Oxybutynin
Side effects
Options:
Hide MedDRA Preferred Terms
,
display all 43 labels
MedDRA Preferred Term
|
Side effect
|
Data for drug
|
Placebo
|
Labels
|
|
1
|
2
|
3
|
4
|
5
|
6
|
7
|
8
|
9
|
10
|
11
|
12
|
13
|
14
|
15
|
16
|
17
|
18
|
19
|
20
|
Gastrointestinal disorder
|
Gastrointestinal disorder
|
postmarketing, 71.4%
|
|
|
|
|
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Constipation
|
Constipation
|
common, 0% - 15.1%
|
0%
|
|
x
|
x
|
|
|
|
x
|
|
|
x
|
x
|
|
|
|
|
|
|
x
|
|
|
Dry mouth
|
Dry mouth
|
common, 0.7% - 72.4%
|
1.7% - 8.3%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Headache
|
Headache
|
common, 1.5% - 8%
|
|
|
|
x
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Infection
|
Infection
|
6.5%
|
|
|
|
|
|
|
|
x
|
|
x
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Diarrhoea
|
Diarrhoea
|
common, 2.3% - 7.9%
|
2.3%
|
|
x
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Loose stools
|
1.4% - 3%
|
|
|
|
|
|
|
|
|
|
x
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Nervousness
|
Nervousness
|
1.5% - 6.5%
|
|
|
|
|
|
|
x
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Tension
|
Nervousness
|
1.5% - 6.5%
|
|
|
|
|
|
|
x
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Tension
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Urinary tract infection
|
Urinary tract infection
|
5.2% - 6.94%
|
4.25%
|
x
|
|
x
|
|
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Infestation
|
Infestation NOS
|
6.5%
|
|
|
|
|
|
|
|
x
|
|
x
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Application site erythema
|
Application site erythema
|
common, 1.7% - 10%
|
0.99% - 2.3%
|
x
|
x
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Somnolence
|
Somnolence
|
postmarketing — 5.6% - 14.1%
|
|
|
x
|
|
|
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Drowsiness
|
|
|
|
|
|
x
|
x
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Urinary hesitation
|
Urinary hesitation
|
1.9% - 8.5%
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
|
Dyspepsia
|
Dyspepsia
|
uncommon, 4.5% - 6%
|
|
|
|
|
|
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Nausea
|
Nausea
|
common, 1.9% - 11.6%
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Application site pruritus
|
Application site pruritus
|
2.1% - 16.8%
|
|
x
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Dizziness
|
Dizziness
|
postmarketing — 1.5% - 16.6%
|
1%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Syncope
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Application site reaction
|
Application site reaction
|
common
|
|
|
x
|
x
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Vision blurred
|
Vision blurred
|
common, 2.3% - 9.6%
|
|
x
|
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Insomnia
|
Insomnia
|
2.8% - 5.5%
|
|
|
|
|
x
|
x
|
x
|
|
x
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Nasal dryness
|
Nasal dryness
|
1.7% - 4.5%
|
|
|
|
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dry eye
|
Keratoconjunctivitis sicca
|
2.5% - 4.2%
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
x
|
|
|
|
x
|
x
|
|
Dry eye
|
2.5% - 3.1%
|
|
x
|
|
|
|
|
x
|
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
|
x
|
Application site rash
|
Application site rash
|
common, 0.9% - 4%
|
0.495% - 0.9%
|
x
|
x
|
x
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Oedema peripheral
|
Oedema peripheral
|
2.5% - 4%
|
|
|
|
|
|
|
x
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Application site vesicles
|
Application site vesicles
|
0% - 4%
|
0%
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Asthenia
|
Fatigue
|
2.06% - 3.1%
|
1%
|
|
|
x
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Asthenia
|
1.7% - 2.5%
|
|
|
|
|
x
|
x
|
x
|
|
x
|
x
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Fatigue
|
Fatigue
|
2.06% - 3.1%
|
1%
|
|
|
x
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Urinary retention
|
Urinary retention
|
uncommon, 1.2% - 6%
|
|
|
|
|
|
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Abdominal pain upper
|
Abdominal pain upper
|
3%
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
x
|
|
|
|
x
|
x
|
|
Residual urine volume
|
Residual urine volume
|
2.3% - 3.5%
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
Cough
|
Cough
|
1.9% - 3%
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cough increased
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Nasopharyngitis
|
Nasopharyngitis
|
1.5% - 2.83%
|
2.25%
|
x
|
|
x
|
|
|
|
|
|
x
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Upper respiratory tract infection
|
Upper respiratory tract infection
|
uncommon, 2.2% - 5.4%
|
5%
|
|
|
x
|
|
|
|
x
|
|
x
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dry skin
|
Dry skin
|
1.8% - 3%
|
|
|
|
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Macule
|
Macule
|
0% - 3%
|
0%
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Visual impairment
|
Abnormal vision
|
0% - 3%
|
0%
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Dry throat
|
Dry throat
|
1.6% - 2.5%
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Viral diarrhoea
|
Viral diarrhoea
|
2.06%
|
1.75%
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Abdominal pain
|
Abdominal pain
|
common, 1.5% - 2.5%
|
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Gastrointestinal pain
|
Abdominal pain
|
common, 1.5% - 2.5%
|
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Back pain
|
Back pain
|
uncommon, 2% - 2.4%
|
|
|
|
|
|
|
|
x
|
|
x
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Dysuria
|
Dysuria
|
uncommon, 0% - 3%
|
0%
|
|
x
|
|
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
|
x
|
Urination impaired
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Nasal congestion
|
Nasal congestion
|
2%
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
x
|
|
|
|
x
|
x
|
|
Sinus headache
|
Sinus headache
|
2%
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
x
|
|
|
|
x
|
x
|
|
Sinus congestion
|
Sinus congestion
|
2%
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
x
|
|
|
|
x
|
x
|
|
Flatulence
|
Flatulence
|
1.2% - 2.5%
|
|
|
|
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Arthralgia
|
Arthralgia
|
1.5% - 2%
|
|
|
|
|
|
|
|
|
|
x
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Musculoskeletal discomfort
|
Arthralgia
|
1.5% - 2%
|
|
|
|
|
|
|
|
|
|
x
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Confusional state
|
Confusional state
|
1% - 2.5%
|
|
|
|
|
|
|
x
|
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Feeling abnormal
|
Confusional state
|
1% - 2.5%
|
|
|
|
|
|
|
x
|
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Malaise
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Depression
|
Depression
|
1.7%
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
Sinusitis
|
Sinusitis
|
1.7%
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
|
x
|
Laryngeal pain
|
Pharyngolaryngeal pain
|
1.5% - 1.9%
|
|
|
|
|
|
|
|
|
|
x
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Oropharyngeal pain
|
Oropharyngeal pain
|
1.5% - 1.9%
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
x
|
|
|
|
|
|
|
|
Bronchitis
|
Bronchitis
|
1.2% - 2%
|
|
|
|
|
|
|
|
|
|
x
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dysphagia
|
Dysphagia
|
1.5%
|
|
|
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
|
|
|
x
|
x
|
x
|
Dysgeusia
|
Dysgeusia
|
1.1% - 1.6%
|
|
|
|
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Taste metallic
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Palpitations
|
Palpitations
|
uncommon, 1.5% - 4.5%
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Blood glucose increased
|
Blood glucose increased
|
1.5%
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
x
|
|
|
|
x
|
x
|
|
Vomiting
|
Vomiting
|
1.2% - 1.5%
|
|
|
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Chest pain
|
Chest pain
|
1.3%
|
|
|
|
|
|
x
|
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
|
x
|
Chest discomfort
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
x
|
|
|
|
|
|
|
|
Hypertension
|
Hypertension
|
1.3%
|
|
|
|
|
|
|
|
|
x
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
|
x
|
Pruritus
|
Pruritus
|
very common, 1.3% - 1.5%
|
|
x
|
|
x
|
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Blood pressure increased
|
Blood pressure increased
|
1% - 1.5%
|
|
|
|
|
|
|
|
|
|
x
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pain in extremity
|
Pain in extremity
|
1% - 1.3%
|
|
|
|
|
|
|
|
|
|
x
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Sinus arrhythmia
|
Sinus arrhythmia
|
1%
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
x
|
|
|
|
x
|
x
|
|
Asthma
|
Asthma
|
1%
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
x
|
|
|
|
x
|
x
|
|
Tongue coated
|
Tongue coated
|
1%
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
x
|
|
|
|
x
|
x
|
|
Cystitis
|
Cystitis
|
1%
|
|
|
|
|
|
|
|
|
|
x
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Bladder pain
|
Cystitis
|
1%
|
|
|
|
|
|
|
|
|
|
x
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Cystitis noninfective
|
Cystitis
|
1%
|
|
|
|
|
|
|
|
|
|
x
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Oedema
|
Oedema
|
1%
|
|
|
|
|
|
x
|
|
|
|
x
|
|
|
|
|
x
|
|
|
|
x
|
x
|
|
Eructation
|
Eructation
|
1%
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
x
|
|
|
|
x
|
x
|
x
|
Flank pain
|
Flank pain
|
1%
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
x
|
|
|
|
x
|
x
|
|
Gastrooesophageal reflux disease
|
Gastrooesophageal reflux disease
|
0.5% - 1.6%
|
|
|
|
|
|
|
|
|
x
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
|
|
Dysphonia
|
Hoarseness
|
1%
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
x
|
|
|
|
x
|
x
|
|
Dysphonia
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
x
|
|
|
|
|
|
|
|
Hypotension
|
Hypotension
|
1%
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
x
|
|
|
|
x
|
x
|
|
Fungal infection
|
Fungal infection
|
uncommon, 1%
|
|
|
|
|
|
|
|
x
|
|
x
|
|
|
|
|
x
|
|
|
|
x
|
x
|
|
Pain
|
Pain
|
1%
|
|
|
|
|
|
|
|
|
|
x
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Thirst
|
Thirst
|
1%
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
|
x
|
x
|
|
|
|
x
|
x
|
x
|
Pollakiuria
|
Pollakiuria
|
1%
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
Micturition urgency
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Eye irritation
|
Eye irritation
|
1%
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
x
|
|
|
|
x
|
x
|
|
Fluid retention
|
Fluid retention
|
1%
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
|
x
|
x
|
|
|
|
x
|
x
|
|
Generalised oedema
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Rhinitis
|
Rhinitis
|
uncommon
|
|
|
|
|
|
|
|
x
|
|
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
|
x
|
Abdominal discomfort
|
Abdominal discomfort
|
uncommon
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
Injury
|
Inflicted injury
|
uncommon
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Accidental injury
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Menopausal symptoms
|
Hot flush
|
uncommon
|
|
|
|
|
|
|
|
x
|
|
|
x
|
x
|
|
x
|
|
|
|
|
|
|
|
Hot flush
|
Hot flush
|
uncommon
|
|
|
|
|
|
|
|
x
|
|
|
x
|
x
|
|
x
|
|
|
|
|
|
|
|
Obstructive airways disorder
|
Airway obstruction NOS
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
x
|
|
x
|
x
|
x
|
|
x
|
|
Anaphylactic shock
|
Anaphylactic shock
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
x
|
|
x
|
x
|
x
|
|
x
|
|
Angioedema
|
Angioedema
|
postmarketing
|
|
|
|
|
|
|
|
|
x
|
|
x
|
x
|
|
x
|
|
x
|
x
|
x
|
|
x
|
|
Arrhythmia
|
Arrhythmia
|
postmarketing
|
|
|
|
|
|
|
|
|
x
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
|
|
Mental disorder
|
Mental disorder
|
postmarketing, 5.5%
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Breast disorder
|
Breast disorder
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
x
|
|
Dermatitis
|
Rash
|
postmarketing
|
|
|
|
|
x
|
|
x
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Dermatitis
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Rash
|
Rash
|
postmarketing
|
|
|
|
|
x
|
|
x
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Eye disorder
|
Eye disorder
|
postmarketing, 9.6%
|
|
|
|
|
|
|
|
x
|
|
x
|
x
|
x
|
|
x
|
x
|
|
|
x
|
x
|
x
|
|
Flushing
|
Flushing
|
postmarketing, 1%
|
|
|
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Glaucoma
|
Glaucoma
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
x
|
|
|
|
x
|
|
|
|
Hallucination
|
Hallucination
|
postmarketing
|
|
|
|
|
x
|
|
x
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cardiac disorder
|
Cardiac disorder
|
postmarketing
|
|
|
|
|
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypersensitivity
|
Hypersensitivity
|
postmarketing
|
|
|
|
|
|
x
|
|
|
|
|
x
|
x
|
|
x
|
|
x
|
x
|
x
|
|
x
|
x
|
Mydriasis
|
Mydriasis
|
postmarketing
|
|
|
|
|
x
|
x
|
x
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
x
|
x
|
Nervous system disorder
|
Nervous system disorder
|
postmarketing, 16.6%
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Psychotic disorder
|
Psychotic disorder
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Paranoia
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
Convulsion
|
Convulsion
|
postmarketing
|
|
|
|
|
|
|
x
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Tachycardia
|
Tachycardia
|
postmarketing
|
|
|
|
|
x
|
x
|
x
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Urethral disorder
|
Urinary tract disorder
|
postmarketing, 8.5%
|
|
|
|
|
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Urinary tract disorder
|
Urinary tract disorder
|
postmarketing, 8.5%
|
|
|
|
|
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Urticaria
|
Urticaria
|
postmarketing, uncommon
|
|
|
|
x
|
|
x
|
|
x
|
x
|
|
x
|
x
|
|
x
|
|
|
x
|
x
|
|
x
|
x
|
Angiopathy
|
Angiopathy
|
postmarketing
|
|
|
|
|
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Agitation
|
Agitation
|
postmarketing
|
|
|
|
|
x
|
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hyperkinesia
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Skin disorder
|
Unspecified disorder of skin and subcutaneous tissue
|
postmarketing
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Memory impairment
|
Memory impairment
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
x
|
|
x
|
|
x
|
|
x
|
|
Accommodation disorder
|
Cycloplegia
|
postmarketing
|
|
|
|
|
x
|
x
|
x
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
x
|
|
Cycloplegia
|
Cycloplegia
|
postmarketing
|
|
|
|
|
x
|
x
|
x
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
x
|
|
Erectile dysfunction
|
Erectile dysfunction
|
postmarketing
|
|
|
|
|
x
|
x
|
x
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Face oedema
|
Face oedema
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
x
|
|
x
|
x
|
x
|
|
x
|
x
|
Hypohidrosis
|
Sweating decreased
|
postmarketing
|
|
|
|
|
x
|
x
|
x
|
|
x
|
|
|
|
|
|
x
|
|
|
|
|
x
|
x
|
Amblyopia
|
Amblyopia
|
|
|
|
|
|
x
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Amnesia
|
Amnesia
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Decreased appetite
|
Anorexia
|
|
|
|
|
|
|
x
|
|
|
x
|
|
x
|
x
|
|
x
|
|
|
|
|
|
|
x
|
Anxiety
|
Anxiety
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Arthritis
|
Arthritis
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Cognitive disorder
|
Cognitive disorder
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
Colitis
|
Colitis
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Conjunctivitis
|
Conjunctivitis
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Connective tissue disorder
|
Connective tissue disorder
|
|
|
|
|
|
|
|
|
x
|
|
x
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Libido decreased
|
Libido decreased
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Disturbance in sexual arousal
|
Libido decreased
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Depersonalisation
|
Depersonalisation
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Epistaxis
|
Epistaxis
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Oesophagitis
|
Oesophagitis
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Angle closure glaucoma
|
Angle closure glaucoma
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
Glossitis
|
Glossitis
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Hair disorder
|
Hair disorder
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Breath odour
|
Breath odour
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Heat stroke
|
Heat stroke
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
Haematuria
|
Haematuria
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Hiccups
|
Hiccups
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Hypoaesthesia
|
Hypoaesthesia
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Influenza
|
Influenza
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Iritis
|
Iritis
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Arthropathy
|
Arthropathy
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Osteoarthritis
|
Arthropathy
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Lung disorder
|
Lung disorder
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Mediastinal disorder
|
Mediastinal disorder
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Melaena
|
Melaena
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Hypertonia
|
Hypertonia
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Nail disorder
|
Nail disorder
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Nightmare
|
Nightmare
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
Nocturia
|
Nocturia
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Paraesthesia
|
Paraesthesia
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Pharyngitis
|
Pharyngitis
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Salivary hypersecretion
|
Salivary hypersecretion
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Stomatitis
|
Stomatitis
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Mouth ulceration
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Shock
|
Syncope
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Syncope
|
Syncope
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Loss of consciousness
|
Syncope
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Tenosynovitis
|
Tenosynovitis
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Tinnitus
|
Tinnitus
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Tongue disorder
|
Tongue disorder
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Erythema
|
Erythema
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Urethritis
|
Urethritis
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Urethritis noninfective
|
Urethritis
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Vasodilation procedure
|
Vasodilation
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
Micturition urgency
|
Micturition urgency
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Mood swings
|
Mood swings
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Affect lability
|
Mood swings
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Depressive symptom
|
Depressive symptom
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
Mouth ulceration
|
Mouth ulceration
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Migraine
|
Migraine
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Blood creatinine increased
|
Creatinine increased
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Tongue discolouration
|
Tongue discolouration
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Generalised oedema
|
Generalised oedema
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Liver function test abnormal
|
Liver function test abnormal
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Drug ineffective
|
Lack of drug effect
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Eye pain
|
Eye pain
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Urethral pain
|
Urethral pain
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Paraesthesia oral
|
Circumoral paresthesia
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Rash pustular
|
Vesiculobullous rash
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Dermatitis bullous
|
Vesiculobullous rash
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Skin discolouration
|
Skin discolouration
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Malnutrition
|
Malnutrition
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
|
x
|
x
|
|
|
|
x
|
x
|
|
Malaise
|
Malaise
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Discomfort
|
Malaise
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Ill-defined disorder
|
Malaise
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Increased appetite
|
Increased appetite
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Thinking abnormal
|
Thinking abnormal
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Mental disability
|
Thinking abnormal
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Chest discomfort
|
Chest discomfort
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
x
|
|
|
|
|
|
|
|
Lacrimation decreased
|
Lacrimation decreased
|
|
|
|
|
|
x
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
Frequent bowel movements
|
Frequent bowel movements
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
x
|
|
|
|
|
|
|
|
Abdominal distension
|
Enlargement abdomen
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Bloated feeling
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Akathisia
|
Akathisia
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Hyperkinesia
|
Hyperkinesia
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Dermatitis atopic
|
Cutaneous hypersensitivity
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Sleep disorder
|
Sleep disorder
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Application site pain
|
Application site burn
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Application site burn
|
Application site burn
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Hypertonic bladder
|
Detrusor instability
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Increased upper airway secretion
|
Increased upper airway secretion
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Paranoia
|
Paranoia
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
Ageusia
|
Ageusia
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Indications
Information about indications was extracted from the indications and usage sections of the labels.
Side effects: | 10 |
Source: | FDA Structured Product Label |
---|
Side effects: | 14 |
Source: | FDA Structured Product Label |
---|
Side effects: | 16 |
Source: | FDA Structured Product Label |
---|
Side effects: | 17 |
Source: | FDA Structured Product Label |
---|
Side effects: | 28 |
Source: | Health Canada |
---|
Side effects: | 32 |
Source: | FDA |
---|
Side effects: | 35 |
Source: | EMA |
---|
Side effects: | 41 |
Source: | medicines.org.au |
---|
Side effects: | 60 |
Source: | FDA Structured Product Label |
---|
Side effects: | 65 |
Source: | FDA Structured Product Label |
---|
Side effects: | 65 |
Source: | FDA Structured Product Label |
---|
Side effects: | 67 |
Source: | FDA Structured Product Label |
---|
Side effects: | 69 |
Source: | FDA Structured Product Label |
---|
Side effects: | 71 |
Source: | FDA Structured Product Label |
---|
Side effects: | 73 |
Source: | FDA Structured Product Label |
---|
Side effects: | 73 |
Source: | FDA Structured Product Label |
---|
Side effects: | 76 |
Source: | FDA Structured Product Label |
---|
Side effects: | 89 |
Source: | Health Canada |
---|
Side effects: | 89 |
Source: | FDA Structured Product Label |
---|
Side effects: | 100 |
Source: | Health Canada |
---|
Color scheme:
standard – alternative
|
|
100%
|
|
|
75%
|
|
|
50%
|
|
|
10%
|
|
|
frequent (1% to 100%)
|
|
|
infrequent (0.1% to 1%)
|
|
|
rare (<0.1%)
|
|
|
postmarketing
|
|
|
0%
|
|
|
no frequency information
|
|
|
not found on label
|