Methotrexate

Side effects and indications

Whenever possible, frequency information about the side effects was extracted from the labels. Aggregated frequency information for the drug and, if available, placebo is shown. To the right, you can click on shaded boxes to be taken to mentions of the side effect on the label. (In some cases, the side effect cannot be highlighted due to conversion problems.) Information about indications was extracted from the indications and usage sections of the labels.

Show MedDRA Preferred Terms

Side effect Data for drug Placebo Labels
1 2 3 4 5 6 7 8 9 10
Aggression def x
Agranulocytosis def x x x x
Alopecia def x x x x x x x x x x
Alveolitis allergic def x
Anaphylactic shock def x
Anaemia def x x x x x x x x x x
Aplastic anaemia def x x x x x x x x
Anorexia def x x x x x x x x x x
Aphasia def x x x x x x x x x
Arthralgia def x x x x x x x x x x
Ataxia def x
Back pain def x
Bone disorder def x
Chest pain def x x x x x x x
Coma def x
Confusional state def x
Conjunctivitis def x x x x x x x x x
Convulsion def x x x x x x x x x
Cough def x x x x x x x x
Cryptococcosis def x x x x x x x x x
Cyanosis def x
Cystitis def x x x x x x x x x
Cytomegalovirus infection def x x x x
Sudden death def x x x x x x x x x x
Dental plaque def x x x x x x x x x
Dermatitis def x x x x x x x x x x
Dermatitis exfoliative def x x x x x x x x x x
Diabetes mellitus def x x x x x x x x x x
Diarrhoea def x x x x x x x x x x
Dizziness def x x x x x x x x x x
Drowsiness def x x x x x x x x x
Dysarthria def x x x x x x x x
Dyspnoea def x
Dysuria def x x x x x x x x
Ecchymosis def x x x x x x x x x x
Oedema def x
Effusion def x x x x x x x x x x
Embolism def x
Enteritis def x x x x x x x x x
Eosinophilia def x x x x
Toxic epidermal necrolysis def x x x x x x x x x
Epistaxis def x x x x x
Erythema multiforme def x x x x x x x x x x
Rash def x x x x x x x x x x
Extravasation def x
Eye disorder def x
Fatigue def x x x x x x x x x x
Intra-uterine death def x x x x
Body temperature increased def x x x x x x x x x x
Fibrosis def x x x x x x x x x
Folliculitis def x
Furunculosis def x x x x x x x x x x
Gingivitis def x x x x x x x x x x
Glossitis def x
Gynaecomastia def x x x x x x x x x x
Headache def x x x x x x x x x x
Haematemesis def x x x x x x x x x x
Haematuria def x x x x x x x x x x
Hemiparesis x x x x x x x x x x
Haemorrhage def x x x x x x x x x x
Hepatitis def x x x x x x x x x
Herpes NOS def x x x x x x x x x
Herpes zoster def x x x x x x x x x
Histoplasmosis def x x x x x x x x x
Hyperbilirubinaemia def x
Hypersensitivity def x
Hypotension def x x x x x x x x x x
Infection def x x x x x x x x x x
Infertility def x x x x x x x x x
Inflammation def x
Irritability def x
Nephropathy def x x x x x x x x x
Renal failure acute def x
Lethargy def x
Leukopenia def x x x x x x x x x
Hepatic cirrhosis def x x x x x x x x x
Lung disorder def x x x x x x x x x x
Lymphoproliferative disorder def x x x x x x x
Melaena def x x x x x x x x x x
Meningitis def x
Meningitis aseptic def x
Menstrual disorder def x x x x x x x x x x
Muscle rigidity def x
Nausea def x x x x x x x x x x
Necrosis def x x x x x x x x x x
Neutropenia def x x x x x x x x
Nocardiosis def x x x x x x x x x
Obstruction def x
Oligospermia def x x x x x x x x x
Opportunistic infection def x x x x x x x x x x
Osteonecrosis def x x x x x x x x x x
Osteoporosis def x x x x x x x x x x
Pain def x x x x x x x x
Pancreatic disorder def x
Pancreatitis def x x x x x x x x x x
Pancytopenia def x x x x x x x x x
Paresis def x x x x x x x x x
Pericardial effusion def x x x x x x x x x
Pericarditis def x x x x x x x x x x
Petechiae def x
Pharyngitis def x x x x x x x x x x
Phlebitis def x
Pleural disorder def x
Pleural effusion def x
Pneumonia def x x x x x x x x x x
Pneumocystis carinii pneumonia def x x x x x x x x x
Polyuria def x
Proteinuria def x x x x
Pruritus def x x x x x x x x x x
Pulmonary oedema def x
Pulmonary embolism def x x x x x x x x x x
Pulmonary fibrosis def x
Rales x
Renal failure def x x x x x x x x x
Respiratory tract infection def x x x x x x x
Retinitis pigmentosa def x
Seizures def x
Skin ulcer def x x x x x x x
Spinal cord disorder def x
Stomatitis def x x x x x x x x x x
Ulcerative stomatitis x x x x x x x x x
Cerebrovascular accident def x
Sweating def x x x x x x x
Telangiectasia def x x x x x x x x x x
Thrombocytopenia def x x x x x x x x x x
Thrombophlebitis def x x x x x x x x
Thrombosis def x x x x x x x x x x
Tinnitus def x x x x x x x x
Tumour lysis syndrome def x x x x x x x x x x
Ulcer def x x x x x x x x x
Erythema def x x x x x x x x x x
Upper respiratory tract infection def x x x x x x x
Ureteric obstruction def x
Uric acid level increased x
Urticaria def x x x x x x x x x x
Vasculitis def x x x x x x x x x x
Venous thrombosis def x x x x x x x x x x
Vomiting def x x x x x x x x x x
Cerebral thrombosis x x x x x x x x x x
Encephalopathy def x x x x x x x x x x
Chills def x x x x x x x x x x
Fever chills x x x x x x x x x x
Hepatic failure def x x x x x
Hypogammaglobulinaemia def x x x x x x x x
Deep vein thrombosis def x x x x x x x x x x
Neck stiffness x
Necrolysis epidermal x x x x x x x x x
Renal tubular disorder def x
Skin necrosis x x x x x x x x x x
Arterial thrombosis x x x x x x x x x
Blindness transient x x x x x x x
Interstitial pneumonia x x x x x x x x x
Vaginal discharge def x x x x x x x x x x
Malaise def x x x x x x x x x x
Myalgia def x x x x x x x x x x
Abdominal discomfort x
Speech impairment NOS x x x x x x x
Discomfort def x x x x x x x x
Abdominal distress x x x x x x x x x
Hepatic enzyme increased x x
Productive cough def x
Skin burning sensation def x x x x x x
Erectile dysfunction def x x x x x x x x x x
Azotaemia def x x x x x x x x x x
Sepsis def x x x x x x x x x
Hepatobiliary disease def x x x x
Hepatitis acute x x x x x x x x
Leukoencephalopathy def x x x x x x x x x
Pneumonia cytomegaloviral x x x x
Cognitive impairment def x x x x x x x x x x
Anaphylactoid reaction x x x x x x x x x
Vision blurred def x x x x x x x x x x
Photosensitivity def x x x x x x x x x x
Blindness def x x x x x x x x
Lymphadenopathy def x x x x x x x x
Dementia def x
Pulmonary lymphoma x
Hematopoiesis depressed x x x x x x
Reaction gastrointestinal x x x x x x x
Alveolitis x x x x
Serum albumin decreased x x x x x x x x
Obstructive airways disorder def x x x x x x x x x
Radiculopathy def x
Acne def x x x x x x x x x x
Hyperuricaemia def x
Haematocrit decreased x x x x x x
Febrile neutropenia def x
Second primary malignancy def x
Thromboembolic event x x x x x x x x x
Lung infection def x
Raised liver function tests x x x x x x x
Pulmonary toxicity x
Gastrointestinal toxicity x
Respiratory failure def x x x x x x x
Urine output x
Death x x x x x x x x x x
Retinal vein thrombosis x x x x x x x x x x
Cytolysis def x x x x x x x x x x
Soft tissue necrosis x x x x x x x x x x
Embolus def x x x x x x x x x
Somnolence def x
Mood alteration NOS def x x x x x x x x x x
Loss of libido x x x x x x x x x x
Indication Labels
Acute lymphocytic leukaemia def x x x x x
Adenoma benign def x x x
Arthritis def x x x x x x x x x
Bladder cancer def x x x
Breast cancer def x x x x x x x x x
Carcinomatosis def x
Choriocarcinoma def x x x x x x x x x x
Cutaneous T-cell lymphoma def x x x x x x
Drug interaction def x x x x x x x
Fungal infection def x x x x x x x x x x
Gastric cancer def x x
Head and neck cancer def x x
Hydatidiform mole def x x x x x x
Juvenile arthritis def x x x x x x x
Leukaemia def x x x x x x
Lung neoplasm malignant def x x x x x x x x
Lymphocytic leukaemia def x x x
Lymphoma def x x x x x x x x x x
Malignant hydatidiform mole def x x x x
Malignant neoplasm of esophagus def x
Melanocytic naevus def x x x x x x x
Meningeal leukemia def x x x
Metastasis def x x
Mycosis fungoides def x x x x x x x x x
Neoplasm def x x x
Neoplasm malignant def x x x x x x x x x x
Oesophageal disorder def x
Osteosarcoma def x x x x
Osteosarcoma metastatic def x x x
Psoriasis def x x x x x x x x x
Psoriatic arthropathy def x x
Rheumatoid arthritis def x x x x x x x x x
Sarcoma def x x
T-cell lymphoma def x x x x x x x
Testis cancer def x

Information

More information: STITCH, PubChem and possibly Wikipedia

ATC Codes: L01BA01, L04AX03

Legend

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infrequent (0.1% to 1%)    
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no frequency information    
not found on label    

Labels

Labels were obtained from different sources and potentially contain different sets of side effects. If you click on the label name, a HTML version of the label will be shown with proteins, chemicals and side efffects highlighted using Reflect.

  1. Methotrexate : 136 side effects (BC Cancer)
  2. METHOTREXATE (METHOTREXATE SODIUM) / METOJECT : 106 side effects (Health Canada)
  3. METHOTREXATE (METHOTREXATE SODIUM) / RATIO-METHOTREXATE SODIUM : 132 side effects (Health Canada)
  4. METHOTREXATE : 134 side effects (FDA XML label)
  5. METHOTREXATE : 136 side effects (FDA XML label)
  6. METHOTREXATE : 136 side effects (FDA XML label)
  7. METHOTREXATE SODIUM / METHOTREXATE SODIUM : 136 side effects (Drugs@FDA)
  8. METHOTREXATE : 143 side effects (FDA XML label)
  9. METHOTREXATE : 145 side effects (FDA XML label)
  10. / Methotrexate Sodium Injection : 146 side effects (FDA CDER)