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Everolimus

More information: STITCH, PubChem and possibly Wikipedia

ATC Codes: L01XE10, L04AA18

Side effects

Options: Show MedDRA Preferred Terms

Side effect Data for drug Placebo Labels
1 2 3 4 5 6 7
Gastrointestinal disorder 50.2% x x x x x x x
Infection 0.7% - 95% x x x x x x x
Infestation NOS 43.6% x x x x x x x
Nervous system disorder 35.3% x x x x x x
Angiopathy 23.7% x x x x x x x
White blood cell count decreased 2% - 43% 0% - 13% x x x
Calcium low 0.5% - 37% 0% - 12% x
Lymphocyte count decreased 2% - 51% 0% - 28% x x
Asthenia very common, 0% - 19% 0% - 20% x x x
Diarrhoea common — 0% - 50% 0% - 25% x x x x x x x
Headache common — 0% - 30% 0% - 15% x x x x x x
Hypercholesterolaemia very common, 0% - 85% 0% - 46% x x x x x
Hyperglycaemia very common, 25% x x x x x
Hyperlipidaemia common — 9.54% - 52.2% x x x x x x
Oedema peripheral very common, 0% - 44.9% 0% - 8% x x x x x x
Haemoglobin decreased 1% - 92% 1% - 79% x x
Glucose increased 1% - 57% 0% - 25% x x
Nausea common — 0% - 32% 0% - 33% x x x x x x x
Hypertension common — 0% - 47.4% 0% - 6% x x x x x x x
Potassium low 4% - 23% 0% - 5% x x
Tremor 12% x
Hypokalaemia common — 2.07% - 12.9% x x x x
Diabetes mellitus common — 0% - 24.9% 0% - 0.5% x x x x x x
Body temperature increased common — 0% - 31% 0% - 18% x x x x x x
Abdominal pain common — 0% - 36% 1% - 32% x x x x x x x
Pruritus common — 0% - 21% 0% - 13% x x x x x
Phosphate low 0% - 40% 0% - 14% x x
Liver function test abnormal 9.96% x x
Pain very common, 3.27% - 15.4% x x x
Weight decreased common — 0% - 28% 0% - 11% x x x x
Vomiting common — 0% - 29% 0% - 21% x x x x x x x
Stomatitis common — 0% - 78% 0% - 26% x x x x x x x
Sodium decreased 1% - 16% 1% - 16% x
Anxiety very common, 0% - 21% 0% - 3% x x x
Creatinine increased 0% - 50% 0% - 34% x x
Phosphatase alkaline increased 0% - 74% 0% - 66% x x
Hepatitis C 7.88% x
Dyspnoea common — 0.5% - 20% 0% - 7% x x x x x x
Albumin low 1% - 13% 0% - 8% x
Insomnia uncommon — 0% - 26.9% 0% - 8% x x x x x x
Mouth ulceration common — 1.24% - 9.39% x x x x x x
Constipation common — 0% - 42.9% 0% - 13% x x x x x
Cough common — 0% - 25% 0% - 13% x x x x x x
Arthralgia common, 0% - 15% 0% - 7% x x x x x
Dysmenorrhoea 6% x
Metrorrhagia 6% x
Menorrhagia common, 6% - 10% x x x
Decreased appetite common — 0% - 30% 0% - 18% x x x x x
Thromboembolic event very common, 1.24% - 12.2% x
Alopecia common x x x x
Anaemia common — 0% - 61% 0% - 49% x x x x x x x
Cellulitis common, 29% x x x x
Chest pain 5% x x
Dysphagia common, 4% x x x x
Dehydration common x x x x
Dysgeusia common — 0% - 19% 0% - 5% x x x x
Dyspepsia common x x x
Epistaxis common — 0% - 22% 0% - 1% x x x x x x
Rash common — 0% - 59% 0% - 19% x x x x x x x
Fatigue common — 0% - 45% 0% - 27% x x x x x
Flatulence common x x x
Gastritis common x x
Gingivitis common x
Haemorrhage common, 3% x x x x
Haemorrhoids 5% x x
Hypertriglyceridaemia common, 0% - 52% 0% - 15% x x x x x
Hypocalcaemia common x x
Irritability common x x
Leukopenia common, 0% - 37% 0% - 21% x x x x x x x
Lymphopenia common, 0% - 20% 0% - 8% x x x x
Nail disorder common, 0% - 22% 0% - 2% x x x
Nasopharyngitis common, 0% - 25% 0% - 13% x x x x
Neutropenia common, 0% - 46% 0% - 41% x x x x x
Otitis media common, 6% x x x
Ovarian cyst common x x
Paraesthesia 5% x x
Pharyngitis common x x
Pneumonia uncommon — 0.5% - 17% 0% x x x x x x x
Renal failure common, 3% x x x x
Pharyngitis streptococcal common, 0% - 10% 0% - 3% x x x
Sinusitis common x x x
Aphthous stomatitis common x x x
Thrombocytopenia common — 0% - 19% 0% - 3% x x x x x x
Urinary tract infection common, 0% - 16% 0% - 6% x x x x x x
Dry mouth common, 0% - 11% 0% - 4% x x x
Hypophosphataemia common, 0% - 49% 0% - 15% x x x x x
Aspartate aminotransferase increased common x x x
Alanine aminotransferase increased common x x x x
Dry skin common, 0% - 13% 0% - 6% x x x x
Viral diarrhoea common x x
Menstruation irregular uncommon — 6% - 10% x x x x
Oral pain common x x x
Myalgia common, 1.66% - 7.17% x x x
Dermatitis acneiform common, 3% x x x x
Tongue ulceration common x x
Blood creatinine increased common x x x
Lung infiltration common x x
Skin exfoliation common x
Menstruation delayed common x x
Mucosal inflammation common x x x
Alveolitis common x x
Acne common, 0% - 22% 0% - 5% x x x x
Pulmonary alveolar haemorrhage common x x
Blood luteinising hormone increased common x x
Blood lactate dehydrogenase increased common x x
Pulmonary toxicity common x x
Vaginal haemorrhage common, 8% x x x
Pleural effusion 1.83% - 25.4% x x x x
Skin lesion common, 4% x x
Erythema uncommon — 4% x x x x
Eyelid oedema common, 4% x x
Onychoclasis common, 4% x x
Oropharyngeal pain common, 0% - 11% 0% - 6% x x x x
Pain in extremity 0% - 14% 0% - 6% x x
Tachycardia common, 2.04% - 7.09% x x x
Proteinuria uncommon — 0.83% - 9.12% x x x x x x
Gastroenteritis 1% - 10% 0% - 3% x x
Chills 4% x x
Pharyngolaryngeal pain 4% x
Dizziness 0% - 12% 0% - 7% x x
Potassium increased 0% - 7% 0.5% - 10% x
Hepatic enzyme abnormal 1.87% - 9.96% x x
Lymphocele 0% - 7.66% x x x
Incisional hernia common, 1.1% - 6.94% x x x
Malaise 0.5% - 45% 0.5% - 27% x x
Pain in jaw 3% x
Platelet count decreased 0% - 45% 0% - 11% x x
Rhinorrhoea 3% x x
Amenorrhoea rare — common x x x x
Erectile dysfunction common, 1.22% - 5.38% x x x
Thrombosis common, 1.1% - 2.19% x x x
Dyspnoea exertional 0.5% - 20% 0% - 7% x
Conjunctivitis uncommon, 2% x x x
Angioedema postmarketing — 1.22% - 5.02% x x x x x x
Back pain 0% - 15% 0% - 11% x x
Oedema 0.5% - 39% 0% - 12% x x x
Respiratory tract infection 1% - 31% 0% - 23% x
Blood bilirubin increased 1% - 10% 0% - 14% x x
Interstitial lung disease common, 0.408% - 2.51% x x x x x
Pancytopenia uncommon — 0% - 3.67% x x x x x
Acute respiratory failure 0.7% x
Pericardial effusion 0.365% - 39.8% x x
Pancreatitis postmarketing — 0% - 1.43% x x x
Aggression uncommon, 0% - 21% 0% - 3% x x x
Flushing uncommon x
Glossodynia uncommon x x
Glossitis uncommon x x x
Cardiac failure congestive uncommon, 1% x x x x
Haemoptysis uncommon x x
Herpes zoster uncommon x x x
Hypersensitivity uncommon, 3% x x x x x
Jaundice uncommon, 0% - 2.07% x x
Renal failure acute uncommon, 0.4% x x x x
Opportunistic infection uncommon x x
Pulmonary embolism postmarketing, uncommon x x x x x
Rhabdomyolysis uncommon x
Deep vein thrombosis uncommon, 1% x x x x x
Rash macular uncommon x x
Rash erythematous uncommon x x
Gingival pain uncommon x x
Sepsis uncommon x x x x x x
Lip ulceration uncommon x x
Bronchitis viral uncommon x x
Rash maculo-papular uncommon x x
Non-cardiac chest pain uncommon x x
Rash generalised uncommon x x
Blood follicle stimulating hormone increased uncommon x x
Ageusia uncommon x x
Renal tubular necrosis 0% - 5.47% x x
Migraine 0% - 30% 0% - 15% x x
Impaired healing rare — 1% x x x x x x
Productive cough 0% - 25% 0% - 13% x
Hepatitis uncommon, 0.358% - 2.07% x x
Coagulopathy uncommon, 0% - 0.733% x x
Wound complication uncommon, 0% - 0.373% x x
Aplasia pure red cell rare, uncommon x x
Acute respiratory distress syndrome rare, uncommon x x
Pancreatitis acute postmarketing x
Cholecystitis postmarketing x
Cholelithiasis postmarketing x
Infertility male postmarketing x
Reflex sympathetic dystrophy postmarketing x
Abdominal distension x
Acidosis x
Angina pectoris x
Anorexia x x
Ascites x
Aspergillosis x x
Atelectasis x
Atrial fibrillation x
Bacteraemia x
Mental disorder x x x x x x
Breast cancer x
Breast disorder x x x x x x
Bronchospasm x
Bronchitis x
Candida infection x x x
Oral candidiasis x
Basal cell carcinoma x
Squamous cell carcinoma x
Connective tissue disorder x x x x x x x
Cytomegalovirus infection x
Sudden death x
Dermatitis exfoliative x
Dysuria x
Endocrine disorder x x x
Eye disorder x x x
Fibrosis x
Folliculitis x
Gastrooesophageal reflux disease x
Gingival hypertrophy x
Glioblastoma x
Glomerulonephritis x
Gout x
Hallucination x
Cardiac arrest x
Cardiac disorder x x x x x
Cardiac failure x
Haematemesis x
Blood disorder x
Haematoma x
Haematuria x
Hemiparesis x
Haemolytic uraemic syndrome x x
Hepatitis B x x
Chronic hepatitis x
Herpes virus infection x
Hirsutism x
Histiocytosis x
Hydronephrosis x
Hypercalcaemia x
Hyperhidrosis x
Hyperkalaemia x
Hyperparathyroidism x
Hypertensive crisis x
Hypertrichosis x
Hypoaesthesia x
Hypoglycaemia x x
Hyponatraemia x
Hypotension x
Immune system disorder x x x
Inflammation x
Influenza x
Seborrhoeic keratosis x
Lethargy x
Leukocytosis x
Cirrhosis alcoholic x
Liver disorder x
Lymphoma x x x
Lymphoproliferative disorder x x x
Mediastinal disorder x x x x x x x
Musculoskeletal pain x
Fungal infection x
Myocardial infarction x
Nasal congestion x
Neoplasm x x
Nephritis interstitial x
Nephrosclerosis x
Neuralgia x
Night sweats x
Osteomyelitis x
Osteonecrosis x
Osteopenia x
Osteoporosis x
Palpitations x
Peritonitis x
Polyuria x
Alveolar proteinosis x x
Pulmonary oedema x
Thrombotic thrombocytopenic purpura common, 0% - 1.46% x x x
Pyelonephritis common, 0% - 2.19% x x x
Pyuria x
Rhinitis 0% - 25% 0% - 13% x
Kaposi's sarcoma x
Convulsion x
Neoplasm skin x
Muscle spasms 0% - 10% 0% - 4% x x
Spondylitis x
Syncope x
Tinea pedis x
Onychomycosis x
Upper respiratory tract infection 0% - 11% 0% - 5% x x x x x
Urethritis x
Pollakiuria x
Urinary tract disorder x x x x x x x
Viral infection x x x
Vitamin B12 deficiency x
Wheezing x
Wound infection x x x
Wound x
Xeroderma 0% - 13% 0% - 6% x
Urinary retention x
Hepatic failure x
Micturition urgency x
Agitation x x
Cataract x
Benign neoplasm x
Lower respiratory tract infection x
Blood urea increased x
Generalised oedema x
Scrotal oedema x
Gonadotropic luteinizing hormone increased x
Hypogonadism male uncommon, 0% - 0.733% x x
Hypomagnesaemia x
Muscular weakness x
Sinus congestion x
Joint swelling x
Malnutrition x x x x x x x
Unspecified disorder of skin and subcutaneous tissue x x x x x x x
Fatal outcomes x x x
Erythropenia x
Abdominal pain upper x
Amenorrhea secondary x x
Chest discomfort x
Hepatic enzyme increased x
Renal vein thrombosis x
Iron deficiency x
Activated partial thromboplastin time prolonged x
Testosterone low uncommon, 0% - 0.733% x x
Dyslipidaemia x
Disease progression x
Wound dehiscence x
Seroma x
Hepatobiliary disease x x x x
Fluid retention x
Glomerulonephropathy x
Metastatic melanoma x
Uraemic syndrome common, 0% - 1.46% x
Lymphorrhoea x
Renal artery thrombosis x
Oral herpes x
Vision blurred x
Hepatic cancer x
Skin papilloma x
Hepatic artery thrombosis x
Renal haemorrhage x
Bladder spasm x
Transaminases increased x
Perirenal haematoma x
Pruritus generalised 0% - 21% 0% - 13% x
Respiratory distress x
Lymphadenopathy x
Blood cholesterol increased x
Nephrotoxicity x
Hot flush x
Serum creatinine increased x
Hyperuricaemia x
End stage liver disease x
Lymphangioleiomyomatosis x x
Thrombocytosis x
Lipids increased x
Blood and lymphatic system disorders x x x x x x
Blood alkaline phosphatase increased x
Blood triglycerides increased x
Graft loss x
Graft thrombosis x x
Colorectal cancer metastatic x
Polyomavirus infections x
BK virus infection x
Incision site pain x
Hepatitis B reactivation x x x
Perinephric collection x
Ileus x
Epigastric discomfort x
Renal impairment x
Procedural pain x
Venous thromboembolism x x
Localised intraabdominal fluid collection x
Hepatocellular carcinoma x
Fasting hyperglycaemia 0% - 14% 0% - 8% x
Thrombotic microangiopathy common, 0% - 1.46% x x
Infectious pneumonitis x x
Somnolence x
Leukocytoclastic vasculitis x
Infection reactivation x x

Indications

Information about indications was extracted from the indications and usage sections of the labels.

CERTICAN / Certican, Tablet

Side effects:71
Source:Medsafe

everolimus / CERTICAN

Side effects:82
Source:medicines.org.au

everolimus / everolimus

Side effects:100
Source:EMA

everolimus / everolimus

Side effects:108
Source:EMA

everolimus / AFINITOR

Side effects:137
Source:medicines.org.au

EVEROLIMUS

Side effects:147
Source:FDA Structured Product Label

EVEROLIMUS

Side effects:243
Source:FDA Structured Product Label

Color scheme:

standard – alternative

    100%
    75%
    50%
    10%
    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    postmarketing
    0%
    no frequency information
    not found on label