Modafinil
  
Side effects 
	
		
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| Side effect | Data for drug | Placebo | Labels | 
|  | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 
| Nausea | postmarketing, 1% - 9% | 3% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Dizziness | postmarketing, 5% | 2% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Insomnia | postmarketing, 4% - 6% | 1% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Anxiety | postmarketing, 4% | 1% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Diarrhoea | postmarketing, 4% | 2% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Dry mouth | postmarketing, 2% - 7% | 1% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Depression | 1% - 3% | 0% - 1% | x | x | x | x | x | x | x |  | x | x | x | x | x | x | x | x | 
| Dyspepsia | 2% | 0% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Rash | postmarketing, 1% - 4% | 0% - 1% | x | x |  |  |  |  |  | x | x | x | x | x | x | x | x | x | 
| Fatigue | postmarketing, 2% | 1% | x | x |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Headache | postmarketing, 1% - 23% | 9% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Palpitations | postmarketing, 2% | 1% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Abdominal pain upper | 2% | 1% | x | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Anorexia | 1% | 0% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Conjunctivitis | 1% |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | 
| Constipation | 1% | 0% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Dermatitis contact | 1% | 0% | x | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Dyspnoea | 1% | 0% | x | x |  |  |  |  |  | x | x | x | x | x | x | x | x |  | 
| Body temperature increased | 1% | 0% | x | x |  |  |  |  |  | x | x | x | x | x | x | x | x | x | 
| Seasonal allergy | 1% | 0% | x | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Hyperhidrosis | postmarketing, 1% | 0% | x | x |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Nervousness | postmarketing, 1% | 0% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Pain | 1% | 0% | x | x |  |  |  |  |  | x | x | x | x | x | x | x | x | x | 
| Paraesthesia | postmarketing, 1% | 0% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Polyuria | 1% | 0% | x | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Pruritus | postmarketing, 1% |  |  |  |  |  |  |  |  | x |  |  |  |  |  | x | x | x | 
| Tachycardia | 1% | 0% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Thirst | 1% | 0% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Tremor | postmarketing, 1% | 0% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Vomiting | postmarketing, 1% | 0% | x | x |  |  |  |  |  | x | x | x | x | x | x | x | x | x | 
| Agitation | postmarketing, 1% | 0% | x | x | x | x | x | x | x |  | x | x | x | x | x | x | x | x | 
| Migraine | 1% | 0% | x | x |  |  |  |  |  | x | x | x | x | x | x | x | x | x | 
| Gamma-glutamyltransferase increased | postmarketing, 1% | 0% | x | x |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Decreased appetite | 1% | 0% | x | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Disturbance in attention | 1% | 0% | x | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Depressed mood | 1% | 0% | x | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Influenza like illness | 1% | 0% | x | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Loose stools | 1% | 0% | x | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Pollakiuria | 0.7% |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  | 
| Muscle twitching | 0.7% |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  | 
| Ataxia | 0.3% |  |  |  |  |  |  |  |  | x |  |  |  |  |  | x | x |  | 
| Cystitis | 0.3% |  |  |  |  |  |  |  |  | x |  |  |  |  |  | x | x |  | 
| Partial hearing loss | 0.3% |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  | 
| Cardiac arrest | 0.3% |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Leukocytosis | 0.3% |  |  |  |  |  |  |  |  | x |  |  |  |  |  | x | x |  | 
| Personality disorder | 0.3% |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  | 
| Hyperacusis | 0.3% |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  | 
| Pain in jaw | 0.3% |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  | 
| Erectile dysfunction | 0.3% |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  | 
| Photosensitivity | 0.3% |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  | 
| Myasthenia | 0.3% |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  | 
| Abdominal pain | postmarketing |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | 
| Aggression | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Agranulocytosis | postmarketing |  |  |  | x | x | x | x | x |  | x | x | x | x | x | x | x |  | 
| Anaphylactic shock | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Angioedema | postmarketing |  |  | x |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Arrhythmia | postmarketing |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  | x | 
| Mental disorder | postmarketing |  | x | x |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Chest pain | postmarketing |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Confusional state | postmarketing |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Connective tissue disorder | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Delusion | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Drug eruption | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Dyskinesia | postmarketing |  |  |  | x | x | x | x | x | x | x | x | x | x | x |  |  | x | 
| Eczema | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Oedema | postmarketing |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Eosinophilia | postmarketing |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Toxic epidermal necrolysis | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Erythema multiforme | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Gastrointestinal disorder | postmarketing |  | x | x |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Hallucination | postmarketing |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  | x | 
| Cardiac disorder | postmarketing |  | x | x |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Hypersensitivity | postmarketing |  |  | x |  |  |  |  |  | x | x | x | x | x | x | x | x | x | 
| Hypertension | postmarketing |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Immune system disorder | postmarketing |  | x | x |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Irritability | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Nervous system disorder | postmarketing |  | x | x |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Psychotic disorder | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | 
| Convulsion | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Stevens-Johnson syndrome | postmarketing |  |  | x |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Suicide attempt | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Urinary tract disorder | postmarketing |  | x | x |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Urticaria | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Angiopathy | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Weight increased | postmarketing |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | 
| Weight decreased | postmarketing |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | 
| Myocardial ischaemia | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Muscular weakness | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Unspecified disorder of skin and subcutaneous tissue | postmarketing |  | x | x |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Malaise | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Thinking abnormal | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Condition aggravated | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Depression aggravated | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Mania | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | 
| Suicidal ideation | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Blood pressure increased | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Electrocardiogram abnormal | postmarketing |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | 
| Urine odour foul | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Tardive dyskinesia | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Albuminuria |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  | 
| Amblyopia |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Amnesia |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  | 
| Anaemia |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  | 
| Arthralgia |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  | 
| Arthritis |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | 
| Asthenia |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | 
| Asthma |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Back pain |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Bronchitis |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | 
| Cataplexy |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x |  |  | x | 
| Neck pain |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | 
| Infection |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | 
| Cough |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Libido decreased |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  | 
| Drowsiness |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Dysgeusia |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Dysmenorrhoea |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  | 
| Ear disorder |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  | 
| Ear pain |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | 
| Ecchymosis |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | 
| Epistaxis |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Flatulence |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Gastroenteritis |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  | 
| Gingivitis |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  | 
| Haematuria |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Herpes simplex |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Hyperglycaemia |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | 
| Hypotension |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | 
| Body temperature decreased |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | 
| Influenza |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Arthropathy |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  | 
| Cramps of lower extremities |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | 
| Lung disorder |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Mediastinal disorder |  |  | x | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Hypertonia |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Obesity |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Pancytopenia |  |  | x | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Abscess periodontal |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | 
| Pharyngitis |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Pneumonia |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  | 
| Psoriasis |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  | 
| Pyuria |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Rhinitis |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Sinusitis |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | 
| Skin disorder |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  | 
| Sweating |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Syncope |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  | 
| Tooth disorder |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | 
| Urinary tract infection |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | 
| Vasodilation |  |  |  |  |  |  |  |  | x | x |  |  |  |  |  |  | x |  | 
| Vertigo |  |  |  |  | x | x | x | x | x |  | x | x | x | x | x | x | x | x | 
| Viral infection |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | 
| Urinary retention |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  | 
| Chills |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Mood swings |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Oedema peripheral |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | 
| Hepatic function abnormal |  |  |  |  |  | x | x | x | x |  | x | x | x | x | x | x | x | x | 
| Mouth ulceration |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Neck stiffness |  |  |  |  | x | x | x | x | x |  | x | x | x | x | x | x | x | x | 
| Ventricular extrasystoles |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  | 
| Accidental injury |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | 
| Eye pain |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Aspartate aminotransferase increased |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  | 
| Dry skin |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  | 
| Orofacial dyskinesia |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | 
| Malnutrition |  |  | x | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Myalgia |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | 
| Increased appetite |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | 
| Psychiatric symptom |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Urine abnormality |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Hepatic enzyme increased |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | 
| Anxiety depression |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  | 
| Anaphylactoid reaction |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Hyperkinesia |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Bradycardia |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  | 
| Cough increased |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x |  | 
| Somnolence |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Abnormal ejaculation |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  | 
| Abnormal vision |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
	 
 
  Indications
	Information about indications was extracted from the indications and usage sections of the labels.
	
 
	  
	  
		| Side effects: | 46 | 
|---|
		| Source: | FDA Structured Product Label | 
|---|
		 
	  
	  
		| Side effects: | 52 | 
|---|
		| Source: | FDA Structured Product Label | 
|---|
		 
	  
	  
		| Side effects: | 52 | 
|---|
		| Source: | FDA Structured Product Label | 
|---|
		 
	  
	  
		| Side effects: | 53 | 
|---|
		| Source: | FDA Structured Product Label | 
|---|
		 
	  
	  
		| Side effects: | 53 | 
|---|
		| Source: | FDA Structured Product Label | 
|---|
		 
	  
	  
		| Side effects: | 53 | 
|---|
		| Source: | FDA Structured Product Label | 
|---|
		 
	  
	  
		| Side effects: | 54 | 
|---|
		| Source: | FDA Structured Product Label | 
|---|
		 
	  
	  
		| Side effects: | 105 | 
|---|
		| Source: | FDA | 
|---|
		 
	  
	  
		| Side effects: | 89 | 
|---|
		| Source: | FDA Structured Product Label | 
|---|
		 
	  
	  
		| Side effects: | 89 | 
|---|
		| Source: | FDA Structured Product Label | 
|---|
		 
	  
	  
		| Side effects: | 89 | 
|---|
		| Source: | FDA Structured Product Label | 
|---|
		 
	  
	  
		| Side effects: | 90 | 
|---|
		| Source: | FDA Structured Product Label | 
|---|
		 
	  
	  
		| Side effects: | 91 | 
|---|
		| Source: | FDA | 
|---|
		 
	  
	  
		| Side effects: | 109 | 
|---|
		| Source: | Health Canada | 
|---|
		 
	  
	  
		| Side effects: | 110 | 
|---|
		| Source: | Health Canada | 
|---|
		 
	  
	  
		| Side effects: | 127 | 
|---|
		| Source: | Medsafe | 
|---|
		 
	  
  
 
  
	Color scheme:
	  
	  standard – alternative
	  
	
	
|  |  | 100% | 
|  |  | 75% | 
|  |  | 50% | 
|  |  | 10% | 
|  |  | frequent (1% to 100%) | 
|  |  | infrequent (0.1% to 1%) | 
|  |  | rare (<0.1%) | 
|  |  | postmarketing | 
|  |  | 0% | 
|  |  | no frequency information | 
|  |  | not found on label |