
Constipation def 10% - 25% x x x x x x x x x x
Tachycardia def postmarketing, 25% x x x x x x x x x x
Nausea def 3% - 17% x x x x x x x x x x
Vomiting def 3% - 17% x x x x x x x x x x
Dyspepsia def 8% - 14% x x x x x
Hypotension def 9% x x x x x x x x x x
Headache def 7% x x x x x x x x x x
Sweating def 6% x x x x x x x x x x
Syncope def 6% x x x x x x x x x x
Tremor def 6% x x x x x x x x x x
Dry mouth def 6% x x x x x x x x x x
Body temperature increased def 5% x x x x x x x x x x
Visual disturbance 5% x x x x x x x x x x
Heartburn def 4% x x x x x x x x x x
Hypertension def 4% x x x x x x x x x x
Nightmare def 4% x x x x x x x x x x
Akinesia 4% x x x x x x x x x x
Agitation def 4% x x x x x x x x x x
Hypokinesia def 4% x x x x x x x x x x
Abdominal discomfort 4% x x x x x x x x x x
Discomfort def 1% - 4% x x x x x x x x x x
Confusional state def 3% x x x x x x x x x x
Convulsion def 3% x x x x x x x x x x
Leukopenia def 3% x x x x x x x x x x
Muscle rigidity def 3% x x x x x x x x x x
Neutropenia def 3% x x x x x x x x x x
Akathisia def 3% x x x x x x x x x x
White blood cell count decreased 3% x x x x x x x x x x
Diarrhoea def 2% x x x x x x x x x x
Rash def 2% x x x x x x x x x x
Fatigue def 2% x x x x x x x x x x
Angina pectoris def 1% x x x x x x x x x x
Anorexia def 1% x x x x x x x x x x
Anxiety def 1% x x x x x x x x x x
Ataxia def 1% x x x x x x x x x x
Chest pain def 1% x x x x x x x x x x
Dyspnoea def postmarketing, 1% x x x x x x x x x x
Eosinophilia def 1% x x x x x x x x x x
Malformation heart (NOS) def 1% x x x x x x x x x x
Incontinence def 1% x x x x x x x x x x
Lethargy def 1% x x x x x x x x x x
Myoclonus def postmarketing, 1% x x x x x x x x x x
Nasal congestion def 1% x x x x x x x x x x
Pain def 1% x x x x x x x x x x
Muscle spasms def postmarketing, 1% x x x x x x x x x x
Urinary retention def 1% x x x x x x x x x x
Micturition urgency def 1% x x x x x x x x x x
Muscular weakness def 1% x x x x x x x x x x
Myalgia def 1% x x x x x x x x x x
Muscle twitching def 1% x x x x x x x x x x
Tenderness def 1% x x x x x x x x x x
Ache def 1% x x x x x x x x x x
Slurred speech 1% x x x x x x x x x x
Throat sore def 1% x x x x x x x x x x
Hyperkinesia def 1% x x x x x x x x x x
Electrocardiogram change def 1% x x x x x x x x x x
Weakness def 1% x x x x x x x x x x
Abnormal ejaculation 1% x x x x x x x x x x
Pancreatitis acute def postmarketing x x x x x x x x x x
Cataplexy def postmarketing x x x x x x x x x x
Cholestasis def postmarketing x x x x x x x x x x
Coma def postmarketing x x x
Dysphagia def postmarketing x x x x x x x x x x
Delirium def postmarketing x x x x x x x x x x
Diabetes mellitus def postmarketing x x
Dyskinesia def postmarketing x x
Oedema def postmarketing x x x x x x x x x x
Effusion def postmarketing x x x x x x x x x x
Embolism def postmarketing x x x x x x x x x x
Erythema multiforme def postmarketing x x x x x x x x x x
Faecalith def postmarketing x x x x x x x x x x
Glaucoma def postmarketing x x x x x x x x x x
Angle closure glaucoma def postmarketing x x x x x x x
Cardiac arrest def postmarketing x x x x
Cardiac failure def postmarketing x x x
Hepatitis def postmarketing x x x x x x x x x x
Hypercholesterolaemia def postmarketing x x x x x
Hyperglycaemia def postmarketing x x x x x x x x x
Diabetic hyperosmolar coma def postmarketing x x x
Hypersensitivity def postmarketing x x x x x x x x x x
Hypertriglyceridaemia def postmarketing x x x x x
Hyponatraemia def postmarketing x x x x x x x x x
Infarction def postmarketing x x x
Infection def postmarketing x x x x x x x x x x
Intestinal obstruction def postmarketing x x x x x x x x x x
Jaundice def postmarketing x x x x x x x x x x
Mitral valve incompetence def postmarketing x x x
Myocardial infarction def postmarketing x x x
Myocarditis def postmarketing x x x
Nephritis def postmarketing x x x x x x x x x x
Nephritis interstitial def postmarketing x x x x x x x x x x
Obstruction def postmarketing x x x x x x x x x x
Pancreatitis def postmarketing x x x x x x x x x x
Ileus paralytic def postmarketing x x x x x x x x x x
Paraesthesia def postmarketing x x x x x x x x x x
Pericardial effusion def postmarketing x x x
Pericarditis def postmarketing x x x
Pleural disorder def postmarketing x x x x x x x x x x
Pleural effusion def postmarketing x x x x x x x x x x
Pneumonia def postmarketing x x x x x x x x x x
Priapism def postmarketing x x x x x x x x x x
Psychotic disorder def postmarketing x x x x x x x x x x
Pulmonary embolism def postmarketing x x x x x x x x x x
Respiratory tract infection def postmarketing x
Rhabdomyolysis def postmarketing x x x x x x x x x x
Status epilepticus def postmarketing x x x x x x x x x x
Swelling def postmarketing x x x x x x x x x x
Thrombocytopenia def postmarketing x x x x x x x x x x
Thrombosis def postmarketing x x x x x x x x x x
Tooth impacted def postmarketing x x x x x x x x x x
Torsade de pointes def postmarketing x
Erythema def postmarketing x x x x x x x x x x
Vasculitis def postmarketing x x x x x x x x x x
Venous thrombosis def postmarketing x x x x x x x x x x
Ventricular fibrillation def postmarketing x x x x x x x x x x
Ventricular tachycardia def postmarketing x
Weight decreased def postmarketing x x x x x x x x x
Lower respiratory tract infection postmarketing x
Deep vein thrombosis def postmarketing x x x x x x x
Acute interstitial nephritis postmarketing x x x x x x x x x x
Periorbital oedema def postmarketing x x x x x x x x x x
Electroencephalogram abnormal postmarketing x x x x x x x x x x
Red blood cell sedimentation rate increased postmarketing x x x x x x x x x x
Respiratory arrest postmarketing x x x
Ketoacidosis postmarketing x x x
Cardiac fibrillation postmarketing x x x x x x x x x x
Throat tightness postmarketing x x
Salivary gland swelling postmarketing x x x x x x x x x x
Protrusion tongue postmarketing x x
Sepsis def postmarketing x x x x x x x x x x
Glucose tolerance impaired def postmarketing x
Photosensitivity def postmarketing x x x x x x x x x x
Dystonia def postmarketing x x
Myasthenic syndrome postmarketing x x x x x x x x x x
Haemoglobin increased def postmarketing x x x x x x x x x x
Tardive dyskinesia def postmarketing x x
Aspiration postmarketing x x x x x x x x x x
Hyperuricaemia def postmarketing x x x x x x x x x
Thrombocytosis def postmarketing x x x x x x x x x x
Cardiomyopathy def postmarketing x x x
Ileus def postmarketing x x x x x x x x x x
Abdominal distension def x x x x x x x x x x
Amnesia def x x x x x x x x x x
Anaemia def x x x x x x x x x x
Arrhythmia def x x x
Arthralgia def x x x x x x x x x x
Bloodshot eye x x x x x x x x x x
Bronchitis def x x x x x x x x x x
Cough def x x x x x x x x x x
Cyanosis def x x x x x x x x x x
Sudden death def x x x
Delusion def x x x x x x x x x x
Dermatitis def x x x x x x x x x x
Distention def x x x x x x x x x x
Dysarthria def x x x x x x x x x x
Dysmenorrhoea def x x x x x x x x x x
Ear disorder def x x x x x x x x x x
Eczema def x x x x x x x x x x
Toxic epidermal necrolysis def x
Epistaxis def x x x x x x x x x x
Eructation def x x x x x x x x x x
Eyelid disorder def x x x x x x x x x x
Gastroenteritis def x x x x x x x x x x
Hallucination def x x x x x x x x x x
Haematemesis def x x x x x x x x x x
Haemorrhage def x x x x x x x x x x
Hyperventilation def x x x x x x x x x x
Body temperature decreased def x x x x x x x x x x
Irritability def x x x x x x x x x x
Laryngitis def x x x x x x x x x x
Leukocytosis def x x x x x x x x x x
Breast pain def x x x x x x x x x x
Mydriasis def x x x x x x x x x x
Numbness def x x x x x x x x x x
Nystagmus def x x x x x x x x x x
Pallor def x x x x x x x x x x
Palpitations def x x x x x x x x x x
Petechiae def x x x x x x x x x x
Phlebitis def x x x x x x x x x x
Pruritus def x x x x x x x x x x
Sneezing def x x x x x x x x x x
Gastric disorder def x x x x x x x x x x
Gastric ulcer def x x x x x x x x x x
Stuttering def x x x x x x x x x x
Thrombophlebitis def x x x x x x x x x x
Tic def x x x x x x x x x x
Ulcer def x x x x x x x x x x
Urticaria def x x x x x x x x x x
Vaginal itching x x x x x x x x x x
Wheezing def x x x x x x x x x x
Chills def x x x x x x x x x x
Fever chills x x x x x x x x x x
Polydipsia def x x x x x x x x x x
Ventricular extrasystoles def x x x x x x x x x x
Abnormal faeces x x x x x x x x x x
Sickness x x x x x x x x x x
Malaise def x x x x x x x x x x
Increased appetite x x x x x x x x x x
Extrapyramidal symptoms x x
Dry throat x x x x x x x x x x
Taste bitter x x x x x x x x x x
Erectile dysfunction def x x x x x x x x x x
Rectal haemorrhage def x x x x x x x x x x
Shakiness x x x x x x x x x x
Suicidal ideation def x
Movements involuntary def x x x x x x x x x x
Bradycardia def x x x x x x x x x x
Dementia def x x x x x x x x x x
Speech loss x x x x x x x x x x
Hot flush def x x x x x x x x x x
Memory loss x x x x x x x x x x
Rhinorrhoea def x x x x x x x x x x
Paranoia def x x x x x x x x x x
Indication Labels
Agranulocytosis def x x x x x x x x x x
Death x x x x
Premenstrual syndrome def x
Schizoaffective disorder def x x x x
Schizophrenia def x x x x x x x x x x
Seizures def x x x x x x x x x x
Suicidal behaviour x x x x
Suicide def x x x x

Information

More information: STITCH, PubChem and possibly Wikipedia or Medpedia

ATC Code: N05AH02

Legend

Color scheme: standard – alternative

100%    
75%    
50%    
10%    
frequent (1% to 100%)    
infrequent (0.1% to 1%)    
rare (<0.1%)    
postmarketing    
0%    
no frequency information    
not found on label    

Labels

Labels were obtained from different sources and potentially contain different sets of side effects. If you click on the label name, a HTML version of the label will be shown with proteins, chemicals and side efffects highlighted using Reflect.

  1. CLOZAPINE / FAZACLO ODT : 187 side effects (Drugs@FDA)
  2. CLOZAPINE / FAZACLO ODT : 186 side effects (Drugs@FDA)
  3. clozapine / Clozaril : 188 side effects (FDA CDER)
  4. CLOZAPINE / CLOZARIL : 191 side effects (Drugs@FDA)
  5. CLOZAPINE / FAZACLO ODT : 191 side effects (Drugs@FDA)
  6. clozapine / Clozaril : 199 side effects (FDA MedWatch)
  7. CLOZAPINE : 205 side effects (FDA XML label)
  8. CLOZAPINE / APO-CLOZAPINE : 204 side effects (Health Canada)
  9. CLOZAPINE / PMS-CLOZAPINE : 204 side effects (Health Canada)
  10. CLOZAPINE / CLOZARIL TAB 25MG : 211 side effects (Health Canada)