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Methotrexate

More information: STITCH, PubChem (stereo-specific compound: 1) and possibly Wikipedia

ATC Codes: L01BA01, L04AX03

Side effects

Options: Hide MedDRA Preferred Terms ,   display all 24 labels

MedDRA Preferred Term Side effect Data for drug Placebo Labels
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Alopecia Alopecia 1-10% x x x x x x x x x x x x x x x x x x x x
Diabetes mellitus Diabetes mellitus 1-10% x x x x x x x x x x x x x x x x x x x
Diabetic x
Dizziness Dizziness 1-10% x x x x x x x x x x x x x x x x x x x
Dermatitis Rash 1-10% x x x x x x x x x x x x x x x x x x x x
Dermatitis x x x x x x x x x x x x x x x x x x x
Rash Rash 1-10% x x x x x x x x x x x x x x x x x x x x
Eruption x
Convulsion Convulsion 1-10% x x x x x x x x x x x x x x x x x x x x
Vasculitis Vasculitis 1-10% x x x x x x x x x x x x x x x x x x x x
Malaise Malaise 1-10% x x x x x x x x x x x x x x x x x x x
Discomfort Malaise 1-10% x x x x x x x x x x x x x x x x x x x
Feeling abnormal Malaise 1-10% x x x x x x x x x x x x x x x x x x x
Confusional state x x x x x x x
Ill-defined disorder Malaise 1-10% x x x x x x x x x x x x x x x x x x x
Myalgia Myalgia 1-10% x x x x x x x x x x x x x x x x x x x x
Musculoskeletal discomfort Myalgia 1-10% x x x x x x x x x x x x x x x x x x x x
Arthralgia x x x x x x x x x x x x x x x x x x x x
Vision blurred Vision blurred 1-10% x x x x x x x x x x x x x x x x x x x
Photosensitivity reaction Photosensitivity 1-10% x x x x x x x x x x x x x x x x x x x
Sunburn x x x x x
Pulmonary toxicity Pulmonary toxicity 2-8% x x x x x x x
Anaphylactic shock Anaphylactic shock 1% x x x x x x
Anaphylactoid reaction x x x x x x x x x x x x x x x x x
Abdominal pain Abdominal pain x
Gastrointestinal pain Abdominal pain x
Abscess Abscess x
Agranulocytosis Agranulocytosis x x x x x x x x x x x
Alveolitis allergic Alveolitis allergic x
Anaemia Anaemia x x x x x x x x x x x x x x x x x x x
Aplastic anaemia Aplastic anaemia x x x x x x x x x x x x x x x x x
Anaemia megaloblastic Anaemia megaloblastic x x x x x x
Decreased appetite Anorexia x x x x x x x x x x x x x x x x x x x
Appetite absent x
Anuria Anuria x
Aphasia Aphasia x x x x x x x x x x x x x x x x x x
Apnoea Apnoea x
Arachnoiditis Arachnoiditis x x x x x
Arthralgia Arthralgia x x x x x x x x x x x x x x x x x x x x
Asthenia Asthenia x
Fatigue x x x x x x x x x x x x x x x x x x x x
Asthma Asthma x
Ataxia Ataxia x x x x
Back pain Back pain x x x x
Bacterial infection Bacterial infection x
Mental disorder Mental disorder x
Bone disorder Bone disorder x x
Breast disorder Breast disorder x
Burkitt's lymphoma Burkitt's lymphoma x
Cardiac tamponade Cardiac tamponade x
Chest pain Chest pain x x x x x x x x x x x x x x x x x
Coma Coma x x x x x x
Infection Infection x x x x x x x x x x x x x x x x x x x
Confusional state Confusional state x x x x x x x
Conjunctivitis Conjunctivitis x x x x x x x x x x x x x x x x
Cough Cough x x x x x x x x x x x x x x x x x
Dry cough x
Cryptococcosis Cryptococcosis x x x x x x x x x x x x x x x x x
Cyanosis Cyanosis x
Cystitis Cystitis x x x x x x x x x x x x x x x x x x
Bladder pain Cystitis x x x x x x x x x x x x x x x x x x
Cystitis noninfective Cystitis x x x x x x x x x x x x x x x x x x
Cyst Cyst x
Cytomegalovirus infection Cytomegalovirus infection x x x x x
Sudden death Sudden death x x x x x x x x x x x x x x x x x x x
Depression Depression x
Dermatitis exfoliative Dermatitis exfoliative x x x x x x x x x x x x x x x x x x x
Diarrhoea Diarrhoea x x x x x x x x x x x x x x x x x x x x
Somnolence Drowsiness x x x x x x x x x x x x x x x x x x x
Somnolence x x x x
Dysarthria Dysarthria x x x x x x x x x x x x x x
Osteoarthritis Dysarthria x x x x x x x x x x x x x x
Dyspepsia Dyspepsia x
Dyspnoea Dyspnoea x x x x x x x
Dysuria Dysuria x x x x x x x x x x x x x x x x x x
Ecchymosis Ecchymosis x x x x x x x x x x x x x x x x x x x x
Enteritis Enteritis x x x x x x x x x x x x x x x x x x x
Eosinophilia Eosinophilia x x x x x x x x x x x
Toxic epidermal necrolysis Toxic epidermal necrolysis x x x x x x x x x x x x x x x x x x x
Necrolysis epidermal x
Epistaxis Epistaxis x x x x x x x x x x
Erythema multiforme Erythema multiforme x x x x x x x x x x x x x x x x x x x x
Stevens-Johnson syndrome x x x x x x x x x x x x x x x x x x x x
Extravasation Extravasation x
Eye disorder Eye disorder x x
Fatigue Fatigue x x x x x x x x x x x x x x x x x x x x
Foetal death Foetal death x x x x x x x x x x
Body temperature increased Body temperature increased x x x x x x x x x x x x x x x x x x x x
Fibrosis Fibrosis x x x x x x x x x x x x x x x x x x
Folliculitis Folliculitis x x x x x x
Multiple fractures Fracture x
Fracture Fracture x
Stress fracture Stress fracture x x x x x x x x x x x x x x x x x
Furuncle Furunculosis x x x x x x x x x x x x x x x x x x x x
Gastrointestinal disorder Gastrointestinal disorder x
Reaction gastrointestinal x x x x x x x x x x
Gingivitis Gingivitis x x x x x x x x x x x x x x x x x x x x
Glossitis Glossitis x x x x x x
Guillain-Barre syndrome Guillain-Barre syndrome x x
Gynaecomastia Gynaecomastia x x x x x x x x x x x x x x x x
Headache Headache x x x x x x x x x x x x x x x x x x x x
Cardiac disorder Cardiac disorder x
Haematemesis Haematemesis x x x x x x x x x x x x x x x x x x x x
Haematuria Haematuria x x x x x x x x x x x x x x x x x x x x
Hemiparesis Hemiparesis x x x x x x x x x x x x x x x x x x x
Haemorrhage Haemorrhage x x x x x x x
Haemoglobin Haemorrhage x x x x x x x
Hepatitis Hepatitis x x x x x x x x x x x x x x x x
Chronic hepatitis Chronic hepatitis x
Herpes simplex Herpes simplex x x x
Herpes zoster Herpes zoster x x x x x x x x x x x x x x x x x x
Histoplasmosis Histoplasmosis x x x x x x x x x x x x x x x x x
Hyperbilirubinaemia Hyperbilirubinaemia x
Hypersensitivity Hypersensitivity x x x x x
Hypotension Hypotension x x x x x x x x x x x x x x x x x x x x
Immunodeficiency Immunodeficiency x
Immune system disorder Immune system disorder x
Infertility Infertility x x x x x x x x x x x x x x x x x x x
Inflammation Inflammation x
Intestinal perforation Intestinal perforation x x x x x
Irritability Irritability x x x x
Nephropathy Nephropathy x x x x x x x x x x x x x x x x x x
Renal failure acute Renal failure acute x
Lethargy Lethargy x x x x
Leukaemia Leukaemia x
Leukopenia Leukopenia x x x x x x x x x x x x x x x x x x
Hepatic cirrhosis Hepatic cirrhosis x x x x x x
Lung disorder Lung disorder x x
Chronic obstructive pulmonary disease Chronic obstructive pulmonary disease x
Bronchial hyperreactivity Chronic obstructive pulmonary disease x
Lymphoproliferative disorder Lymphoproliferative disorder x x x x x x x x x x x
X-linked lymphoproliferative syndrome Lymphoproliferative disorder x x x x x x x x x x x
Malabsorption Malabsorption x x x x x x
Mediastinal disorder Mediastinal disorder x
Megacolon Megacolon toxic x x x x x x
Melaena Melaena x x x x x x x x x x x x x x x x x x x
Meningism Meningism x
Meningitis aseptic Meningitis aseptic x x
Fungal infection Fungal infection x
Nausea Nausea x x x x x x x x x x x x x x x x x x x x
Necrosis Necrosis x x x x x
Neoplasm Neoplasm x x
Nervous system disorder Nervous system disorder x
Neurological impairment x
Neutropenia Neutropenia x x x x x x x x x x x x x x
Nocardiosis Nocardiosis x x x x x x x x x x x x x x x x x x
Nodule Nodule x
Azoospermia Oligospermia x x x x x x x x x x x x x x x x x x x
Oliguria Oliguria x
Opportunistic infection Opportunistic infection x x x x x x x x x x x x x x x x x x x
Osteonecrosis Osteonecrosis x x x x x x x x x x x x x x x
Aseptic necrosis x x x x x
Osteoporosis Osteoporosis x x x x x x x x x x x x x x x
Pain Pain x x
Pancreatitis Pancreatitis x x x x x x x x x x x x x x x x x x x
Pancytopenia Pancytopenia x x x x x x x x x x x x x x x x x x
Bone marrow depression x x x x x x
Paraplegia Paraplegia x x x
Monoplegia Paraplegia x x x
Diplegia Paraplegia x x x
Paresis Paresis x x x x x x x x x x x x x x x x
Paronychia Paronychia x
Pericardial effusion Pericardial effusion x x x x x x x x x x x x x x x x x x x x
Pericarditis Pericarditis x x x x x x x x x x x x x x x x x x x x
Petechiae Petechiae x x x x x x x
Pharyngitis Pharyngitis x x x x x x x x x x x x x x x x x x x x
Pleural effusion Pleural effusion x x
Pleurisy Pleurisy x
Pneumonia Pneumonia x x x x x x x x x x x x x x x x
Polyp Polyp x
Polyuria Polyuria x
Urine output increased Polyuria x
Proteinuria Proteinuria x x x x x x x x x x x
Protein urine present Proteinuria x x x x x x x x x x x
Pruritus Pruritus x x x x x x x x x x x x x x x x x x x x
Pulmonary oedema Pulmonary oedema x
Pulmonary embolism Pulmonary embolism x x x x x x x x x x x x x x x x x x x x
Pulmonary fibrosis Pulmonary fibrosis x x
Radiation skin injury Dermatitis radiation NOS x x x x x
Rales Rales x
Renal failure Renal failure x x x x x x x x x x x x x x x x x x x
Retinal disorder Retinal disorder x
Sepsis Septicemia x x x x x
Sepsis x x x x x x x x x x x x x x x x x
Skin ulcer Skin ulcer x x x x x x x x x x x x x x x
Spinal cord disorder Spinal cord disorder x
Stevens-Johnson syndrome Stevens-Johnson syndrome x x x x x x x x x x x x x x x x x x x x
Stomatitis Stomatitis x x x x x x x x x x x x x x x x x x x x
Mouth ulceration Ulcerative stomatitis x x x x x x x x x x x x x x x x x
Cerebrovascular accident Cerebrovascular accident x
Sunburn Sunburn x x x x x
Hyperhidrosis Sweating x x x x x x x x x x x
Telangiectasia Telangiectasia x x x x x x x x x x x x x x x x x x x x
Thrombocytopenia Thrombocytopenia x x x x x x x x x x x x x x x x x
Thrombophlebitis Thrombophlebitis x x x x x x x x x x x x x x x x x x
Tinnitus Tinnitus x x x x x x x x x x x x x x x x x
Tumour lysis syndrome Tumour lysis syndrome x x x x x x x x x x x x x x x x x x
Ulcer Ulcer x x x x x x
Erythema Erythema x x x x x x
Upper respiratory tract infection Upper respiratory tract infection x x x x x x x x x x x
Ureteric obstruction Ureteric obstruction x
Urethral disorder Urinary tract disorder x
Urinary tract disorder Urinary tract disorder x
Urticaria Urticaria x x x x x x x x x x x x x x x x x x x
Vaginal inflammation Vaginal inflammation x x x x x
Vaginal infection Vaginal inflammation x x x x x
Angiopathy Angiopathy x
Vertigo Vertigo x
Vomiting Vomiting x x x x x x x x x x x x x x x x x x x x
Cerebral thrombosis Cerebral thrombosis x x x x x x x x x x x x x x x x x x x x
Hidradenitis Hidradenitis x
Encephalopathy Encephalopathy x x x x x x x x x x x x x x x x x x x
Chills Chills x x x x x x x x x x x x x x x x x x x
Hepatic failure Hepatic failure x x x x x x x x x x
Hepatic insufficiency x
Burning sensation Burning sensation x
Stupor Stupor x
Depressed level of consciousness Stupor x
Hypogammaglobulinaemia Hypogammaglobulinaemia x x x x x x x x x x x x x x x x x
Deep vein thrombosis Deep vein thrombosis x x x x x x x x x x x x x x x x x x x x
Cranial nerve paralysis Cranial nerve paralysis x x x
Musculoskeletal stiffness Neck stiffness x
Nuchal rigidity Neck stiffness x
Nuchal rigidity x x x
Leukocytoclastic vasculitis Allergic cutaneous angiitis x
Impaired healing Impaired healing x
Skin necrosis Skin necrosis x x x x x x x x x x x x x x x x
Skin exfoliation Skin necrosis x x x x x x x x x x x x x x x x
Arterial thrombosis Arterial thrombosis x x x x x x x x x x x x x x x x x x
Blindness transient Blindness transient x x x x x x x x x x x x x x x
Malnutrition Malnutrition x
Skin hyperpigmentation Skin hyperpigmentation x x x x x
Leukoderma Leukoderma x x x x
Skin disorder Unspecified disorder of skin and subcutaneous tissue x
Interstitial lung disease Interstitial pneumonia x x x x x x x x x x x x x x x x x
Lung fibrosis interstitial x x x x x
Vaginal discharge Vaginal discharge x x x x x x x x x x x x x x x x x x x x
Abdominal discomfort Abdominal discomfort x
Abdominal distress x x x x x x x x x x x x x x x x x x
Speech disorder Speech impairment NOS x x x x x x x x x x x x x
Motor dysfunction Motor dysfunction x x x
Nail disorder Nail changes x x x x x
Hypervigilance Hypervigilance x
Neurotoxicity Neurotoxicity x x
CNS toxicity x x x
Hepatotoxicity Hepatotoxicity x x x x x x x x x x x x
Lung infiltration Lung infiltration x x x x x
Hepatic enzyme increased Hepatic enzyme increased x x x x x x
Gastrointestinal ulcer Gastrointestinal ulcer x
Paraesthesia Paresthesia of limbs x
Hepatic fibrosis Hepatic fibrosis x
Dysgeusia Taste metallic x
Erectile dysfunction Erectile dysfunction x x x x x x x x x x x x x x x x x x x x
Azotaemia Azotaemia x x x x x x x x x x x x x x x x x x x x
Skin discolouration Skin depigmentation x
Skin depigmentation Skin depigmentation x
Hepatobiliary disease Hepatobiliary disease x x x x x x x
Hepatitis acute Hepatitis acute x x x x x x x x x x x x x x
Leukoencephalopathy Leukoencephalopathy x x x x x x x x x x x x x x x x
Pneumonia cytomegaloviral Pneumonia cytomegaloviral x x x x x x x x x
Thermal burn Scald x x x x x x x x x x
Mucosal inflammation Mucosal inflammation x x x x x
Cognitive disorder Cognitive impairment x x x x x x x x x x x x x x x x x x x
Anaphylactoid reaction Anaphylactoid reaction x x x x x x x x x x x x x x x x x
Liver disorder Chronic liver disease x x x x
Hepatic atrophy Hepatic atrophy x x x x x
Lymphadenopathy Lymphadenopathy x x x x x x x x x x x x x x x x
Dementia Dementia x x x x x x
Lymphoma Pulmonary lymphoma x
Paralysis Paralysis x
Visual impairment Visual disturbance x
Visual impairment x
Alveolitis Alveolitis x x x x x x x x x x
Blood albumin decreased Serum albumin decreased x x x x x x x x x x x x x x x
Obstructive airways disorder Obstructive airways disorder x x x x x x x x x x x x x x x x x
Hypoxia Hypoxemia x x x x x
Radiculopathy Radiculopathy x
Blood uric acid increased Hyperuricaemia x
Hyperuricaemia Hyperuricaemia x
Haematocrit decreased Haematocrit decreased x x x x x x x x x x x
Febrile neutropenia Febrile neutropenia x
Partial seizures Partial seizures x x
Infestation Infestation NOS x
Embolism Thromboembolic event x x x x x x x x x x x x x x x x x x x
Carcinogenicity Carcinogenicity x x x x x
Lung infection Lung infection x
Liver function test abnormal Raised liver function tests x x x x x x x x x x x
Insomnia Insomnia x
Psoriasis Psoriatic plaque x x x
Ocular discomfort Ocular discomfort x x x x x x x x x x x x x x x x x
Gastrointestinal ulcer haemorrhage Gastrointestinal ulcer haemorrhage x x x x x x x x x x x x x x x x x
Gastrointestinal toxicity Gastrointestinal toxicity x
Respiratory failure Respiratory failure x x x x x x x x x x x x
Urine output Urine output x
Retinal vein thrombosis Retinal vein thrombosis x x x x x x x x x x x x x x x x x x x x
Pneumocystis jirovecii pneumonia Pneumocystis jirovecii pneumonia x x x x x x x x x x x x x x x
Soft tissue necrosis Soft tissue necrosis x x x x x x x x x x x x x x x
Herpes simplex hepatitis Herpes simplex hepatitis x x
Mood swings Mood alteration NOS x x x x x x x x x x x x x x x x x x x
Loss of libido Loss of libido x x x x