Stavudine
Side effects
Options:
Hide MedDRA Preferred Terms
MedDRA Preferred Term
|
Side effect
|
Data for drug
|
Placebo
|
Labels
|
|
1
|
2
|
3
|
4
|
5
|
6
|
7
|
8
|
9
|
10
|
Headache
|
Headache
|
49% - 54%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Neuropathy peripheral
|
Neuropathy
|
39% - 52%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Neuritis
|
common
|
|
|
|
|
|
|
|
|
x
|
|
x
|
Neuropathy peripheral
|
postmarketing, common
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Diarrhoea
|
Diarrhoea
|
common, 44% - 50%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Nausea
|
Nausea
|
common, 39% - 44%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Vomiting
|
Vomiting
|
uncommon, 39% - 44%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Neurological symptom
|
Neurological symptom
|
common, 39% - 52%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Dermatitis
|
Rash
|
common, 35% - 40%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Rash
|
Rash
|
common, 35% - 40%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Dyspepsia
|
Dyspepsia
|
common
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
Asthenia
|
Fatigue
|
common
|
|
|
|
|
|
|
|
|
x
|
|
x
|
Asthenia
|
very rare — uncommon
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Fatigue
|
Fatigue
|
common
|
|
|
|
|
|
|
|
|
x
|
|
x
|
Neuritis
|
Neuritis
|
common
|
|
|
|
|
|
|
|
|
x
|
|
x
|
Paraesthesia
|
Paraesthesia
|
common
|
|
|
|
|
|
|
|
|
x
|
|
x
|
Tingling sensation
|
|
|
x
|
x
|
x
|
x
|
|
|
|
x
|
x
|
|
Pruritus
|
Pruritus
|
common
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
Hyperlactacidaemia
|
Asymptomatic hyperlactatemia
|
common
|
|
|
|
|
|
|
|
|
|
|
x
|
Symptomatic hyperlactatemia
|
very rare, postmarketing
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Hyperlactacidaemia
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Anxiety
|
Anxiety
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
x
|
Arthralgia
|
Arthralgia
|
uncommon
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Musculoskeletal discomfort
|
Arthralgia
|
uncommon
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Myalgia
|
postmarketing, uncommon
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Gynaecomastia
|
Gynaecomastia
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
x
|
Jaundice
|
Jaundice
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
x
|
Nervous system disorder
|
Nervous system disorder
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
x
|
Urticaria
|
Urticaria
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
x
|
Mood swings
|
Mood swings
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
x
|
Affect lability
|
Mood swings
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
x
|
Malnutrition
|
Malnutrition
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
x
|
Hepatobiliary disease
|
Hepatobiliary disease
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
x
|
Abdominal pain
|
Abdominal pain
|
postmarketing, common
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Gastrointestinal pain
|
Abdominal pain
|
postmarketing, common
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Lactic acidosis
|
Lactic acidosis
|
postmarketing, uncommon
|
|
|
|
|
|
x
|
x
|
x
|
|
|
x
|
Lactic acidosis syndrome
|
very rare
|
|
|
|
|
|
|
|
|
x
|
|
x
|
Anaemia
|
Anaemia
|
postmarketing, rare
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Decreased appetite
|
Anorexia
|
postmarketing, uncommon
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Diabetes mellitus
|
Diabetes mellitus
|
very rare, postmarketing
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
x
|
x
|
Body temperature increased
|
Body temperature increased
|
postmarketing
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Blood disorder
|
Blood disorder
|
postmarketing
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hepatitis
|
Hepatitis
|
postmarketing, uncommon
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Hyperglycaemia
|
Hyperglycaemia
|
postmarketing, rare
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
x
|
x
|
Hypersensitivity
|
Hypersensitivity
|
postmarketing
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Leukopenia
|
Leukopenia
|
postmarketing
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Lipodystrophy acquired
|
Lipodystrophy
|
postmarketing, common
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
x
|
Metabolic disorder
|
Metabolic disorder
|
postmarketing
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
x
|
|
Neutropenia
|
Neutropenia
|
very rare, postmarketing
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
x
|
Pancreatitis
|
Pancreatitis
|
postmarketing, uncommon
|
|
|
|
|
|
x
|
x
|
x
|
|
|
x
|
Thrombocytopenia
|
Thrombocytopenia
|
very rare, postmarketing
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Chills
|
Chills
|
postmarketing
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hepatic failure
|
Hepatic failure
|
very rare, postmarketing
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Myalgia
|
Myalgia
|
postmarketing, uncommon
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Hepatotoxicity
|
Hepatotoxicity
|
postmarketing
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Insomnia
|
Insomnia
|
postmarketing
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Lipoatrophy
|
Lipoatrophy
|
postmarketing, common
|
|
|
|
|
|
x
|
x
|
x
|
|
|
x
|
Hepatic steatosis
|
Hepatic steatosis
|
postmarketing, rare
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Mental disorder
|
Mental disorder
|
very rare
|
|
|
|
|
|
|
|
|
|
|
x
|
Connective tissue disorder
|
Connective tissue disorder
|
very rare
|
|
|
|
|
|
|
|
|
|
|
x
|
Endocrine disorder
|
Endocrine disorder
|
very rare
|
|
|
|
|
|
|
|
|
|
|
x
|
Gastrointestinal disorder
|
Gastrointestinal disorder
|
very rare
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Skin disorder
|
Unspecified disorder of skin and subcutaneous tissue
|
very rare
|
|
|
|
|
|
|
|
|
|
|
x
|
Autoimmune disorder
|
Autoimmune disorder
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Back pain
|
Back pain
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Bronchitis
|
Bronchitis
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Conjunctivitis
|
Conjunctivitis
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Constipation
|
Constipation
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Depression
|
Depression
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
Dizziness
|
Dizziness
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
Dysgeusia
|
Dysgeusia
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Dysuria
|
Dysuria
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Eructation
|
Eructation
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Flatulence
|
Flatulence
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Basedow's disease
|
Basedow's disease
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Guillain-Barre syndrome
|
Guillain-Barre syndrome
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Haematuria
|
Haematuria
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Hepatitis B
|
Hepatitis B
|
|
|
|
|
|
|
|
|
|
x
|
|
|
Hepatomegaly
|
Hepatomegaly
|
|
|
|
|
|
|
x
|
x
|
x
|
|
|
x
|
Hyperbilirubinaemia
|
Hyperbilirubinaemia
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Hypercholesterolaemia
|
Hypercholesterolaemia
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Hypertriglyceridaemia
|
Hypertriglyceridaemia
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Blood triglycerides increased
|
Hypertriglyceridaemia
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Breast enlargement
|
Hypertrophy of breast
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Inflammation
|
Inflammation
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Influenza
|
Influenza
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Insulin resistance
|
Insulin resistance
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Nephrolithiasis
|
Calculus of kidney
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Liver disorder
|
Liver disorder
|
|
|
|
|
|
|
|
|
|
x
|
|
|
Hepatocellular injury
|
Liver disorder
|
|
|
|
|
|
|
|
|
|
x
|
|
|
Foetor hepaticus
|
Liver disorder
|
|
|
|
|
|
|
|
|
|
x
|
|
|
Lung disorder
|
Lung disorder
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Fungal infection
|
Fungal infection
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Hypoaesthesia
|
Numbness
|
|
|
x
|
x
|
x
|
x
|
|
|
|
x
|
x
|
|
Sensory loss
|
Numbness
|
|
|
x
|
x
|
x
|
x
|
|
|
|
x
|
x
|
|
Opportunistic infection
|
Opportunistic infection
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Osteonecrosis
|
Osteonecrosis
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Pain
|
Pain
|
|
|
x
|
x
|
x
|
x
|
|
|
|
x
|
x
|
|
Pharyngitis
|
Pharyngitis
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Rhinitis
|
Rhinitis
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Sinusitis
|
Sinusitis
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Hyperhidrosis
|
Sweating
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Urinary tract infection
|
Urinary tract infection
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Weight decreased
|
Weight decreased
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Dry mouth
|
Dry mouth
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Hepatic function abnormal
|
Hepatic function abnormal
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Stomatitis
|
Mouth ulceration
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Mouth ulceration
|
Mouth ulceration
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Peripheral sensory neuropathy
|
Peripheral sensory neuropathy
|
|
|
x
|
x
|
x
|
x
|
|
|
|
x
|
x
|
|
Injury
|
Accidental injury
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Dry skin
|
Dry skin
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Polyneuropathy
|
Polyneuropathy
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Haemoglobin decreased
|
Haemoglobin decreased
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Thinking abnormal
|
Thinking abnormal
|
|
|
|
|
|
|
|
|
|
x
|
|
x
|
Mental disability
|
Thinking abnormal
|
|
|
|
|
|
|
|
|
|
x
|
|
x
|
Abnormal dreams
|
Abnormal dreams
|
|
|
|
|
|
|
|
|
|
x
|
|
x
|
Lipohypertrophy
|
Buffalo hump
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Cough
|
Cough increased
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Stillbirth
|
Stillbirth
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Acne
|
Acne
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Fat redistribution
|
Fat redistribution
|
|
|
x
|
x
|
x
|
x
|
|
|
|
x
|
x
|
|
Mitochondrial toxicity
|
Mitochondrial toxicity
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Respiratory failure
|
Respiratory failure
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Somnolence
|
Somnolence
|
|
|
|
|
|
|
|
|
|
x
|
|
x
|
Indications
Information about indications was extracted from the indications and usage sections of the labels.
Side effects: | 27 |
Source: | FDA Structured Product Label |
---|
Side effects: | 32 |
Source: | FDA Structured Product Label |
---|
Side effects: | 33 |
Source: | FDA Structured Product Label |
---|
Side effects: | 33 |
Source: | FDA |
---|
Side effects: | 34 |
Source: | FDA Structured Product Label |
---|
Side effects: | 34 |
Source: | FDA Structured Product Label |
---|
Side effects: | 34 |
Source: | FDA Structured Product Label |
---|
Side effects: | 45 |
Source: | FDA |
---|
Side effects: | 66 |
Source: | Health Canada |
---|
Side effects: | 70 |
Source: | EMA |
---|
Color scheme:
standard – alternative
|
|
100%
|
|
|
75%
|
|
|
50%
|
|
|
10%
|
|
|
frequent (1% to 100%)
|
|
|
infrequent (0.1% to 1%)
|
|
|
rare (<0.1%)
|
|
|
postmarketing
|
|
|
0%
|
|
|
no frequency information
|
|
|
not found on label
|