Letrozole
Side effects
Options: Show MedDRA Preferred Terms, display all 29 labels
| Side effect | Data for drug | Placebo | Labels | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | |||
| Flushing | 0.117% - 49.7% | 0% - 43.3% | x | x | x | x | x | x | x | x | x | x | x | x | ||||||||
| Musculoskeletal disorder | 2.77% - 38.2% | 1.94% - 32.5% | x | x | x | x | x | x | x | x | x | x | x | x | ||||||||
| Nervous system disorder | 2.54% - 33.7% | 2.25% - 31.8% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Gastrointestinal disorder | 1.68% - 28.3% | 1.63% - 28.4% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Skin disorder | 0.663% - 32.4% | 0.622% - 30.6% | x | x | x | x | x | x | x | x | x | x | x | x | ||||||||
| Hot flush | very common, 3% - 38% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Night sweats | 10.7% - 17.4% | x | x | x | x | x | x | x | x | x | x | x | ||||||||||
| Sweating | 1-22% | x | ||||||||||||||||||||
| Nausea | common, 0.117% - 17% | 0.389% - 8.24% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Metabolic disorder | 0.936% - 21.5% | 1.24% - 20.9% | x | x | x | x | x | x | x | x | x | x | x | x | ||||||||
| Fracture | common, 4% - 13.8% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Arthralgia | very common, 0.975% - 25.2% | 0.777% - 18.1% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Fatigue | common, 0.151% - 11-30% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Dyspnoea | uncommon, 0.819% - 18% | 0.7% - 5.32% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Headache | common, 0.204% - 20.1% | 0.661% - 19.7% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Lymphoedema | 7% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||
| Mental disorder | 0.819% - 12.5% | 0.622% - 10.7% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Pain | 5% - 7% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Abdominal pain | uncommon, 5% - 9% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Chest pain | 3% - 9% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Chest wall pain | 6% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Constipation | common, 0.0251% - 11.3% | 0.0777% - 11.8% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Cough | uncommon, 5% - 13% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Hypertension | uncommon, 4% - 8% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Vulvovaginal dryness | 0% - 5.35% | 0% - 4.94% | x | x | x | x | x | x | x | x | x | x | x | x | ||||||||
| Back pain | 0.176% - 70.5% | 0.272% - 4.35% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Asthenia | 0.151% - 33.6% | 0.272% - 32.1% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||
| Infection | 1.56% - 6.48% | 1.28% - 6.34% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Dyspepsia | common, 3% - 6% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Rash | common, 3% - 12% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Influenza | 4% - 6% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||
| Viral infection | 3% - 6% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||
| Vomiting | common, 0.0755% - 9% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Weight decreased | uncommon, 0.125% - 7% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Oedema peripheral | common, 3% - 9-17% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Myalgia | common, 0.312% - 12-21% | 0.233% - 4.74% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||
| Increased appetite | common, 1% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||
| Sweating increased | common, 0.039% - 24.2% | 0% - 22.4% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Infestation NOS | 1.56% - 6.48% | 1.28% - 6.34% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Diarrhoea | common, 0.468% - 8% | 0.311% - 5.56% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Bone pain | common, 0.1% - 22% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Anorexia | common, 0.0251% - 6% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Insomnia | uncommon, 0.078% - 7% | 0.0777% - 4.66% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Arthritis | uncommon, 0.39% - 25.2% | 0.194% - 4.82% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||
| Alopecia | common, 2.09% - 3.43% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Pain in extremity | 0.1% - 10% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||
| Neoplasm malignant | 1.33% - 4.86% | x | x | x | x | x | x | x | x | x | x | x | x | |||||||||
| Lethargy | 0.151% - 10.2% | x | x | x | x | x | x | x | x | x | x | x | ||||||||||
| Malaise | 0.151% - 10.2% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||
| Osteopenia | 0.0502% - 3.55% | x | x | x | x | x | x | x | x | x | ||||||||||||
| Dizziness | common, 0.0252% - 14.2% | 0.233% - 13.3% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Hypercholesterolaemia | common, 0% - 52.3% | 0.194% - 15.5% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Urinary tract infection | uncommon, 3% - 6% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||
| Weight increased | common, 0.679% - 15.4% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Somnolence | uncommon, 2% - 9% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Depression | common, 0.351% - 4.86% | x | x | x | x | x | x | x | x | x | x | x | ||||||||||
| Nephropathy | 0.468% - 5.07% | 0.233% - 3.89% | x | x | x | x | x | x | x | x | x | x | x | x | ||||||||
| Osteoporosis | common, 0.125% - 6% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Angiopathy | 2.3% - 53.6% | 2.88% - 47.8% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Cerebrovascular accident | uncommon, 1.15% - 2.86% | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||||
| Pruritus | uncommon, 1% - 5% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Breast pain | uncommon, 0.0252% - 7% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Vaginal discharge | uncommon, 2% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||
| Lightheadedness | 0.0252% - 3.43% | x | x | x | x | x | x | x | x | x | x | x | ||||||||||
| Angina pectoris | 0.176% - 24% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Vaginal irritation | 0.0502% - 4.53% | x | x | x | x | x | x | x | x | x | x | x | ||||||||||
| Myocardial infarction | 0.276% - 15% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Cataract | uncommon, 0.654% - 2.21% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Thromboembolism | 0.6% | x | ||||||||||||||||||||
| Anxiety | uncommon | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Dysgeusia | uncommon | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Oedema | uncommon, 0.0251% - 18.4% | 0.117% - 16.2% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Body temperature increased | uncommon | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Leukopenia | uncommon | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Palpitations | uncommon | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Stomatitis | uncommon | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Tachycardia | uncommon | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Thirst | uncommon | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Thrombophlebitis | uncommon | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Pollakiuria | uncommon | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Urticaria | uncommon | x | x | x | x | x | x | x | x | x | x | x | x | |||||||||
| Dry mouth | uncommon | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Dry skin | uncommon | x | x | x | x | |||||||||||||||||
| Memory impairment | uncommon | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Vaginal dryness | uncommon | x | x | x | x | |||||||||||||||||
| Dysaesthesia | uncommon | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Tumour pain | uncommon | x | x | x | x | |||||||||||||||||
| Mucosal dryness | uncommon | x | x | x | x | |||||||||||||||||
| Vaginal haemorrhage | uncommon, 0.0252% - 13.1% | 0.194% - 6.65% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Myocardial ischaemia | 0.245% - 0.368% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||
| Anaphylactic shock | very rare, postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||||
| Angioedema | very rare, postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||||
| Carpal tunnel syndrome | postmarketing | x | x | x | x | x | ||||||||||||||||
| Toxic epidermal necrolysis | very rare, postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | |||||||||
| Erythema multiforme | very rare, postmarketing | x | x | x | x | x | x | x | x | x | x | x | ||||||||||
| Hepatitis | very rare, postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | |||||||||
| Pulmonary embolism | rare | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Arterial thrombosis | rare | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Trigger finger | postmarketing | x | x | x | x | x | ||||||||||||||||
| Vision blurred | postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Cerebrovascular infarction | rare | x | x | x | x | |||||||||||||||||
| Bone disorder | x | x | ||||||||||||||||||||
| Breast disorder | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Cardiovascular disorder | x | x | x | x | x | x | x | x | x | |||||||||||||
| Transient ischaemic attack | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Connective tissue disorder | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||
| Coronary heart disease | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Cyst | x | x | x | x | ||||||||||||||||||
| Endometrial hyperplasia | x | x | x | x | x | x | x | x | x | |||||||||||||
| Eye disorder | x | x | x | x | ||||||||||||||||||
| Cardiac disorder | x | x | x | x | ||||||||||||||||||
| Cardiac failure | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||||
| Hemiparesis | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Haemorrhage | x | |||||||||||||||||||||
| Hypercalcaemia | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Hypoaesthesia | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||||
| Irritability | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||||
| Leg pain | x | x | x | x | x | x | x | x | x | x | ||||||||||||
| Mediastinal disorder | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Menopause | x | x | x | x | x | x | ||||||||||||||||
| Musculoskeletal pain | x | x | x | x | x | x | x | x | x | x | x | |||||||||||
| Neoplasm | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Nervousness | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||||
| Paraesthesia | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||||
| Phlebitis | x | |||||||||||||||||||||
| Pleural effusion | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Polyp | x | x | x | x | ||||||||||||||||||
| Urinary tract disorder | x | x | x | x | ||||||||||||||||||
| Venous thrombosis | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Vertigo | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Portal vein thrombosis | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Malnutrition | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Unspecified disorder of skin and subcutaneous tissue | x | x | x | x | ||||||||||||||||||
| Rash vesicular | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||||
| Decreased appetite | x | |||||||||||||||||||||
| Rash erythematous | x | x | x | x | x | x | x | x | x | x | ||||||||||||
| Eye irritation | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||||
| Gravitational oedema | x | x | x | x | x | x | x | x | x | x | ||||||||||||
| Leg edema | x | x | x | x | x | x | x | x | x | x | ||||||||||||
| Edema of lower extremities | x | |||||||||||||||||||||
| Pain in arm | x | x | x | x | x | x | x | x | x | x | ||||||||||||
| Dermatitis psoriasiform | x | x | x | x | x | x | x | |||||||||||||||
| Hepatobiliary disease | x | x | x | x | ||||||||||||||||||
| Anxiety depression | x | x | ||||||||||||||||||||
| Rash maculo-papular | x | x | x | x | x | x | x | x | x | x | ||||||||||||
| Endometrial cancer | x | x | x | |||||||||||||||||||
| Haemorrhagic stroke | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Cancer pain | x | x | x | x | x | x | x | x | x | x | ||||||||||||
| Oestrogen deficiency | x | x | x | x | x | x | x | x | x | x | x | x | ||||||||||
| Thromboembolic event | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||
| Oestrogenic effect | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
Indications
Information about indications was extracted from the indications and usage sections of the labels.
| Indication | Labels | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Advanced breast cancer | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Breast cancer | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Breast cancer stage IV | x | x | x | x | x | x | x | x | x | x | x | |||||||||||
| Disease progression | x | x | x | x | x | x | x | x | ||||||||||||||
| Hepatic cirrhosis | x | |||||||||||||||||||||
| Hepatic function abnormal | x | |||||||||||||||||||||
| Hepatic impairment | x | |||||||||||||||||||||
| Menopause | x | x | ||||||||||||||||||||
| Neoplasm | x | |||||||||||||||||||||
| Neoplasm malignant | x | |||||||||||||||||||||
| Renal impairment | x | |||||||||||||||||||||
Color scheme:
standard – alternative
| 100% | ||
| 75% | ||
| 50% | ||
| 10% | ||
| frequent (1% to 100%) | ||
| infrequent (0.1% to 1%) | ||
| rare (<0.1%) | ||
| postmarketing | ||
| 0% | ||
| no frequency information | ||
| not found on label |
