Bortezomib

Side effects and indications

Whenever possible, frequency information about the side effects was extracted from the labels. Aggregated frequency information for the drug and, if available, placebo is shown. To the right, you can click on shaded boxes to be taken to mentions of the side effect on the label. (In some cases, the side effect cannot be highlighted due to conversion problems.) Information about indications was extracted from the indications and usage sections of the labels.

Show MedDRA Preferred Terms

Side effect Data for drug Placebo Labels
1 2 3 4 5 6 7 8 9
Asthenia def 11.8% - 60.7% x x x x x x x x
Diarrhoea def 0% - 57.4% x x x x x x x x x
Nausea def 0% - 57.4% x x x x x x x x x
Constipation def 0% - 42.3% x x x x x x x x x
Neuropathy peripheral def 7.25% - 36.3% x x x x x x x x x
Neuropathy def postmarketing, 7.25% - 36.3% x x x x x x x x x
Mental disorder def postmarketing, 2.72% - 35.3% x x x x x x
Vomiting def 0% - 35.3% x x x x x x x x x
Body temperature increased def 0% - 35% x x x x x x x x x
Thrombocytopenia def 3.63% - 34.7% x x x x x x x x x
Anorexia def 0% - 33.8% x x x x x x x x x
Decreased appetite 0% - 33.8% x x x x x x x x
Paraesthesia def 0% - 27.5% x x x x x x x x x
Dysaesthesia def 0% - 27.5% x x x x x x x
Anaemia def 9.37% - 26.3% x x x x x x x x x
Headache def 0% - 25.7% x x x x x x x x x
Cough def 0% - 21.1% x x x x x x x x x
Dyspnoea def postmarketing, 4.83% - 19.6% x x x x x x x x x
Neutropenia def 2.42% - 18.7% x x x x x x x x x
Rash def postmarketing, 0% - 18.4% x x x x x x x x x
Insomnia def 0% - 18.1% x x x x x x x x x
Abdominal pain def 0% - 16% x x x x x x x x x
Pain def postmarketing, 0% - 16% x x x x x x x x x
Bone pain def 0% - 15.7% x x x x x x x x x
Pain in extremity def 0% - 15.1% x x x x x x x x
Infection def postmarketing, 3.63% - 14.5% x x x x x x x x x
Back pain def 0% - 13.9% x x x x x x x x x
Arthralgia def 0% - 13.6% x x x x x x x x x
Dizziness def 0% - 13.6% x x x x x x x x x
Nasopharyngitis def 0% - 13.6% x x x x x x x
Vertigo def postmarketing, 0% - 13.6% x x x x x x x x x
Herpes NOS def postmarketing, 0% - 12.7% x x x x x x x x x
Herpes zoster def 0% - 12.7% x x x x x x x x x
Cramp muscle def 0% - 12.4% x x x x x x x x x
Myalgia def 0% - 11.8% x x x x x x x x
Rigors 0% - 11.2% x x x x x x x x x
Oedema def postmarketing, 0% - 10.6% x x x x x x x x x
Edema of lower extremities 0% - 10.6% x x x x x x
Acidosis def postmarketing x
Renal tubular acidosis def postmarketing x
Pancreatitis acute def postmarketing x x x x x x x x
Amyloidosis def postmarketing x x x x x x x
Anaphylactic shock def postmarketing x x x x x x x
Angina pectoris def postmarketing x x x x x x
Angioedema def postmarketing x x x
Ascites def postmarketing x x x x x x x
Aspergillosis def postmarketing x x x x x
Ataxia def postmarketing x x x x x x x
Atelectasis def postmarketing x x x x x x x
Atrial fibrillation def postmarketing x x x x x x x
Atrial flutter def postmarketing x x x x x x x
Atrioventricular block def postmarketing x x x x
Bacteraemia def postmarketing x x x x x x x
Neoplasm malignant def postmarketing x x x x x x x x
Candidiasis def postmarketing x x x x x
Oral candidiasis def postmarketing x x x x x
Cardiac tamponade def postmarketing x x x x x
Transient ischaemic attack def postmarketing x x x x x x x
Cholestasis def postmarketing x x x x x
Colitis def postmarketing x x x x x
Coma def postmarketing x x x x x x x
Confusional state def postmarketing x x x x x x x
Convulsion def postmarketing x x x x x x x
Cystitis def postmarketing x x x x x
Deafness def postmarketing x x x x
Dysphagia def postmarketing x x x x x x x
Diplopia def postmarketing x x x x x x
Disseminated intravascular coagulation def postmarketing x x x x x x x x
Drug hypersensitivity def postmarketing x x x x x x x
Duodenitis def postmarketing x x x x x
Dysarthria def postmarketing x x x x x x x
Dysautonomia def postmarketing x x x x x x x
Effusion def postmarketing x x x x x x x
Embolism def postmarketing x x x x x x x
Toxic epidermal necrolysis def postmarketing x x x
Grand mal convulsion def postmarketing x x x x x x
Epistaxis def postmarketing x x x x x x x x
Eye disorder def postmarketing x x x x x
Faecalith def postmarketing x x x x x x x
Cardiac flutter postmarketing x x x x x x x
Gastritis def postmarketing x x x x x x x
Gastroenteritis def postmarketing x x x x x
Gastrooesophageal reflux disease def postmarketing x x
Gastrointestinal disorder def postmarketing x x x x x x x
Hearing loss bilateral def postmarketing x
Cardiac arrest def postmarketing x x x x x x x x
Block heart def postmarketing x
Cardiac disorder def postmarketing x x x x x x x
Cardiac failure def postmarketing x x x x x x x x x
Haematemesis def postmarketing x x x x x x x
Haematoma def postmarketing x x x x x x x
Subdural haematoma def postmarketing x x x x x x x
Haematuria def postmarketing x x x x x x x
Haemoptysis def postmarketing x x x x x x
Haemorrhage def postmarketing x x x x x x x x
Hepatitis def postmarketing x x x x x x
Keratitis herpetic def postmarketing x x x
Herpes virus infection def postmarketing x x x x
Hydronephrosis def postmarketing x x x x x x x
Hyperbilirubinaemia def postmarketing x x x x x x x x
Hyperkalaemia def postmarketing x x x x
Hypernatraemia def postmarketing x x x x x
Hypersensitivity def postmarketing x x x x x x x x
Hypertension def postmarketing x x x x x x x x
Pulmonary hypertension def postmarketing x x x x x x
Hypocalcaemia def postmarketing x x x x x x x
Hypokalaemia def postmarketing x x x x x x x
Hyponatraemia def postmarketing x x x x x x x
Immune system disorder def postmarketing x x x x x x x
Inappropriate antidiuretic hormone secretion def postmarketing x
Incontinence def postmarketing x x x x x x
Infarction def postmarketing x x x x x x x x
Intestinal obstruction def postmarketing x x x x x x x
Intestinal perforation def postmarketing x x x x x x x
Ischaemia def postmarketing x x x x x x x x
Calculus of kidney def postmarketing x x x x x x x
Renal failure acute def postmarketing x x
Laryngeal oedema def postmarketing x x
Leukopenia def postmarketing x x
Listeriosis def postmarketing x x x x x
Lung disorder def postmarketing x x x
Chronic obstructive pulmonary disease def postmarketing x x x x x x x
Lymphopenia def postmarketing x x
Mediastinal disorder def postmarketing x x x x x
Melaena def postmarketing x x x x x x x
Meningoencephalitis def postmarketing x x x
Myocardial infarction def postmarketing x x x x x x x
Neoplasm def postmarketing x x x x x x x x
Nephritis def postmarketing x x x x x x x
Nephrotic syndrome def postmarketing x
Nervous system disorder def postmarketing x x x x x
Neuralgia def postmarketing x x x x x
Obstruction def postmarketing x x x x x x x x
Optic nerve disorder def postmarketing x
Pancreatitis def postmarketing x x x x x x x x
Ileus paralytic def postmarketing x x x x x x x
Paraplegia def postmarketing x x x
Pericardial effusion def postmarketing x x x x x x x
Pericarditis def postmarketing x x x x x
Peritonitis def postmarketing x x x x
Petechiae def postmarketing x x x x
Phlebitis def postmarketing x x
Pleural disorder def postmarketing x x x x x x x
Pleural effusion def postmarketing x x x x x x x
Pneumonia def postmarketing x x x x x x x x x
Pneumonia aspiration def postmarketing x x x x x
Post herpetic neuralgia def postmarketing x x
Psychotic disorder def postmarketing x x x x x x x x x
Pulmonary oedema def postmarketing x x
Pulmonary embolism def postmarketing x x x x x x x
Renal failure def postmarketing x x x x x x x x
Acute respiratory distress syndrome def postmarketing x x x x x x x
Retinitis pigmentosa def postmarketing x x x x x x x
Seizures def postmarketing x x
Shock def postmarketing x x x x x x
Cardiogenic shock def postmarketing x x x x x x
Septic shock def postmarketing x x x x x
Sinusitis def postmarketing x x
Skin disorder def postmarketing x
Muscle spasms def postmarketing x x x x x x x
Spinal cord compression def postmarketing x x x x x x
Stomatitis def postmarketing x x x x x x x x
Cerebrovascular accident def postmarketing x x x x x x x
Subarachnoid haemorrhage def postmarketing x
Tachycardia def postmarketing x x x x x x x
Thrombosis def postmarketing x x x x x x x
Tooth impacted def postmarketing x x x x x x x
Torsade de pointes def postmarketing x x x x
Toxoplasmosis def postmarketing x x x x x
Tumour lysis syndrome def postmarketing x x x x
Erythema def postmarketing x x x x x
Urinary incontinence def postmarketing x x x x x x
Urinary tract infection def postmarketing x x x x x
Urinary tract disorder def postmarketing x x x x
Urticaria def postmarketing x x x x x x
Angiopathy def postmarketing x x x x x
Vasculitis def postmarketing x x x
Venous thrombosis def postmarketing x x x x x x x
Ventricular tachycardia def postmarketing x x x x x x x
Viral infection def postmarketing x x x x x
Urinary retention def postmarketing x x x x x x x
Acute febrile neutrophilic dermatosis def postmarketing x x
Encephalopathy def postmarketing x x x x x x
Hepatic failure def postmarketing x x x x x
Agitation def postmarketing x x x x x x x
Cystitis haemorrhagic postmarketing x x x x x
Deep vein thrombosis def postmarketing x x x x x
Atrioventricular block complete def postmarketing x x x x x
Necrolysis epidermal postmarketing x x x
Myocardial ischaemia def postmarketing x x x x x x x
Renal tubular disorder def postmarketing x
Hepatocellular injury postmarketing x
Injection site pain postmarketing x x
Portal vein thrombosis def postmarketing x x x x x x
Acute pulmonary oedema postmarketing x
Colitis ischaemic def postmarketing x x x x x
Sinus arrest def postmarketing x x x x x
Dyspnoea exertional postmarketing x x x x x x
Cardiac fibrillation postmarketing x x x x x x x
Motor dysfunction postmarketing x x x x x x x
Small intestinal obstruction def postmarketing x x x x x x x
Lung infiltration postmarketing x x x x x x x
Hepatic haemorrhage def postmarketing x x x x x
Hypoxia def postmarketing x x x x x x x
Sepsis def postmarketing x x x x x x x
Umbilical cord compression def postmarketing x x x x x x
Hepatobiliary disease def postmarketing x x x x
Cardiac amyloidosis postmarketing x x x x x x x
Leukoencephalopathy def postmarketing x x x
Solid tumour def postmarketing x x x x x x
Acute psychosis postmarketing x
Duodenitis haemorrhagic postmarketing x x x x x
Vision blurred def postmarketing x x x x x x x x x
Haematological malignancy def postmarketing x x x x x x
Suicidal ideation def postmarketing x x x x x x x
Hyperkinesia def postmarketing x x
Bladder spasm def postmarketing x x x x x x x
Bradycardia def postmarketing x x x x
Transaminases increased postmarketing x
Blindness def postmarketing x
Large intestinal obstruction postmarketing x x x x x
Respiratory distress def postmarketing x x x x x x x
Bilateral hydronephrosis postmarketing x x x x x x x
Paralysis def postmarketing x x x x x x x
Face oedema def postmarketing x x x x x
Haemorrhagic stroke postmarketing x x x x x x x
Deafness bilateral def postmarketing x x x x
Cardio-respiratory arrest def postmarketing x x x x x x
Aspiration postmarketing x x x x x
Dissecting aortic aneurysm, thoracic postmarketing x x x x x x x
COPD exacerbation postmarketing x x x x x x x
Hyperuricaemia def postmarketing x x x x x x x x
Infestation NOS postmarketing x x x x x x x
Mental status changes postmarketing x
Catheter related infection def postmarketing x x
Ischaemic stroke postmarketing x
Neutrophilic dermatosis postmarketing x
Respiratory failure def postmarketing x x x x x x x x x
Ileus def postmarketing x x x x x x x x
Hearing impaired def postmarketing x x x x x x
Reversible posterior leukoencephalopathy syndrome def postmarketing x x x
Cytolysis def postmarketing x x x x x
Gastritis haemorrhagic postmarketing x x x x x x
Cerebral haemorrhage def postmarketing x x x x x x
Leukocytoclastic vasculitis def postmarketing x x
Aggression def x
Anxiety def x x x x x x x x x
Arrhythmia def x
Bronchitis def x
Chest wall pain def x
Connective tissue disorder def x x
Cytopenia def x
Sudden death def x x x x x
Dehydration def x x x x x x x x x
Dysgeusia def x x x x x x x x x
Dyspepsia def x x x x x x x x x
Enteritis def x
Extravasation def x
Failure to thrive def x
Fatigue def x x x x x x x x x
Flushing def x
Gastrointestinal haemorrhage def x x x
Cardiac failure congestive def x x x x x x x x x
Herpes simplex def x x
Herpes zoster ophthalmic def x
Hypercalcaemia def x x x x
Hyperglycaemia def x x x x x x
Hypoaesthesia def x x
Hypoproteinaemia def x
Hypotension def x x x x x x x x x
Orthostatic hypotension def x x x x x x x x
Infertility def x
Lethargy def x
Leukaemia def x
Meningitis def x x x x x
Musculoskeletal pain def x x
Numbness def x
Pancreatic disorder def x
Prurigo def x
Pruritus def x x x x x x x x
Respiratory insufficiency def x x x x x
Respiratory tract infection def x x x x x x x x x
Swelling def x
Syncope def x
Upper respiratory tract infection def x x x x x x x x x
Ureteric obstruction def x
Uric acid level increased x
Weight decreased def x
Meningitis bacterial def x x x x x
Burning sensation def x
Oedema peripheral def x x x
Hypochloraemia def x
Hypophosphataemia def x
Peripheral sensory neuropathy def x x x x x x x x x
Hypomagnesaemia def x
Haemoglobin decreased def x
Joint stiffness def x
Polyarthritis def x
Acute hepatic failure def x
Lightheadedness x
Muscle stiffness x
Rash macular x
Rash papular x
Disability def x x x x x x x
Malaise def x x x x x x x x
Abdominal discomfort x
Abdominal pain upper x x
Stools watery def x
Discomfort def x
Rash erythematous x
Peripheral motor neuropathy def x x x x x
Productive cough def x
Frequent bowel movements x
Albright's disease x
Autonomic neuropathy def x
Cutaneous vasculitis x
Holt-Oram syndrome def x
Platelet count decreased x x x x x x x x x
Stiffness x
Red blood cell count decreased x
Left ventricular ejection fraction x
Pruritus generalised x
Rash generalised x
Anaemia NOS aggravated x
Sterility def x
Cancer in remission x
Glomerulonephropathy x
Febrile neutropenia def x x x x x
Pain worsened x
Hypotensive x
Pulmonary toxicity x
Urine output x
Death x x x x x x x
Weakness def x x x x x x x x
Indication Labels
Adverse reaction def x
Disease progression def x x
Lymphoma def x x x
Mantle cell lymphoma def x x x
Multiple myeloma def x x x x x x x x x

Information

More information: STITCH, PubChem and possibly Wikipedia or Medpedia

ATC Code: L01XX32

Legend

Color scheme: standard – alternative

100%    
75%    
50%    
10%    
frequent (1% to 100%)    
infrequent (0.1% to 1%)    
rare (<0.1%)    
postmarketing    
0%    
no frequency information    
not found on label    

Labels

Labels were obtained from different sources and potentially contain different sets of side effects. If you click on the label name, a HTML version of the label will be shown with proteins, chemicals and side efffects highlighted using Reflect.

  1. bortezomib / Velcade : 71 side effects (FDA MedWatch)
  2. Bortezomib : 110 side effects (BC Cancer)
  3. bortezomib / Velcade : 162 side effects (FDA MedWatch)
  4. bortezomib / Velcade : 162 side effects (FDA CDER)
  5. BORTEZOMIB / VELCADE : 217 side effects (Drugs@FDA)
  6. bortezomib / Velcade : 222 side effects (FDA MedWatch)
  7. BORTEZOMIB / VELCADE : 243 side effects (Drugs@FDA)
  8. bortezomib : 253 side effects (FDA XML label)
  9. BORTEZOMIB (BORTEZOMIB MANNITOL BORONIC ESTER) / VELCADE : 272 side effects (Health Canada)