|
Side effect
|
Data for drug
|
Placebo
|
Labels
|
|
|
1
|
2
|
3
|
4
|
5
|
|
Thrombocytopenia
|
very common, 9% - 42%
|
|
x
|
x
|
x
|
x
|
x
|
|
Hyperbilirubinaemia
|
very common
|
|
|
x
|
x
|
x
|
x
|
|
Neutropenia
|
very common, 11% - 42%
|
|
x
|
x
|
x
|
x
|
x
|
|
Unspecified disorder of skin and subcutaneous tissue
|
0% - 36%
|
|
x
|
x
|
x
|
x
|
x
|
|
Lipase increased
|
very common, 4% - 18%
|
|
x
|
x
|
x
|
x
|
x
|
|
Blood phosphorus decreased
|
very common
|
|
|
x
|
|
x
|
x
|
|
Hypophosphataemia
|
uncommon — 6% - 17%
|
|
x
|
x
|
x
|
x
|
x
|
|
Malnutrition
|
1% - 17%
|
|
x
|
x
|
x
|
x
|
x
|
|
Anaemia
|
common, 4% - 27%
|
|
x
|
x
|
x
|
x
|
x
|
|
Blood bilirubin increased
|
common — 1% - 9%
|
|
x
|
x
|
x
|
x
|
x
|
|
Mediastinal disorder
|
0% - 27%
|
|
x
|
x
|
x
|
x
|
x
|
|
Angiopathy
|
1% - 11%
|
|
x
|
x
|
x
|
x
|
x
|
|
Infection
|
0% - 24%
|
|
x
|
x
|
x
|
x
|
x
|
|
Infestation NOS
|
0% - 24%
|
|
x
|
x
|
x
|
x
|
x
|
|
Abdominal distension
|
uncommon, common
|
|
x
|
x
|
x
|
x
|
x
|
|
Amnesia
|
common
|
|
|
x
|
x
|
x
|
x
|
|
Angina pectoris
|
uncommon, common
|
|
x
|
x
|
x
|
x
|
x
|
|
Anorexia
|
common
|
|
x
|
|
|
x
|
x
|
|
Anxiety
|
uncommon, common
|
|
x
|
x
|
x
|
x
|
x
|
|
Arrhythmia
|
common
|
|
|
x
|
x
|
x
|
x
|
|
Atrial fibrillation
|
uncommon, common
|
|
x
|
x
|
x
|
x
|
x
|
|
Atrioventricular block
|
common
|
|
|
x
|
x
|
x
|
x
|
|
Back pain
|
common
|
|
x
|
x
|
x
|
x
|
x
|
|
Neck pain
|
common
|
|
|
|
x
|
x
|
x
|
|
Chest pain
|
uncommon, common
|
|
x
|
x
|
x
|
x
|
x
|
|
Confusional state
|
common
|
|
x
|
|
x
|
x
|
x
|
|
Conjunctivitis
|
uncommon, common
|
|
x
|
x
|
x
|
x
|
x
|
|
Connective tissue disorder
|
common, 0% - 19%
|
|
x
|
x
|
x
|
x
|
x
|
|
Contusion
|
common
|
|
|
x
|
x
|
x
|
x
|
|
Cough
|
common
|
|
x
|
x
|
x
|
x
|
x
|
|
Dermatitis
|
common
|
|
|
x
|
x
|
x
|
x
|
|
Diabetes mellitus
|
common
|
|
x
|
x
|
x
|
x
|
x
|
|
Dizziness
|
common
|
|
x
|
x
|
x
|
x
|
x
|
|
Dysgeusia
|
common
|
|
|
x
|
x
|
x
|
x
|
|
Dyspnoea
|
common
|
|
x
|
x
|
x
|
x
|
x
|
|
Ear pain
|
common
|
|
x
|
|
x
|
x
|
x
|
|
Eczema
|
common
|
|
x
|
x
|
x
|
x
|
x
|
|
Eosinophilia
|
common
|
|
|
x
|
x
|
x
|
x
|
|
Epistaxis
|
uncommon, common
|
|
x
|
x
|
x
|
x
|
x
|
|
Eye haemorrhage
|
uncommon, common
|
|
x
|
|
x
|
x
|
x
|
|
Body temperature increased
|
common
|
|
x
|
x
|
x
|
x
|
x
|
|
Flank pain
|
uncommon, common
|
|
|
x
|
x
|
x
|
x
|
|
Flatulence
|
common
|
|
x
|
x
|
x
|
x
|
x
|
|
Flushing
|
common
|
|
x
|
x
|
x
|
x
|
x
|
|
Cardiac flutter
|
common
|
|
x
|
|
x
|
x
|
x
|
|
Folliculitis
|
common
|
|
|
x
|
x
|
x
|
x
|
|
Hypercalcaemia
|
common
|
|
x
|
|
x
|
x
|
x
|
|
Hypercholesterolaemia
|
common, 0% - 1%
|
|
|
x
|
x
|
x
|
x
|
|
Hyperglycaemia
|
common, 1% - 12%
|
|
x
|
x
|
x
|
x
|
x
|
|
Hyperhidrosis
|
common
|
|
x
|
x
|
x
|
x
|
x
|
|
Hyperkalaemia
|
uncommon — 1% - 6%
|
|
x
|
x
|
x
|
x
|
x
|
|
Hyperlipidaemia
|
common
|
|
|
x
|
x
|
x
|
x
|
|
Hypertension
|
common
|
|
x
|
x
|
x
|
x
|
x
|
|
Hypertriglyceridaemia
|
common
|
|
|
x
|
x
|
x
|
x
|
|
Hypoaesthesia
|
uncommon, common
|
|
x
|
x
|
x
|
x
|
x
|
|
Hyponatraemia
|
uncommon — 1% - 7%
|
|
x
|
|
x
|
x
|
x
|
|
Eye pruritus
|
common
|
|
|
x
|
x
|
x
|
x
|
|
Lymphopenia
|
common
|
|
|
x
|
x
|
x
|
x
|
|
Musculoskeletal pain
|
uncommon, common
|
|
x
|
x
|
x
|
x
|
x
|
|
Nasopharyngitis
|
common
|
|
x
|
x
|
x
|
x
|
x
|
|
Night sweats
|
common
|
|
x
|
x
|
x
|
x
|
x
|
|
Pain
|
uncommon, common
|
|
|
x
|
x
|
x
|
x
|
|
Palpitations
|
common
|
|
x
|
x
|
x
|
x
|
x
|
|
Pancreatitis
|
uncommon, common
|
|
x
|
x
|
x
|
x
|
x
|
|
Pancytopenia
|
uncommon, common
|
|
x
|
x
|
x
|
x
|
x
|
|
Paraproteinaemia
|
common
|
|
|
x
|
x
|
x
|
x
|
|
Paraesthesia
|
uncommon, common
|
|
x
|
x
|
x
|
x
|
x
|
|
Neuropathy peripheral
|
common
|
|
x
|
x
|
x
|
x
|
x
|
|
Pharyngitis
|
uncommon, common
|
|
x
|
x
|
x
|
x
|
x
|
|
Rhinitis
|
common
|
|
|
x
|
x
|
x
|
x
|
|
Tachycardia
|
common
|
|
|
x
|
x
|
x
|
x
|
|
Tinnitus
|
common
|
|
|
|
x
|
x
|
x
|
|
Upper respiratory tract infection
|
common
|
|
|
x
|
x
|
x
|
x
|
|
Pollakiuria
|
uncommon, common
|
|
x
|
x
|
x
|
x
|
x
|
|
Urticaria
|
common
|
|
x
|
x
|
x
|
x
|
x
|
|
Vertigo
|
common
|
|
x
|
x
|
x
|
x
|
x
|
|
Weight increased
|
common
|
|
x
|
x
|
x
|
x
|
x
|
|
Weight decreased
|
common
|
|
x
|
x
|
x
|
x
|
x
|
|
Xerophthalmia
|
common
|
|
|
x
|
x
|
x
|
x
|
|
Hyperphosphataemia
|
common
|
|
x
|
|
x
|
x
|
x
|
|
Hepatic function abnormal
|
common
|
|
|
x
|
x
|
x
|
x
|
|
Periorbital oedema
|
uncommon, common
|
|
x
|
x
|
x
|
x
|
x
|
|
Ventricular extrasystoles
|
common
|
|
|
x
|
|
|
|
|
Gamma-glutamyltransferase increased
|
common
|
|
x
|
x
|
x
|
x
|
x
|
|
Hypomagnesaemia
|
common
|
|
x
|
|
x
|
x
|
x
|
|
Electrocardiogram QT prolonged
|
common
|
|
x
|
x
|
x
|
x
|
x
|
|
Dry skin
|
common, 0% - 10%
|
|
x
|
x
|
x
|
x
|
x
|
|
Haemoglobin decreased
|
uncommon, common
|
|
|
x
|
x
|
x
|
x
|
|
Malaise
|
uncommon, common
|
|
x
|
x
|
x
|
x
|
x
|
|
Dyspnoea exertional
|
common
|
|
x
|
x
|
x
|
x
|
x
|
|
Abdominal discomfort
|
common
|
|
x
|
x
|
x
|
x
|
x
|
|
Disorientation
|
common
|
|
x
|
|
x
|
x
|
x
|
|
Dysphoria
|
common
|
|
|
x
|
x
|
x
|
x
|
|
Chest discomfort
|
common
|
|
|
x
|
x
|
x
|
x
|
|
Dry eye
|
uncommon, common
|
|
x
|
x
|
x
|
x
|
x
|
|
Extrasystoles
|
common
|
|
|
|
x
|
x
|
x
|
|
Electrolyte imbalance
|
common
|
|
|
|
x
|
x
|
x
|
|
Skin papilloma
|
common
|
|
|
x
|
x
|
x
|
x
|
|
Bradycardia
|
uncommon, common
|
|
x
|
x
|
x
|
x
|
x
|
|
Musculoskeletal chest pain
|
common
|
|
x
|
|
x
|
x
|
x
|
|
Non-cardiac chest pain
|
common
|
|
|
x
|
x
|
x
|
x
|
|
Blood glucose increased
|
common
|
|
x
|
|
|
|
|
|
Febrile neutropenia
|
common
|
|
x
|
x
|
x
|
x
|
x
|
|
Blood insulin increased
|
common
|
|
|
x
|
|
x
|
x
|
|
Blood alkaline phosphatase increased
|
common
|
|
x
|
x
|
x
|
x
|
x
|
|
Blood amylase increased
|
common
|
|
x
|
x
|
x
|
x
|
x
|
|
Blood creatine phosphokinase increased
|
common
|
|
|
|
|
x
|
|
|
Insomnia
|
common
|
|
x
|
x
|
x
|
x
|
x
|
|
Oral papilloma
|
common
|
|
|
x
|
x
|
x
|
x
|
|
Hearing impaired
|
common
|
|
x
|
|
x
|
x
|
x
|
|
Dysphonia
|
common
|
|
x
|
|
x
|
x
|
x
|
|
Mental disorder
|
0% - 12%
|
|
x
|
x
|
x
|
x
|
x
|
|
Dyspepsia
|
common, 0% - 6%
|
|
x
|
x
|
x
|
x
|
x
|
|
Alanine aminotransferase increased
|
common — 3% - 9%
|
|
x
|
x
|
x
|
x
|
x
|
|
Nervous system disorder
|
very common, 1% - 35%
|
|
x
|
x
|
x
|
x
|
x
|
|
Erythema
|
common, 0% - 6%
|
|
x
|
x
|
x
|
x
|
x
|
|
Aspartate aminotransferase increased
|
common — 1% - 3%
|
|
x
|
x
|
x
|
x
|
x
|
|
Oedema peripheral
|
common, 0% - 17%
|
|
|
x
|
x
|
x
|
x
|
|
Rash
|
0% - 37%
|
|
x
|
x
|
x
|
x
|
x
|
|
Diarrhoea
|
0% - 30%
|
|
x
|
x
|
x
|
x
|
x
|
|
Hypocalcaemia
|
uncommon — 1% - 5%
|
|
x
|
x
|
x
|
x
|
x
|
|
Hypokalaemia
|
uncommon — 1% - 9%
|
|
x
|
x
|
x
|
x
|
x
|
|
Bone pain
|
common, 0% - 6%
|
|
x
|
x
|
x
|
x
|
x
|
|
Albumin low
|
0% - 4%
|
|
x
|
|
x
|
|
|
|
Headache
|
1% - 22%
|
|
x
|
x
|
x
|
x
|
x
|
|
Fatigue
|
very common, 0% - 17%
|
|
x
|
x
|
x
|
x
|
x
|
|
Gastrointestinal disorder
|
very common, 1% - 37%
|
|
x
|
x
|
x
|
x
|
x
|
|
Arthralgia
|
0% - 9%
|
|
x
|
x
|
x
|
x
|
x
|
|
Nausea
|
0% - 34%
|
|
x
|
x
|
x
|
x
|
x
|
|
Muscle spasms
|
0% - 29%
|
|
x
|
x
|
x
|
x
|
x
|
|
Vomiting
|
0% - 18%
|
|
x
|
x
|
x
|
x
|
x
|
|
Arteriosclerosis
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Arthritis
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Blepharitis
|
uncommon
|
|
x
|
x
|
x
|
x
|
x
|
|
Blister
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Body temperature altered
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Bronchitis
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Candida infection
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Oral candidiasis
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Pleuritic pain
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Cholestasis
|
uncommon
|
|
|
|
x
|
x
|
x
|
|
Conjunctival haemorrhage
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Conjunctivitis allergic
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Cyanosis
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Dehydration
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Sensitivity of teeth
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Drug eruption
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Diplopia
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Dysuria
|
uncommon
|
|
x
|
x
|
x
|
x
|
x
|
|
Ecchymosis
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Localised oedema
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Enterocolitis
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Erythema multiforme
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Erythema nodosum
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Gastritis
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Gastroenteritis
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Gastrooesophageal reflux disease
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Gastrointestinal haemorrhage
|
uncommon
|
|
x
|
x
|
x
|
x
|
x
|
|
Gingivitis
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Gout
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Gynaecomastia
|
uncommon
|
|
x
|
x
|
x
|
x
|
x
|
|
Cardiomegaly
|
uncommon
|
|
x
|
|
|
|
x
|
|
Cardiac failure
|
uncommon
|
|
x
|
x
|
x
|
x
|
x
|
|
Cardiac murmur
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Haematemesis
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Haematoma
|
uncommon
|
|
x
|
x
|
x
|
x
|
x
|
|
Haematuria
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Haemorrhoids
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Hepatitis
|
uncommon
|
|
x
|
|
|
|
|
|
Hepatitis toxic
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Hepatomegaly
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Herpes virus infection
|
uncommon
|
|
|
x
|
|
x
|
x
|
|
Hyperaemia
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Hyperaesthesia
|
uncommon
|
|
x
|
x
|
x
|
x
|
x
|
|
Hyperparathyroidism secondary
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Pulmonary hypertension
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Hypertensive crisis
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Hyperthyroidism
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Hypoglycaemia
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Hypotension
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Hypothyroidism
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Intermittent claudication
|
uncommon
|
|
|
x
|
x
|
|
|
|
Jaundice
|
uncommon
|
|
x
|
x
|
x
|
x
|
x
|
|
Lethargy
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Leukocytosis
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Breast pain
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Melaena
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Myocardial infarction
|
uncommon
|
|
x
|
x
|
x
|
x
|
x
|
|
Nocturia
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Optic neuritis
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Papilloedema
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Pericardial effusion
|
uncommon
|
|
x
|
x
|
x
|
x
|
x
|
|
Pericarditis
|
uncommon
|
|
x
|
x
|
x
|
x
|
x
|
|
Petechiae
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Pleural effusion
|
uncommon
|
|
x
|
x
|
x
|
x
|
x
|
|
Pleurisy
|
uncommon
|
|
x
|
x
|
x
|
x
|
x
|
|
Pneumonia
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Psoriasis
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Pulmonary oedema
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Renal failure
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Restless legs syndrome
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Shock haemorrhagic
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Skin ulcer
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Gastric ulcer
|
uncommon
|
|
x
|
x
|
x
|
x
|
x
|
|
Stomatitis
|
uncommon
|
|
x
|
x
|
x
|
x
|
x
|
|
Syncope
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Thrombosis
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Thyroiditis
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Tinea pedis
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Tremor
|
uncommon
|
|
x
|
x
|
x
|
x
|
x
|
|
Loss of consciousness
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Urinary incontinence
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Urinary tract infection
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Wheezing
|
uncommon
|
|
|
|
x
|
x
|
x
|
|
Dry mouth
|
uncommon
|
|
x
|
x
|
x
|
x
|
x
|
|
Chills
|
uncommon
|
|
x
|
x
|
x
|
x
|
x
|
|
Micturition urgency
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Photopsia
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Photophobia
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Mouth ulceration
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Migraine
|
uncommon
|
|
x
|
x
|
x
|
x
|
x
|
|
Skin atrophy
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Blood urea increased
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Swelling face
|
uncommon
|
|
x
|
x
|
x
|
x
|
x
|
|
Globulins decreased
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Haemorrhage intracranial
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Retroperitoneal haemorrhage
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Skin hypertrophy
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Muscular weakness
|
uncommon
|
|
x
|
x
|
x
|
x
|
x
|
|
Eye pain
|
uncommon
|
|
x
|
x
|
x
|
x
|
x
|
|
Skin discolouration
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Joint swelling
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Eyelid oedema
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Skin hyperpigmentation
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Interstitial lung disease
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Oesophageal pain
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Increased appetite
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Disturbance in attention
|
uncommon
|
|
|
|
x
|
x
|
x
|
|
Visual acuity reduced
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Eye irritation
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Hepatotoxicity
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Blood creatinine increased
|
uncommon
|
|
x
|
|
|
|
x
|
|
Gravitational oedema
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Skin exfoliation
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Dermal cyst
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Pain of skin
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Subcutaneous abscess
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Furuncle
|
uncommon
|
|
|
|
x
|
x
|
x
|
|
Dyslipidaemia
|
uncommon
|
|
|
x
|
|
x
|
x
|
|
Erectile dysfunction
|
uncommon
|
|
x
|
x
|
x
|
x
|
x
|
|
Ventricular dysfunction
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Sepsis
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Arterial occlusion
|
uncommon
|
|
|
|
|
|
x
|
|
Rectal haemorrhage
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Eye swelling
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Anal abscess
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Chorioretinopathy
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Vision blurred
|
uncommon
|
|
x
|
x
|
x
|
x
|
x
|
|
Photosensitivity
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Dysaesthesia
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Sebaceous hyperplasia
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Blood pressure increased
|
uncommon
|
|
|
|
|
|
x
|
|
Influenza like illness
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Chromaturia
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Face oedema
|
uncommon
|
|
x
|
x
|
x
|
x
|
x
|
|
Blood glucose decreased
|
uncommon
|
|
x
|
|
|
|
x
|
|
Throat irritation
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Hyperuricaemia
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Thrombocytosis
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Blood parathyroid hormone increased
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Blood lactate dehydrogenase increased
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Blood bilirubin unconjugated increased
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Blood insulin decreased
|
uncommon
|
|
|
x
|
|
x
|
x
|
|
Gastrointestinal ulcer perforation
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Pharyngolaryngeal pain
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Insulin C-peptide decreased
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Hyperkeratosis
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Arterial stenosis limb
|
uncommon
|
|
|
|
x
|
|
|
|
Subileus
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Musculoskeletal stiffness
|
uncommon
|
|
|
|
x
|
x
|
x
|
|
Troponin increased
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Peripheral arterial occlusive disease
|
uncommon
|
|
|
x
|
x
|
x
|
|
|
Brain oedema
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Ocular surface disease
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Exfoliative rash
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Coronary artery disease
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Oropharyngeal pain
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Oesophagitis ulcerative
|
uncommon
|
|
x
|
|
x
|
x
|
x
|
|
Feeling hot
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Hiatus hernia
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
|
Visual impairment
|
uncommon
|
|
|
|
x
|
x
|
x
|
|
Decreased appetite
|
uncommon — 0% - 8%
|
|
x
|
x
|
x
|
x
|
x
|
|
Abdominal pain
|
0% - 10%
|
|
x
|
x
|
x
|
x
|
x
|
|
Asthenia
|
common, 0% - 9%
|
|
x
|
x
|
x
|
x
|
x
|
|
Constipation
|
0% - 12%
|
|
x
|
x
|
x
|
x
|
x
|
|
Pain in extremity
|
1% - 7%
|
|
x
|
x
|
x
|
x
|
x
|
|
Pruritus
|
0% - 24%
|
|
x
|
x
|
x
|
x
|
x
|
|
Creatinine increased
|
0% - 1%
|
|
x
|
x
|
x
|
x
|
x
|
|
Phosphatase alkaline increased
|
0% - 1%
|
|
x
|
|
x
|
|
|
|
Myalgia
|
1% - 12%
|
|
x
|
x
|
x
|
x
|
x
|
|
Tumour lysis syndrome
|
rare
|
|
|
x
|
|
x
|
x
|
|
Alopecia
|
common, 0% - 14%
|
|
x
|
x
|
x
|
x
|
x
|
|
Appetite disorder
|
|
|
|
x
|
|
|
|
|
Breast disorder
|
|
|
x
|
x
|
x
|
x
|
x
|
|
Transient ischaemic attack
|
|
|
|
|
x
|
|
|
|
Cyst
|
|
|
|
x
|
|
|
|
|
Oedema
|
|
|
x
|
|
|
|
|
|
Endocrine disorder
|
|
|
x
|
x
|
x
|
x
|
x
|
|
Eye disorder
|
|
|
x
|
x
|
x
|
x
|
x
|
|
Cardiac disorder
|
|
|
x
|
x
|
x
|
x
|
x
|
|
Haemorrhage
|
|
|
|
|
|
x
|
x
|
|
Herpes simplex
|
|
|
x
|
|
|
|
|
|
Hypersensitivity
|
|
|
|
x
|
x
|
x
|
x
|
|
Immune system disorder
|
|
|
|
x
|
x
|
x
|
x
|
|
Influenza
|
|
|
|
|
x
|
|
|
|
Bundle branch block left
|
|
|
|
x
|
|
|
|
|
Leukopenia
|
|
|
x
|
|
x
|
|
|
|
Menorrhagia
|
|
|
|
x
|
x
|
x
|
x
|
|
Neoplasm
|
|
|
|
x
|
x
|
x
|
x
|
|
Polyp
|
|
|
|
x
|
|
|
|
|
Torsade de pointes
|
|
|
|
x
|
|
x
|
x
|
|
Urinary tract disorder
|
|
|
x
|
x
|
x
|
x
|
x
|
|
Oesophageal ulcer
|
|
|
|
x
|
|
|
|
|
Abdominal pain upper
|
|
|
|
x
|
x
|
x
|
x
|
|
Nipple swelling
|
|
|
|
x
|
x
|
x
|
x
|
|
Hepatobiliary disease
|
|
|
x
|
x
|
x
|
x
|
x
|
|
Fluid retention
|
|
|
|
|
|
x
|
x
|
|
Breast induration
|
|
|
|
x
|
x
|
x
|
x
|
|
Diastolic dysfunction
|
|
|
|
x
|
|
|
|
|
Blood and lymphatic system disorders
|
|
|
x
|
x
|
x
|
x
|
x
|
|
Ear and labyrinth disorders
|
|
|
x
|
x
|
x
|
x
|
x
|
|
Blood potassium decreased
|
|
|
x
|
|
|
|
|
|
Myelosuppression
|
|
|
x
|
x
|
x
|
x
|
x
|
