Lorazepam
Side effects
Options:
Hide MedDRA Preferred Terms
MedDRA Preferred Term
|
Side effect
|
Data for drug
|
Placebo
|
Labels
|
|
1
|
2
|
3
|
4
|
5
|
6
|
7
|
8
|
9
|
10
|
11
|
12
|
13
|
14
|
15
|
Dizziness
|
Dizziness
|
6.9%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Asthenia
|
Asthenia
|
infrequent, 4.2%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Fatigue
|
|
|
|
|
|
|
|
x
|
x
|
x
|
|
|
|
|
|
|
|
Somnolence
|
Somnolence
|
1.54% - 3.75%
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Drowsiness
|
|
|
|
|
|
|
|
x
|
x
|
x
|
|
|
|
|
|
|
|
Balance disorder
|
Unsteadiness
|
3.4%
|
|
x
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Respiratory failure
|
Respiratory failure
|
1.25% - 2.35%
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Hypoventilation
|
infrequent, 0.769% - 2.5%
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Apnoea
|
Apnoea
|
postmarketing — 1.18% - 1.25%
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Headache
|
Headache
|
infrequent, 1.18% - 1.25%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Hypoxia
|
Hypoventilation
|
infrequent, 0.769% - 2.5%
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Hypoventilation
|
Hypoventilation
|
infrequent, 0.769% - 2.5%
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Hypochromic anaemia
|
Hypochromic anaemia
|
0% - 1.25%
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Leukocytosis
|
Leukocytosis
|
0% - 1.25%
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Thrombocytosis
|
Thrombocytosis
|
0% - 1.25%
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Acidosis
|
Acidosis
|
infrequent, 0.769%
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Ataxia
|
Ataxia
|
infrequent
|
|
|
|
|
|
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Coma
|
Coma
|
postmarketing — 0.769% - 1.25%
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
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x
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x
|
x
|
x
|
x
|
Infection
|
Infection
|
infrequent, 0.769%
|
|
|
|
|
|
|
|
|
|
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x
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x
|
x
|
x
|
x
|
x
|
Confusional state
|
Confusional state
|
infrequent
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Feeling abnormal
|
Confusional state
|
infrequent
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Cystitis
|
Cystitis
|
infrequent, 0.769%
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Bladder pain
|
Cystitis
|
infrequent, 0.769%
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Cystitis noninfective
|
Cystitis
|
infrequent, 0.769%
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Hallucination
|
Hallucination
|
infrequent
|
|
x
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Hyperventilation
|
Hyperventilation
|
infrequent, 0.769%
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Myoclonus
|
Myoclonus
|
infrequent
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Nausea
|
Nausea
|
infrequent, 0.769%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Convulsion
|
Convulsion
|
postmarketing — 0.769%
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Salivary hypersecretion
|
Salivary hypersecretion
|
infrequent
|
|
|
|
|
x
|
x
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Tremor
|
Tremor
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Vomiting
|
Vomiting
|
infrequent, 0.769%
|
|
|
|
|
x
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Chills
|
Chills
|
infrequent
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Stupor
|
Stupor
|
infrequent, 0% - 1.18%
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Depressed level of consciousness
|
Stupor
|
infrequent, 0% - 1.18%
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
CNS depression NOS
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Agitation
|
Agitation
|
infrequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Excitement
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
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Excitability
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
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|
Injection site reaction
|
Injection site reaction
|
infrequent, 0.769%
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Liver function test abnormal
|
Liver function test abnormal
|
infrequent, 0.769%
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Blood alkaline phosphatase increased
|
Phosphatase alkaline increased
|
infrequent
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Thinking abnormal
|
Thinking abnormal
|
infrequent, 0.769%
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Mental disability
|
Thinking abnormal
|
infrequent, 0.769%
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Brain oedema
|
Brain oedema
|
postmarketing — 0.769%
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Hypertension
|
Hypertension
|
0.1%
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Hypotension
|
Hypotension
|
0% - 2.35%
|
|
x
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Amnesia
|
Amnesia
|
postmarketing
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Amnesia transient
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
Arrhythmia
|
Arrhythmia
|
postmarketing
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Coagulopathy
|
Coagulopathy
|
postmarketing
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Delirium
|
Delirium
|
postmarketing
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Gastrointestinal haemorrhage
|
Gastrointestinal haemorrhage
|
postmarketing
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Cardiac arrest
|
Cardiac arrest
|
postmarketing
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Atrioventricular block
|
Block heart
|
postmarketing
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Pulmonary hypertension
|
Pulmonary hypertension
|
postmarketing
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Nervousness
|
Nervousness
|
postmarketing
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Tension
|
Nervousness
|
postmarketing
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Neuroleptic malignant syndrome
|
Neuroleptic malignant syndrome
|
postmarketing
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Pericardial effusion
|
Pericardial effusion
|
postmarketing
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Pneumothorax
|
Pneumothorax
|
postmarketing
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Pulmonary oedema
|
Pulmonary oedema
|
postmarketing
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Tachycardia
|
Tachycardia
|
postmarketing
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Thrombocytopenia
|
Thrombocytopenia
|
postmarketing
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Urinary incontinence
|
Urinary incontinence
|
postmarketing
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Ventricular arrhythmia
|
Ventricular arrhythmia
|
postmarketing
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Pulmonary haemorrhage
|
Pulmonary haemorrhage
|
postmarketing
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Hepatocellular injury
|
Hepatocellular injury
|
postmarketing
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Liver injury
|
Hepatocellular injury
|
postmarketing
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Respiratory arrest
|
Respiratory arrest
|
postmarketing
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Bradycardia
|
Bradycardia
|
postmarketing
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Sleep apnoea syndrome
|
Obstructive sleep apnea syndrome
|
postmarketing
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Sleep apnoea syndrome
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
Paralysis
|
Paralysis
|
postmarketing
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Aggression
|
Aggression
|
|
|
x
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Agranulocytosis
|
Agranulocytosis
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
Obstructive airways disorder
|
Airway obstruction NOS
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Obstructive airways disorder
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
Alopecia
|
Alopecia
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
Constipation
|
Constipation
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
Diplopia
|
Diplopia
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Dysarthria
|
Dysarthria
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
Slurred speech
|
|
|
|
|
|
|
|
x
|
x
|
x
|
|
|
|
|
|
|
|
Osteoarthritis
|
Dysarthria
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
Dermatitis
|
Rash
|
|
|
|
|
|
x
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Rash
|
Rash
|
|
|
|
|
|
x
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Fatigue
|
Fatigue
|
|
|
|
|
|
|
|
x
|
x
|
x
|
|
|
|
|
|
|
|
Gangrene
|
Gangrene
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Hostility
|
Hostility
|
|
|
x
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Hypersensitivity
|
Hypersensitivity
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
Hyponatraemia
|
Hyponatraemia
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
Body temperature decreased
|
Body temperature decreased
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
Hypothermia
|
Body temperature decreased
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
Inappropriate antidiuretic hormone secretion
|
Inappropriate antidiuretic hormone secretion
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
Irritability
|
Irritability
|
|
|
|
|
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Jaundice
|
Jaundice
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
Lethargy
|
Lethargy
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
Pain
|
Pain
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Pancytopenia
|
Pancytopenia
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
Psychotic disorder
|
Psychotic disorder
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Sleep disorder
|
Sleep disturbance
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
|
|
|
|
|
Vertigo
|
Vertigo
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
Dry mouth
|
Dry mouth
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
Arterial spasm
|
Arterial spasm
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Injection site pain
|
Injection site pain
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Disorientation
|
Disorientation
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
|
|
|
|
|
Memory impairment
|
Memory impairment
|
|
|
|
x
|
x
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
Anterograde amnesia
|
Anterograde amnesia
|
|
|
|
|
|
x
|
x
|
x
|
|
|
|
|
|
|
|
|
|
Extrapyramidal disorder
|
Extrapyramidal symptoms
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
Respiratory depression
|
Respiratory depression
|
|
|
x
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Pulmonary function test decreased
|
Respiratory depression
|
|
|
x
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Euphoric mood
|
Euphoric mood
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
Erectile dysfunction
|
Erectile dysfunction
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
Erythema
|
Redness
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Mania
|
Mania
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Vision blurred
|
Vision blurred
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Suicidal ideation
|
Suicidal ideation
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
Disinhibition
|
Disinhibition
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
Gastrointestinal disorder
|
Gastrointestinal symptom NOS
|
|
|
|
x
|
x
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
Application site pain
|
Application site pain
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Instillation site pain
|
Application site pain
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Sedation
|
Oversedation
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
Visual impairment
|
Visual disturbance
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
Hypersomnia
|
Hypersomnia
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Indications
Information about indications was extracted from the indications and usage sections of the labels.
Side effects: | 10 |
Source: | FDA Structured Product Label |
---|
Side effects: | 11 |
Source: | FDA Structured Product Label |
---|
Side effects: | 11 |
Source: | FDA Structured Product Label |
---|
Side effects: | 14 |
Source: | medicines.org.au |
---|
Side effects: | 14 |
Source: | Medsafe |
---|
Side effects: | 23 |
Source: | Health Canada |
---|
Side effects: | 47 |
Source: | FDA Structured Product Label |
---|
Side effects: | 47 |
Source: | FDA Structured Product Label |
---|
Side effects: | 57 |
Source: | FDA Structured Product Label |
---|
Side effects: | 76 |
Source: | FDA Structured Product Label |
---|
Side effects: | 76 |
Source: | FDA Structured Product Label |
---|
Side effects: | 76 |
Source: | FDA Structured Product Label |
---|
Side effects: | 76 |
Source: | FDA Structured Product Label |
---|
Side effects: | 76 |
Source: | FDA Structured Product Label |
---|
Side effects: | 76 |
Source: | FDA Structured Product Label |
---|
Color scheme:
standard – alternative
|
|
100%
|
|
|
75%
|
|
|
50%
|
|
|
10%
|
|
|
frequent (1% to 100%)
|
|
|
infrequent (0.1% to 1%)
|
|
|
rare (<0.1%)
|
|
|
postmarketing
|
|
|
0%
|
|
|
no frequency information
|
|
|
not found on label
|