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Diclofenac

More information: STITCH, PubChem and possibly Wikipedia

ATC Codes: D11AX18, M01AB05, M02AA15, S01BC03

Side effects

Options: Show MedDRA Preferred Terms,   display all 49 labels

Side effect Data for drug Placebo Labels
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Dry skin postmarketing, 0% - 41.9% 0.301% - 6.86% x x
Gastrointestinal disorder 6% - 9% 6% x x x x x x x x
Induration 2% - 9% x
Upper respiratory tract infection 8%
Skin exfoliation 4% - 24% x x
Application site reaction 1.13% - 84% 0.904% - 2.17% x x x
Nasopharyngitis 6%
Anorexia common x x x x x x x
Flatulence common, 2% - 3.84% 0% - 2% x x x x x x x x x x x x x x
Headache postmarketing — 0% - 32.7% 2% - 26.9% x x x x x x x x x x x x x x x x x
Vertigo common x x x x x x x x x x x x
Vomiting common, 3% - 9% 1% - 12% x x x x x x x x x x x x x x x x
Injection site reaction common
Injection site pain common
Eruption common x x
Transaminases increased common x x x x x
Injection site induration common
Rash postmarketing — 0% - 46% 1.51% - 2.86% x x x x x x x x x x x x x x x x
Malnutrition 2% - 8% x x
Influenza 0% - 10% 4.57% x
Infection 2.71% - 11.5% 2.41% - 4.57% x x x x x
Cough 4% x
Pharyngitis postmarketing, 2% - 8% 3.92% - 6.86% x x
Pruritus very rare — 1% - 59% 0.602% - 8% x x x x x x x x x x x x x x x x x
Osteoarthritis 2.6% - 5% x
Application site rash 3.5% 0.685% x
Urinary tract infection 0.775% - 7%
Bronchitis 3%
Diarrhoea postmarketing — 0% - 6% 2.11% - 3% x x x x x x x x x x x x x x x x
Nausea postmarketing — 0% - 27% 0.904% - 37% x x x x x x x x x x x x x x x x x
Pain in extremity 3% 1%
Abdominal pain upper 3% 1% x
Procedural pain 3%
Nervous system disorder 2% - 3% x x x x x x
Ecchymosis 2.09% 0.301% x x x x
Abdominal pain postmarketing — 0% - 5.93% 3.01% - 5.14% x x x x x x x x x x x x x x x
Arthralgia 0% - 40.4% 37.1% x
Back pain postmarketing, 0% - 15.4% 7.43% x x
Dermatitis 1% - 2% x x x x x
Dermatitis contact postmarketing, 0% - 33% 0% - 1.81% x x
Dyspepsia postmarketing — 0% - 9.62% 1% - 4% x x x x x x x x x x x x x x x
Pain postmarketing, 0% - 30% 10.9% x x
Rhinitis 2% x x
Abdominal discomfort 2% x
Blood creatinine increased 2% 0%
Skin carcinoma 0% - 6% x
Contusion 0.775% - 3%
Conjunctivitis 0% - 4% x x x x x
Sinus congestion 0.775% - 1.54%
Application site induration 0.775% - 1.54%
Accidental injury postmarketing, 0% - 4% 2.11% x x
Dizziness postmarketing — 0% - 10% 0.5% - 16% x x x x x x x x x x x x x x x x x
Paraesthesia very rare — 0% - 20% 0.904% - 10.3% x x x x x x x x x x x x x x x
Creatinine increased postmarketing, 0% - 2% x x
Myalgia postmarketing, 0% - 3% x x
Somnolence rare, 1% 1% - 1.83% x x x x x x x x x
Application site pruritus 0.767% 0.114% x
Rheumatoid arthritis 0.7% x
Application site erythema 0.657% 0.342% x
Breath odour postmarketing, 1.21% 0.301% x
Sinusitis 0% - 5% 0.602% - 1% x x
Application site paraesthesia 0.548% 0.342% x
Dysgeusia very rare — 0% - 3.81% 4.57% x x x x x x
Hypercholesterolaemia 0% - 2% x
Hyperaesthesia 0% - 3% x
Hyperglycaemia 0% - 2% x x x x
Skin ulcer 0% - 2% x
Migraine 0% - 2% x
Creatine phosphokinase increased 0% - 4% x
Vesiculobullous rash 0% - 4% x
Scab 1%
Acne 0% - 4% x
Application site dryness 0.438% 0.342% x x
Application site vesicles 0.329% 0% x
Application site irritation common, 0.219% 0% x x
Flushing 0.2% x x
Application site papules 0.11% 0% x
Asthma postmarketing — 0% - 2% x x x x x x x x x x x x x x x
Cardiovascular disorder postmarketing x
Drowsiness postmarketing, rare x x x x x x x x x x
Dyspnoea postmarketing — 0% - 2% x x x x x x x x x x x x
Ear pain postmarketing x
Oedema postmarketing — 0% - 33% 0% - 32% x x x x x x x x x x x x x x x x
Eye disorder postmarketing x x x x x x
Gastritis rare x x x x x x x x x x
Gastroenteritis postmarketing x
Gastrointestinal haemorrhage rare x x x x x x x x x x x x
Haematemesis rare x x x x x x x x x x x
Haemorrhage rare x x x x x x x x x x x x x x
Hepatitis rare x x x x x x x x x x x x x x
Hypersensitivity postmarketing — 0% - 3% x x x x x x x x x x x x
Hypotension rare x x x x x x x x x x x x x x
Jaundice rare x x x x x x x x x x x x x x
Laryngospasm postmarketing x
Laryngitis postmarketing x
Cramps of lower extremities postmarketing x
Lethargy postmarketing x
Liver disorder rare x x x x x
Melaena rare x x x x x x x x x x x x x
Proctitis rare x
Shock rare x x x x x x
Ulcerative stomatitis postmarketing x
Swelling postmarketing
Urticaria postmarketing — 0.2% x x x x x x x x x x x x x x x x
Dry mouth postmarketing x x x x x x x
Body odor postmarketing x
Cataract postmarketing x
Mouth ulceration postmarketing x
Neck stiffness postmarketing x
Diarrhoea haemorrhagic rare x x x x x x x x x x
Injection site necrosis rare
Lack of drug effect postmarketing x
Eye pain postmarketing, 0% - 2% x x
Skin discolouration postmarketing x
Intestinal ulcer rare x
Decreased appetite postmarketing, common x x x
Swollen tongue postmarketing
Gastrointestinal ulcer rare x x x x x
Lip swelling postmarketing x x
Skin burning sensation postmarketing
Rectal haemorrhage postmarketing x x x x
Anaphylactoid reaction rare x x x x x x x x
Blood pressure increased postmarketing
Abnormal vision postmarketing x x
Agranulocytosis very rare x x x x x x x x x x x x x x
Alopecia very rare, 0% - 2% x x x x x x x x x x x x x x
Anaemia very rare x x x x x x x x x x
Aplastic anaemia very rare x x x x x x x x x x x x x x
Haemolytic anaemia very rare x x x x x x x x x
Angioedema very rare x x x x x x x x x x x
Anxiety very rare, 0% - 2% x x x x x x x x x x x x x x
Chest pain very rare — 0% - 2% x x x x x x x x x
Colitis very rare x x x x x x x x x x
Colitis ulcerative very rare x x x x x x x x x
Constipation very rare, 0% - 8% 0.301% - 4% x x x x x x x x x x x x x x x x
Crohn's disease very rare x x x x x x x x x
Dermatitis exfoliative very rare x x x x x x x x x x x x x
Diplopia very rare x x x x x x x x x x
Eczema very rare, postmarketing x x x x x x x x x x x x x
Toxic epidermal necrolysis very rare x x x x x x x x x x x x
Erythema multiforme very rare x x x x x x x x x x x x x x
Oesophageal disorder very rare x x x x x
Glossitis very rare x x x x x x x x x x x
Cardiac failure very rare x x x x x x x x
Haematuria very rare, 0% - 2% x x x x x x x x x x x x x x
Haemorrhoids very rare x
Hypertension very rare — 0% - 3% 1% x x x x x x x x x x x x x
Irritability very rare x x x x x x x x x x x
Renal failure acute very rare x x x x x x x x x x x
Renal papillary necrosis very rare x x x x x x x x x x x
Leukopenia very rare x x x x x x x x x x x x
Meningitis aseptic very rare x x x x x x x x x x
Myocardial infarction very rare x x x x x x x x x x x
Nephritis interstitial very rare x x x x x x x x x x x
Nephrotic syndrome very rare x x x x x x x x x x x
Nightmare very rare x x x x x x x x x x
Palpitations very rare, postmarketing x x x x x x x x x x x x x x x
Pancreatitis very rare x x x x x x x x x x x x x
Pneumonia very rare, 0% - 2% x x x x x x x x x x x x x
Proteinuria very rare x x x x x x x x x x x x x x
Psychotic disorder very rare x x x x x x x x x x x
Purpura very rare x x x x x x x x x x x
Henoch-Schonlein purpura very rare x x x x x x x x x x
Convulsion very rare x x x x x x x x x x x x x x
Stevens-Johnson syndrome very rare x x x x x x x x x x x x x x
Stomatitis very rare x x x x x x x x x x x
Cerebrovascular accident very rare x x x x x x
Thrombocytopenia very rare x x x x x x x x x x x x x x
Tinnitus very rare x x x x x x x x x x x x x x
Tremor very rare x x x x x x x x x x x x x x
Tubulointerstitial nephritis very rare x x x
Erythema very rare — 4% x x x x x x x x x x x x
Vasculitis very rare x x x x x x x x x x x
Encephalopathy very rare x x
Hepatic failure very rare x x x x x x
Dermatitis bullous very rare x x x
Injection site abscess very rare
Hemorrhagic colitis very rare x x x x x x x x x
Hepatic necrosis very rare x x x x x x
Photosensitivity reaction very rare, 0% - 3% x x x x x x x x x
Disorientation very rare x x x x x x x x x x x
Memory impairment very rare x x x x x x x x x
Bullous eruption very rare x x x x x x x x
Erectile dysfunction very rare x x x
Hepatitis fulminant very rare, rare x x x x x x x x x x
Vision blurred very rare, postmarketing x x x x x x x x x x x x x x x
Face oedema very rare, postmarketing x x x x x x
Visual disturbance very rare x x
Toxic shock syndrome very rare x
Hemorrhoids aggravated very rare x
Insomnia very rare x x x x x x x x x x x x x x x
Hearing impaired very rare x x x x x x x x x x
Intestinal diaphragm disease very rare x x x
Visual impairment very rare x x x x x x
Abdominal cramps x x
Abdominal distension x x
Amblyopia x x
Anaphylactic shock x x x x x x
Angina pectoris x x x
Aphasia
Arrhythmia x x x x x x
Arteriosclerosis
Arthritis
Asthenia postmarketing, 0% - 2% x x x x x x
Mental disorder x x x x x x
Bronchospasm x x
Carcinoma
Neck pain 0% - 2% x
Tongue coated x x x
Coma x x x
Confusional state x x x
Conjunctivitis allergic x
Corneal disorder x
Corneal oedema x
Corneal opacity x
Ulcerative keratitis x
Cystitis x x x
Dental caries
Depression
Dysmenorrhoea
Dysthymic disorder
Dysuria x x x
Eosinophilia x x x x x
Epistaxis x x
Eructation x x x
Oesophagitis x x x
Fatigue x x x
Body temperature increased x x x x
Vitreous floaters x x
Furunculosis
Gingivitis
Gout
Hair disorder
Hallucination x x x
Partial hearing loss x x x
Cardiac disorder x x x x x x
Cardiac failure congestive x x x x x x
Heartburn x x x
Hepatorenal syndrome x x
Hernia
Herpes simplex 0% - 2% x
Hyperventilation x x
Hypoaesthesia x
Hypoglycaemia x x
Immune system disorder x x x x x x
Intestinal perforation x x
Iritis x
Eye pruritus x
Arthropathy 0% - 7.69% 12% - 15.4% x
Keratitis x
Lacrimal disorder x x
Laryngeal oedema x x
Mediastinal disorder x x x x x
Meningitis x x x
Cramp muscle x x
Hypertonia x
Nail disorder
Nervousness x x x
Neuritis
Night blindness x x
Nocturia x x
Oliguria x x x x x
Pancytopenia x x x
Peptic ulcer x x x x x x
Abscess periodontal
Phlebitis 0% - 2% x
Polyuria x x x
Rectal disorder
Renal failure x x x
Scotoma x x
Seborrhoeic dermatitis x
Skin nodule 0% - 2% x
Speech disorder
Aphthous stomatitis x x x
Sweating x
Syncope x x x
Tachycardia x x x x x
Taste disorders x x x
Testicular disorder
Thirst
Toothache
Ulcer x x x x x x x x
Pollakiuria x x
Urinary tract disorder x x x x x x
Angiopathy x x x x x
Vasodilation x x
Viral infection x
Weight increased x
Weight decreased x x
Wheezing
Chills 0% - 2% x x
Burning sensation x
Rash pustular
Oedema peripheral
Hypokinesia 0% - 2% x
Hepatic function abnormal x x
Bleeding time prolonged x x x
Ventricular extrasystoles x x
Hyperchlorhydria x x x
Skin hypertrophy x
Kidney function abnormal x x x
Bone pain
Purpuric rash x
Aspartate aminotransferase increased 0% - 3% x
Alanine aminotransferase increased 0% - 4% 0% x
Skin irritation x
Ocular hyperaemia x
Corneal deposits x
Eyelid oedema x
Unspecified disorder of skin and subcutaneous tissue x x x x x
Prostatic specific antigen increased
Lightheadedness
Stomach ache
Malaise x x x x x x x x
Epigastric pain x
Thinking abnormal
Respiratory depression x x x
Cerebration impaired x x x
Eye irritation x
Hepatic enzyme increased x x x
Erythema of eyelid x
Azotaemia x x
Sepsis x x x
Punctate keratitis x x
Hepatobiliary disease x x x x x
Fluid retention x x
Redness
Epidermolysis x
Atrophy x
Corneal perforation x
Secondary anemia x x
Photosensitivity x x x x x x
Exacerbation of asthma x
Corneal erosion x
Platelet count decreased x
Lacrimation x
Rash maculo-papular 0% - 2% x
Hyperkinesia x
Gastrointestinal symptom NOS x
Bradycardia
Lymphadenopathy x x x
Coordination abnormal x x
Bad taste x
Water retention x
Swelling of eyelid x
Cough increased
Gait disturbance
Stinging
Sweating increased 0.612% x x x
Creatinine abnormal NOS x
Urinary abnormalities x x x
Eyelids pruritus x
Infestation NOS
Blood and lymphatic system disorders x x x x x
Ear and labyrinth disorders x x x x
Allergic conditions x
Sleep disorder
Eye allergy x
Corneal infiltrates x
Allergic skin reaction x x
Myasthenia
Corneal thinning x
Abrasion NOS
Conjunctival hyperaemia x
Appetite absent
Tingling sensation
Vaginal haemorrhage x x

Indications

Information about indications was extracted from the indications and usage sections of the labels.

DICLOFENAC

Side effects:6
Source:FDA Structured Product Label

DICLOFENAC

Side effects:9
Source:FDA Structured Product Label

Diclofenac

Side effects:13
Source:FDA Structured Product Label

Diclofenac

Side effects:16
Source:FDA Structured Product Label

DICLOFENAC SODIUM / VOLTAREN OPHTHA

Side effects:46
Source:Health Canada

DICLOFENAC

Side effects:61
Source:FDA Structured Product Label

DICLOFENAC POTASSIUM / SANDOZ-DICLOFENAC RAPIDE

Side effects:91
Source:Health Canada

DICLOFENAC POTASSIUM / VOLTAREN RAPIDE TABLETS 50MG

Side effects:98
Source:Health Canada

Diclofenac

Side effects:98
Source:FDA Structured Product Label

diclofenac

Side effects:100
Source:FDA Structured Product Label

DICLOFENAC

Side effects:101
Source:FDA Structured Product Label

Diclofenac sodium / DICLOFENAC TABLETS

Side effects:104
Source:medicines.org.au

Diclofenac

Side effects:105
Source:FDA Structured Product Label

VOLTAREN D / Voltaren D, Dispersible tablet

Side effects:106
Source:Medsafe

VOLTAREN / Voltaren, Suppository

Side effects:109
Source:Medsafe

DICLOFENAC SODIUM / SOLARAZE

Side effects:148
Source:FDA

Color scheme:

standard – alternative

    100%
    75%
    50%
    10%
    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    postmarketing
    0%
    no frequency information
    not found on label