Search results :

Retinoic acid

More information: STITCH, PubChem (stereo-specific compounds: 1, 2, 3) and possibly Wikipedia

ATC Codes: D10AD01, D10AD04, D10BA01, D11AX19, L01XX14, L01XX22

Side effects

Options: Show MedDRA Preferred Terms,   display all 37 labels

Side effect Data for drug Placebo Labels
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Body temperature increased 83% x
Bone pain 20-30% - 77% x
Mucosal dryness 77%
Shivering 63% x
Dyspnoea 60% x
Vomiting 51% - 57% x x
Dermatitis postmarketing — 3.8% - 55% x x x x x x
Oedema peripheral common, 52% x
Nasal congestion 24-65%
Serum creatinine increased 20-56%
Gastrointestinal haemorrhage 34% x
Chest discomfort 32%
Abdominal pain 31% x x
Disseminated intravascular coagulation 26%
Gastrointestinal disorder 26%
Respiratory insufficiency 26% x
Mucosal inflammation 26%
Arrhythmia 23% x
Diarrhoea postmarketing, 23% x x
Weight increased 23% - 32%
Ototoxicity 19-25%
Pleural effusion 20% x
Sweating increased 20%
Anorexia 17%
Anxiety postmarketing, 17% x x
Constipation 17% x x
Injection site reaction 17%
Blood bilirubin increased 16% x
Excoriation very common x x
Skin irritation very common, 3.8% - 6.4% x x x x x
Tenderness very common x
Skin exfoliation common — 1.44% - 50% x x x x x x
Skin tenderness very common x
Redness very common x x x x
Application site erythema very common x
Application site pruritus very common x
Application site stinging very common x
Dyspepsia 14%
Hypotension 14%
Pneumonia 14%
Rales 14%
Wheezing expiratory 14%
Retinoic acid syndrome postmarketing, 25% x
Abdominal distension 11%
Confusional state 11% x
Hypertension 11%
Phlebitis uncommon, 11% x
Eye irritation postmarketing, 11% x x
Renal impairment 11%
Dysuria 9%
Flank pain 9%
Hepatosplenomegaly 9%
Agitation 9%
Intracranial pressure increased postmarketing, 9% x x
Cerebral haemorrhage 9%
Cellulitis uncommon, 8% x
Embolism 8%
Skin burning sensation very common, 1.64% - 7.86% x x
Erythema very common, 0.205% - 41% x x x x x x x x x x x x x
Alopecia postmarketing, 13% - 14% x x x x x x
Hallucination 6%
Cardiac failure 6%
Pallor 6%
Pericarditis 6%
Lung infiltration 6%
Face oedema 6%
Fluid imbalance 6%
Inflammation common x x
Skin ulcer common x
Skin discolouration common x
Stinging common x x x x x x x
Tingling sensation common x x
Pain postmarketing — 0% - 37% x x x x x x x
Pruritus postmarketing — 0.616% - 30% x x x x x x x x x x x x x x x x
Dry skin postmarketing — 1.64% - 24-65% x x x x x x x x x x
Rash postmarketing — 1% - 54% x x x x x x x x x
Acidosis 3%
Ascites 3%
Dermatitis exfoliative common, 0% - 9% x x x
Oedema postmarketing — 0% - 29% x x x x x x x x x x x x
Body temperature decreased 3%
Renal failure acute 3%
Laryngeal oedema 3%
Liver disorder 3%
Lung disorder 3%
Osteitis 3%
Paraesthesia postmarketing — 0% - 22% x x x x x x x x x
Pulmonary oedema 3%
Scotoma 3%
Telangiectasia 3% x
Ulcer 3%
Pollakiuria 3%
Prostatomegaly 3%
Renal tubular necrosis 3%
Swelling postmarketing, common x x
Hyperaesthesia 2% x
Pain of skin very common, 0% - 1.04% x x
Rosacea 1% x
Skin disorder very common, 0% - 8% x x x
Papule 1% x
Acne postmarketing, 1% - 5% x
Bacterial infection uncommon x
Angiopathy uncommon x
Vesiculobullous rash uncommon x
Rash maculo-papular uncommon x
Aggression postmarketing x x
Agranulocytosis postmarketing x x x
Anaphylactic shock postmarketing
Anaemia postmarketing x x x x x
Arthralgia postmarketing, 20-30% x x x x
Arthritis postmarketing x x x x
Asthenia postmarketing x x x x
Asthma postmarketing, 3% x
Back pain postmarketing x x
Behavior disorder postmarketing x
Mental disorder postmarketing x x x x
Blepharitis postmarketing x x x x
Bronchospasm postmarketing x x x x x
Cardiovascular disorder postmarketing
Central nervous system disorder postmarketing x
Cheilitis postmarketing, 24-65% - 96% x x x x x
Colitis postmarketing x x x x x
Infection postmarketing — 58% x x x x
Conjunctivitis postmarketing, 19% x x x x x
Contusion postmarketing x x x x
Corneal opacity postmarketing x x x x x
Deafness postmarketing
Diabetes mellitus postmarketing
Dizziness postmarketing, 20% x x x x x
Drowsiness postmarketing x x x x
Eczema postmarketing x x x
Toxic epidermal necrolysis postmarketing x
Epistaxis postmarketing x x x x x
Erythema multiforme postmarketing x
Erythema nodosum postmarketing x x
Oesophagitis postmarketing x x
Fatigue postmarketing x x x x
Flushing postmarketing, 23% x x x x x
Gingivitis postmarketing x x x x
Glomerulonephritis postmarketing x x x x
Headache postmarketing, 29-90% - 86% x x x x x x
Partial hearing loss postmarketing x x
Haematuria postmarketing x x
Haemorrhage postmarketing — 60% x x x x x x
Hepatitis postmarketing, 3% x x x x
Herpes simplex postmarketing x x x x
Hirsutism postmarketing x x x x x
Hoarseness postmarketing x x
Hyperostosis postmarketing x x x x x
Hypersensitivity postmarketing, uncommon x x x x x x x x
Hypertriglyceridaemia postmarketing x x x x
Hypervitaminosis A postmarketing x x
Ileitis postmarketing x x x x
Inflammatory bowel disease postmarketing x x x x x
Keratitis postmarketing x x x x x
Lethargy postmarketing x x x x
Menstrual disorder postmarketing x x x x
Myositis postmarketing x
Nasopharyngitis postmarketing x
Nausea postmarketing x x x x x x
Nervousness postmarketing x x x x
Neutropenia postmarketing x x x x
Optic neuritis postmarketing x x x x
Palpitations postmarketing x x x x
Pancreatitis postmarketing x x x x x x
Papilloedema postmarketing
Paronychia postmarketing x x x x x
Pregnancy postmarketing x
Proteinuria postmarketing x x x x
Benign intracranial hypertension postmarketing x x x x x x
Psychotic disorder postmarketing x x x x
Renal failure postmarketing
Respiratory tract infection postmarketing x x x x
Rhabdomyolysis postmarketing x x
Seborrhoeic dermatitis postmarketing x x x
Convulsion postmarketing x x x x x
Stevens-Johnson syndrome postmarketing x
Cerebrovascular accident postmarketing x x x x
Suicide postmarketing x x x
Suicide attempt postmarketing x x x x
Sunburn postmarketing, 0.616% - 1.04% x x x x x
Sweating postmarketing x x x x x x
Syncope postmarketing x x x
Tachycardia postmarketing x x x x
Tendonitis postmarketing x x x x
Thrombocytopenia postmarketing x x x
Tinnitus postmarketing x x x
Urticaria postmarketing x x x x x x
Vasculitis postmarketing x x x x x
Disorder sight postmarketing x x x
Wegener's granulomatosis postmarketing x x x x
Weight decreased postmarketing, 17% x x x x
Dry mouth postmarketing, 1% x x x
Acute febrile neutrophilic dermatosis postmarketing x
Mood swings postmarketing x x x x
Photophobia postmarketing x x x x
Pyogenic granuloma postmarketing x x x x x
Cataract postmarketing x x x x x
Allergic cutaneous angiitis postmarketing x x
Skin atrophy postmarketing x
Epiphyses premature fusion postmarketing x x x x
Impaired healing postmarketing x x x
Phosphatase alkaline increased postmarketing x x
Oesophageal ulcer postmarketing x x
Sensory disturbance postmarketing
Abnormalities of the hair postmarketing x x x
Photosensitivity reaction postmarketing x x x x x x
Skin hyperpigmentation postmarketing, common x x x
Leukoderma postmarketing x x x x x x x x x
Unspecified disorder of skin and subcutaneous tissue postmarketing x x
Scab postmarketing, very common x x x x x
Eruptive xanthoma postmarketing x x x
Nail dystrophy postmarketing x x x x x
Contact lens intolerance postmarketing
Malaise postmarketing, 66% x x x x x
Myalgia postmarketing, 14% x x x
Nasal dryness postmarketing, 51% x x x x x
Application site oedema postmarketing
Dry throat postmarketing
Hepatotoxicity postmarketing x x x x
Depression aggravated postmarketing
Erythema facial postmarketing x x x x
Creatine phosphokinase serum increased postmarketing
Violent postmarketing x x x
Sepsis postmarketing x x
Acne fulminans postmarketing x x x x x
Excessive granulation tissue postmarketing x x x
Dry eye postmarketing x x x x
Vision blurred postmarketing x
Photosensitivity postmarketing
Suicidal ideation postmarketing x x x
Violent behavior postmarketing
Gastrointestinal symptom NOS postmarketing x x x x
Frank hematuria postmarketing x x x
Lymphadenopathy postmarketing — 10% x x x x x x
Localized exfoliation postmarketing — 1.44% - 11.6% x x x x x x x x x x x x
Application site rash postmarketing
Visual disturbance postmarketing, 17% x x x x x
Skin fragility postmarketing x x x x
Lip dry postmarketing x x x
Blood glucose increased postmarketing x x
Basophilia postmarketing x
Hyperuricaemia postmarketing x x x x x
Thrombocytosis postmarketing x
Alopecia reversible postmarketing x
Decreased night vision postmarketing x x x x x
Insomnia postmarketing, 14% x x x x x
Hearing impaired postmarketing x x x
Exostosis postmarketing
Visual impairment postmarketing x
Acquired immunodeficiency syndrome x x x
Pancreatitis acute x
Agnosia
Anger x
Aphasia
Asthenopia x
Blister x x
Clotting
Neoplasm malignant
Candida infection
Cerebellar syndrome
Neck pain x
Chest pain x
Coma
Cough
Cyanosis
Cystitis
Dysphagia
Dehydration
Depression x
Dermatitis contact x
Dry eye syndrome x
Duodenal ulcer
Dysarthria
Ear disorder
Ear pain
Eye disorder x
Facial paralysis
Fasciitis
Flatulence
Folliculitis x
Gastritis
Gout
Hair disorder x
Cardiac arrest
Cardiomegaly
Cardiac failure congestive
Cardiac murmur
Hemiplegia
Hordeolum x
Hypercalcaemia x
Hypercholesterolaemia
Hyperlipidaemia x
Pulmonary hypertension
Irritability x
Ischaemia
Leukocytosis
Miliaria x
Multi-organ failure
Musculoskeletal pain x
Myocardial infarction x
Myocarditis
Nail disorder
Nervous system disorder x
Numbness
Ochronosis x
Ophthalmoplegia
Pain in extremity x
Pericardial effusion
Neuropathy peripheral
Pharyngitis
Renal infarct x
Retinal haemorrhage
Cardiomyopathy secondary NOS
Septicemia
Shock
Sinusitis
Skin infection x
Spinal cord disorder
Stomatitis
Thrombosis x
Tremor
Loss of consciousness
Upper respiratory tract infection x
Urinary tract infection
Urinary tract disorder
Wheezing
Xeroderma
Xerophthalmia
Encephalopathy
Panic attack x
Genital ulceration x
Application site reaction x
CNS depression NOS
Creatine phosphokinase increased x
Red blood cell sedimentation rate increased x x
Lactic dehydrogenase activity increased x
Hyporeflexia
Decreased tolerance x
Lacrimation increased x
Skin striae x
Ocular hyperaemia x
Malnutrition
Allergic contact dermatitis x
Acneiform eruption x
Lightheadedness
Distress
Tachypnoea
Decreased appetite x
Asterixis
Teratogenicity x x
Hallucination, auditory x
Discomfort x
Visual acuity reduced x
Neurologic reaction
Euphoric mood x
Ear buzzing
Upset stomach
Buccal mucosa ulceration
Edema of lower extremities
Groin pain
Weight fluctuation x
Auditory disorder NOS x
Dermatitis perioral x
Ileitis regional x
Rectal haemorrhage x
Scrotal ulcer
Generalized aching
Lividity x
Cushingoid
Chapped lips x
Secondary infection x
Respiratory distress
Dementia
Eschar x
Forgetfulness
Fluid overload
Gait disturbance
Cutaneous hypersensitivity x
Blood cholesterol increased x
Drug interaction x
Hypoxemia
Febrile neutropenia
White blood cell count decreased x
Dry scalp
Infestation NOS x
Blood and lymphatic system disorders x
Blood alkaline phosphatase increased x
Blood triglycerides increased x
Local reaction x x x
Headache occurring
Musculoskeletal stiffness x
Musculoskeletal discomfort x
Cerebellar oedema
Sensitisation x
Post-traumatic pain
Slow speech
Somnolence
Unspecified visual loss

Indications

Information about indications was extracted from the indications and usage sections of the labels.

TRETINOIN / RETIN-A MICRO

Side effects:3
Source:Health Canada

tretinoin

Side effects:3
Source:FDA Structured Product Label

TRETINOIN / VITAMIN A ACID 0.01% GEL

Side effects:5
Source:Health Canada

Tretinoin

Side effects:7
Source:FDA Structured Product Label

Tretinoin

Side effects:8
Source:FDA Structured Product Label

TRETINOIN

Side effects:8
Source:FDA Structured Product Label

alitretinoin

Side effects:8
Source:FDA Structured Product Label

Tretinoin

Side effects:8
Source:FDA Structured Product Label

tretinoin

Side effects:8
Source:FDA Structured Product Label

Tretinoin

Side effects:9
Source:FDA Structured Product Label

Isotretinoin

Side effects:13
Source:medicines.org.au

ALITRETINOIN / PANRETIN

Side effects:20
Source:FDA

/ TRI-LUMA

Side effects:24
Source:FDA

alitretinoin / alitretinoin

Side effects:40
Source:EMA

ISOTRETINOIN / CLARUS

Side effects:101
Source:Health Canada

isotretinoin / Accutane

Side effects:102
Source:FDA

isotretinoin

Side effects:112
Source:FDA Structured Product Label

ISOTRETINOIN

Side effects:148
Source:FDA Structured Product Label

Color scheme:

standard – alternative

    100%
    75%
    50%
    10%
    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    postmarketing
    0%
    no frequency information
    not found on label