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More information: STITCH, PubChem (stereo-specific compound: 1) and possibly Wikipedia

ATC Code: L02AE01

Side effects

Options: Show MedDRA Preferred Terms

Side effect Data for drug Placebo Labels
1 2
Loss of libido 75% - 84.8% x x
Erectile dysfunction 75% - 79.4% x
Hot flush 38.5% - 72% x x
Menorrhagia 22% - 23.8% x
Headache 16.5% - 28.5% x x
Acne 5.36% - 32.1% x
Vaginal dryness 7.34% - 28.6% x x
Asthenia 7.14% - 22% x x
Nasal irritation 12.5% x
Mood swings 7.14% - 13.8% x x
Libido decreased 7.34% - 11.9% x
Injection site reaction 5.4% - 11.9% x
Nausea 6.55% - 8.26% x x
Dizziness 5.5% - 8.93% x x
Depression 5.5% - 7.74% x
Arthralgia 4.76% x
Insomnia 4.76% x
Pain 4.6% x x
Application site reaction 0% - 7.74% x
Swelling 3.3% x
Digestion impaired 3% x
Oedema 2.98% x x
Breast pain 2.98% x
Weight increased 2.98% x
Migraine 2.98% x x
Gastrointestinal fullness 2.98% x
Gynaecomastia 2.6% x x
Nervousness 2.38% x x
Paraesthesia 2.38% x x
Weight decreased 2.38% x
Urticaria 1.8% - 2% x x
Dry mouth 1.8% x
Nasal dryness 1.8% x
Sweating increased 1.8% x x
Dysgeusia 1.79% x
Pain in extremity 1.79% x
Rhinitis 1.79% x
Skin disorder 1.79% x
Vaginal inflammation 1.79% x
Dry skin 1.79% x x
Myalgia 1.79% x
Dyspareunia 1.79% x x
Pruritus 1.3% x x
Clinical flare reaction 1.3% x
Anxiety 1.19% x x
Constipation 1.19% x x
Hirsutism 1.19% x
Hostility 1.19% x
Menstrual disorder 1.19% x
Palpitations 1.19% x x
Purpura 1.19% x
Upper respiratory tract infection 1.19% x
Neck stiffness 1.19% x
Abdominal pain x
Abortion spontaneous x
Amnesia x
Back pain x
Mental disorder x x
Breast disorder x
Infection x
Connective tissue disorder x x
Cyst x
Diarrhoea x x
Drowsiness x x
Dyspnoea x
Ear disorder x
Ear pain x
Epistaxis x
Rash x x
Eye disorder x x
Fatigue x x
Feminization x
Body temperature increased x
Flatulence x
Gastrointestinal disorder x x
Cardiac disorder x x
Hoarseness x
Hydronephrosis x x
Hypersensitivity x x
Hypogonadism x
Immune system disorder x
Leukopenia x x
Leukorrhea x
Mediastinal disorder x
Menopause x
Metrorrhagia x
Neoplasm x
Nervous system disorder x x
Osteopenia x
Ovarian cyst x x
Pelvic pain x
Pituitary adenoma x x
Polyp x
Ectopic pregnancy x
Multiple pregnancy x
Premenstrual syndrome x
Pulmonary embolism x x
Shoulder pain x
Sleep disturbance x
Spinal cord compression x
Syncope x
Thrombocytopenia x x
Thrombosis x x
Tinnitus x x
Tremor x
Angiopathy x x
Vertigo x
Vomiting x x
Urinary retention x
Oedema peripheral x
Mouth ulceration x
Breast atrophy x
Generalised oedema x
Lactation female x
Bone pain x x
Withdrawal bleed x
Accommodation disorder x
Allergic asthma x
Malnutrition x x
Unspecified disorder of skin and subcutaneous tissue x x
Welts x
Stomach ache x
Vaginal discharge x x
Malaise x
Increased appetite x
Abdominal pain lower x
Thinking abnormal x
Vaginal discomfort x
Oestrogen low x
Increased thirst x x
Throat sore x
Auditory disorder NOS x
Breast tenderness x
Dry eye x
Atrophy x
Anaphylactoid reaction x
Vision blurred x x
Photosensitivity x
Splitting nails x
Stiffness x
Application site pain x
Neurological impairment x x
Gastrointestinal pain x
Infestation NOS x
Blood and lymphatic system disorders x
Ear and labyrinth disorders x
Administration site reaction x
Sleep disorder x
Local reaction x
Tumour pain x
Serum testosterone increased x
Musculoskeletal discomfort x
Lymphostasis x x
Rhinorrhoea x
Parosmia x
Breast enlargement x
Tumour compression x
Somnolence x
Vaginal haemorrhage x
Bleeding breakthrough x
Visual impairment x x


Information about indications was extracted from the indications and usage sections of the labels.

SUPREFACT / Suprefact, Solution for injection

Side effects:82


Side effects:131
Source:Health Canada

Color scheme:


    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    no frequency information
    not found on label