Side effect information for Trazodone

Side effects

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MedDRA Preferred Term	Side effect	Data for drug	Placebo	Labels
				1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17
Somnolence	Drowsiness	23.9% - 40.8%	6.3% - 19.6%	x	x				x	x	x	x	x	x	x	x	x	x	x	x
Somnolence	Somnolence	3.96% - 46%	19.1%			x								x	x	x	x	x	x	x
Dry mouth	Dry mouth	14.8% - 33.8%	8.4% - 20.3%	x	x	x			x	x	x	x	x	x	x	x	x	x	x	x
Dizziness	Lightheadedness	19.7% - 28%	5.3% - 15.2%	x	x				x	x	x	x	x	x	x	x	x	x	x	x
	Dizziness	3.47% - 28%	5.3% - 15.2%	x	x	x			x	x	x	x	x	x	x	x	x	x	x	x
	Syncope	postmarketing, 2.8% - 4.5%	1.3% - 2.1%	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Asthenia	Fatigue	5.7% - 14.9%	2.5% - 8.33%	x	x	x			x	x	x	x	x	x	x	x	x	x	x	x
Asthenia	Asthenia	postmarketing		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Fatigue	Fatigue	5.7% - 14.9%	2.5% - 8.33%	x	x	x			x	x	x	x	x	x	x	x	x	x	x	x
Nervousness	Nervousness	6.4% - 14.8%	8.2% - 10.5%	x	x				x	x	x	x	x	x	x	x	x	x	x	x
Tension	Nervousness	6.4% - 14.8%	8.2% - 10.5%	x	x				x	x	x	x	x	x	x	x	x	x	x	x
Tension	Tension			x	x
Headache	Headache	0.99% - 33.2%	5.3% - 27%	x	x	x			x	x	x	x	x	x	x	x	x	x	x	x
Constipation	Constipation	7% - 7.92%	1.96% - 5.7%	x	x	x			x	x	x	x	x	x	x	x	x	x	x	x
Vision blurred	Vision blurred	5.45% - 14.7%	0% - 4.2%	x	x	x			x	x	x	x	x	x	x	x	x	x	x	x
Weight decreased	Weight decreased	3.2% - 5.7%	2.5% - 3.2%						x	x	x	x	x	x	x	x	x	x	x	x
Back pain	Back pain	5.45%	3.43%			x
Hypotension	Hypotension	3.8% - 7%	0% - 1.1%		x				x	x	x	x	x	x	x	x	x	x	x	x
Pain	Pain	5.1% - 5.6%	2.5% - 3.2%						x	x	x	x	x	x	x	x	x	x	x	x
Pain	Ache	5.1% - 5.6%	2.5% - 3.2%						x	x	x	x	x	x	x	x	x	x	x	x
Nightmare	Nightmare	1.1% - 5.1%	1.1% - 5.7%	x	x				x	x	x	x	x	x	x	x	x	x	x	x
Abnormal dreams	Vivid dreams	1.1% - 5.1%	1.1% - 5.7%						x	x	x	x	x	x	x	x	x	x	x	x
Abnormal dreams	Abnormal dreams	postmarketing				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Visual impairment	Visual disturbance	frequent				x
Confusional state	Confusional state	0.99% - 5.7%	0% - 7.6%	x	x	x			x	x	x	x	x	x	x	x	x	x	x	x
Feeling abnormal	Confusional state	0.99% - 5.7%	0% - 7.6%	x	x	x			x	x	x	x	x	x	x	x	x	x	x	x
Feeling abnormal	Malaise	0% - 2.8%	0%						x	x	x	x	x	x	x	x	x	x	x	x
Gastric disorder	Gastric disorder	3.5% - 5.7%	4.2% - 4.4%						x	x	x	x	x	x	x	x	x	x	x	x
Diarrhoea	Diarrhoea	0% - 9.41%	1.1% - 11.3%	x	x	x			x	x	x	x	x	x	x	x	x	x	x	x
Sinus congestion	Sinus congestion	2.8% - 5.7%	0% - 3.2%						x	x	x	x	x	x	x	x	x	x	x	x
Tremor	Tremor	2.8% - 5.1%	1.1% - 3.8%	x	x	x			x	x	x	x	x			x	x	x	x	x
Tachycardia	Tachycardia	0% - 7%	0% - 7%	x	x				x	x	x	x	x	x	x	x	x	x	x	x
Agitation	Excitement	1.1% - 5.1%	1.1% - 5.7%	x	x				x	x	x	x	x	x	x	x	x	x	x	x
Agitation	Agitation	postmarketing		x	x	x		x				x	x	x	x	x	x	x	x	x
Weight increased	Weight increased	1.4% - 4.5%	0% - 1.9%	x	x				x	x	x	x	x	x	x	x	x	x	x	x
Anger	Anger	1.3% - 3.5%	2.5% - 6.3%	x	x				x	x	x	x	x	x	x	x	x	x	x	x
Hostility	Hostility	1.3% - 3.5%	2.5% - 6.3%	x	x				x	x	x	x	x	x	x	x	x	x	x	x
Disorientation	Disorientation	0% - 2.1%	0%	x	x	x			x	x	x	x	x	x	x	x	x	x	x	x
Coordination abnormal	Coordination abnormal	0.99% - 4.9%	0%			x			x	x	x	x	x	x	x	x	x	x	x	x
Hyperhidrosis	Sweating	1.4%	1.1%	x	x				x	x	x	x	x	x	x	x	x	x	x	x
Hyperhidrosis	Hyperhidrosis	infrequent				x
Malaise	Malaise	0% - 2.8%	0%						x	x	x	x	x	x	x	x	x	x	x	x
Discomfort	Malaise	0% - 2.8%	0%						x	x	x	x	x	x	x	x	x	x	x	x
Ill-defined disorder	Malaise	0% - 2.8%	0%						x	x	x	x	x	x	x	x	x	x	x	x
Memory impairment	Memory impairment	1.4%	0%	x	x	x			x	x	x	x	x	x	x	x	x	x	x	x
Ocular hyperaemia	Eye redness	0% - 2.8%	0%						x	x	x	x	x	x	x	x	x	x	x	x
Cold sweat	Sticky skin	1.4%	1.1%						x	x	x	x	x	x	x	x	x	x	x	x
Sticky skin	Sticky skin	1.4%	1.1%						x	x	x	x	x	x	x	x	x	x	x	x
Libido decreased	Libido decreased	1.1% - 1.3%	1.1%			x				x	x	x	x	x	x	x	x	x	x	x
Disturbance in sexual arousal	Libido decreased	1.1% - 1.3%	1.1%			x				x	x	x	x	x	x	x	x	x	x	x
Disturbance in sexual arousal	Libido increased			x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x
Dyspnoea	Dyspnoea	1.1% - 1.3%	0% - 1.1%	x	x	x			x	x	x	x	x	x	x	x	x	x	x	x
Hypertension	Hypertension	1.3% - 2.1%	1.1%	x	x				x	x	x	x	x	x	x	x	x	x	x	x
Gait disturbance	Gait disturbance	infrequent, 0.99%				x								x	x	x	x	x	x	x
Balance disorder	Balance disorder	0.99%				x								x	x	x	x	x	x	x
Dysgeusia	Bad taste	0% - 1.4%	0%						x	x	x	x	x	x	x	x	x	x	x	x
	Dysgeusia					x
	Taste peculiar			x	x
Amnesia	Amnesia	infrequent				x
Gastrooesophageal reflux disease	Reflux esophagitis	infrequent				x
Flushing	Flushing	infrequent				x
Hypersensitivity	Hypersensitivity	infrequent				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Hypoaesthesia	Hypoaesthesia	infrequent				x
Hypoaesthesia	Numbness			x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x
Speech disorder	Speech disorder	infrequent				x
Speech disorder	Speech impairment NOS			x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x
Photophobia	Photophobia	infrequent				x
Eye pain	Eye pain	infrequent				x
Photosensitivity reaction	Photosensitivity reaction	infrequent				x
Photosensitivity reaction	Photosensitivity			x	x
Muscle twitching	Muscle twitching	infrequent		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Bladder pain	Bladder pain	infrequent				x
Dry eye	Dry eye	infrequent				x
Deafness	Hearing impaired	infrequent				x
Hearing impaired	Hearing impaired	infrequent				x
Alopecia	Alopecia	postmarketing				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Haemolytic anaemia	Haemolytic anaemia	postmarketing		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Anxiety	Anxiety	postmarketing		x	x	x		x				x	x	x	x	x	x	x	x	x
Aphasia	Aphasia	postmarketing, infrequent				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Apnoea	Apnoea	postmarketing		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Arrhythmia	Arrhythmia	postmarketing		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Ataxia	Ataxia	postmarketing		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Atrial fibrillation	Atrial fibrillation	postmarketing		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Cholestasis	Cholestasis	postmarketing				x					x		x	x	x	x	x	x	x	x
Diplopia	Diplopia	postmarketing		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Oedema	Oedema	postmarketing, 2.8% - 7%	1.1% - 1.3%	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Oesophageal achalasia	Oesophageal achalasia	postmarketing				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Dermatitis	Rash	postmarketing		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Rash	Rash	postmarketing		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Rash	Eruption			x	x
Hallucination	Hallucination	postmarketing		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Cardiac arrest	Cardiac arrest	postmarketing		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Atrioventricular block	Block heart	postmarketing			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Cardiac failure congestive	Cardiac failure congestive	postmarketing				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Hirsutism	Hirsutism	postmarketing				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Hyperbilirubinaemia	Hyperbilirubinaemia	postmarketing				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Orthostatic hypotension	Orthostatic hypotension	postmarketing		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Inappropriate antidiuretic hormone secretion	Inappropriate antidiuretic hormone secretion	postmarketing				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Jaundice	Jaundice	postmarketing				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Leukocytosis	Leukocytosis	postmarketing				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Methaemoglobinaemia	Methaemoglobinaemia	postmarketing		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Myocardial infarction	Myocardial infarction	postmarketing		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Acute coronary syndrome	Myocardial infarction	postmarketing		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Nausea	Nausea	postmarketing, 0.99% - 20.8%	1.1% - 12.7%	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Palpitations	Palpitations	postmarketing, 0% - 7%	0% - 7%	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Paraesthesia	Paraesthesia	postmarketing, 0% - 1.4%	0%	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Paraesthesia	Tingling of extremity			x	x
Priapism	Priapism	postmarketing		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Pruritus	Pruritus	postmarketing, 0% - 2.8%	0%	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Psoriasis	Psoriasis	postmarketing				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Psychotic disorder	Psychotic disorder	postmarketing				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Psychotic disorder	Paranoia			x	x
Salivary hypersecretion	Salivary hypersecretion	postmarketing		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Cerebrovascular accident	Cerebrovascular accident	postmarketing				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Shock	Syncope	postmarketing, 2.8% - 4.5%	1.3% - 2.1%	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Syncope	Syncope	postmarketing, 2.8% - 4.5%	1.3% - 2.1%	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Loss of consciousness	Syncope	postmarketing, 2.8% - 4.5%	1.3% - 2.1%	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Torsade de pointes	Torsade de pointes	postmarketing				x								x	x	x	x	x	x	x
Urinary incontinence	Urinary incontinence	postmarketing, infrequent				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Urticaria	Urticaria	postmarketing				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Vasodilation procedure	Vasodilation	postmarketing				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Ventricular tachycardia	Ventricular tachycardia	postmarketing		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Vertigo	Vertigo	postmarketing, infrequent		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Vomiting	Vomiting	postmarketing, 9.9% - 12.7%	1.1% - 9.5%	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Urinary retention	Urinary retention	postmarketing		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Chills	Chills	postmarketing				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Stupor	Stupor	postmarketing				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Depressed level of consciousness	Stupor	postmarketing				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Amylase increased	Amylase increased	postmarketing				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Ventricular extrasystoles	Ventricular extrasystoles	postmarketing		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Paranoia	Paranoid reaction	postmarketing				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Paranoia	Paranoia			x	x
Electrocardiogram QT prolonged	Electrocardiogram QT prolonged	postmarketing				x								x	x	x	x	x	x	x
Extrapyramidal disorder	Extrapyramidal symptoms	postmarketing				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Nail discolouration	Leukonychia	postmarketing				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Death	Found dead (cause undetermined)	postmarketing				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Bradycardia	Bradycardia	postmarketing		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Grand mal convulsion	Tonic-clonic seizures	postmarketing		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Surgery	Surgical intervention	postmarketing					x	x	x	x	x	x	x
Tardive dyskinesia	Tardive dyskinesia	postmarketing				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Insomnia	Insomnia	postmarketing, 6.4% - 9.9%	10.5% - 12%	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Breast enlargement	Breast enlargement	postmarketing				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Abdominal pain	Abdominal pain					x
Gastrointestinal pain	Abdominal pain					x
Anaemia	Anaemia						x	x	x	x	x	x	x	x	x	x	x	x	x	x
Decreased appetite	Anorexia			x	x
Decreased appetite	Decreased appetite	0% - 3.5%	5.3%						x	x	x	x	x	x	x	x	x	x	x	x
Arthralgia	Arthralgia			x	x
Musculoskeletal discomfort	Arthralgia			x	x
Musculoskeletal discomfort	Myalgia					x
Chest pain	Chest pain			x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x
Delusion	Delusion			x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x
Polyuria	Diuresis				x
Body temperature increased	Body temperature increased			x	x
Flatulence	Flatulence						x	x	x	x	x	x	x	x	x	x	x	x	x	x
Angle closure glaucoma	Angle closure glaucoma																		x	x
Haematuria	Haematuria			x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x
Hyponatraemia	Hyponatraemia					x								x	x	x	x	x	x	x
Incontinence	Incontinence			x	x
Libido increased	Libido increased			x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x
Eye pruritus	Eye pruritus			x	x
Jaundice cholestatic	Jaundice cholestatic			x	x
Lethargy	Lethargy			x	x
Miosis	Miosis			x	x
Nasal congestion	Nasal congestion			x	x
Night sweats	Night sweats					x
Sensory loss	Numbness			x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x
Orgasm abnormal	Orgasm abnormal					x
Completed suicide	Suicide					x								x	x	x	x	x	x	x
Suicide attempt	Suicide attempt				x
Tinnitus	Tinnitus	infrequent, 0% - 1.4%	0%	x	x	x			x	x	x	x	x	x	x	x	x	x	x	x
Pollakiuria	Pollakiuria			x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x
Pollakiuria	Micturition urgency					x
Vasculitis	Vasculitis			x
Poor quality sleep	Wakefulness				x
Micturition urgency	Micturition urgency					x
Sinus bradycardia	Sinus bradycardia						x	x	x	x	x	x	x	x	x		x	x	x	x
Hypokinesia	Hypokinesia				x
Migraine	Migraine					x
Menstruation irregular	Menstruation irregular			x	x
Musculoskeletal stiffness	Muscle stiffness			x	x
Myalgia	Myalgia					x
Increased appetite	Increased appetite			x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x
Dysarthria	Slurred speech			x	x
Sedation	Tranquillisation excessive				x
Disturbance in attention	Cerebration impaired			x	x
Mental disability	Cerebration impaired			x	x
Hypomania	Hypomania			x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x
Erectile dysfunction	Erectile dysfunction					x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Akathisia	Akathisia			x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x
Retrograde ejaculation	Retrograde ejaculation			x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x
Dyskinesia	Movements involuntary			x	x
Mean arterial pressure	Mean arterial pressure				x
Sexual dysfunction	Sexual dysfunction					x
Electrocardiogram PR prolongation	Electrocardiogram PR prolongation			x	x
Serotonin syndrome	Serotonin syndrome					x								x	x	x	x	x	x	x
Haemorrhagic disorder	Hemorrhage abnormal					x								x	x	x	x	x	x	x
Abdominal discomfort	Gastrointestinal discomfort			x	x
Leukocytoclastic vasculitis	Leukocytoclastic vasculitis				x

Indication	Labels
Agitation				x	x	x	x	x	x	x
Anxiety				x	x	x	x	x	x	x
Bradypsychic response				x	x	x	x	x	x	x
Cerebration impaired				x	x	x	x	x	x	x
Decreased interest				x	x	x	x	x	x	x
Depressive disorder	x	x		x	x	x	x	x	x	x
Drug interaction		x
Dysphoria				x	x	x	x	x	x	x
Fatigability				x	x	x	x	x	x	x
Feeling guilty				x	x	x	x	x	x	x
Major depression			x								x	x	x	x	x	x	x
Major depressive disorder, single episode				x	x	x	x	x	x	x
Sexual dysfunction				x	x	x	x	x	x	x
Suicidal ideation				x	x	x	x	x	x	x

Side effects:	90
Source:	Health Canada

Side effects:	98
Source:	Health Canada

Side effects:	107
Source:	FDA Structured Product Label

Side effects:	73
Source:	FDA Structured Product Label

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Trazodone

Side effects

Indications

TRAZODONE HYDROCHLORIDE / TRAZOREL

TRAZODONE HYDROCHLORIDE / DESYREL TAB 50MG

Trazodone

TRAZODONE

TRAZODONE

TRAZODONE

TRAZODONE

trazodone

TRAZODONE

Trazodone

TRAZODONE

TRAZODONE

Trazodone

TRAZODONE

TRAZODONE

Trazodone

TRAZODONE

Color scheme:

		100%
		75%
		50%
		10%
		frequent (1% to 100%)
		infrequent (0.1% to 1%)
		rare (<0.1%)
		postmarketing
		0%
		no frequency information
		not found on label