Rofecoxib

Side effects and indications

Whenever possible, frequency information about the side effects was extracted from the labels. Aggregated frequency information for the drug and, if available, placebo is shown. To the right, you can click on shaded boxes to be taken to mentions of the side effect on the label. (In some cases, the side effect cannot be highlighted due to conversion problems.) Information about indications was extracted from the indications and usage sections of the labels.

Show MedDRA Preferred Terms

Side effect Data for drug Placebo Labels
1 2 3 4 5
Abdominal pain def postmarketing x x x x x
Congenital anomaly def postmarketing x
Agranulocytosis def postmarketing x x x x
Anaemia def postmarketing x x x
Aplastic anaemia def postmarketing x x x
Angina pectoris def postmarketing x x x x x
Angina unstable def postmarketing x x x x x
Angioedema def postmarketing x x x x
Breast cancer def postmarketing x x x x x
Bronchospasm def postmarketing x x x x
Neoplasm malignant def postmarketing x x x x x
Transient ischaemic attack def postmarketing x x x x x
Cholecystitis def postmarketing x x x x x
Colitis def postmarketing x x x x x
Confusional state def postmarketing x x x x
Dizziness def postmarketing x x x x x
Alveolar osteitis def postmarketing x x x x x
Duodenal ulcer def postmarketing x x x x x
Dyspepsia def postmarketing x x x x x
Oedema def postmarketing x x x x x
Embolism def postmarketing x x x x x
Toxic epidermal necrolysis def postmarketing x
Epilepsy def postmarketing x x x
Oesophageal disorder def postmarketing x x x x
Gastrointestinal haemorrhage def postmarketing x x x x x
Hallucination def postmarketing x x x x
Cardiac failure def postmarketing x x x x x
Cardiac failure congestive def postmarketing x x x x x
Heartburn def postmarketing x x x x x
Haemorrhage def postmarketing x x x x x
Hepatitis def postmarketing x x x x
Hyperkalaemia def postmarketing x x x x
Hypersensitivity def postmarketing x x x x x
Hypertension def postmarketing x x x x x
Hypertensive crisis postmarketing x x x
Hyponatraemia def postmarketing x x x x
Infarction def postmarketing x x x x x
Intestinal obstruction def postmarketing x x x x x
Jaundice def postmarketing x x x x
Renal failure acute def postmarketing x x x x
Renal failure chronic def postmarketing x x x x
Leukopenia def postmarketing x x x x
Lymphoma def postmarketing x x x x x
Meningitis def postmarketing x x x x
Meningitis aseptic def postmarketing x x x x
Myocardial infarction def postmarketing x x x x x
Nausea def postmarketing x x x x x
Neoplasm def postmarketing x x x x x
Nephritis def postmarketing x x x x
Nephritis interstitial def postmarketing x x x x
Obstruction def postmarketing x x x x x
Pancreatitis def postmarketing x x x x x
Pancytopenia def postmarketing x x x
Pulmonary oedema def postmarketing x x x x
Pulmonary embolism def postmarketing x x x x x
Renal failure def postmarketing x x x x
Gastric ulcer def postmarketing x x x x
Cerebrovascular accident def postmarketing x x x x x
Thrombocytopenia def postmarketing x x x x
Thrombosis def postmarketing x x x x x
Toothache def postmarketing x x x x x
Ulcer def postmarketing x x x x x
Vasculitis def postmarketing x x x x
Venous thrombosis def postmarketing x x x x
Vomiting def postmarketing x x x x x
Dry mouth def postmarketing x x x x x
Hepatic failure def postmarketing x x x x
Oedema peripheral def postmarketing x x x x x
Deep vein thrombosis def postmarketing x x x x
Allergic cutaneous angiitis def postmarketing x x x x
Necrolysis epidermal postmarketing x x x
Oesophageal ulcer def postmarketing x x x x
Photosensitivity reaction def postmarketing x
Disability def postmarketing x
Epigastric pain postmarketing x x x
Gastric perforation def postmarketing x x x x
Edema of lower extremities postmarketing x x x x x
Duodenal perforation def postmarketing x x x x
Anaphylactoid reaction postmarketing x x x x
Analgesia postmarketing x x x x x
Photosensitivity def postmarketing x
Gastrointestinal symptom NOS postmarketing x x x x
Urolithiasis def postmarketing x x x x x
Alveolitis postmarketing x x x x x
Epilepsy aggravated postmarketing x x x
Hypertensive postmarketing x x x
Death postmarketing x
Somnolence def postmarketing x x x x x
Abdominal distension def x x x x x
Abscess def x x x x x
Alopecia def x x x x x
Anxiety def x x x x x
Arthralgia def x x x x x
Asthenia def x x x x x
Asthma def x x x x x
Atrial fibrillation def x x x x x
Back pain def x x x x x
Mental disorder def x
Blister def x x x x x
Bronchitis def x x x x x
Bursitis def x x x x x
Carcinoma def x x x x x
Basal cell carcinoma def x x x x x
Cellulitis def x x x x x
Chest pain def x x x x x
Conjunctivitis def x x x x x
Constipation def x x x x x
Cough def x x x x x
Cystitis def x x x x x
Cyst def x x x x x
Dental caries def x x x x x
Dermatitis def x x x x x
Dermatitis atopic def x x x x x
Dermatitis contact def x x x x x
Diarrhoea def x x x x x
Dysgeusia def x x x x x
Dyspnoea def x x x x x
Dysuria def x x x x x
Epistaxis def x x x x x
Oesophagitis def x x x x x
Rash def x x x x x
Fatigue def x x x x x
Body temperature increased def x x x x x
Flatulence def x x x x x
Flushing def x x x x x
Gastritis def x x x x x
Gastroenteritis def x x x x x
Gastrooesophageal reflux disease def x x x x x
Haematochezia def x x x x x
Haematoma def x x x x x
Haemorrhoids def x x x x x
Hernia def x x x x x
Diaphragmatic hernia def x x x x x
Herpes NOS def x x x x x
Herpes simplex def x x x x x
Herpes zoster def x x x x x
Hypercholesterolaemia def x x x x x
Hypoaesthesia def x x x x x
Cerumen impaction x x x x x
Infection def x x x x x
Influenza def x x x x x
Arthropathy def x x x x x
Laryngitis def x x x x x
Breast mass def x x x x x
Menopause def x x x x x
Menstrual disorder def x x x x
Cramp muscle def x x x x x
Myopathy def x x x x x
Musculoskeletal pain def x x x x x
Fungal infection def x x x x x
Nasal congestion def x x x x x
Nocturia def x x x x x
Otitis def x x x x x
Otitis media def x x x x x
Postoperative pain def x x x x x
Palpitations def x x x x x
Paraesthesia def x x x x x
Pelvic pain def x x x x x
Pharyngitis def x x x x x
Pneumonia def x x x x x
Pruritus def x x x x x
Respiratory tract infection def x x x x x
Rhinitis def x x x x x
Sciatica def x x x x x
Sinusitis def x x x x x
Muscle spasms def x x x x x
Gastric disorder def x x x x x
Stomatitis def x x x x x
Aphthous stomatitis def x x x x x
Sweating def x x x x x
Swelling def x x x x x
Syncope def x x x x x
Tachycardia def x x x x x
Tendonitis def x x x x x
Tinnitus def x x x x x
Tonsillitis def x x x x x
Tooth impacted def x x x x x
Erythema def x x x x x
Upper respiratory tract infection def x x x x
Urinary tract infection def x x x x x
Urticaria def x x x x x
Vaginal inflammation def x x x x x
Venous insufficiency def x x x x
Vertigo def x x x x x
Viral syndrome x x x x x
Weight increased def x x x x x
Urinary retention def x x x x
Chills def x x x x x
Oral lesion x x x x x
Mouth ulceration def x x x x x
Ventricular extrasystoles def x x x x x
Muscular weakness def x x x x x
Joint swelling x x x x x
Myalgia def x x x x x
Cardiac fibrillation x x x x x
Abdominal tenderness x x x x x
Discomfort def x x x x x
Tenderness def x x x x x
Dry throat x x x x x
Menopausal symptoms def x x x x x
Heart rate irregular x x x x x
Pain in arm x x x x x
Pulmonary congestion x x x x x
Xerosis x x x x x
Fluid retention x x x x x
Gastric flu x x x x x
Vision blurred def x x x x x
Atopy def x x x x x
Stiffness x x x x x
Bradycardia def x x x x x
Neuropathy def x x x x x
Upper limb oedema x x x x x
Oral infection x x x x x
Gas def x x x x x
Insomnia def x x x x x
Epigastric discomfort x x x x x
Weakness def x x x x x
Rhinitis allergic def x x x x x
Indication Labels
Acute pain def x x x x x
Arthritis def x x x x
Aura x x
Cluster headache def x x
Dysmenorrhoea def x x x x x
Headache def x x
Juvenile arthritis def x
Migraine def x x
Osteoarthritis def x x x x x
Pain def x x x x x
Primary dysmenorrhea x x x x x
Rheumatoid arthritis def x x x x

Information

More information: STITCH, PubChem and possibly Wikipedia or Medpedia

ATC Code: M01AH02

Legend

Color scheme: standard – alternative

100%    
75%    
50%    
10%    
frequent (1% to 100%)    
infrequent (0.1% to 1%)    
rare (<0.1%)    
postmarketing    
0%    
no frequency information    
not found on label    

Labels

Labels were obtained from different sources and potentially contain different sets of side effects. If you click on the label name, a HTML version of the label will be shown with proteins, chemicals and side efffects highlighted using Reflect.

  1. ROFECOXIB / VIOXX : 170 side effects (Drugs@FDA)
  2. rofecoxib / Vioxx : 205 side effects (FDA CDER)
  3. rofecoxib / Vioxx : 211 side effects (FDA CDER)
  4. rofecoxib / Vioxx : 211 side effects (FDA MedWatch)
  5. ROFECOXIB / VIOXX : 212 side effects (Drugs@FDA)