| MedDRA Preferred Term | Side effect | Data for drug | Placebo | Labels | 
|  | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 
| Cough | Cough | 46% - 57% | 46% |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Cough increased | 6% - 10% |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Oedema peripheral | Oedema peripheral | 8% - 62% | 9% - 62% |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Stomatitis | Mouth ulceration | 23% | 23% |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Mouth ulceration | Mouth ulceration | 23% | 23% |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Chest pain | Chest pain | 21% |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Oedema | Oedema | 4% - 54% | 5% - 54% |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Sleep disorder | Sleep disorder | 15% - 21% | 15% |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Infection | Infection | 2% - 16% | 1% |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Headache | Headache | postmarketing — 2% - 62% | 3% - 62% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Hypertension | Hypertension | postmarketing, 11% - 38% | 8% - 38% | x | x | x | x | x | x | x | x | x |  |  | x | x | x | 
| Myalgia | Myalgia | 0.5% - 57% | 2.5% - 46% |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Musculoskeletal discomfort | Myalgia | 0.5% - 57% | 2.5% - 46% |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Arthralgia | 0% - 6% | 0% - 6% | x | x | x | x | x | x | x | x | x |  |  | x | x | x | 
| Body temperature increased | Body temperature increased | 1.4% - 11% | 11% |  |  |  |  |  | x |  |  |  |  |  | x | x | x | 
| Nausea | Nausea | postmarketing — 1% - 23% | 2% - 23% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Sinusitis | Sinusitis | 7% |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Bronchitis | Bronchitis | 3% - 7% |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Anorectal disorder | Rectal disorder | 4% - 5% |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Hallucination | Hallucination | postmarketing — 8% | 1% |  |  |  |  |  |  | x | x | x | x | x | x | x | x | 
| Diarrhoea | Diarrhoea | postmarketing — 1% - 23% | 0% - 23% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Injury | Accidental injury | 3% - 5% |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Dysmenorrhoea | Dysmenorrhoea | 1% - 8% | 1% - 4% | x | x | x | x | x | x |  |  |  |  |  |  |  | x | 
| Somnolence | Somnolence | 0.9% - 23% | 23% |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Abdominal pain | Abdominal pain | 1% - 12% | 0% - 11% | x | x | x | x | x | x | x | x | x |  |  | x | x | x | 
| Gastrointestinal pain | Abdominal pain | 1% - 12% | 0% - 11% | x | x | x | x | x | x | x | x | x |  |  | x | x | x | 
| Decreased appetite | Anorexia | 0.5% - 3% | 2% |  |  |  |  |  |  | x | x | x |  |  | x | x | x | 
| Asthenia | Asthenia | 0% - 43% | 1% - 15% |  |  |  |  |  |  | x | x | x |  |  | x | x | x | 
| Fatigue |  |  |  | x | x | x | x | x |  |  |  |  |  |  |  |  | 
| Dehydration | Dehydration | 2% |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  | 
| Dizziness | Dizziness | postmarketing — 1% - 31% | 0% - 31% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Herpes simplex | Herpes simplex | 2% |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  | 
| Pharyngitis | Pharyngitis | 1% - 13% | 1% |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Rhinitis | Rhinitis | 1.3% - 14% | 1.5% - 2% |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Tooth disorder | Tooth disorder | 1% - 3% |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Vomiting | Vomiting | postmarketing — 1% - 8% | 0% - 7% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Insomnia | Insomnia | 0% - 21% | 0% - 15% |  |  |  |  |  |  | x | x | x |  |  | x | x | x | 
| Nasopharyngitis | Rhinorrhoea | 2% |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  | 
| Nasopharyngitis |  |  |  | x | x | x | x | x |  |  |  |  |  |  |  |  | 
| Rhinorrhoea | Rhinorrhoea | 2% |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  | 
| Pain | Pain | 1% - 43% | 1% - 31% |  |  |  |  |  |  | x | x | x |  |  | x | x | x | 
| Constipation | Constipation | 1% - 21% | 0% - 15% |  |  |  |  |  |  | x | x | x |  |  | x | x | x | 
| Chills | Chills | 1% - 1.6% |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Back pain | Back pain | 0.5% - 29% | 2% - 15% |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Depression | Depression | 0% - 21% | 0% - 15% | x |  |  |  |  |  | x | x | x |  |  | x | x | x | 
| Dyspepsia | Dyspepsia | 0% - 4% | 0% - 2% |  |  |  |  |  |  | x | x | x |  |  | x | x | x | 
| Flatulence | Flatulence | 0% - 1.8% | 0% |  |  |  |  |  |  | x | x | x |  |  | x | x | x | 
| Anaemia | Anaemia | 0% - 12% | 0% - 12% | x |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Leukopenia | Leukopenia | very rare — 0.6% - 8% | 0.2% - 8% | x |  |  |  |  |  | x | x | x | x | x | x | x | x | 
| Dyspnoea | Dyspnoea | postmarketing — 7% - 38% | 5% - 38% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Dermatitis | Rash | postmarketing — 1% - 14% | 0% - 1% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Rash | Rash | postmarketing — 1% - 14% | 0% - 1% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Arthralgia | Arthralgia | 0% - 6% | 0% - 6% | x | x | x | x | x | x | x | x | x |  |  | x | x | x | 
| Eczema | Eczema | 0% - 1% | 0% - 1% |  |  |  |  |  |  | x | x | x |  |  |  |  |  | 
| Influenza | Influenza | 0% - 7% | 0% - 1% |  |  |  |  |  |  | x | x | x |  |  |  |  | x | 
| Nervousness | Nervousness | 0% - 1% |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Tension | Nervousness | 0% - 1% |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Paraesthesia | Paraesthesia | 0% - 1% | 0% - 1% |  |  |  |  |  |  | x | x | x |  |  |  |  |  | 
| Pruritus | Pruritus | postmarketing — 0% - 5% | 0% - 2% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Dry mouth | Dry mouth | 0% - 3% | 0% - 1% |  |  |  |  |  |  | x | x | x |  |  | x | x | x | 
| Migraine | Migraine | 1% | 1% |  |  |  |  |  |  | x | x | x |  |  |  |  | x | 
| Acne | Acne | 1% | 0% |  |  |  |  |  |  | x | x | x |  |  |  |  | x | 
| Aggression | Aggression | postmarketing |  | x | x | x | x | x | x | x | x | x |  |  |  |  |  | 
| Alopecia | Alopecia | postmarketing |  |  | x | x | x | x | x |  |  |  |  |  |  |  |  | 
| Anaphylactic shock | Anaphylactic shock | very rare — rare |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Aplastic anaemia | Aplastic anaemia | postmarketing |  | x | x | x | x | x | x | x | x | x |  |  |  |  |  | 
| Angioedema | Angioedema | very rare, postmarketing |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Ataxia | Ataxia | very rare, postmarketing |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Coma | Coma | very rare, postmarketing |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Confusional state | Confusional state | postmarketing — 7% | 2% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Feeling abnormal | Confusional state | postmarketing — 7% | 2% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Dysarthria | Dysarthria | very rare, postmarketing |  |  | x | x | x | x | x | x | x | x | x | x | x | x |  | 
| Osteoarthritis | Dysarthria | very rare, postmarketing |  |  | x | x | x | x | x | x | x | x | x | x | x | x |  | 
| Erythema multiforme | Erythema multiforme | postmarketing |  | x | x | x | x | x | x | x | x | x |  |  |  |  |  | 
| Haemolytic uraemic syndrome | Haemolytic uraemic syndrome | postmarketing |  |  | x | x | x | x | x | x | x | x |  |  |  |  |  | 
| Hepatitis | Hepatitis | very rare — rare |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Hypersensitivity | Hypersensitivity | postmarketing |  | x | x | x | x | x | x | x | x | x |  |  | x |  | x | 
| Immune system disorder | Immune system disorder | postmarketing |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Mediastinal disorder | Mediastinal disorder | postmarketing |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Nervous system disorder | Nervous system disorder | postmarketing |  |  |  |  |  |  |  |  |  |  | x | x |  | x |  | 
| Psychotic disorder | Psychotic disorder | very rare, postmarketing |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Thrombotic thrombocytopenic purpura | Thrombotic thrombocytopenic purpura | postmarketing |  |  | x | x | x | x | x | x | x | x |  |  |  |  |  | 
| Renal failure | Renal failure | very rare, postmarketing |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Renal impairment | postmarketing, rare |  |  |  |  |  |  |  |  |  | x | x | x | x | x |  | 
| Convulsion | Convulsion | very rare, postmarketing |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Tachycardia | Tachycardia | postmarketing |  | x | x | x | x | x | x | x | x | x |  |  |  |  |  | 
| Thrombocytopenia | Thrombocytopenia | very rare — 0.1% - 5% | 0.7% - 5% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Tremor | Tremor | very rare — 4% | 6% |  | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Urticaria | Urticaria | very rare, postmarketing |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Immunodeficiency | Immunocompromised | very rare, postmarketing |  |  |  |  |  |  |  |  |  | x | x | x | x | x |  | 
| Encephalopathy | Encephalopathy | very rare, postmarketing |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Agitation | Agitation | very rare, postmarketing |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Skin disorder | Unspecified disorder of skin and subcutaneous tissue | postmarketing |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Microangiopathic haemolytic anaemia | Microangiopathic haemolytic anaemia | postmarketing |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | 
| Abdominal discomfort | Abdominal discomfort | postmarketing, rare |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | 
| Neurological symptom | Neurologic reaction | postmarketing |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | 
| Blood creatinine increased | Blood creatinine increased | postmarketing |  |  |  |  |  |  |  | x | x | x |  |  |  |  |  | 
| Creatinine increased |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Hepatobiliary disease | Hepatobiliary disease | postmarketing |  |  |  |  |  |  |  |  |  |  | x | x |  | x |  | 
| Mania | Mania | postmarketing |  | x | x | x | x | x | x |  |  |  |  |  |  |  |  | 
| Photosensitivity reaction | Photosensitivity | postmarketing, uncommon |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Menorrhagia | Prolonged menses | postmarketing |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | 
| Face oedema | Face oedema | postmarketing |  | x | x | x | x | x | x | x | x | x |  |  |  |  |  | 
| Altered state of consciousness | Depressed level of consciousness | postmarketing, rare |  | x |  | x | x | x | x | x | x | x | x | x | x | x | x | 
| Depressed level of consciousness | Depressed level of consciousness | postmarketing, rare |  | x |  | x | x | x | x | x | x | x | x | x | x | x | x | 
| Renal pain | Renal pain | very rare, postmarketing |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Hallucinations, mixed | Auditory and visual hallucinations | postmarketing |  | x | x | x | x | x | x |  |  |  |  |  |  |  |  | 
| Renal impairment | Renal impairment | postmarketing, rare |  |  |  |  |  |  |  |  |  | x | x | x | x | x |  | 
| Leukocytoclastic vasculitis | Leukocytoclastic vasculitis | postmarketing |  |  | x | x | x | x | x | x | x | x |  |  |  |  |  | 
| Urethral disorder | Urinary tract disorder | very rare, postmarketing |  |  |  |  |  |  |  |  |  |  | x | x |  | x |  | 
| Urinary tract disorder | Urinary tract disorder | very rare, postmarketing |  |  |  |  |  |  |  |  |  |  | x | x |  | x |  | 
| Liver function test abnormal | Raised liver function tests | very rare — rare |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Thrombotic microangiopathy | Thrombotic microangiopathy | very rare, postmarketing |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Renal failure acute | Renal failure acute | very rare, postmarketing |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Cytomegalovirus infection | Cytomegalovirus infection |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Fatigue | Fatigue |  |  |  | x | x | x | x | x |  |  |  |  |  |  |  |  | 
| Gastrointestinal disorder | Gastrointestinal disorder |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  |  | 
| Haematuria | Haematuria |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  | 
| Upper respiratory tract infection | Upper respiratory tract infection |  |  |  | x | x | x | x | x |  |  |  |  |  |  |  |  | 
| Urinary tract infection | Urinary tract infection |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Blood alkaline phosphatase increased | Phosphatase alkaline increased |  |  |  | x | x | x | x | x |  |  |  |  |  |  |  |  | 
| Aspartate aminotransferase increased | Aspartate aminotransferase increased |  |  |  | x | x | x | x | x |  |  |  |  |  |  |  |  | 
| Alanine aminotransferase increased | Alanine aminotransferase increased |  |  |  | x | x | x | x | x |  |  |  |  |  |  |  |  | 
| Platelet count decreased | Platelet count decreased |  |  |  | x | x | x | x | x |  |  |  |  |  |  |  |  |