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Doxorubicin

More information: STITCH, PubChem (stereo-specific compounds: 1, 2, 3) and possibly Wikipedia

ATC Codes: L01DB01, L01DB03

Side effects

Options: Show MedDRA Preferred Terms,   display all 37 labels

Side effect Data for drug Placebo Labels
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Neutropenia common — 1.6% - 95.8% x x x x x x x x x x x x x x x
Leukopenia uncommon — 1.5% - 98.1% x x x x x x x x x x x x x x x x x
Alopecia common — 6.7% - 95.5% x x x x x x x x x x x x x x x x x x x
Nausea postmarketing — 0% - 92.4% x x x x x x x x x x x x x x x x x x x x
Vomiting common — 0% - 92.4% x x x x x x x x x x x x x x x x x x x x
Fatigue 0% - 46% x x x x x x
Immunodeficiency very common
Opportunistic infection very common
Injection site reaction 2-20% x x x x x x x
Mucosal inflammation postmarketing, 0% - 58.5% x x x x x x x x x x x x x x x x x
Asthenia postmarketing — 0% - 51.5% x x x x x x x x x x x x x
Anaemia uncommon — 0% - 72.2% x x x x x x x x x x x x x x x x
Neuropathy peripheral 1% - 45% x
Constipation very common, 0% - 31% x x x x x
Amenorrhoea 0% - 71.8% x x x x x x x x x x x x
Skin discolouration common, 6.1% x x x
Pharyngitis common, 0% - 17.9% x x x x
Dry skin common, 5.5% - 5.9% x x x
Thrombocytopenia uncommon — 0% - 51.4% x x x x x x x x x x x x x x x x x x
Hot flush postmarketing, 0% - 69.1% x x x x x x x x x x x x x
Dyspepsia common, 0% - 14% x x x x
Somnolence common, 5.1% x x x x
Hypochromic anaemia common, 3.5% - 9.6% x x
Anxiety common x x
Arthralgia common x
Back pain common, 0.9% - 11.7% x x x x
Cachexia common x
Cardiovascular disorder common x
Chest pain common x x x x
Dysphagia common x x x
Dermatitis exfoliative common x x x
Diarrhoea postmarketing — 0% - 50.7% x x x x x x x x x x x x x x x x x x x x
Dysgeusia common x x x
Dyspnoea common, 1% - 23.4% x x x x x
Dysuria common x x
Epistaxis common x x x x
Flatulence common x
Gastritis common x
Gingivitis common x
Headache common, 0% - 14.9% x x x x
Hyperbilirubinaemia common x x x
Hypertension common x
Hypotension common x x x x
Orthostatic hypotension common x
Cramps of lower extremities common x
Breast pain common x x
Hypertonia common x
Musculoskeletal pain common x
Nasopharyngitis common
Pain in extremity common
Paraesthesia common, 0% - 11.7% x x
Retinitis common x x
Skin disorder common x x
Skin ulcer common x
Sweating common x x
Upper respiratory tract infection common x
Urinary tract infection common x x
Vaginal inflammation common x
Dry mouth common
Ventricular arrhythmia common x x x
Oedema peripheral common x x
Mouth ulceration common x x x
Muscular weakness common x
Bone pain common x x
Vesiculobullous rash common x x
Myalgia common x x x
Blood creatinine increased common
Vision blurred common x
Rash maculo-papular common x x
Neuropathy common, 0.6% - 9.2% x
Musculoskeletal chest pain common
Metastases to liver common
Cough increased common, 0% - 11.5% x x x
Serum creatinine increased common
Ejection fraction decreased common
Cardiotoxicity uncommon — 18-65% x
Insomnia common x x x
Dizziness common, 0% - 10.2% x x x x
Mucous membrane disorder very common, 0% - 14.5% x x x
Herpes zoster common, 0% - 9% x x x x x
Oral candidiasis common, 0.8% - 5.6% x x x
Eye disorder 3%
Neuralgia 0% - 20%
Oedema uncommon, common x x x
Stomatitis postmarketing — 0% - 41.4% x x x x x x x x x x x x x x x x x x x
Weight decreased common, 0% - 4% x x x x x
Anorexia postmarketing — 0% - 21.7% x x x x x x x x x x x x x x x x x x
Laboratory test abnormal 0% - 5.8%
Arrhythmia 0.5-3% x x x x x x x
Infection postmarketing — 0% - 25.9% x x x x x x x x x x x x x x x x x
Lethargy 0% - 72.7% x x x x x x x x
Red blood cell disorders 0% - 5%
Rash postmarketing — 0% - 28.5% x x x x x x x x x x x x x x x
Febrile neutropenia 0% - 6.1% x x x x x x x x x x x x x
Body temperature increased postmarketing — 0% - 30.6% x x x x x x x x x x x x x x x x x x x x
Scrotal erythema common, 1%
Sepsis postmarketing — 0.9% - 1.2% x x x x x x x x x x x
Abdominal pain postmarketing — 0% - 8.2% x x x x x x x x x x x x
Shock postmarketing, 0.9% - 1% x x x x x x x x x x x x x x
Neuritis uncommon, 0.8% - 8% x
Breast disorder 1%
Pain postmarketing — 1.2% - 7.4% x x x x x x x x x x x x x
Amblyopia uncommon x
Cardiac failure congestive uncommon x x x x x x x x x
Nail disorder uncommon x x
Palpitations uncommon x x
Rhinitis uncommon x x x
Anaphylactoid reaction uncommon x
Enlargement abdomen uncommon x x
Myelosuppression uncommon x x x x x x x x x x x x
Cardiomyopathy uncommon x x x x x x x x
Ovarian cancer uncommon
Herpes simplex common, 0% - 6% x x x
Myelodysplastic syndrome 0.3-0.6% x
Leukaemia 0% - 1-10% x x x x x x x
Venous thrombosis postmarketing, uncommon
Venous thromboembolism postmarketing, uncommon
Anaphylactic shock postmarketing x x x x x x x x x x x x x x x
Neoplasm malignant postmarketing
Coma postmarketing x x x
Conjunctivitis postmarketing — 0% - 38.4% x x x x x x x x x x x x x x x x x
Connective tissue disorder postmarketing x
Cyst postmarketing
Dehydration postmarketing, common x x x x x x x x x x x x x x x x x
Toxic epidermal necrolysis very rare, postmarketing x
Erythema multiforme very rare, postmarketing x x
Oesophagitis postmarketing, common x x x x x x x x x x x x x x x x x x
Flushing postmarketing — 1% - 5% x x x x x x x x x x x x x
Gastrointestinal disorder postmarketing x x x
Haematochezia postmarketing x
Blood disorder postmarketing x
Haemorrhage postmarketing x x x x x x x x x x x x x x x
Hypersensitivity postmarketing, common x x x x x x x x x x x x x x x x
Immune system disorder postmarketing x x
Keratitis postmarketing, 0% - 38.4% x x x x x x x x x x x
Acute myeloid leukaemia postmarketing x
Mediastinal disorder postmarketing x x x x
Oral neoplasm postmarketing
Neoplasm postmarketing
Phlebitis postmarketing — 0.3% - 4.8% x x x x x x x x x
Pneumonia postmarketing, common x x x x x x
Polyp postmarketing
Pruritus postmarketing, common x x x x x x x x x x x x
Pulmonary embolism postmarketing, uncommon x x x x
Convulsion postmarketing, uncommon x x x x
Cardiogenic shock postmarketing x
Muscle spasms postmarketing, common x
Stevens-Johnson syndrome very rare, postmarketing x
Thromboembolism postmarketing x x x x x x
Thrombophlebitis postmarketing, uncommon x x x x x x x x x x x
Ulcer postmarketing x x x x x x x x x x x x x
Erythema postmarketing x x x x x x x x x
Urinary tract disorder postmarketing x x x
Urticaria postmarketing x x x x x x x x x x x x x x x x
Angiopathy postmarketing x x x
Weight increased postmarketing x x x x
Chills postmarketing — 0.3% - 6.4% x x x x x x x x x x x x x x x x x x
Burning sensation postmarketing x x x x x x x x x x
Aspartate aminotransferase increased postmarketing — common x
Alanine aminotransferase increased postmarketing, common x x
Malnutrition postmarketing x x x x x
Skin hyperpigmentation postmarketing x x x x x x x x x x x x x x x
Unspecified disorder of skin and subcutaneous tissue postmarketing x x x x
Fatal outcomes postmarketing x
Malaise postmarketing — 0.4% - 4.8% x x x x x x x x x x x
Peripheral motor neuropathy postmarketing x
Acral erythema postmarketing x x x x
Caecitis postmarketing x
Phlebosclerosis postmarketing x x x x x
Tumour necrosis postmarketing, uncommon x
Gastric erosions postmarketing x x
Photosensitivity postmarketing x x x x x x x x x x x x
Chemical cystitis postmarketing x x x x
Lacrimation postmarketing, common x x x x x x x x
Embolism arterial postmarketing x x
Hyperuricaemia postmarketing x x x x x x x x
Infestation NOS postmarketing x x x
Necrotising colitis postmarketing x
Radiation recall reaction (dermatologic) postmarketing x x x x x x x x x x x x x
Abscess x
Lactic acidosis x
Agranulocytosis x x x
Albuminuria x x
Aplastic anaemia x
Angina pectoris x
Anuria x
Ascites x x
Asthma x
Ataxia x
Atrioventricular block x x
Azoospermia x x x x
Balanitis x
Mental disorder x
Blister x x x x x
Bone disorder x
Bronchitis x
Bundle branch block x x x x x x
Candida infection x x
Skin candida x
Vaginal moniliasis x x
Congestive cardiomyopathy x
Cellulitis x x x x x x x
Neck pain x
Cholangitis sclerosing x
Colitis x x
Confusional state x
Cough 0% - 12% x x x
Cryptococcosis x x
Cystitis x
Delirium x
Dermatitis x x
Drug eruption
Dermatitis atopic
Dermatitis contact x
Fungal skin infection x x
Diabetes mellitus x
Diplopia
Drowsiness x
Dysarthria
Dyskinesia
Ecchymosis x
Eczema
Effusion x
Eosinophilia x
Eructation x
Erythema nodosum x
Extravasation x x x x x x x
Faecalith x
Folliculitis x x
Furunculosis x x
Gastrointestinal haemorrhage x x
Gingival bleeding x
Glossitis x x
Glycosuria x
Cardiac arrest x x
Heart malformation x
Cardiac disorder x
Cardiomegaly x
Cardiac failure x x x x
Haematemesis
Haematuria x x x
Hemiplegia x
Haemoptysis x
Hepatitis x x
Hepatomegaly x
Hepatosplenomegaly x
Herpes labialis x
Hiccups x
Hydronephrosis x
Hypercalcaemia x x
Hyperaesthesia x
Hyperglycaemia x x x
Hyperkalaemia x
Hyperlipidaemia x
Hypernatraemia x
Hyperventilation x
Hypoaesthesia x
Hypocalcaemia x x
Hypoglycaemia x
Hypokalaemia x x x
Hyponatraemia x x
Hypoproteinaemia x
Body temperature decreased x
Immune status
Inflammation x
Influenza x
Jaundice x x
Jaundice cholestatic x
Arthropathy
Ketosis x
Renal failure acute x x
Laryngitis x
Acute lymphocytic leukaemia x x x x x
Myeloid leukaemia
Leukoplakia oral x
Leukorrhea x
Lung disorder
Lymphangitis x
Lymphoedema x
Lymphopenia x x
Mastitis x
Melaena x
Premature menopause x
Multi-organ failure x
Hypotonia x
Fungal infection x
Myelodysplasia
Myocarditis x x x
Myositis x
Necrosis x x x x x x x x x x
Nervous system disorder x
Nervousness x
Nocturia x
Nystagmus
Oligospermia x x
Oliguria x x
Optic neuritis x x x
Other conjunctivitis x
Otitis media x
Pancreatitis x
Pancytopenia
Pelvic pain x
Penicillin allergy x x
Pericardial effusion x x x x
Pericarditis x x x
Abscess periodontal x
Petechiae x
Pleural effusion x x
Pneumothorax x
Supraventricular extrasystoles
Proctitis x
Prostatic disorder
Psoriasis x
Pulmonary oedema x
Purpura x
Radiation injury x
Rectal disorder
Renal failure x
Scotoma x
Seborrhoeic dermatitis
Septicemia x x x x x x x x
Septic shock x x x x x x
Salivary hypersecretion x
Sinusitis x x
Skin nodule x
Gastric ulcer x
Aphthous stomatitis x x
Ulcerative stomatitis x
Cerebrovascular accident
Syncope x
Tachycardia x x x
Sinus tachycardia x x x
Testicular disorder
Thrombosis x x
Tinnitus x
Toxoplasmosis x x x
Tumour lysis syndrome x x x
Ureteric obstruction x
Urethral obstruction x
Pollakiuria
Vasodilation x
Ventricular tachycardia x x x
Vertigo x
Viral infection x x
Tachyarrhythmia x x
Peripheral vascular disorder
Hepatic failure x
Agitation x
Mood swings x x
Rash pustular x
Onycholysis x x
Hypochloraemia x
Hyperphosphataemia
Hypophosphataemia x
Cystitis haemorrhagic x x
Hypokinesia x
Hepatic function abnormal x
Migraine x
Peripheral sensory neuropathy
Blood urea increased
Creatinine increased
Diarrhoea haemorrhagic
Generalised oedema x
Oedema genital x
Ventricular extrasystoles x
Injection site haemorrhage x
Hypermagnesaemia x
Hypomagnesaemia x
Injection site inflammation x
Kidney function abnormal x
Lactic dehydrogenase activity increased x
Hepatocellular injury
Liver function test abnormal
Bone marrow depression
Skin necrosis x x
Retrosternal pain x
Eye pain x
Injection site pain x
Phosphatase alkaline increased x x x
Prothrombin level increased x x
Hyporeflexia
Thromboplastin decreased
Oesophageal ulcer x
Polyneuropathy
Leukoderma
Pseudolymphoma
Injection site infection x x
Oral pain x
Dyspnoea exertional
Gallop rhythm x
Increased appetite x
Decreased appetite
Abdominal pain upper
Rectal tenesmus x
Thinking abnormal x
Abnormal dreams
Rash erythematous x
Neurotoxicity x x
Gravitational oedema
Urine abnormality
Bullous eruption x
Leg edema x
Ventricular dysfunction x
Rectal haemorrhage x
Hepatobiliary disease x
Eruption
Dry eye x
Redness x
Hypolipidaemia x
Red blood cell abnormality
Warmth x
Dysaesthesia 0% - 10%
Skin scaly x
Rigors x
QRS voltage decreased x
Bradycardia x x x x
Transaminases increased x x
Secondary infection
Blindness x
Lymphadenopathy x
Electrocardiogram ST segment depression x x
Coordination abnormal x
Influenza like illness
Paralysis
Face oedema x
Gait disturbance x
Stinging x
Drug interaction
Bilirubin total increased
Thrombocytosis
Blood and lymphatic system disorders x
Hand and foot syndrome secondary to sickle cell anaemia x
Local reaction x
Bladder constriction x
Leukemia secondary x x x x x x x x
Alopecia reversible x
Serum bilirubin increased x x
Neutropenic sepsis x
Myasthenia x
Left ventricular ejection fraction decreased x x x
Gastrointestinal toxicity x
Ileus x x
Abnormal pigmentation
Ocular toxicity x
Urine output x x
Sensitisation x
Parosmia x
Rash papular
Dysphonia x
Pneumocystis jirovecii pneumonia
Acute cardiac toxicity x
Ageusia x
Proctitis ulcerative x
Metastatic neoplasm x
Metastatic disease
Vaginal haemorrhage x
Abnormal vision x

Indications

Information about indications was extracted from the indications and usage sections of the labels.

Indication Labels
Acquired immunodeficiency syndrome x x x
Acute leukaemia x
Acute lymphocytic leukaemia x x x x x
Acute myeloid leukaemia x x x x x
Bladder cancer x
Bladder cancer stage IV x
Bladder carcinoma x x
Bladder neoplasm x
Bladder transitional cell carcinoma x
Bladder transitional cell carcinoma metastatic x
Bone sarcoma x
Brain neoplasm x
Breast cancer x x x x x x x x x x
Breast cancer stage IV x x x x x
Bronchial carcinoma x x x x
Carcinoma x x x x
Carcinoma breast x x x x x
Carcinoma of lung x x
Carcinoma stomach x x x x x x
Carcinoma testes x
Cardiotoxicity x x x
Endometrial cancer x
Ewing's sarcoma x x
Generalized illness x x
Hepatic function abnormal x
Hepatocellular carcinoma x x
Hodgkin's disease x x x x x x x
Hypersensitivity x
Kaposi's sarcoma x
Kaposi's sarcoma AIDS related x x x
Leukaemia x
Lymphoma x x x x x x
Malignant melanoma x x
Menopause x x
Metastasis x
Metastatic carcinoma x x
Metastatic gastric adenocarcinoma x
Neoplasm x x x x x x x x x x x
Neoplasm malignant x x x x x
Nephroblastoma x x x x x
Neuroblastoma x x x x x x
Node-positive breast cancer x
Non-Hodgkin's lymphoma x x x x x x
Non-small cell lung cancer x x
Osteosarcoma x
Ovarian cancer x x x
Ovarian carcinoma x x x x x
Ovarian epithelial cancer x
Ovarian epithelial cancer stage IV x
Plasma cell myeloma x x x
Prostate cancer x
Prostate carcinoma x
Renal carcinoma x
Rhabdomyosarcoma x
Sarcoma x x x x x x x
Small cell lung cancer x x
Solid tumour x
Squamous cell carcinoma x
Thymoma x
Thyroid carcinoma x x x x x x

DOXORUBICIN

Side effects:40
Source:FDA Structured Product Label

epirubicin

Side effects:42
Source:FDA Structured Product Label

EPIRUBICIN

Side effects:44
Source:FDA Structured Product Label

doxorubicin / doxorubicin hydrochloride

Side effects:44
Source:EMA

Doxorubicin

Side effects:49
Source:BC Cancer

epirubicin hydrochloride / Ellence

Side effects:49
Source:FDA

EPIRUBICIN HYDROCHLORIDE / PHARMORUBICIN PFS

Side effects:51
Source:Health Canada

DOXORUBICIN

Side effects:55
Source:FDA Structured Product Label

WARNINGS / ADRIAMYCIN Solution for Injection

Side effects:59
Source:medicines.org.au

DOXORUBICIN HYDROCHLORIDE / MYOCET

Side effects:60
Source:Health Canada

Epirubicin

Side effects:61
Source:BC Cancer

EPIRUBICIN

Side effects:64
Source:FDA Structured Product Label

epirubicin

Side effects:65
Source:FDA Structured Product Label

DOXORUBICIN

Side effects:93
Source:FDA Structured Product Label

DOXORUBICIN

Side effects:93
Source:FDA Structured Product Label

DOXORUBICIN HYDROCHLORIDE / DOXIL

Side effects:232
Source:FDA

Color scheme:

standard – alternative

    100%
    75%
    50%
    10%
    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    postmarketing
    0%
    no frequency information
    not found on label