Side effect information for Bortezomib

Side effects

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Side effect	Data for drug	Labels
		1	2	3	4	5	6	7	8	9	10	11
Neuropathy	40%	x	x	x	x		x	x	x			x
Mental disorder	0.604% - 49.1%	x	x	x	x				x	x	x	x
Plasma cell myeloma	8% - 57%								x	x	x
Asthenic conditions	0% - 72.3%	x	x	x	x		x	x	x	x	x
Anaemia	0% - 37%	x	x	x	x	x	x	x	x	x	x	x
Mantle cell lymphoma	3% - 55%								x	x	x
Hypoaesthesia	11%					x
Thrombocytopenia	1.2% - 55%	x	x	x	x	x	x	x	x	x	x	x
Epistaxis	10%					x	x	x	x	x	x	x
Musculoskeletal pain	10%					x						x
Neuropathy peripheral	0% - 54.8%	x	x	x	x		x	x	x	x	x
Diarrhoea	0% - 57.4%	x	x	x	x		x	x	x	x	x	x
Peripheral sensory neuropathy	5% - 9%	x	x	x	x	x	x	x	x	x	x	x
Pneumonia	0% - 11.9%	x	x	x	x	x	x	x	x	x	x	x
Dyspnoea	0.302% - 22.6%	x	x	x	x	x	x	x	x	x	x	x
Neuralgia	0% - 9%								x	x	x	x
Dehydration	0% - 18.4%	x	x	x	x	x	x	x	x	x	x	x
Vomiting	0% - 36%	x	x	x	x	x	x	x	x	x	x	x
Body temperature increased	0% - 36.8%	x	x	x	x	x	x	x	x	x	x	x
Nausea	0% - 64%	x	x	x	x	x	x	x	x	x	x	x
Infection	0.301% - 20.8%	x	x	x	x	x	x	x	x	x	x	x
Hypotension	0% - 14.8%	x	x	x	x	x	x	x	x	x	x	x
Hyperglycaemia	2% - 3%	x	x	x	x				x	x	x
Neutropenia	0% - 24.1%	x	x	x	x	x	x	x	x	x	x	x
Bone pain	0% - 16.2%	x	x	x	x	x	x	x	x	x	x
Decreased appetite	0% - 43.4%	x	x	x	x		x	x	x	x	x	x
Constipation	0% - 49.7%	x	x	x	x	x	x	x	x	x	x	x
Oedema	0% - 28.4%	x	x	x	x		x	x	x	x	x	x
Abdominal pain	0% - 16%	x	x	x	x	x	x	x	x	x	x	x
Fatigue	0% - 41%	x	x	x	x	x	x	x	x	x	x	x
Hypercalcaemia	2%	x	x	x	x				x	x		x
Herpes zoster	0% - 13%	x	x	x	x	x	x	x	x	x	x	x
Pain in extremity	0% - 25.9%	x	x	x	x	x	x	x	x	x	x	x
Arthralgia	0% - 26.3%	x	x	x	x	x	x	x	x	x	x
Dysaesthesia	0% - 27.5%	x	x	x	x		x	x	x	x	x	x
Paraesthesia	0% - 27.5%	x	x	x	x	x	x	x	x	x	x	x
Dizziness	0% - 23.2%	x	x	x	x	x	x	x	x	x	x	x
Back pain	0% - 14.9%	x	x	x	x	x	x	x	x	x	x
Headache	0% - 27.6%	x	x	x	x	x	x	x	x	x	x	x
Insomnia	0% - 27.2%	x	x	x	x	x	x	x	x	x	x
Rash	0% - 27.7%	x	x	x	x	x	x	x	x	x	x	x
Anxiety	0% - 14%	x	x	x	x	x	x	x	x	x	x
Angina pectoris	1%					x			x	x	x	x
Arrhythmia	1%					x						x
Diplopia	1%					x			x	x	x	x
Enteritis	1%					x						x
Haemorrhage	1%					x						x
Hyperbilirubinaemia	1%					x	x	x	x	x	x	x
Hypersensitivity	1%					x	x	x	x	x	x	x
Pulmonary hypertension	1%					x			x	x	x	x
Psychotic disorder	1%	x	x	x	x	x	x	x	x	x	x	x
Renal failure	1%	x				x	x	x	x	x	x
Convulsion	1%					x
Stomatitis	1%					x	x	x	x	x	x	x
Tumour lysis syndrome	1%					x	x	x	x	x	x	x
Hepatic failure	1%					x			x	x	x	x
Sepsis	1%					x
Febrile neutropenia	1%					x	x	x			x	x
Left ventricular ejection fraction decreased	1%					x
Respiratory failure	1%	x	x	x	x	x	x	x	x	x	x	x
Hearing impaired	1%					x			x	x	x	x
Cough	0% - 21.1%	x	x	x	x	x	x	x	x	x	x	x
Myalgia	0% - 14%	x	x	x	x		x	x	x	x	x	x
Acute febrile neutrophilic dermatosis	postmarketing, 1%					x					x	x
Nasopharyngitis	0% - 14%	x	x	x	x	x			x	x	x
Anorexia	0% - 33.8%	x	x	x	x	x	x	x	x	x	x
Cramp muscle	0% - 24%	x	x	x	x	x	x	x	x	x
Pancreatitis acute	postmarketing, 1%					x	x	x	x	x	x	x
Cardiac tamponade	postmarketing								x	x	x	x
Disseminated intravascular coagulation	postmarketing, 1%					x	x	x	x	x	x	x
Dysautonomia	postmarketing						x	x	x	x	x
Toxic epidermal necrolysis	postmarketing								x	x	x	x
Hepatitis	postmarketing								x	x	x	x
Herpes NOS	postmarketing								x	x	x
Ophthalmic herpes simplex	postmarketing								x	x	x
Progressive multifocal leukoencephalopathy	postmarketing										x
Lung disorder	postmarketing								x	x	x	x
Meningoencephalitis	postmarketing								x	x	x
Optic nerve disorder	postmarketing										x	x
Encephalopathy	postmarketing, 1%					x			x	x	x	x
Atrioventricular block complete	postmarketing								x	x	x
Colitis ischaemic	postmarketing								x	x	x	x
Blindness	postmarketing										x	x
Deafness bilateral	postmarketing								x	x	x
Abdominal distension												x
Acidosis												x
Adjustment disorder												x
Respiratory alkalosis												x
Amyloidosis												x
Anaphylactic shock							x	x	x	x	x	x
Haemolytic anaemia												x
Angina unstable												x
Angioedema									x	x	x	x
Anxiety disorder												x
Apnoea												x
Arthritis												x
Ascites							x	x	x	x	x	x
Aspergillosis									x	x	x
Asthenia	0% - 11%	x	x	x	x		x	x	x	x	x	x
Ataxia							x	x	x	x	x
Atelectasis							x	x	x	x	x	x
Atrial flutter							x	x	x	x	x	x
Atrioventricular block												x
Bacteraemia							x	x	x	x	x	x
Bacterial infection												x
Blister												x
Coagulopathy												x
Platelet disorder												x
Bone disorder												x
Breast disorder												x
Bronchial disorder												x
Bronchospasm												x
Bronchitis										x	x
Bronchopneumonia												x
Burn												x
Neoplasm malignant												x
Oral candidiasis									x	x	x
Renal cell carcinoma												x
Cardiovascular disorder												x
Cellulitis												x
Transient ischaemic attack							x	x	x	x	x	x
Cerebrovascular disorder												x
Cheilitis												x
Chest pain												x
Cholelithiasis												x
Cholestasis									x	x	x	x
Tongue coated												x
Cognitive disorder												x
Colitis												x
Coma							x	x	x	x	x	x
Confusional state							x	x	x	x	x	x
Conjunctivitis												x
Connective tissue disorder										x	x	x
Contusion												x
Cushing's syndrome												x
Cyst												x
Deafness												x
Sudden death		x	x	x	x				x	x	x
Libido decreased												x
Decubitus ulcer												x
Dysphagia							x	x	x	x	x	x
Delirium												x
Dermatitis												x
Diabetes mellitus												x
Gastrointestinal malformation												x
Drooling												x
Drug hypersensitivity							x	x	x	x	x
Dysarthria							x	x	x	x	x
Dysgeusia	0% - 13%		x	x	x	x	x	x	x	x	x	x
Dyskinesia												x
Dyspepsia	0% - 13.2%		x	x	x	x	x	x	x	x	x	x
Ear disorder												x
Ecchymosis												x
Endocrine disorder												x
Endophthalmitis												x
Epididymitis												x
Epilepsy												x
Grand mal convulsion							x	x	x	x	x
Erythema multiforme												x
Erythromelalgia												x
Oesophagitis												x
Exophthalmos												x
Extravasation						x						x
Eye disorder									x	x	x	x
Eye haemorrhage												x
Face injury												x
Failure to thrive												x
Chronic fatigue syndrome												x
Faecal incontinence												x
Faecalith							x	x	x	x	x
Anal fissure												x
Fistula												x
Flatulence												x
Flushing												x
Fracture							x	x	x	x	x	x
Gastritis												x
Gastroenteritis									x	x	x
Gastrooesophageal reflux disease									x	x	x	x
Gastrointestinal disorder							x	x	x	x	x	x
Gastrointestinal haemorrhage							x	x				x
Gingival bleeding												x
Gingival hypertrophy												x
Gout												x
Hair disorder												x
Hallucination												x
Cardiac arrest		x	x	x	x		x	x	x	x	x
Cardiac disorder							x	x	x	x	x	x
Cardiac failure												x
Cardiac failure congestive		x	x	x	x	x	x	x	x	x	x
Cardiac valve disease												x
Haematemesis							x	x	x	x	x	x
Blood disorder												x
Haematoma												x
Subdural haematoma							x	x	x	x	x
Haematuria							x	x	x	x	x	x
Haemoptysis							x	x	x	x	x	x
Haemorrhagic disorder												x
Hepatomegaly												x
Hernia												x
Genital herpes												x
Herpes simplex									x	x	x	x
Ophthalmic herpes zoster									x
Herpes virus infection									x	x	x	x
Meningoencephalitis herpetic												x
Hiccups												x
Hordeolum												x
Hyperaemia												x
Hyperhidrosis												x
Hyperkalaemia									x	x	x	x
Hypernatraemia									x	x	x	x
Hypertension							x	x		x	x	x
Hyperthyroidism												x
Hyperventilation												x
Hypocalcaemia							x	x	x	x	x	x
Hypokalaemia							x	x	x	x	x	x
Hyponatraemia							x	x	x	x	x	x
Orthostatic hypotension							x	x	x	x		x
Hypothyroidism												x
Hypovolaemic shock												x
Ichthyosis												x
Immune system disorder							x	x	x	x	x	x
Inappropriate antidiuretic hormone secretion												x
Infarction						x
Infertility						x
Inflammation												x
Influenza												x
Intestinal obstruction							x	x	x	x	x
Irritable bowel syndrome												x
Irritability												x
Ischaemia						x
Calculus of kidney							x	x	x	x	x
Renal failure acute						x						x
Renal failure chronic												x
Laryngeal oedema									x	x	x
Lethargy												x
Leukaemia						x
Plasma cell leukaemia												x
Leukocytosis												x
Leukopenia									x	x	x	x
Listeriosis									x	x	x
Liver disorder												x
Chronic obstructive pulmonary disease												x
Lymphoedema												x
Lymphoma						x
Lymphopenia									x	x	x	x
Mastoiditis												x
Mediastinal disorder									x	x	x	x
Megacolon												x
Melaena							x	x	x	x	x
Meningitis												x
Metabolic disorder												x
Oral disorder												x
Multi-organ failure												x
Hypotonia												x
Myopathy												x
Fungal infection												x
Mycosis fungoides												x
Myocardial infarction							x	x	x	x	x	x
Nail disorder												x
Neoplasm						x						x
Nephritis							x	x	x	x	x
Nervous system disorder									x	x	x	x
Night sweats												x
Numbness						x
Oliguria												x
Pain						x						x
Pallor												x
Palpitations												x
Pancreatitis												x
Pancytopenia												x
Ileus paralytic							x	x	x	x	x
Paresis												x
Pelvic pain												x
Pericardial effusion							x	x	x	x	x	x
Pericarditis									x	x	x	x
Periodontitis												x
Peritonitis									x	x	x	x
Petechiae												x
Phlebitis									x	x	x	x
Pleural effusion							x	x	x	x	x	x
Pleurisy												x
Pneumonia aspiration									x	x	x
Pneumothorax												x
Polyp												x
Post herpetic neuralgia									x	x	x	x
Prostatitis												x
Proteinuria												x
Pruritus	0% - 12%		x	x	x	x	x	x		x	x	x
Psoriasis												x
Pulmonary oedema							x	x				x
Pulmonary embolism							x	x	x	x	x	x
Pulmonary fibrosis												x
Purpura												x
Radiation injury												x
Radiculitis												x
Proctalgia												x
Reflexes abnormal												x
Acute respiratory distress syndrome							x	x	x	x	x	x
Respiratory insufficiency		x	x	x	x				x	x	x
Respiratory tract infection											x
Restless legs syndrome												x
Retinitis												x
Rhabdomyolysis												x
Salivary gland disorder												x
Sciatica												x
Scotoma												x
Seborrhoeic dermatitis												x
Shock												x
Cardiogenic shock		x	x	x	x				x	x	x	x
Septic shock									x	x	x	x
Sinusitis									x	x	x
Skin disorder												x
Skin infection												x
Skin lesion												x
Skin ulcer												x
Muscle spasms												x
Speech disorder												x
Spinal cord compression							x	x	x	x	x	x
Staphylococcal infection												x
Stevens-Johnson syndrome												x
Syncope												x
Tachycardia												x
Temporomandibular joint syndrome												x
Testicular disorder												x
Thirst												x
Thrombophlebitis												x
Tinnitus												x
Tonsillitis												x
Torsade de pointes									x	x	x	x
Toxoplasmosis									x	x	x
Tremor												x
Ulcer												x
Loss of consciousness												x
Erythema												x
Upper respiratory tract infection	0% - 18%		x	x	x	x	x	x
Ureteric obstruction						x
Pollakiuria												x
Urinary incontinence							x	x	x	x	x
Urinary tract infection									x	x	x	x
Micturition disorder												x
Urinary tract disorder									x	x	x
Urticaria						x			x	x	x	x
Angiopathy									x	x	x	x
Vasculitis												x
Venous insufficiency												x
Ventricular tachycardia							x	x	x	x	x
Vertigo	0% - 21.1%	x	x	x	x	x	x	x	x	x	x	x
Viral infection												x
Vitamin B12 deficiency												x
Vitamin B complex deficiency												x
Weight increased												x
Weight decreased											x	x
Wheezing												x
Laceration												x
Urinary retention							x	x	x	x	x	x
Hypocapnia												x
Meningitis bacterial		x	x	x	x				x	x	x
Chills											x	x
Orthopnoea												x
Agitation							x	x	x	x	x	x
Photopsia												x
Photophobia												x
Livedo reticularis												x
Synovial cyst												x
Oedema peripheral						x				x	x
Hyperchloraemia												x
Hypochloraemia												x
Hyperphosphataemia												x
Hypophosphataemia												x
Cystitis haemorrhagic									x	x	x
Epstein-Barr virus infection												x
Lower respiratory tract infection												x
Mouth ulceration												x
Deep vein thrombosis							x	x	x	x	x	x
Migraine												x
Alcohol intolerance												x
Corneal lesion												x
Tongue oedema												x
Enzyme abnormality												x
Impaired healing												x
Injection site haemorrhage												x
Haemorrhage intracranial												x
Hypermagnesaemia												x
Hypomagnesaemia												x
Injection site reaction												x
Large intestine perforation							x	x	x	x	x
Myocardial ischaemia							x	x	x	x	x
Muscular weakness												x
Eye pain												x
Injection site pain									x	x	x	x
Dry skin												x
Polyneuropathy												x
Joint swelling												x
Lacrimation increased												x
Portal vein thrombosis							x	x	x	x	x
Vulval ulceration												x
Abnormal faeces												x
Joint stiffness												x
Malnutrition							x	x	x	x	x	x
Photosensitivity reaction												x
Unspecified disorder of skin and subcutaneous tissue									x	x	x	x
Interstitial lung disease												x
Hyperviscosity syndrome												x
Rectal discharge												x
Disability		x	x	x	x		x	x	x	x	x
Malaise		x	x	x	x		x	x	x	x	x	x
Muscle twitching												x
Dyspnoea exertional							x	x	x	x	x
Tachypnoea												x
Cardiac fibrillation												x
Cold sweat												x
Increased appetite												x
Abdominal discomfort												x
Abdominal pain upper	0%									x	x
Disturbance in attention												x
Motor dysfunction							x	x	x	x	x	x
Tenderness												x
Peripheral motor neuropathy		x	x	x	x				x			x
Neurotoxicity												x
Dry throat												x
Eye irritation												x
Small intestinal obstruction							x	x	x	x	x
Hepatotoxicity												x
Oral mucosal petechiae									x	x	x
Chest discomfort												x
Lung infiltration							x	x	x	x	x	x
Hepatic haemorrhage									x	x	x	x
Nerve root lesion												x
Pain in jaw												x
Throat tightness												x
Gastrointestinal obstruction												x
Epididymal tenderness												x
Edema of lower extremities	0% - 13%	x	x	x	x				x	x
Genital pain												x
Frequent bowel movements						x
Lip swelling												x
Skin induration												x
Hypoxia												x
Erectile dysfunction												x
Azotaemia												x
Ventricular dysfunction												x
Aplasia												x
Autonomic neuropathy												x
Autonomic nervous system imbalance												x
Cutaneous vasculitis						x
Lip pain												x
Hepatobiliary disease									x	x	x	x
Fluid retention												x
Cardiac amyloidosis							x	x	x	x	x
Eye swelling												x
Ear haemorrhage												x
Transfusion reaction												x
Cytomegalovirus hepatitis												x
Change of bowel habit												x
Solid tumour							x	x	x	x	x
Skin mass												x
Dry eye												x
Papule												x
Redness											x
Duodenitis haemorrhagic									x	x	x
Electrolyte imbalance												x
Vision blurred	0% - 11%		x	x	x	x	x	x	x	x	x
Platelet count decreased							x	x	x	x	x
Joint injury												x
Eye discharge												x
Sensation of foreign body												x
Suicidal ideation							x	x	x	x	x	x
Rigors	0% - 11.8%	x	x	x	x	x	x	x	x	x		x
Bladder spasm							x	x	x	x	x
Bradycardia									x	x	x	x
Urine analysis abnormal												x
Large intestinal obstruction							x	x	x	x	x
Respiratory distress							x	x	x	x	x
Non-cardiac chest pain												x
Blood gases abnormal												x
Lymphadenopathy												x
Dementia												x
Poor peripheral circulation												x
Toxic skin eruption												x
Bilateral hydronephrosis							x	x	x	x	x
Paralysis							x	x	x	x	x	x
Affective disorder												x
Sinus arrest									x	x	x	x
Coronary artery insufficiency											x	x
Injection site phlebitis												x
Face oedema									x	x	x	x
Fluid overload												x
Hypovolaemia												x
Fibrillation atrial aggravated							x	x	x	x	x
Eyelid infection												x
Feeling of body temperature change												x
Vein discolouration												x
Pigmentation disorder												x
Haemorrhagic stroke							x	x	x	x	x
Gait disturbance												x
Jessner's lymphocytic infiltration												x
International normalised ratio abnormal												x
Blood glucose abnormal												x
Sensation of heaviness												x
Cardio-respiratory arrest			x	x	x		x	x				x
Breast disorder female												x
Ear infection												x
Throat irritation												x
Presyncope												x
Hypoxemia												x
Acne												x
COPD exacerbation							x	x	x	x	x
Hyperuricaemia						x	x	x	x	x	x
C-reactive protein increased												x
Memory loss												x
Vestibular neuronitis												x
Thrombocytosis												x
Infestation NOS							x	x	x	x	x	x
Blood and lymphatic system disorders							x	x	x	x	x	x
Ear and labyrinth disorders									x	x	x	x
Sleep disorder												x
Injection site erythema									x	x	x
Pulmonary alveolar haemorrhage												x
Dacryoadenitis acquired												x
Peripheral neuropathy aggravated		x	x	x	x		x	x	x	x
Local reaction											x
Haemorrhage subcutaneous												x
Gastrointestinal motility disorder												x
Blood test abnormal												x
Peripheral embolism							x	x	x	x	x	x
Budd-Chiari syndrome												x
Thrombocytopenic purpura												x
Gastrointestinal ulcer perforation												x
Catheter related infection									x	x	x
Cardiotoxicity											x
Tooth infection												x
General physical health deterioration												x
Anal sphincter atony												x
Cardiomyopathy												x
Pulmonary toxicity						x					x
Ear discomfort												x
Respiratory tract congestion												x
Catheter related complication									x	x	x	x
Urinary tract signs and symptoms												x
Catheter site pain												x
Erythrosis												x
Peripheral sensorimotor neuropathy												x
Troponin I increased												x
Gastrointestinal toxicity											x
Gastric pH decreased												x
Joint effusion												x
Ileus						x						x
Rhinorrhoea												x
Lymphocytic infiltration												x
Urine output						x
Increased upper airway secretion												x
Brain stem syndrome												x
Parosmia												x
Dysacusis												x
Brain oedema												x
Dysphonia												x
Gastrointestinal inflammation												x
Renal impairment												x
Device related infection												x
Procedural pain												x
Uric acid abnormal												x
Gastritis haemorrhagic							x	x	x	x	x
Oropharyngeal blistering												x
Oropharyngeal pain												x
Platelet aggregation increased												x
Cerebral haemorrhage						x			x	x	x	x
Upper-airway cough syndrome												x
Bladder irritation												x
Leukocytoclastic vasculitis									x	x	x
Vaginal haemorrhage												x
Posterior reversible encephalopathy syndrome									x	x	x	x
Visual impairment												x
Abnormal vision												x

Side effects:	58
Source:	FDA

Side effects:	63
Source:	FDA

Side effects:	63
Source:	FDA

Side effects:	63
Source:	FDA

Side effects:	84
Source:	BC Cancer

Search results :

Bortezomib

Side effects

Indications

BORTEZOMIB / VELCADE

bortezomib / Velcade

bortezomib / Velcade

BORTEZOMIB / VELCADE

Bortezomib

bortezomib / Velcade

bortezomib / Velcade

BORTEZOMIB / VELCADE

bortezomib / Velcade

bortezomib

bortezomib / bortezomib

Legend

Color scheme:

Indication	Labels
Cerebrovascular accident										x
Diarrhoea					x
Disease progression						x	x
Haematological malignancy						x	x	x	x	x
Mantle cell lymphoma	x							x	x	x
Neuropathy peripheral								x	x
Plasma cell myeloma	x	x	x	x	x	x	x	x	x	x	x
Sepsis										x

		100%
		75%
		50%
		10%
		frequent (1% to 100%)
		infrequent (0.1% to 1%)
		rare (<0.1%)
		postmarketing
		0%
		no frequency information
		not found on label

Side effects:	214
Source:	FDA Structured Product Label