Capecitabine

Side effects and indications

Whenever possible, frequency information about the side effects was extracted from the labels. Aggregated frequency information for the drug and, if available, placebo is shown. To the right, you can click on shaded boxes to be taken to mentions of the side effect on the label. (In some cases, the side effect cannot be highlighted due to conversion problems.) Information about indications was extracted from the indications and usage sections of the labels.

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Side effect Data for drug Placebo Labels
1 2 3 4 5 6 7 8
Lymphopenia def 13% - 94% x x x x x x x x
Anaemia def 1% - 80% x x x x x x x x
Stomatitis def 1% - 62% x x x x x x x x
Diarrhoea def postmarketing, 2% - 61% x x x x x x x x
Nausea def postmarketing, 1% - 53% x x x x x x x x
Hyperbilirubinaemia def postmarketing, 2% - 48% x x x x x x x x
Fatigue def 4% - 46% x x x x x x x x
Neutropenia def 1% - 46% x x x x x x x x
Weakness def 4% - 46% x x x x x x
Dermatitis def 1% - 37% x x x x x x x
Vomiting def postmarketing, 1% - 37% x x x x x x x x
Abdominal pain def 1% - 35% x x x x x x x x
Pain def 1% - 35% x x x x x x x x
Decreased appetite 1% - 31% x x x x x x
Thrombocytopenia def 1% - 24% x x x x x x x x
Anorexia def 3% - 23% x x x x x x x x
Body temperature increased def 1% - 21% x x x x x x x x
Paraesthesia def 1% - 21% x x x x x x x x
Blood bilirubin increased def 20% x x x
Constipation def 1% - 17% x x x x x x x x
Oedema def 1% - 15% x x x x x x x x
Eye irritation 10% - 15% x x x x x x x x
Dyspnoea def 1% - 14% x x x x x x x x
Dysgeusia def 1% - 11% x x x x x x
Back pain def 2% - 10% x x x x x x
Headache def 1% - 10% x x x x x x x x
Peripheral sensory neuropathy def 4% - 10% x x x x
Discomfort def 10% x x x x x x
Neuropathy def 4% - 10% x x x x x x
Gastrointestinal motility disorder 1% - 10% x x x x x
Myalgia def 9% x x x x x x x x
Arthralgia def 1% - 8% x x x x x x
Cough def 1% - 8% x x x x x x
Dehydration def 1% - 8% x x x x x x x x
Dizziness def 1% - 8% x x x x x x x x
Dyspepsia def 8% x x x x x x x
Thrombosis def postmarketing, 1% - 8% x x x x x x x
Venous thrombosis def postmarketing, 1% - 8% x x x x x x x
Vertigo def 1% - 8% x x x x x x
Insomnia def 7% - 8% x x x x x x x x
Nail disorder def 7% x x x x x x x
Skin discolouration def 1% - 7% x x x x x x x
Alopecia def 2% - 6% x x x x x x x
Chest pain def 1% - 6% x x x x x x x
Epistaxis def 1% - 6% x x x x x x x
Gastrointestinal haemorrhage def 1% - 6% x x x x x x x
Haemorrhage def 1% - 6% x x x x x x x
Pain in extremity def 1% - 6% x x x x x x x x
Tenderness def 2% - 6% x x x x x x
Throat sore def 2% - 6% x x x x x x
Ileus def postmarketing, 1% - 6% x x x x x x
Mood alteration NOS def 5% - 6% x x x x x x
Pharyngeal disorder def 5% x x x x x x
Visual impairment def 2% - 5% x x x x x x
Calcium low 2.3% x x x
WBC abnormal NOS 2.2% x x x
Ca++ increased 1.1% x x x
Haemoglobin decreased def 1% x x x
Platelet count decreased 1% x x x
Embolism def postmarketing x x x x x x x
Enterocolitis def postmarketing x x x x x x
Hepatitis def postmarketing x x x x x x x
Unspecified disorder of intestine def postmarketing x
Intestinal obstruction def postmarketing x x
Metastasis def postmarketing x x
Obstruction def postmarketing x x
Ileus paralytic def postmarketing x
Pulmonary embolism def postmarketing x x x x x x x
Thrombophlebitis def postmarketing x x x x x x
Hepatic failure def postmarketing x x x x x x
Deep vein thrombosis def postmarketing x x
Hepatitis cholestatic postmarketing x x x x x x x
Gastrointestinal perforation postmarketing x
Metastases to liver def postmarketing x x
Necrotizing enterocolitis def postmarketing x x x x x x
Thromboembolic event postmarketing x
Gastrointestinal toxicity postmarketing x
Abdominal distension def x x x x x x
Ageusia def x x x x x
Agranulocytosis def x x x x x
Amnesia def x
Angina pectoris def x x
Arrhythmia def x x
Arthritis def x x x x x x
Ascites def x x x x x x
Asthenia def x x x x x
Asthma def x x x x x
Ataxia def x x x x x x x
Atrial fibrillation def x x x x x x
Balanoposthitis x
Blister def x
Coagulopathy def x x x x x x x
Bronchospasm def x x
Bronchitis def x x x x x x
Bronchopneumonia def x x x x x x
Cachexia def x x x x x x
Candidiasis def x x x x x x x
Oral candidiasis def x x x x x x
Cellulitis def x
Transient ischaemic attack def x
Neck pain def x
Colitis def x
Coma def x x x x x
Confusional state def x x x x x x x
Conjunctivitis def x x x x x x x
Deafness def x
Sudden death def x
Libido decreased def x
Dysphagia def x x x x x x
Diabetes mellitus def x
Distention def x x x x
Drug hypersensitivity def x x x x x x
Duodenitis def x
Dysarthria def x x x x x x
Dysuria def x
Ear pain def x
Ecchymosis def x x
Effusion def x x x x x x
Palmar erythema x
Oesophageal disorder def x x x x x
Oesophagitis def x x
Rash def x x x x x x
Eye disorder def x
Facial paralysis def x
Liver fatty def x
Fibrosis def x x x x x x x
Flushing def x x x x x x
Localised infection x
Food allergy def x
Gastritis def x
Gastroenteritis def x x x x
Gastrointestinal disorder def x x
Cardiac arrest def x
Cardiac failure def x x
Haematemesis def x
Haematoma def x
Haematuria def x
Haemoptysis def x x x x x x
Haemorrhoids def x
Coma hepatic x x x x
Hepatomegaly def x
Hernia def x
Herpes NOS def x
Herpes simplex def x
Herpes zoster def x
Hiccups def x
Hirsutism def x
Hoarseness def x x x x x x
Hydronephrosis def x
Hyperglycaemia def x
Hypersensitivity def x x x x x x x
Hypertension def x x x x x x x
Hypertriglyceridaemia def x x x x x x x
Hypoaesthesia def x x x x x
Hypocalcaemia def x
Hypokalaemia def x x x x x x
Hypotension def x x x x x x x
Orthostatic hypotension def x x x x x
Hypothyroidism def x
Ichthyosis def x
Incontinence def x
Infarction def x x
Infection def x x x x x x x
Influenza def x x x x x x
Intertrigo def x
Irritability def x x x x x x
Jaundice def x x x x x
Keratoconjunctivitis def x x x x x x
Keratosis def x
Actinic keratosis def x
Laryngitis def x x x x x x
Leg ulcer def x
Lethargy def x x x x x
Leukopenia def x x x x x x
Lipoma def x
Lymphoedema def x x x x x x x
Mediastinal disorder def x x
Melaena def x
Metrorrhagia def x
Fungal infection def x x x x x x
Myocardial infarction def x x
Myocarditis def x x x x x x
Myoclonus def x
Nervous system disorder def x x
Neuralgia def x
Nocturia def x x x
Otitis def x
Otitis media def x
Pancytopenia def x x x x x
Paronychia def x
Pericardial effusion def x x x x x x
Neuropathy peripheral def x x x x x
Pharyngitis def x
Phlebitis def x x x x x x
Pleural disorder def x x x x x
Pleural effusion def x x x x
Pneumonia def x x x x x x
Pneumothorax def x
Polyuria def x
Postoperative complications NOS def x
Pruritus def x x x x x x
Pruritus genital x
Purpura def x x x x x x
Rales x
Rectal disorder def x
Proctalgia def x x x x x x
Renal failure def x x x x x
Respiratory tract infection def x x
Rhinitis def x
Rosacea def x
Shivering def x
Skin lesion x
Skin ulcer def x x x x x
Sneezing def x
Somatoform disorder def x
Gastric ulcer def x x x x x x
Cerebrovascular accident def x x x x x x x
Superinfection def x
Sweating def x x x x x x x
Swelling def x x
Syncope def x x x x x
Tachycardia def x x x x x x
Supraventricular tachycardia def x x x x x
Thirst def x x x x x x
Tongue disorder x
Tremor def x x x x x x
Ulcer def x x x x x x x
Loss of consciousness def x x x x x x x
Erythema def x x x
Upper respiratory tract infection def x x
Urinary incontinence def x
Urinary tract infection def x x x x x x
Urinary tract disorder def x
Urticaria def x
Varicose vein def x
Weight increased def x x x x x x
Weight decreased def x x x x
Idiopathic thrombocytopenic purpura def x x x x x x
Dry mouth def x x x x x
Urinary retention def x
Ulcer foot def x
Encephalopathy def x x x x x x x
Orthopnoea x
Oedema peripheral def x
Onycholysis def x x x x x
Cataract def x
Hepatic function abnormal x x x x x x x
Food intolerance x
Lower respiratory tract infection x
Migraine def x x x x x
Diarrhoea haemorrhagic x x x x
Ventricular extrasystoles def x x x x x
Hypomagnesaemia def x x x x x x
Liver function test abnormal x x x x x x
Bone marrow depression def x x x x x x
Muscular weakness def x x x x x x
Bone pain def x x x x x x x
Phosphatase alkaline increased x
Alanine aminotransferase increased def x
Oesophageal ulcer def x x x x x
Polyneuropathy def x x x x x
Sensory disturbance def x x
Lacrimation increased def x x x x x
Calcaneal spur def x
Joint stiffness def x
Malnutrition def x
Photosensitivity reaction def x x x x x x
Scab x
Odynophagia x
Nail discolouration def x x x x x
Sickness x x x x x x
Injection site infection x
Muscle twitching def x
Cardiac fibrillation x x x x x x
Chest tightness x
Increased appetite x x
Abdominal pain upper x x x
Tension def x
Nail changes def x
Rash erythematous x x x x x
Vaginal pain def x
Skin exfoliation x
Edema of lower extremities x
Hepatic fibrosis x x x x x x x
Neck oedema of def x
Personality change def x
Sepsis def x x x x x x
Nerve paralysis x
Nasal ulcer x
Rectal haemorrhage def x
Fluid retention x
Peroneal nerve palsy def x
Found dead (cause undetermined) x
Walking difficulty x x x x x
Cushingoid x
Extrasystoles def x x x x x x
Renal impairment def x x x x x x
Chest mass NOS x x x x x x
Photosensitivity def x x x x x x x x
Premenstrual tension def x
Nipple disorder x
Lacrimation def x x x x x
Rigors x
Stiffness x
Bradycardia def x x x x x x
Respiratory distress def x x x x x x x
Blood pressure increased x
Sudden death, cause unknown x
Coordination abnormal x x x x x x
Influenza like illness x
Hepatic pain def x
Urine colour abnormal def x
Paralysis def x
Ear feels clogged x
Face oedema def x
Depressed level of consciousness def x
Localised skin reaction x
Prothrombin level decreased x x x x x
Balance disorder x x x x x
Sedation x x x x x x
Hot flush def x x x x x x
Serum creatinine increased x
Sweating increased x x x x x x x
Dissecting aortic aneurysm, thoracic x x
Febrile neutropenia def x x x x x
Infestation NOS x
Arterial disorder def x
Redness of face x
Thrombocytopenic purpura def x x x x x x
Potassium low x
Sodium decreased x
Hyperkeratosis def x
Neutropenic sepsis x x x x x
Cardiomyopathy def x x
Idiopathic thrombocytopenia x x x x
Dysphasia def x x x x x x
Rhinorrhoea def x x x x
Mental disability x
Death x
Radiation recall reaction (dermatologic) def x
Coronary artery disease def x
Tingling sensation def x
Indication Labels
Adjuvant therapy def x x x
Breast cancer def x x x x x x
Breast cancer stage IV def x x x x x
Carcinoma def x x x x
Colon cancer def x x x
Colorectal cancer x x x x x x
Colorectal cancer metastatic x x x
Large intestine carcinoma def x x x
Malignant neoplasm of pancreas def x
Neoplasm def x x
Neoplasm malignant def x x x x x x

Information

More information: STITCH, PubChem and possibly Wikipedia or Medpedia

ATC Code: L01BC06

Legend

Color scheme: standard – alternative

100%    
75%    
50%    
10%    
frequent (1% to 100%)    
infrequent (0.1% to 1%)    
rare (<0.1%)    
postmarketing    
0%    
no frequency information    
not found on label    

Labels

Labels were obtained from different sources and potentially contain different sets of side effects. If you click on the label name, a HTML version of the label will be shown with proteins, chemicals and side efffects highlighted using Reflect.

  1. Capecitabine : 55 side effects (BC Cancer)
  2. / Xeloda capecitabine Tablets : 88 side effects (FDA CDER)
  3. / Xeloda capecitabine Tablets : 141 side effects (FDA CDER)
  4. capecitabine / XELODA : 170 side effects (FDA MedWatch)
  5. Capecitabine / Xeloda : 174 side effects (FDA CDER)
  6. CAPECITABINE : 188 side effects (FDA XML label)
  7. capecitabine : 191 side effects (FDA XML label)
  8. CAPECITABINE / XELODA 150MG : 304 side effects (Health Canada)