|
Side effect
|
Data for drug
|
Placebo
|
Labels
|
|
|
1
|
2
|
3
|
4
|
5
|
6
|
7
|
8
|
9
|
10
|
|
Infestation NOS
|
59.4%
|
59.5%
|
|
x
|
x
|
|
|
|
|
|
|
x
|
|
Gastrointestinal disorder
|
11.1% - 69.2%
|
9.48% - 64.2%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Somnolence
|
11.4% - 37.5%
|
11.4%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Angiopathy
|
17.9% - 39.3%
|
6.03% - 22.8%
|
|
x
|
x
|
|
|
|
|
|
|
x
|
|
Malnutrition
|
14.1% - 41%
|
14.7% - 38.4%
|
|
|
x
|
|
|
|
|
|
|
x
|
|
Mental disorder
|
8.12% - 38.5%
|
3.45% - 41.8%
|
|
x
|
x
|
|
|
|
|
|
|
x
|
|
Endocrine disorder
|
4.17% - 37.5%
|
22.9%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Rash
|
0% - 31.4%
|
31.4%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Nervous system disorder
|
very common, 20.1% - 68.8%
|
8.62% - 59.5%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Body temperature increased
|
0% - 23.5%
|
17.1%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Leukopenia
|
0% - 25.8%
|
0.431% - 8.57%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hyperglycaemia
|
1.96% - 79.4%
|
13.8%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cardiac disorder
|
15%
|
11.6%
|
|
x
|
x
|
|
|
|
|
|
|
x
|
|
Fatigue
|
1.96% - 79.4%
|
15.5%
|
x
|
x
|
x
|
|
|
|
|
|
x
|
x
|
|
Headache
|
0% - 22.5%
|
11.4%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Deep vein thrombosis
|
11.5% - 12.8%
|
1.72%
|
|
x
|
x
|
|
|
|
|
|
|
x
|
|
Dyspnoea
|
postmarketing, 2.94% - 42.2%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Mediastinal disorder
|
11.5%
|
5.6%
|
|
x
|
x
|
|
|
|
|
|
|
x
|
|
Pneumonia
|
7.26% - 15%
|
6.03% - 12.1%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Peripheral sensory neuropathy
|
10.3%
|
5.17%
|
x
|
|
x
|
|
|
|
|
|
x
|
x
|
|
Blood and lymphatic system disorders
|
10.3%
|
7.33%
|
|
x
|
x
|
|
|
|
|
|
|
x
|
|
Thrombocytopenia
|
0% - 11.3%
|
0%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Muscular weakness
|
0.98% - 40.2%
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
Depressed level of consciousness
|
2.94% - 15.7%
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Asthenia
|
2.9% - 23.9%
|
1.72% - 20.3%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Lymphopenia
|
postmarketing, 0% - 12.1%
|
0%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Anaemia
|
0% - 14.5%
|
0.431% - 8.57%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Embolism
|
1.96% - 22.5%
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
Thrombosis
|
1.96% - 22.5%
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Bone pain
|
0% - 36.3%
|
|
|
|
|
|
|
|
|
|
x
|
|
|
Pulmonary embolism
|
6.84%
|
1.72%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pruritus
|
2.78% - 8.33%
|
5.71%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Confusional state
|
1.96% - 28.4%
|
0.862%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Oedema
|
0% - 56.9%
|
8.19%
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypocalcaemia
|
postmarketing, 0.98% - 71.6%
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dry mouth
|
0% - 11.8%
|
5.71%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pain
|
0% - 64.7%
|
5.71%
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pharyngitis
|
4.17% - 8.33%
|
5.71%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Rash maculo-papular
|
4.17% - 18.8%
|
5.71%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Paraesthesia
|
0% - 15.6%
|
6.47% - 11.4%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Lymphadenopathy
|
0% - 12.5%
|
8.57%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypotension
|
1.96% - 15.7%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypertension
|
0% - 11.8%
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Infection
|
postmarketing, 0% - 59.4%
|
2.86% - 59.5%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Febrile neutropenia
|
postmarketing, 1.96% - 27.5%
|
|
x
|
x
|
x
|
|
|
|
x
|
x
|
x
|
x
|
|
Hyperlipidaemia
|
0% - 9.4%
|
2.86%
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Back pain
|
0% - 5.6%
|
0%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Oral candidiasis
|
0% - 11.1%
|
0%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Constipation
|
0% - 54.9%
|
0% - 21.1%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Fungal skin infection
|
0% - 9.4%
|
0%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Diarrhoea
|
0% - 18.8%
|
17.1%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dizziness
|
0% - 19.6%
|
0% - 13.8%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Nausea
|
0% - 28.4%
|
2.86% - 11.6%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Sinusitis
|
3.1% - 8.33%
|
5.71%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Chills
|
0% - 11.4%
|
11.4%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Oedema peripheral
|
0% - 34.2%
|
0% - 24.6%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Accidental injury
|
0% - 5.6%
|
2.86%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Rhinitis
|
0% - 11.4%
|
11.4%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Neutropenia
|
postmarketing, 0.98% - 42.7%
|
1.29% - 2.59%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Skin exfoliation
|
0% - 30.4%
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
Neuropathy peripheral
|
3.42%
|
0%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Abdominal pain
|
2.78% - 4.17%
|
11.4%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Albuminuria
|
0% - 8.33%
|
5.71%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Nail disorder
|
0% - 4.2%
|
0%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Bronchopneumonia
|
2.99%
|
1.29%
|
|
|
|
|
|
|
|
|
|
x
|
|
Anxiety
|
0% - 25.5%
|
1.29% - 9.48%
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Neuropathy
|
0% - 53.9%
|
0%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Anorexia
|
0% - 28.4%
|
5.71%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Aspartate aminotransferase increased
|
0% - 12.5%
|
5.71%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Erectile dysfunction
|
0% - 8.33%
|
0%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Myocardial ischaemia
|
2.56%
|
0.862%
|
|
|
|
|
|
|
|
|
|
x
|
|
Ear and labyrinth disorders
|
2.56%
|
0%
|
|
|
x
|
|
|
|
|
|
|
x
|
|
Arthralgia
|
0% - 12.7%
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
Depression
|
0% - 23.5%
|
8.19%
|
|
x
|
x
|
|
|
|
|
|
x
|
x
|
|
Hyponatraemia
|
postmarketing, 1.96% - 48%
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Weight decreased
|
0% - 22.5%
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
Vomiting
|
0% - 11.8%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cerebrovascular accident
|
postmarketing, 2.56%
|
0.431%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dyspepsia
|
0% - 18.6%
|
9.05%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hyperkalaemia
|
postmarketing, 0% - 19.6%
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypokalaemia
|
postmarketing, 0% - 22.5%
|
1.29%
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Weight increased
|
0% - 21.6%
|
1.72%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Lightheadedness
|
0% - 19.6%
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
Myalgia
|
0% - 16.7%
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Amenorrhoea
|
postmarketing
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Angioedema
|
postmarketing
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Arrhythmia
|
postmarketing
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Atrial fibrillation
|
postmarketing, 4.7%
|
3.45%
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Breast disorder
|
postmarketing
|
|
|
|
x
|
|
|
|
|
|
|
x
|
|
Cholestasis
|
postmarketing
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Deafness
|
postmarketing
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Diplopia
|
postmarketing
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Enuresis
|
postmarketing
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Toxic epidermal necrolysis
|
postmarketing
|
|
x
|
x
|
x
|
|
|
|
|
|
|
x
|
|
Grand mal convulsion
|
postmarketing
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
|
Erythema multiforme
|
postmarketing
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Erythema nodosum
|
postmarketing
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Gastrointestinal haemorrhage
|
postmarketing
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Gynaecomastia
|
postmarketing
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hodgkin's disease
|
postmarketing
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypercalcaemia
|
postmarketing
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Hypersensitivity
|
postmarketing
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypothyroidism
|
postmarketing
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Immune system disorder
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Intestinal obstruction
|
postmarketing
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Intestinal perforation
|
postmarketing
|
|
|
x
|
|
|
|
|
|
x
|
x
|
x
|
|
Renal failure acute
|
postmarketing
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Labyrinthine disorder
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Lethargy
|
postmarketing
|
|
|
|
x
|
|
|
|
x
|
x
|
x
|
x
|
|
Erythroleukaemia
|
postmarketing
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Chronic myeloid leukaemia
|
postmarketing
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Liver disorder
|
postmarketing
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
Lymphoedema
|
postmarketing
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Menstrual disorder
|
postmarketing
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
Metrorrhagia
|
postmarketing
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Myocardial infarction
|
postmarketing
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Myxoedema
|
postmarketing
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Nystagmus
|
postmarketing
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Oliguria
|
postmarketing
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pancytopenia
|
postmarketing
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Parkinson's disease
|
postmarketing
|
|
|
x
|
|
|
|
|
|
|
|
x
|
|
Petechiae
|
postmarketing
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pleural effusion
|
postmarketing
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Purpura
|
postmarketing
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Renal failure
|
postmarketing
|
|
|
x
|
|
|
|
|
|
|
|
x
|
|
Convulsion
|
postmarketing
|
|
|
x
|
x
|
|
|
|
x
|
x
|
x
|
x
|
|
Septic shock
|
postmarketing
|
|
|
x
|
x
|
|
|
|
|
|
|
x
|
|
Sick sinus syndrome
|
postmarketing
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Status epilepticus
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Gastric ulcer
|
postmarketing
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Aphthous stomatitis
|
postmarketing
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Suicide attempt
|
postmarketing
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Syncope
|
postmarketing, 3.42%
|
0.431%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Tachycardia
|
postmarketing
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Tumour lysis syndrome
|
postmarketing
|
|
x
|
x
|
x
|
|
|
|
|
x
|
x
|
x
|
|
Loss of consciousness
|
postmarketing
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Urinary tract disorder
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Urticaria
|
postmarketing
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Stupor
|
postmarketing
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Footdrop
|
postmarketing
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Migraine
|
postmarketing
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Gastrointestinal perforation
|
postmarketing
|
|
|
|
x
|
|
|
|
|
|
|
|
|
Hypomagnesaemia
|
postmarketing
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Liver function test abnormal
|
postmarketing
|
|
|
|
x
|
|
|
|
|
|
|
|
|
Phosphatase alkaline increased
|
postmarketing
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Interstitial lung disease
|
postmarketing
|
|
|
x
|
x
|
|
|
|
|
|
|
x
|
|
Hangover
|
postmarketing
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Consciousness abnormal
|
postmarketing
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Galactorrhoea
|
postmarketing
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Sepsis
|
postmarketing
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Electrolyte imbalance
|
postmarketing
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Dysaesthesia
|
postmarketing
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Bradycardia
|
postmarketing
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Sexual dysfunction
|
postmarketing
|
|
|
x
|
x
|
|
|
|
|
|
|
x
|
|
Mental status changes
|
postmarketing
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
White blood cell count low
|
postmarketing
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Hearing impaired
|
postmarketing
|
|
|
x
|
|
|
|
|
|
|
|
x
|
|
Multiple congenital abnormalities
|
0% - 9.4%
|
0%
|
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
|
Acquired immunodeficiency syndrome
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Agranulocytosis
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Alopecia
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Amblyopia
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Amnesia
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Amyloidosis
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Aplastic anaemia
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypochromic anaemia
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Anaemia macrocytic
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Anaemia megaloblastic
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Angina pectoris
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Apnoea
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Arthritis
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Ascites
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Ataxia
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Atrioventricular block
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
Benign neoplasm of skin
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Bone disorder
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
Bronchospasm
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
Bronchitis
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Candida infection
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Causalgia
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cellulitis
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Transient ischaemic attack
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Neck pain
|
0% - 4.2%
|
0%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Chest pain
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cholangitis
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Colitis
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Conjunctivitis
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cough
|
0% - 18.6%
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cyanosis
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Libido decreased
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dysphagia
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dehydration
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Demyelination
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
Dermatitis exfoliative
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Diabetes mellitus
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Drowsiness
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dysgeusia
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dyskinesia
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Eczema
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Eosinophilia
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Epistaxis
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Eructation
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Oesophagitis
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Eye disorder
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Flatulence
|
0% - 8.33%
|
5.71%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Gastroenteritis
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Gingival disorder
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cardiac arrest
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cardiac failure
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cardiac failure congestive
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Blood disorder
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
Haematuria
|
0% - 11.1%
|
2.86%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hepatitis
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hepatomegaly
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hernia
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Herpes simplex
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hostility
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hyperbilirubinaemia
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypercholesterolaemia
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hyperaesthesia
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypoaesthesia
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Hypoglycaemia
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypoproteinaemia
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Orthostatic hypotension
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Ichthyosis
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Inappropriate antidiuretic hormone secretion
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Influenza
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Jaundice cholestatic
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Arthropathy
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Lacrimal disorder
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cramps of lower extremities
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Leukaemia
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Acute myeloid leukaemia
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
Leukocytosis
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Lung disorder
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Meningitis
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Menopause
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
Cramp muscle
|
|
|
x
|
|
x
|
|
|
|
|
|
|
|
|
Hypertonia
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Myelodysplastic syndrome
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
Nervousness
|
0% - 9.4%
|
0%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Neuralgia
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Neuritis
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Numbness
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
Orchitis
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Palpitations
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pancreatitis
|
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pericarditis
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Periodontitis
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Peritonitis
|
|
|
|
x
|
x
|
|
|
|
|
|
|
x
|
|
Proteinuria
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Psoriasis
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Psychotic disorder
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pulmonary oedema
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Emphysema
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pyuria
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Rales
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Retinitis
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Seborrhoeic dermatitis
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Skin disorder
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Skin ulcer
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
Stevens-Johnson syndrome
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Stomatitis
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Sweating
|
0% - 12.5%
|
11.4%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Thromboembolism
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Thrombophlebitis
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Tinnitus
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Tooth disorder
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Toothache
|
0% - 4.2%
|
0%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Tremor
|
0% - 26.5%
|
0% - 12.5%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Upper respiratory tract infection
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pollakiuria
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Vasodilation
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Venous thrombosis
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
Vertigo
|
0% - 8.33%
|
0%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Viral infection
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Peripheral vascular disorder
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Microcytic anaemia
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Sinus bradycardia
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
Burning sensation
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
Hypoalgesia
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Agitation
|
0% - 25.5%
|
0%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Mood swings
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Neck stiffness
|
0% - 4.2%
|
0%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hormone level abnormal
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Blood urea increased
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Creatinine increased
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Tongue discolouration
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Lactic dehydrogenase activity increased
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Skin necrosis
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Eye pain
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Circumoral paresthesia
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Disorder periosteal
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Vesiculobullous rash
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hyporeflexia
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Alanine aminotransferase increased
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Skin discolouration
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dry skin
|
0% - 20.6%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Arterial thrombosis
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
Polyneuropathy
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Photosensitivity reaction
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Unspecified disorder of skin and subcutaneous tissue
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
Disability
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
Malaise
|
0% - 8.33%
|
0%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Increased appetite
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Teratogenicity
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Thinking abnormal
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Euphoric mood
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Bone tenderness
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Creatinine low
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pain in arm
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Spleen palpable
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Disease progression
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
|
|
Mental state abnormal
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
Dry eye
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Anxiety depression
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
Parotid gland enlargement
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Vision blurred
|
|
|
|
x
|
x
|
|
|
|
|
|
|
x
|
|
Photosensitivity
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Avitaminosis
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Enlargement abdomen
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Platelet count decreased
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
Hyperkinesia
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dementia
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Coordination abnormal
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Toxic skin eruption
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
Face oedema
|
0% - 4.2%
|
0%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Visual disturbance
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
Lipase increased
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Gait disturbance
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Drug interaction
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
Serum creatinine increased
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Acne
|
0% - 11.1%
|
0%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hyperuricaemia
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Diverticular perforation
|
|
|
|
x
|
x
|
|
|
|
|
|
|
x
|
|
Thromboembolic event
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
Raised liver function tests
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cerebral ischaemia
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Insomnia
|
0% - 47.1%
|
5.71%
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Phosphorus low
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Myasthenia
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Bronchopneumopathy
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
Pneumocystis jirovecii pneumonia
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
Tingling sensation
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
Mood alteration NOS
|
|
|
|
|
x
|
|
|
|
|
|
|
x
|
|
Posterior reversible encephalopathy syndrome
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
Arterial thromboembolism
|
|
|
|
|
|
|
|
|
|
|
|
x
|
