Busulfan

Side effects and indications

Whenever possible, frequency information about the side effects was extracted from the labels. Aggregated frequency information for the drug and, if available, placebo is shown. To the right, you can click on shaded boxes to be taken to mentions of the side effect on the label. (In some cases, the side effect cannot be highlighted due to conversion problems.) Information about indications was extracted from the indications and usage sections of the labels.

Show MedDRA Preferred Terms

Side effect Data for drug Placebo Labels (show all 11)
1 2 3 4 5 6 7 8 9 10
Nausea def 98% x x x x x x x x x x
Stomatitis def 97% x x x x x x x
Mucosal inflammation def 97% x x x x x x x x x x
Vomiting def 95% x x x x x x x x x x
Anorexia def 85% x x x x x x x x x x
Diarrhoea def 84% x x x x x x x
Insomnia def 84% x x x x x x
Body temperature increased def 80% x x x x x x x
Hypomagnesaemia def 77% x x x x x x x
Abdominal pain def 72% x x x x x x x
Anxiety def 72% x x x x x x
Pain def 23% - 72% x x x x x x x
Headache def 69% x x x x x x
Hyperglycaemia def 66% x x x x x x x
Hypokalaemia def 64% x x x x x x x
Rash def 57% x x x x x x x x x x
Asthenia def 51% x x x x x x
Hyperbilirubinaemia def 49% x x x x x x x x x
Hypocalcaemia def 49% x x x x x x
Chills def 46% x x x x x x
Dyspepsia def 44% x x x x x x
Rhinitis def 44% x x x x x x
Tachycardia def 44% x x x x x x x
Constipation def 38% x x x x x x x
Oedema def 28% - 36% x x x x x x
Hypertension def 36% x x x x x x x
Lung disorder def 34% x x x x x x
Thrombosis def 33% x x x x x x x
Dizziness def 30% x x x x x x x
Cough def 28% x x x x x x x
Pruritus def 28% x x x x x x
Chest pain def 26% x x x x x x
Hypersensitivity def 26% x x x x x x x
Dry mouth def 26% x x x x x x
Dyspnoea def 25% x x x x x x x
Epistaxis def 25% x x x x x x
Inflammation def 25% x x x x x x
Rectal disorder def 25% x x x x x x
Vasodilation def 25% x x x x x x
Injection site inflammation 25% x x x x x x
Back pain def 23% x x x x x x x
Hypertrophy def 23% x x x x x
Enlargement abdomen def 23% x x x x x
Creatinine increased def 21% x x x x x
Infection def postmarketing x x x x x x x x x x
Fungal infection def postmarketing x
Neoplasm def postmarketing x x
Neutropenia def postmarketing x
Tumour lysis syndrome def postmarketing x
Angiopathy def postmarketing x
Viraemia def postmarketing x
Sepsis def postmarketing x x x x
Haematological malignancy def postmarketing x x x x x
Febrile neutropenia def postmarketing x
Cytolysis def postmarketing x x
Adrenal insufficiency def x x x
Agranulocytosis def x x x x x x
Alopecia def x x x x x x x x x x
Amenorrhoea def x
Anaemia def x x x x x x x x x x
Aplastic anaemia def x x x x
Anhidrosis x x x
Arrhythmia def x x x x x x x
Arthralgia def x x x x x x x
Asthma def x x x x x
Atelectasis def x x x x x
Atrial fibrillation def x x x x x x
Cardiac tamponade def x x x x x
Coma def x x x x x x
Confusional state def x x x x x x
Cystitis def x x x x x x
Delirium def x x x x x x
Dermatitis def x x x x x
Dermatitis exfoliative def x x x x x
Dysuria def x x x x x x x
Ear disorder def x x x x x
Effusion def x x x x x x
Erythema multiforme def x x x
Erythema nodosum def x x x x x x x
Oesophageal disorder def x x x x
Varices oesophageal def x x x x
Oesophagitis def x x x x x x
Extravasation def x
Fatigue def x x x
Fibrosis def x x x x x x x x x
Flushing def x x x x x
Gastrointestinal haemorrhage def x
Graft versus host disease def x x x x x x
Gynaecomastia def x x x x
Hallucination def x x x x x x
Block heart def x x x
Cardiomegaly def x x x x x x
Cardiac failure def x x x x x
Haematemesis def x x x x x x
Haematuria def x x x x x x x
Haemoptysis def x x x x
Haemorrhage def x x x x x x
Venoocclusive liver disease def x x x x x
Hepatitis def x
Hepatomegaly def x x x x x x
Hiccups def x x x x x
Hyperventilation def x x x x x x
Hyponatraemia def x x x x x x
Hypotension def x x x x x x
Infertility def x
Jaundice def x x x x x x x x x x
Jaundice cholestatic def x x
Lens disorder def x x x
Lethargy def x x x x x
Chronic phase chronic myeloid leukemia def x x x x x
Leukopenia def x x x x
Menopause def x
Myasthenia gravis def x x x
Necrosis def x x x
Nervousness def x
Oliguria def x x x x x x x
Opportunistic infection def x
Pancreatic disorder def x x x
Pancreatitis def x x x x x
Pancytopenia def x x
Pericardial effusion def x x x x x x
Pericarditis def x
Pharyngitis def x x x x x x
Pleural disorder def x x x x x
Pleural effusion def x x x x x
Pneumonia def x x x x x x x x x
Porphyria def x x x
Pulmonary fibrosis def x x x x x x
Pulmonary valve incompetence def x
Rales x
Seizures def x x x x x x x x x x
Serum sickness def x
Sinusitis def x x x x
Thalassaemia def x x x x
Thrombocytopenia def x x x x x x x x x
Erythema def x x x x x x x x
Urticaria def x x x
Varicose vein def x x x x
Weight increased def x x x x x
Weight decreased def x x x
Encephalopathy def x x x x x x
Agitation def x x x x x x
Acute leukaemia def x
Hypophosphataemia def x x x x x x x
Cystitis haemorrhagic x x x x x x
Cataract def x x x x
Hepatitis cholestatic x
Atrioventricular block complete def x x x
Blood urea increased x
Ventricular extrasystoles def x x x x x x
Bone marrow depression def x
Hepatic necrosis def x x x
Injection site pain x x x x x x
Prothrombin level increased x x
Skin discolouration def x x x x x
Porphyria cutanea tarda def x x x
Skin hyperpigmentation def x x x x
Interstitial pneumonia x x x x x
Rash vesicular x x x x x x
Cheilosis x x x
Sickness x
Melanodermia x x x
Myalgia def x x x x x x x
Breath sounds abnormal x
Cardiac fibrillation x x x x x x
Discomfort def x x x x x x
Neurological symptom x x x x x
Femoral artery thrombosis x
Rash bullous x x x x x
Endocardial fibrosis x x x x
Menopausal symptoms def x
Lung fibrosis interstitial x x x x x x x x
Hypoxia def x x x x x
Disease progression def x
Aplasia x
Atrophy def x x x
Dysplasia def x
Extrasystoles def x x x x x x
Capillary leak syndrome def x
Rash maculo-papular def x x x x x x
Withdrawn x x x
Bradycardia def x
Discomfort rectal x x x x x x
Fluid overload def x x x x x
Hot flush def x x x x x
Drug interaction def x x x
Serum creatinine increased x
Acne def x x x x x
Dissecting aortic aneurysm, thoracic x
Urate x x x
Hyperuricaemia def x x x x
Second primary malignancy def x
Dry cough x
Myelosuppression def x x x x x x x x x x
Acute graft versus host disease def x
Chronic graft versus host disease def x x x x x
Pulmonary toxicity x
Myasthenia def x x x
Venoocclusive disease def x x x x x x
Organ failure x x x x x x
Hyperuricosuria x x x
Respiratory failure def x x x x x x
Ileus def x x x x x x
Death x x x x x x
Bone marrow aplastic x
Insufficiency renal def x
Electrolyte disturbance x
Weakness def x x x
Somnolence def x x x x x
Cerebral haemorrhage def x x x x x
Indication Labels
Acute lymphocytic leukaemia def x
Acute myeloid leukaemia def x
Breast cancer def x
Chronic myeloid leukaemia def x x x x x x
Disease recurrence x
Leukaemia def x x x x x x x x x x
Lymphocytic leukaemia def x
Lymphoma def x
Multiple myeloma def x
Myelodysplastic syndrome def x
Myeloid leukaemia def x x x x x x
Neoplasm malignant def x
Ovarian cancer def x

Information

More information: STITCH, PubChem and possibly Wikipedia

ATC Code: L01AB01

Legend

Color scheme: standard – alternative

100%    
75%    
50%    
10%    
frequent (1% to 100%)    
infrequent (0.1% to 1%)    
rare (<0.1%)    
postmarketing    
0%    
no frequency information    
not found on label    

Labels

Labels were obtained from different sources and potentially contain different sets of side effects. If you click on the label name, a HTML version of the label will be shown with proteins, chemicals and side efffects highlighted using Reflect.

  1. BUSULFAN / MYLERAN : 54 side effects (Drugs@FDA)
  2. BUSULFAN / MYLERAN : 54 side effects (Drugs@FDA)
  3. busulfan / Myleran : 55 side effects (FDA CDER)
  4. Busulfan : 72 side effects (BC Cancer)
  5. BUSULFAN / BUSULFEX : 117 side effects (Drugs@FDA)
  6. BUSULFAN / BUSULFEX : 118 side effects (Health Canada)
  7. BUSULFAN / BUSULFEX : 127 side effects (Drugs@FDA)
  8. busulfan / BUSULFEX : 128 side effects (FDA CDER)
  9. BUSULFAN / BUSULFEX : 129 side effects (Drugs@FDA)
  10. Busulfan : 140 side effects (FDA XML label)