Brimonidine
Side effects
Options:
Hide MedDRA Preferred Terms
MedDRA Preferred Term
|
Side effect
|
Data for drug
|
Placebo
|
Labels
|
|
1
|
2
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3
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4
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5
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6
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7
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8
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9
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10
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11
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12
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13
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14
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15
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16
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17
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Endophthalmitis
|
Ocular hyperaemia
|
7.7% - 24.8%
|
|
|
|
|
|
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x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
|
|
|
Ocular hyperaemia
|
Ocular hyperaemia
|
7.7% - 24.8%
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
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x
|
|
|
|
|
|
Eye redness
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
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Conjunctival hyperaemia
|
Conjunctival hyperaemia
|
18.2%
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Pain
|
Stinging
|
common — 7.1% - 35.5%
|
|
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
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x
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x
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x
|
x
|
x
|
x
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Pain
|
2.6% - 5.1%
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
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x
|
x
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|
|
|
|
|
Somnolence
|
Drowsiness
|
very common, 1% - 15.2%
|
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
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x
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x
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|
|
|
|
|
Somnolence
|
postmarketing — 55%
|
|
|
|
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x
|
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x
|
|
|
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x
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x
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x
|
x
|
x
|
x
|
x
|
x
|
Asthenia
|
Fatigue
|
very common, 1% - 15.2%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Asthenia
|
common, 1.6%
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
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x
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x
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x
|
x
|
x
|
x
|
x
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Fatigue
|
Fatigue
|
very common, 1% - 15.2%
|
|
|
|
x
|
x
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x
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x
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x
|
x
|
x
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x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Hyperaemia
|
Hyperaemia
|
common, very common
|
|
|
|
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x
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|
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|
|
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Headache
|
Headache
|
very common, 2.4% - 17%
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
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x
|
x
|
x
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x
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x
|
x
|
Conjunctivitis allergic
|
Conjunctivitis allergic
|
common, 9.2%
|
|
|
|
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x
|
x
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|
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|
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|
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x
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x
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x
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x
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x
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Dry mouth
|
Dry mouth
|
very common, 1% - 21%
|
|
|
x
|
x
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x
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x
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x
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x
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x
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x
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x
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x
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x
|
x
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x
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x
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x
|
x
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Sensation of foreign body
|
Sensation of foreign body
|
common — 0% - 15.5%
|
|
|
|
x
|
x
|
x
|
x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
|
x
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Pruritus
|
Pruritus
|
postmarketing — 1% - 9.8%
|
|
|
x
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|
|
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x
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x
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x
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x
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x
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x
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x
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x
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x
|
x
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|
|
Eye pruritus
|
Eye pruritus
|
common, 8.2%
|
|
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x
|
x
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|
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x
|
x
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|
|
|
|
|
|
x
|
x
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Vision blurred
|
Vision blurred
|
0% - 18%
|
|
x
|
|
|
x
|
x
|
x
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x
|
x
|
x
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x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Vital dye staining cornea present
|
Corneal staining
|
4.1% - 9.2%
|
|
|
|
|
|
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x
|
x
|
x
|
x
|
x
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|
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|
Conjunctival follicles
|
Conjunctival follicles
|
very common, 1% - 8.5%
|
|
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|
x
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|
x
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x
|
x
|
x
|
x
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|
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Visual impairment
|
Visual disturbance
|
common, 6.1%
|
|
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|
|
x
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x
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|
|
|
|
|
|
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x
|
x
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x
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x
|
x
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Abnormal vision
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
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|
|
|
|
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Eye irritation
|
Burning sensation in eye
|
5.3%
|
|
|
|
|
|
x
|
|
|
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Eye irritation
|
common — 1.6%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Oedema
|
Oedema
|
common
|
|
|
|
|
|
|
x
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Nasopharyngitis
|
Nasopharyngitis
|
5%
|
|
x
|
|
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Common cold
|
|
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|
|
|
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|
|
x
|
x
|
x
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Rosacea
|
Rosacea
|
5%
|
|
x
|
|
|
|
|
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|
|
|
|
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Conjunctival oedema
|
Conjunctival oedema
|
common, 1.3% - 6.3%
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Lacrimation increased
|
Lacrimation
|
common
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Lacrimation increased
|
common, 2.6%
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Gastrointestinal disorder
|
Gastrointestinal symptom NOS
|
common
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
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Gastrointestinal disorder
|
rare
|
|
|
x
|
|
|
|
x
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Intraocular pressure increased
|
Intraocular pressure increased
|
4%
|
|
x
|
|
|
|
|
|
|
|
|
|
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|
|
|
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Eye pain
|
Eye pain
|
common, 1.8%
|
|
|
|
x
|
x
|
x
|
x
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Ocular stinging
|
|
|
|
|
|
|
x
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
Blepharitis
|
Blepharitis
|
common, 1.6%
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Photophobia
|
Photophobia
|
common, 0.5% - 8.4%
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Dry eye
|
Dry eye
|
common, 2.9%
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Keratoconjunctivitis sicca
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
Dizziness
|
Dizziness
|
uncommon, common
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Syncope
|
very rare, postmarketing
|
|
|
|
|
|
|
x
|
|
|
|
x
|
x
|
x
|
|
|
|
|
x
|
Flushing
|
Flushing
|
0% - 10%
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Eyelid oedema
|
Eyelid oedema
|
common, 2.1%
|
|
|
x
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Erythema of eyelid
|
Erythema of eyelid
|
0% - 5.2%
|
|
|
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Skin burning sensation
|
Skin burning sensation
|
0.604% - 4%
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Conjunctivitis
|
Follicular conjunctivitis
|
common, 1.3%
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Conjunctivitis
|
uncommon
|
|
|
|
|
x
|
|
x
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Blepharoconjunctivitis
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Conjunctival discharge
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
|
|
|
Punctate keratitis
|
Punctate keratitis
|
common, 1.3%
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
Superficial punctate keratopathy
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Eye discharge
|
Eye discharge
|
common, 1.3%
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Rhinitis
|
Rhinitis
|
1.1%
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Common cold
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
Erythema
|
Erythema
|
postmarketing — 0.906% - 8%
|
|
x
|
|
|
x
|
|
|
|
|
|
|
|
|
|
x
|
|
|
x
|
Skin warm
|
0% - 0.909%
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Erythema facial
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Dermatitis
|
Dermatitis
|
0.302% - 0.909%
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Rash
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Dermatitis contact
|
Dermatitis contact
|
0.302% - 0.909%
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Allergic contact dermatitis
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Arrhythmia
|
Arrhythmia
|
uncommon
|
|
|
|
|
|
|
x
|
|
|
|
x
|
x
|
x
|
|
|
|
|
|
Depression
|
Depression
|
uncommon
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
Dysgeusia
|
Dysgeusia
|
uncommon
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Hypertrophy
|
Hypertrophy
|
uncommon
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Palpitations
|
Palpitations
|
uncommon
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
|
|
|
Pharyngitis
|
Pharyngitis
|
uncommon
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Nasal dryness
|
Nasal dryness
|
uncommon
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Eye oedema
|
Eye oedema
|
uncommon
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Skin warm
|
Skin warm
|
0% - 0.909%
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Paraesthesia
|
Paraesthesia
|
0.302% - 0.606%
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Acne
|
Acne
|
0.302% - 0.606%
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Hypersensitivity
|
Hypersensitivity
|
postmarketing — 0% - 9.9%
|
|
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Systemic allergic reaction
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
Nasal congestion
|
Nasal congestion
|
0% - 0.606%
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Pain of skin
|
Pain of skin
|
0% - 0.606%
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Apnoea
|
Apnoea
|
postmarketing
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Coma
|
Coma
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
x
|
Dyspnoea
|
Dyspnoea
|
rare
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Rash
|
Rash
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Glaucoma
|
Developmental glaucoma
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
Developmental glaucoma
|
Developmental glaucoma
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
Hypotension
|
Hypotension
|
very rare, postmarketing
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Body temperature decreased
|
Body temperature decreased
|
postmarketing
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Hypothermia
|
Body temperature decreased
|
postmarketing
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Iritis
|
Iritis
|
postmarketing, uncommon
|
|
|
|
|
x
|
|
x
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Lethargy
|
Lethargy
|
postmarketing
|
|
|
|
|
|
x
|
|
|
x
|
x
|
|
|
x
|
|
|
|
|
x
|
Miosis
|
Miosis
|
postmarketing
|
|
|
|
|
|
|
x
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Hypotonia
|
Hypotonia
|
postmarketing
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Muscle relaxant therapy
|
Hypotonia
|
postmarketing
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Nausea
|
Nausea
|
postmarketing
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
Pallor
|
Pallor
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
x
|
Blanching
|
|
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
|
|
|
Shock
|
Syncope
|
very rare, postmarketing
|
|
|
|
|
|
|
x
|
|
|
|
x
|
x
|
x
|
|
|
|
|
x
|
Syncope
|
Syncope
|
very rare, postmarketing
|
|
|
|
|
|
|
x
|
|
|
|
x
|
x
|
x
|
|
|
|
|
x
|
Loss of consciousness
|
Syncope
|
very rare, postmarketing
|
|
|
|
|
|
|
x
|
|
|
|
x
|
x
|
x
|
|
|
|
|
x
|
Loss of consciousness
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
Tachycardia
|
Tachycardia
|
postmarketing, uncommon
|
|
|
|
|
|
|
x
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Vasodilation procedure
|
Vasodilation
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
Respiratory depression
|
Respiratory depression
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
x
|
Pulmonary function test decreased
|
Respiratory depression
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
x
|
Bradycardia
|
Bradycardia
|
postmarketing, uncommon
|
|
|
|
|
|
x
|
x
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Eyelids pruritus
|
Eyelids pruritus
|
postmarketing, uncommon
|
|
|
|
|
x
|
|
|
|
|
|
|
x
|
x
|
|
|
|
x
|
x
|
Accidental exposure to product
|
Accidental ingestion
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
Hypertension
|
Hypertension
|
very rare
|
|
|
|
|
|
|
x
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
Insomnia
|
Insomnia
|
very rare
|
|
|
|
|
|
|
x
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
Anxiety
|
Anxiety
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
Arthralgia
|
Arthralgia
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
Musculoskeletal discomfort
|
Arthralgia
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
Myalgia
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
Arthritis
|
Arthritis
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
Mental disorder
|
Mental disorder
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
Bronchitis
|
Bronchitis
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Chest pain
|
Chest pain
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
Infection
|
Infection
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Conjunctival haemorrhage
|
Conjunctival haemorrhage
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
Corneal oedema
|
Corneal oedema
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Cough
|
Cough
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Cyanosis
|
Cyanosis
|
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
|
|
|
|
|
|
|
|
Diabetes mellitus
|
Diabetes mellitus
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
Dyspepsia
|
Dyspepsia
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Eye disorder
|
Eye disorder
|
|
|
|
x
|
|
x
|
|
x
|
|
|
|
|
|
x
|
|
|
|
|
|
Eye infection
|
Eye infection
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
Vitreous floaters
|
Vitreous floaters
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Cardiac disorder
|
Cardiac disorder
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
x
|
|
|
|
|
|
Hordeolum
|
Hordeolum
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
Hypercholesterolaemia
|
Hypercholesterolaemia
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Immune system disorder
|
Immune system disorder
|
|
|
|
|
|
x
|
|
x
|
|
|
|
|
|
x
|
|
|
|
|
|
Influenza
|
Influenza
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Iridocyclitis
|
Iridocyclitis
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
Anterior uveitis
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
x
|
|
|
|
|
|
Arthropathy
|
Arthropathy
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
Osteoarthritis
|
Arthropathy
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
Keratitis
|
Keratitis
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Mediastinal disorder
|
Mediastinal disorder
|
|
|
|
x
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
Nervous system disorder
|
Nervous system disorder
|
|
|
|
x
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
Osteoporosis
|
Osteoporosis
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
Respiratory tract infection
|
Respiratory tract infection
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
Scotoma
|
Scotoma
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Sinusitis
|
Sinusitis
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Swelling
|
Swelling
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
Angiopathy
|
Angiopathy
|
|
|
|
x
|
|
|
|
x
|
|
|
|
|
|
x
|
|
|
|
|
|
Vitreous detachment
|
Vitreous detachment
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Burning sensation
|
Burning sensation
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Cataract
|
Cataract
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Dry skin
|
Dry skin
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Skin irritation
|
Skin irritation
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Vitreous disorder
|
Vitreous disorder
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Skin disorder
|
Unspecified disorder of skin and subcutaneous tissue
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Scab
|
Scab
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
Myalgia
|
Myalgia
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
Discomfort
|
Discomfort
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Eyelid retraction
|
Eyelid retraction
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Peripheral coldness
|
Peripheral coldness
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Corneal erosion
|
Corneal erosion
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Face oedema
|
Face oedema
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
Skin discomfort
|
Skin discomfort
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Rash papular
|
Rash papular
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Feeling hot
|
Feeling hot
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Hypoxia
|
Hypoventilation
|
|
|
|
|
|
|
x
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
Respiratory failure
|
Hypoventilation
|
|
|
|
|
|
|
x
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
Hypoventilation
|
Hypoventilation
|
|
|
|
|
|
|
x
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
Blindness
|
Unspecified visual loss
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
Indications
Information about indications was extracted from the indications and usage sections of the labels.
Side effects: | 17 |
Source: | FDA Structured Product Label |
---|
Side effects: | 25 |
Source: | EMA |
---|
Side effects: | 12 |
Source: | FDA |
---|
Side effects: | 36 |
Source: | medicines.org.au |
---|
Side effects: | 38 |
Source: | Health Canada |
---|
Side effects: | 54 |
Source: | Medsafe |
---|
Side effects: | 26 |
Source: | Health Canada |
---|
Side effects: | 38 |
Source: | Health Canada |
---|
Side effects: | 40 |
Source: | Health Canada |
---|
Side effects: | 47 |
Source: | FDA Structured Product Label |
---|
Side effects: | 48 |
Source: | FDA Structured Product Label |
---|
Side effects: | 56 |
Source: | medicines.org.au |
---|
Side effects: | 69 |
Source: | FDA |
---|
Side effects: | 70 |
Source: | FDA Structured Product Label |
---|
Side effects: | 68 |
Source: | FDA |
---|
Side effects: | 69 |
Source: | FDA |
---|
Side effects: | 75 |
Source: | FDA Structured Product Label |
---|
Color scheme:
standard – alternative
|
|
100%
|
|
|
75%
|
|
|
50%
|
|
|
10%
|
|
|
frequent (1% to 100%)
|
|
|
infrequent (0.1% to 1%)
|
|
|
rare (<0.1%)
|
|
|
postmarketing
|
|
|
0%
|
|
|
no frequency information
|
|
|
not found on label
|