| Side effect | Data for drug | Placebo | Labels | 
|  | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 
| Appetite absent | very common |  | x |  |  |  |  |  |  |  | x | x |  |  |  |  |  |  |  |  |  | x | 
| Nausea | very rare — 1% - 47% | 0% - 12% | x | x | x | x | x |  | x | x |  | x | x | x | x | x | x | x | x | x | x | x | 
| Diarrhoea | common — 1% - 19% | 1% - 11% | x |  |  | x |  |  |  |  |  | x | x | x |  | x | x | x |  | x | x | x | 
| Tremor | common — 1% - 23% | 1% - 4% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Application site erythema | common, 1% - 13% |  |  |  |  | x |  | x |  |  | x |  | x |  |  |  |  |  |  |  |  |  | 
| Anaemia | frequent |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  | x | x | x | x | x | 
| Angina pectoris | frequent |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Arthralgia | infrequent, frequent |  |  |  |  |  |  |  |  |  |  | x |  | x | x |  |  | x | x | x | x | x | 
| Arthritis | frequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Ataxia | frequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Atrial fibrillation | postmarketing — frequent |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Back pain | frequent |  |  |  |  |  |  |  |  |  |  | x |  |  |  | x | x | x | x | x | x | x | 
| Bronchitis | frequent |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | x | x | x | x | x | 
| Basal cell carcinoma | frequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Transient ischaemic attack | frequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  | x | x | x | x | 
| Cerebrovascular disorder | frequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Chest pain | rare — frequent |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | 
| Infection | frequent |  | x | x | x | x | x | x | x | x | x | x |  | x | x |  |  | x | x | x | x | x | 
| Confusional state | uncommon — 8% | 7% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Constipation | frequent, 5% | 4% |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | 
| Dehydration | postmarketing — 1% - 2% | 1% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Depression | common, 2% - 6% | 1% - 4% |  | x | x | x | x |  | x | x | x | x | x | x | x | x | x | x | x |  | x | x | 
| Dyskinesia | common — 3% | 1% |  | x | x |  | x |  | x | x |  |  | x |  |  | x | x |  | x | x | x | x | 
| Dyspepsia | common — 8% - 9% | 4% | x | x | x | x | x | x | x | x | x | x | x |  |  | x | x | x | x | x | x | x | 
| Dyspnoea | infrequent — 2% | 1% |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x |  | x | x | x | x | 
| Eczema | infrequent, frequent |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | 
| Oedema | infrequent — frequent |  |  |  |  | x |  | x |  |  | x |  |  | x |  |  |  | x | x | x | x | x | 
| Epistaxis | frequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Rash | postmarketing — frequent |  | x | x | x | x | x | x | x | x | x | x | x |  | x | x | x | x | x | x | x | x | 
| Extrapyramidal disorder | frequent | 0% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Faecal incontinence | frequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Body temperature increased | frequent |  |  |  |  |  | x | x | x | x | x |  |  |  |  |  |  | x | x | x | x | x | 
| Fracture | frequent |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | x | x | x | x | x | 
| Gastritis | infrequent, frequent |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | 
| Cardiac failure | frequent |  |  |  |  |  |  | x |  |  |  |  |  | x | x |  |  | x | x | x | x | x | 
| Haematuria | infrequent, frequent |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | 
| Hypersensitivity | infrequent, frequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Hypokalaemia | infrequent, frequent |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | 
| Hypotension | infrequent — frequent |  |  |  | x |  | x |  | x | x |  |  | x | x | x | x | x | x | x | x | x | x | 
| Orthostatic hypotension | frequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Cramps of lower extremities | frequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Leg pain | frequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Myocardial infarction | frequent |  | x |  |  | x |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | 
| Nasopharyngitis | frequent |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  |  |  |  |  |  | 
| Nightmare | frequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Palpitations | frequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Paraesthesia | frequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Pharyngitis | frequent |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | x | x | x | x | x | 
| Pneumonia | frequent |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  |  |  |  |  | x | 
| Prostatic disorder | frequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Convulsion | postmarketing — frequent |  | x | x | x | x | x | x | x | x | x | x | x |  | x | x | x | x | x | x | x | x | 
| Sinusitis | frequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Skin disorder | frequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Tinnitus | infrequent, frequent |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | 
| Tooth disorder | frequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Upper respiratory tract infection | frequent |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | x | x | x | x | x | 
| Urinary tract infection | very rare — 1% - 10% | 1% - 6% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Vertigo | frequent, 0% - 2% | 1% |  |  |  |  |  |  |  |  |  | x | x | x | x |  |  | x | x | x | x | x | 
| Viral infection | frequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Vomiting | very rare — 0.4% - 31% | 0% - 6% | x | x | x | x | x |  | x | x |  | x | x | x | x | x | x | x | x | x | x | x | 
| Trauma | frequent, 10% | 9% |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | x | x | x | x | x | 
| Agitation | postmarketing — 1% - 14% | 2% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Oedema peripheral | frequent |  |  |  |  |  |  |  |  |  |  | x |  | x | x |  |  | x | x | x | x | x | 
| Cataract | frequent |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | 
| Paranoid reaction | frequent |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | x | x | x | x | x | 
| Malaise | uncommon — 4% - 5% | 2% | x | x | x | x | x | x | x | x | x | x |  |  |  | x | x | x | x | x | x | x | 
| Myalgia | infrequent, frequent |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  | x | x | x | x | x | 
| Decreased appetite | frequent, 1% - 9% | 1% - 5% |  |  |  |  |  |  |  |  |  |  | x | x |  | x | x |  |  |  |  |  | 
| Hallucination, visual | frequent |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  | 
| Trembling | common |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  |  |  |  |  |  | 
| Rigors | frequent | 0% |  | x | x |  | x |  | x | x |  |  |  |  |  |  |  | x | x | x | x | x | 
| Bradycardia | infrequent — frequent |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Gait disturbance | frequent, 4% | 0% |  | x | x |  | x |  | x | x |  |  | x |  |  | x | x | x | x | x | x | x | 
| Hot flush | frequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Somnolence | uncommon — 1% - 6% | 1% - 3% | x | x | x | x | x | x | x | x | x | x | x |  |  | x | x | x | x | x | x | x | 
| Abdominal pain | common, 1% - 13% | 1% - 6% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Anxiety | common, 1% - 5% | 1% - 3% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Fatigue | common, 0% - 9% | 0% - 5% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Flatulence | frequent, 4% | 2% |  |  |  |  |  |  |  |  |  | x |  |  |  | x | x | x | x | x | x | x | 
| Hallucination | very rare — 2% - 5% | 3% | x | x | x | x | x | x | x | x | x | x | x |  | x | x | x | x | x | x | x | x | 
| Headache | common, 1% - 17% | 2% - 12% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Nervousness | 4% | 3% |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | x | x | x | x | x | 
| Rhinitis | 4% | 3% |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | x | x | x | x | x | 
| Abdominal pain upper | 1% - 4% | 1% - 2% |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x |  | x | x | x | x | 
| Sweating increased | common — 2% - 4% | 1% |  |  |  |  |  | x |  |  | x | x | x |  |  | x | x | x | x | x | x | x | 
| Anorexia | 1% - 17% | 0% - 3% |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Cardiovascular disorder | 3% | 2% |  |  |  |  |  |  |  |  |  | x |  |  |  | x | x | x | x | x | x | x | 
| Dizziness | common, 0% - 21% | 0% - 11% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Hypertension | very rare — 1% - 3% | 2% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Parkinson's disease | postmarketing — 3% | 1% |  |  |  |  |  |  |  | x |  |  | x |  |  |  |  |  |  | x | x | x | 
| Syncope | uncommon — 3% | 2% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Weight decreased | common — 1% - 8% | 0% - 1% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Cogwheel rigidity | common, 3% | 0% |  |  | x |  | x |  | x | x |  |  | x |  |  | x | x |  |  |  |  |  | 
| Bradykinesia | common — 2% - 4% | 2% |  | x | x |  | x |  | x | x |  |  | x |  |  | x | x |  | x | x | x | x | 
| Influenza-like symptoms | frequent, 3% | 2% |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | x | x | x | x | x | 
| Insomnia | infrequent — 1% - 9% | 2% - 7% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Aggressive reaction | 3% | 2% |  |  |  |  |  |  |  |  |  | x |  |  |  | x | x | x | x | x | x | x | 
| Conjunctivitis | infrequent, frequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | 
| Pain | infrequent, frequent |  |  |  |  |  |  | x |  |  | x | x |  | x |  |  |  | x | x | x | x | x | 
| Application site pruritus | common, 1% - 4% |  |  |  |  | x |  | x |  |  | x |  | x | x |  |  |  |  |  |  |  |  | 
| Asthenia | common, 0% - 6% | 0% - 2% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Eructation | 2% | 1% |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | x | x | x | x | x | 
| Hyperhidrosis | uncommon — 2% | 1% | x | x | x | x | x |  | x | x | x | x |  |  |  |  |  |  |  |  |  | x | 
| Pruritus | postmarketing — 1.7% - 2% | 1% | x | x | x | x | x | x | x | x | x | x | x | x | x |  |  |  |  |  |  | x | 
| Pollakiuria | infrequent, 2% | 1% |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  |  |  |  |  | x | 
| Parkinsonism | 2% | 1% |  | x | x |  | x |  | x | x |  |  |  | x | x | x | x |  | x | x | x | x | 
| Abnormal vision | 2% | 1% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Urinary incontinence | infrequent — 1% - 3% | 2% |  |  |  | x |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Aggression | postmarketing — 0.4% - 3% |  | x | x | x | x | x | x | x | x | x | x | x |  |  | x | x |  |  |  |  |  | 
| Abscess | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Adams-Stokes syndrome | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | 
| Adenocarcinoma | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Albuminuria | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Alopecia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Amnesia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Hypochromic anaemia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Aneurysm | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Aphasia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Apnoea | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Apraxia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Arrhythmia | very rare — uncommon |  | x | x | x | x | x |  | x | x | x | x | x | x | x |  |  |  |  |  |  | x | 
| Rheumatoid arthritis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Atrioventricular block | postmarketing — uncommon |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Bacterial infection | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Bladder disorder | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Neurogenic bladder | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | 
| Blepharitis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Blepharospasm | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | 
| Bone disorder | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Brain disorder NOS | uncommon |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  | 
| Breast cancer | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Bronchospasm | infrequent |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | 
| Bundle branch block | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Bursitis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Cachexia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Candida infection | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Carcinoma | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Skin cancer | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Cellulitis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Cholecystitis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  | x | x | x | x | x | 
| Cholelithiasis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Colitis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Coma | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Conjunctival haemorrhage | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Cough | infrequent, frequent |  |  |  |  |  |  |  |  |  |  | x |  |  |  | x | x | x | x | x | x | x | 
| Cystitis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Deafness | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Libido decreased | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Dysphagia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Delirium | infrequent, uncommon |  | x |  |  | x | x | x | x | x | x | x | x | x |  |  | x | x | x | x | x | x | 
| Delusion | infrequent, frequent |  |  |  |  |  |  |  |  |  |  | x |  | x | x |  |  | x | x | x | x | x | 
| Dental caries | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Depersonalisation | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Dermatitis | infrequent |  |  |  |  |  |  |  |  |  |  |  | x | x | x |  |  |  |  |  |  | x | 
| Dermatitis contact | infrequent, uncommon |  |  |  |  | x |  |  |  |  | x |  |  |  |  | x | x | x | x | x | x | x | 
| Diabetes mellitus | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Diplopia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Diverticulitis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  |  | x | x | x | x | 
| Drowsiness | uncommon |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  | 
| Duodenal ulcer | rare, infrequent |  | x | x | x | x | x | x | x | x | x | x | x |  | x | x | x | x | x | x | x | x | 
| Dysgeusia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Dysuria | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Ear disorder | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Ear pain | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Epilepsy | infrequent |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  |  | x | x | x | x | 
| Oesophagitis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Congenital eye disorder | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Eyelid disorder | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Flushing | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Furunculosis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Gastroenteritis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Gastrooesophageal reflux disease | infrequent |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | 
| Gastrointestinal haemorrhage | very rare — uncommon |  | x | x | x | x | x | x | x | x | x | x |  |  | x | x | x | x | x | x | x | x | 
| Gingivitis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Glaucoma | infrequent |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | 
| Glossitis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Goitre | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Gout | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Breath odour | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Cardiac arrest | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Haematemesis | infrequent |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | 
| Haematochezia | infrequent |  |  |  |  |  |  |  |  |  |  |  | x | x | x |  |  |  |  |  |  |  | 
| Haematoma | infrequent, frequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Subdural haematoma | infrequent |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  |  |  |  |  |  | 
| Hemiparesis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | 
| Haemorrhage | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Haemorrhoids | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Hernia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Herpes simplex | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Herpes zoster | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Hiccups | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Hip fracture | infrequent |  |  |  |  |  |  |  |  |  |  |  | x | x | x |  |  |  |  |  |  |  | 
| Hypercholesterolaemia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Hyperglycaemia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Hyperlipidaemia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  |  | x | x | x | x | 
| Hyperventilation | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Hypoaesthesia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Hypoglycaemia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Hyponatraemia | infrequent |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | 
| Body temperature decreased | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Hypothyroidism | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Libido increased | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Inflammation | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Intestinal obstruction | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Arthropathy | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Calculus of kidney | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Renal failure acute | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Laryngitis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Leukocytosis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Lung disorder | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Mastitis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | 
| Breast pain | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Melaena | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Meniere's disease | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | 
| Metrorrhagia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Cramp muscle | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Hypertonia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Fungal infection | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Myoclonus | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | 
| Nail disorder | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Neoplasm | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Neuralgia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Neurosis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Nocturia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  | x | x | x | x | x | 
| Nystagmus | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Oliguria | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x |  | 
| Osteoporosis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Otitis externa | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Otitis media | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Pallor | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Pancreatitis | very rare — infrequent |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Paresis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Peptic ulcer | infrequent |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  |  |  |  |  | x | 
| Neuropathy peripheral | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Peritonitis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | 
| Personality disorder | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x |  | 
| Phlebitis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Pleural effusion | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Polyuria | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Supraventricular extrasystoles | infrequent |  |  |  |  | x |  |  |  |  | x |  | x | x | x |  |  |  |  |  |  |  | 
| Pruritus genital | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Psychotic disorder | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Pulmonary oedema | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Pulmonary embolism | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Emphysema | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Purpura | infrequent, frequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Pyuria | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Rectal disorder | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Renal failure | infrequent |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  |  |  |  |  |  | 
| Respiratory insufficiency | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Restless legs syndrome | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | 
| Retinal disorder | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | 
| Seborrhoeic dermatitis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Salivary hypersecretion | infrequent — 2% | 0% |  | x | x |  | x |  | x | x |  |  | x | x | x | x | x | x | x | x | x | x | 
| Sick sinus syndrome | postmarketing, infrequent |  | x | x | x | x | x | x | x | x | x | x |  |  |  | x | x | x | x | x | x | x | 
| Skin ulcer | infrequent, frequent |  |  |  |  |  |  |  |  |  |  |  | x | x | x |  |  | x | x | x | x | x | 
| Muscle spasms | infrequent |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  |  |  |  |  |  | 
| Speech disorder | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Gastric ulcer | infrequent, uncommon |  |  |  |  | x |  | x |  |  | x |  |  |  | x | x | x | x | x | x | x | x | 
| Ulcerative stomatitis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Cerebrovascular accident | infrequent, uncommon |  | x |  |  | x |  |  |  |  | x | x | x | x |  |  | x |  |  |  |  |  | 
| Suicide attempt | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x |  | 
| Sunburn | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Sweating | uncommon |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  | 
| Tachycardia | postmarketing, infrequent |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Supraventricular tachycardia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Tendonitis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Thirst | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Thrombocytopenia | infrequent, frequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Thrombophlebitis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Thrombosis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Onychomycosis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Erythema | postmarketing — 1.1% |  | x |  |  | x |  | x | x | x | x | x | x | x | x |  | x |  |  |  |  |  | 
| Urethral disorder | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Micturition disorder | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Urticaria | postmarketing, infrequent |  | x |  |  | x |  | x | x | x | x | x | x |  |  | x | x | x | x | x | x | x | 
| Uterine disorder | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Vaginal inflammation | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Varicose vein | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Angiopathy | infrequent |  | x | x | x |  | x | x | x | x |  |  | x | x | x |  |  |  |  |  |  | x | 
| Vasculitis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | 
| Syncope vasovagal | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | 
| Vestibular disorder | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Common wart | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Weight increased | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Dry mouth | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Urinary retention | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Sudden cardiac death | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | 
| Micturition urgency | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Apathy | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Mood swings | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Hypokinesia | infrequent — 2% - 4% | 0% |  | x | x |  | x |  | x | x |  |  | x |  |  | x | x | x | x | x | x | x | 
| Migraine | infrequent |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | 
| Periorbital oedema | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Generalised oedema | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Haemorrhage intracranial | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x |  | x | x | x | 
| Skin hypertrophy | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Myocardial ischaemia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Kidney function abnormal | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Muscular weakness | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Bone pain | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Retrosternal pain | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Eye pain | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Phosphatase alkaline increased | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | 
| Electrocardiogram QT prolonged | infrequent |  |  |  |  |  |  |  |  |  |  |  | x | x | x |  |  |  |  |  |  |  | 
| Hyporeflexia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Hyperreflexia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Skin discolouration | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Dry skin | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Tendon disorder | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Spine malformation | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Abnormal chest sounds NOS | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Muscle stiffness | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  | x | x | x | x | 
| Vaginitis atrophic | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Increased appetite | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Rectal tenesmus | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Rash erythematous | infrequent |  |  |  |  |  |  |  |  |  |  |  | x | x | x |  |  |  |  |  |  | x | 
| Muscle contractions involuntary | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Cerebration impaired | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Peripheral ischaemia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Bullous eruption | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Skin cold clammy | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Lacrimation abnormal NOS | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Skin exfoliation | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Dermal cyst | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Erectile dysfunction | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Sepsis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Rectal haemorrhage | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Extrasystoles | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Vision blurred | infrequent |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x |  | x | x | x | x | 
| Rash maculo-papular | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Suicidal ideation | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Hyperkinesia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Stiffness | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Neuropathy | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Lymphadenopathy | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Dementia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  | x | x | 
| Prostatic adenoma | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | 
| Coordination abnormal | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Congenital joint malformation | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Electrocardiogram abnormal | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Face oedema | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Lipase increased | infrequent |  |  |  |  |  |  |  |  |  |  |  | x | x | x |  |  |  |  |  |  |  | 
| Heart sounds abnormal | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Carcinoma colon | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Bladder carcinoma | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Unspecified circulatory system disorder | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Infection parasitic | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Increased prolactin level | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | 
| Sleep disorder | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Blood amylase increased | infrequent |  |  |  |  |  |  |  |  |  |  |  | x | x | x |  |  |  |  |  |  |  | 
| Blood creatine phosphokinase increased | infrequent |  |  |  |  |  |  |  |  |  |  |  | x | x | x |  |  |  |  |  |  |  | 
| Unwell | uncommon |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  | 
| Endometrial hypertrophy | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | 
| Hyperkeratosis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Large intestine polyp | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Freezing phenomenon | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | 
| Dysphonia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Coronary artery disease | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Anaemia vitamin B12 deficiency | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Renal cyst | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Ageusia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Vaginal haemorrhage | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Mental disorder | postmarketing |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Blister | postmarketing |  | x |  |  | x |  |  |  |  | x | x | x |  |  |  | x |  |  |  |  |  | 
| Dermatitis atopic | postmarketing |  | x |  |  | x |  | x | x | x | x | x | x |  |  |  | x |  |  |  |  |  | 
| Cardiac disorder | postmarketing |  | x | x | x | x | x | x | x | x | x |  | x | x | x |  |  |  |  |  |  |  | 
| Hepatitis | postmarketing |  | x | x | x | x | x | x | x | x | x | x |  |  |  | x | x |  |  |  |  |  | 
| Stevens-Johnson syndrome | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  | x |  | x | x |  | x | x | x | x | 
| Liver function test abnormal | postmarketing |  |  |  |  | x |  |  |  |  | x |  | x |  |  |  |  |  |  |  |  |  | 
| Malnutrition | postmarketing |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Unspecified disorder of skin and subcutaneous tissue | postmarketing |  | x | x | x | x | x | x | x | x | x |  | x | x | x | x | x |  |  |  |  | x | 
| Hepatobiliary disease | postmarketing |  | x | x | x |  | x | x | x | x |  | x |  | x | x | x | x |  |  |  |  |  | 
| Cutaneous hypersensitivity | postmarketing, rare |  | x |  | x |  |  | x | x | x | x | x | x |  |  | x | x |  |  |  |  |  | 
| Application site hypersensitivity | postmarketing |  |  |  |  | x |  |  |  |  | x |  | x |  |  |  |  |  |  |  |  |  | 
| Stomach ache | very rare |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  | 
| Oesophageal rupture | very rare |  | x | x | x | x | x | x | x | x | x | x |  | x |  |  |  |  |  |  |  | x | 
| Coagulopathy |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Breast disorder |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  |  |  |  |  |  | 
| Collagen disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Connective tissue disorder |  |  |  | x |  |  |  |  |  |  |  |  |  | x | x |  |  |  |  |  |  |  | 
| Drooling |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Dysarthria |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Eye disorder |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x |  |  |  |  |  |  |  | 
| Gastrointestinal disorder |  |  | x | x | x | x | x | x | x | x | x |  | x |  |  | x | x |  | x | x | x | x | 
| Chronic obstructive pulmonary disease |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  |  |  |  |  |  | 
| Mediastinal disorder |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x |  |  |  |  |  |  |  | 
| Movement disorder |  | 0% |  | x | x |  | x |  | x | x |  |  |  |  |  |  |  |  |  |  |  | x | 
| Muscle rigidity |  | 0% |  | x | x |  | x |  | x | x |  |  |  |  |  |  |  |  |  |  |  | x | 
| Musculoskeletal disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Nervous system disorder |  |  | x | x | x | x | x | x | x | x | x |  | x | x | x | x | x |  | x | x | x | x | 
| Urinary tract disorder |  |  |  |  |  | x |  | x |  |  | x |  |  | x | x | x | x | x | x | x | x | x | 
| Disorder sight |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Skin irritation |  |  |  |  |  | x |  | x |  |  | x |  | x | x | x |  |  |  |  |  |  |  | 
| Red blood cell disorders |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Cardiac fibrillation |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Motor dysfunction |  | 0% |  | x | x |  | x |  | x | x |  |  |  |  |  |  |  |  |  |  |  | x | 
| Extrapyramidal symptoms |  |  |  | x | x |  | x | x | x | x | x |  |  |  |  |  |  |  |  |  |  | x | 
| Application site oedema |  |  |  |  |  |  |  | x |  |  | x |  |  |  |  |  |  |  |  |  |  |  | 
| Anxiety depression |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Duodenitis haemorrhagic |  |  |  |  |  | x |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  | 
| Hyperpyrexia |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  |  |  |  |  |  | 
| Application site irritation |  |  |  |  |  |  |  | x |  |  | x |  | x | x | x |  |  |  |  |  |  |  | 
| Application site rash |  |  |  |  |  |  |  | x |  |  | x |  | x | x | x |  |  |  |  |  |  |  | 
| Balance disorder |  |  |  | x | x |  | x |  | x | x |  |  |  |  |  |  |  |  |  |  |  | x | 
| Stinging |  |  |  |  |  |  |  | x |  |  | x |  |  | x |  |  |  |  |  |  |  |  | 
| Infestation NOS |  |  | x | x | x | x | x | x | x | x |  |  |  | x | x |  |  |  |  |  |  |  | 
| Blood and lymphatic system disorders |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  |  |  |  |  |  | 
| Ear and labyrinth disorders |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x |  |  |  |  |  |  |  | 
| Asthenic conditions |  |  |  |  |  |  |  | x |  |  | x |  |  |  |  |  |  |  |  |  |  |  | 
| Raised liver function tests |  |  |  | x | x |  | x | x | x | x |  |  |  |  |  |  |  |  |  |  |  |  | 
| Application site burn |  |  |  |  |  |  |  | x |  |  | x |  |  | x |  |  |  |  |  |  |  |  | 
| Application site eczema |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  |  |  |  |  |  | 
| Musculoskeletal stiffness |  | 0% |  | x | x |  | x |  | x | x |  |  |  |  |  |  |  |  |  |  |  | x | 
| Benign prostatic hyperplasia |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  |  |  |  |  |  |