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More information: STITCH, PubChem (stereo-specific compound: 1) and possibly Wikipedia

ATC Code: L02AE01

Side effects

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MedDRA Preferred Term Side effect Data for drug Placebo Labels
1 2
Loss of libido Loss of libido 75% - 84.8% x x
Erectile dysfunction Erectile dysfunction 75% - 79.4% x
Menopausal symptoms Hot flush 38.5% - 72% x x
Hot flush Hot flush 38.5% - 72% x x
Menorrhagia Menorrhagia 22% - 23.8% x
Headache Headache 16.5% - 28.5% x x
Acne Acne 5.36% - 32.1% x
Vulvovaginal dryness Vaginal dryness 7.34% - 28.6% x x
Asthenia Asthenia 7.14% - 22% x x
Fatigue x x
Nasal discomfort Nasal irritation 12.5% x
Mood swings Mood swings 7.14% - 13.8% x x
Affect lability Mood swings 7.14% - 13.8% x x
Libido decreased Libido decreased 7.34% - 11.9% x
Disturbance in sexual arousal Libido decreased 7.34% - 11.9% x
Injection site reaction Injection site reaction 5.4% - 11.9% x
Nausea Nausea 6.55% - 8.26% x x
Dizziness Dizziness 5.5% - 8.93% x x
Syncope x
Depression Depression 5.5% - 7.74% x
Arthralgia Arthralgia 4.76% x
Musculoskeletal discomfort Arthralgia 4.76% x
Myalgia 1.79% x
Musculoskeletal discomfort x
Insomnia Insomnia 4.76% x
Pain Pain 4.6% x x
Application site reaction Application site reaction 0% - 7.74% x
Swelling Swelling 3.3% x
Dyspepsia Digestion impaired 3% x
Gastrointestinal disorder Digestion impaired 3% x
Gastrointestinal disorder x x
Oedema Oedema 2.98% x x
Breast pain Breast pain 2.98% x
Weight increased Weight increased 2.98% x
Migraine Migraine 2.98% x x
Abdominal distension Gastrointestinal fullness 2.98% x
Gynaecomastia Gynaecomastia 2.6% x x
Nervousness Nervousness 2.38% x x
Tension Nervousness 2.38% x x
Paraesthesia Paraesthesia 2.38% x x
Weight decreased Weight decreased 2.38% x
Urticaria Urticaria 1.8% - 2% x x
Welts x
Dry mouth Dry mouth 1.8% x
Nasal dryness Nasal dryness 1.8% x
Hyperhidrosis Sweating increased 1.8% x x
Dysgeusia Dysgeusia 1.79% x
Pain in extremity Pain in extremity 1.79% x
Rhinitis Rhinitis 1.79% x
Skin disorder Skin disorder 1.79% x
Unspecified disorder of skin and subcutaneous tissue x x
Vaginal inflammation Vaginal inflammation 1.79% x
Vaginal infection Vaginal inflammation 1.79% x
Dry skin Dry skin 1.79% x x
Myalgia Myalgia 1.79% x
Dyspareunia Dyspareunia 1.79% x x
Pruritus Pruritus 1.3% x x
Condition aggravated Clinical flare reaction 1.3% x
Anxiety Anxiety 1.19% x x
Constipation Constipation 1.19% x x
Hirsutism Hirsutism 1.19% x
Hostility Hostility 1.19% x
Menstrual disorder Menstrual disorder 1.19% x
Palpitations Palpitations 1.19% x x
Purpura Purpura 1.19% x
Vascular purpura Purpura 1.19% x
Upper respiratory tract infection Upper respiratory tract infection 1.19% x
Musculoskeletal stiffness Neck stiffness 1.19% x
Stiffness x
Nuchal rigidity Neck stiffness 1.19% x
Abdominal pain Abdominal pain x
Stomach ache x
Gastrointestinal pain Abdominal pain x
Gastrointestinal pain x
Abortion spontaneous Abortion spontaneous x
Amnesia Amnesia x
Back pain Back pain x
Mental disorder Mental disorder x x
Breast disorder Breast disorder x
Infection Infection x
Connective tissue disorder Connective tissue disorder x x
Cyst Cyst x
Diarrhoea Diarrhoea x x
Somnolence Drowsiness x x
Somnolence x
Dyspnoea Dyspnoea x
Ear disorder Ear disorder x
Ear pain Ear pain x
Epistaxis Epistaxis x
Dermatitis Rash x x
Rash Rash x x
Eye disorder Eye disorder x x
Fatigue Fatigue x x
Feminisation acquired Feminization x
Body temperature increased Body temperature increased x
Flatulence Flatulence x
Cardiac disorder Cardiac disorder x x
Dysphonia Hoarseness x
Hydronephrosis Hydronephrosis x x
Hypersensitivity Hypersensitivity x x
Hypogonadism Hypogonadism x
Immune system disorder Immune system disorder x
Leukopenia Leukopenia x x
Vaginal discharge Leukorrhea x
Vaginal discharge x x
Mediastinal disorder Mediastinal disorder x
Menopause Menopause x
Metrorrhagia Metrorrhagia x
Bleeding breakthrough x
Neoplasm Neoplasm x
Nervous system disorder Nervous system disorder x x
Neurological impairment x x
Osteopenia Osteopenia x
Ovarian cyst Ovarian cyst x x
Pelvic pain Pelvic pain x
Pituitary tumour benign Pituitary adenoma x x
Polyp Polyp x
Ectopic pregnancy Ectopic pregnancy x
Multiple pregnancy Multiple pregnancy x
Premenstrual syndrome Premenstrual syndrome x
Pulmonary embolism Pulmonary embolism x x
Musculoskeletal pain Shoulder pain x
Sleep disorder Sleep disturbance x
Sleep disorder x
Spinal cord compression Spinal cord compression x
Shock Syncope x
Syncope Syncope x
Loss of consciousness Syncope x
Thrombocytopenia Thrombocytopenia x x
Thrombosis Thrombosis x x
Tinnitus Tinnitus x x
Tremor Tremor x
Angiopathy Angiopathy x x
Vertigo Vertigo x
Vomiting Vomiting x x
Urinary retention Urinary retention x
Oedema peripheral Oedema peripheral x
Stomatitis Mouth ulceration x
Mouth ulceration Mouth ulceration x
Breast atrophy Breast atrophy x
Generalised oedema Generalised oedema x
Fluid retention Generalised oedema x
Galactorrhoea Lactation female x
Bone pain Bone pain x x
Withdrawal bleed Withdrawal bleed x
Accommodation disorder Accommodation disorder x
Asthma Allergic asthma x
Malnutrition Malnutrition x x
Abdominal pain upper Stomach ache x
Malaise Malaise x
Discomfort Malaise x
Feeling abnormal Malaise x
Ill-defined disorder Malaise x
Increased appetite Increased appetite x
Abdominal pain lower Abdominal pain lower x
Thinking abnormal Thinking abnormal x
Mental disability Thinking abnormal x
Vulvovaginal discomfort Vaginal discomfort x
Blood oestrogen decreased Oestrogen low x
Thirst Increased thirst x x
Oropharyngeal discomfort Throat sore x
Oropharyngeal pain Throat sore x
Hearing impaired Auditory disorder NOS x
Breast tenderness Breast tenderness x
Dry eye Dry eye x
Atrophy Atrophy x
Anaphylactic shock Anaphylactoid reaction x
Anaphylactoid reaction Anaphylactoid reaction x
Vision blurred Vision blurred x x
Photosensitivity reaction Photosensitivity x
Onychoclasis Splitting nails x
Application site pain Application site pain x
Instillation site pain Application site pain x
Infestation Infestation NOS x
Administration site reaction Administration site reaction x
Local reaction Local reaction x
Tumour pain Tumour pain x
Blood testosterone increased Serum testosterone increased x
Lymphostasis Lymphostasis x x
Nasopharyngitis Rhinorrhoea x
Rhinorrhoea Rhinorrhoea x
Parosmia Parosmia x
Breast enlargement Breast enlargement x
Tumour compression Tumour compression x
Vaginal haemorrhage Vaginal haemorrhage x
Visual impairment Visual impairment x x


Information about indications was extracted from the indications and usage sections of the labels.

SUPREFACT / Suprefact, Solution for injection

Side effects:82


Side effects:131
Source:Health Canada

Color scheme:


    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    no frequency information
    not found on label